| MeSH term | MeSH ID | Detail |
|---|---|---|
| Nephrosis, Lipoid | D009402 | 2 associated lipids |
| Vascular System Injuries | D057772 | 2 associated lipids |
| Thromboangiitis Obliterans | D013919 | 4 associated lipids |
| Bird Diseases | D001715 | 4 associated lipids |
| Cerebral Infarction | D002544 | 6 associated lipids |
| Peripheral Arterial Disease | D058729 | 7 associated lipids |
| Carotid Artery Injuries | D020212 | 8 associated lipids |
| Obesity, Morbid | D009767 | 8 associated lipids |
| Liver Diseases, Alcoholic | D008108 | 13 associated lipids |
| Vasculitis | D014657 | 14 associated lipids |
lauric acid
lauric acid is a lipid of Fatty Acyls (FA) class. Lauric acid is associated with abnormalities such as Infection, Renal tubular disorder, Hypertensive disease, Obesity and Mycoses. The involved functions are known as Transcription, Genetic, Signal Transduction, Mutation, metaplastic cell transformation and Anabolism. Lauric acid often locates in Skin, Plasma membrane, Cytoplasmic matrix, Body tissue and Palmar surface. The associated genes with lauric acid are Gene Family, SLC33A1 gene, Homologous Gene, Open Reading Frames and P4HTM gene. The related lipids are Fatty Acids, Oleic Acids, Palmitates, Stearates and 9,11-linoleic acid.
Cross Reference
Introduction
To understand associated biological information of lauric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with lauric acid?
lauric acid is suspected in Renal tubular disorder, Hypertensive disease, Infection, Renal vascular disorder, Obesity, Mycoses and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with lauric acid
PubChem Associated disorders and diseases
What pathways are associated with lauric acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with lauric acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with lauric acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with lauric acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with lauric acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with lauric acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with lauric acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lo KW et al. | Effects of fatty acids on growth and poly-3-hydroxybutyrate production in bacteria. | 2005 | Appl. Biochem. Biotechnol. | pmid:15920264 |
| Takenaka S et al. | Adaptation of Pseudomonas sp. strain 7-6 to quaternary ammonium compounds and their degradation via dual pathways. | 2007 | Appl. Environ. Microbiol. | pmid:17261523 |
| Schallmey A et al. | Characterization of cytochrome P450 monooxygenase CYP154H1 from the thermophilic soil bacterium Thermobifida fusca. | 2011 | Appl. Microbiol. Biotechnol. | pmid:21057946 |
| Beyer N et al. | P450 fused to phosphite dehydrogenase allows phosphite-driven selective oxidations. | 2017 | Appl. Microbiol. Biotechnol. | pmid:27900443 |
| Ren Q et al. | Enatiomerically pure hydroxycarboxylic acids: current approaches and future perspectives. | 2010 | Appl. Microbiol. Biotechnol. | pmid:20393709 |
| Hama S et al. | Transesterification of phosphatidylcholine in sn-1 position through direct use of lipase-producing Rhizopus oryzae cells as whole-cell biocatalyst. | 2011 | Appl. Microbiol. Biotechnol. | pmid:21468705 |
| Lu XY et al. | Production of poly(3-hydroxybutyrate- co-3-hydroxyhexanoate) with flexible 3-hydroxyhexanoate content in Aeromonas hydrophila CGMCC 0911. | 2004 | Appl. Microbiol. Biotechnol. | pmid:12920488 |
| Chung A et al. | Microbial production of 3-hydroxydodecanoic acid by pha operon and fadBA knockout mutant of Pseudomonas putida KT2442 harboring tesB gene. | 2009 | Appl. Microbiol. Biotechnol. | pmid:19271216 |
| Chen GQ et al. | Industrial scale production of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate). | 2001 | Appl. Microbiol. Biotechnol. | pmid:11693933 |
| Kojima K et al. | A simple method for isolation and construction of markerless cyanobacterial mutants defective in acyl-acyl carrier protein synthetase. | 2016 | Appl. Microbiol. Biotechnol. | pmid:27704180 |
| Sato S et al. | Expression and characterization of (R)-specific enoyl coenzyme A hydratases making a channeling route to polyhydroxyalkanoate biosynthesis in Pseudomonas putida. | 2011 | Appl. Microbiol. Biotechnol. | pmid:21327961 |
| Di Bello D et al. | Presence and inducibility by beta-naphthoflavone of CYP1A1, CYP1B1 and phase II enzymes in Trematomus bernacchii, an Antarctic fish. | 2007 | Aquat. Toxicol. | pmid:17643506 |
| Nabb DL et al. | Comparison of basal level metabolic enzyme activities of freshly isolated hepatocytes from rainbow trout (Oncorhynchus mykiss) and rat. | 2006 | Aquat. Toxicol. | pmid:16935359 |
| Thibaut R et al. | Regio-specific hydroxylation of nonylphenol and the involvement of CYP2K- and CYP2M-like iso-enzymes in Atlantic salmon (Salmo salar). | 2002 | Aquat. Toxicol. | pmid:11792434 |
| Dohme F et al. | Digestive and metabolic utilization of lauric, myristic and stearic acid in cows, and associated effects on milk fat quality. | 2004 | Arch Anim Nutr | pmid:15195905 |
| Geiger F et al. | Trochanteric fractures in the elderly: the influence of primary hip arthroplasty on 1-year mortality. | 2007 | Arch Orthop Trauma Surg | pmid:17899138 |
| Berschauer F et al. | [Nutritive physiological effect of dietary fats in growing swine rations. 3. Effect of sunflower and coconut kernels on protein and fat retention, backfat fatty acid pattern and various blood parameters in piglets]. | 1983 | Arch Tierernahr | pmid:6370196 |
| Helali E and Hashem H | [Qualitative and quantitative studies on the metabolism of fatty acids, in particular on that of linoleic acid in calves]. | 1975 | Arch Tierernahr | pmid:1233966 |
| Honoré B et al. | Cobinding of bilirubin and laurate to human serum albumin: spectroscopic characterization of stoichiometric complexes. | 1988 | Arch. Biochem. Biophys. | pmid:3178221 |
| Kolattukudy PE and Rogers L | Biosynthesis of 3-hydroxy fatty acids, the pheromone components of female mallard ducks, by cell-free preparations from the uropygial gland. | 1987 | Arch. Biochem. Biophys. | pmid:3813530 |
| Shet Ms et al. | The omega-hydroxlyation of lauric acid: oxidation of 12-hydroxlauric acid to dodecanedioic acid by a purified recombinant fusion protein containing P450 4A1 and NADPH-P450 reductase. | 1996 | Arch. Biochem. Biophys. | pmid:8651697 |
| Brodersen R et al. | Cobinding of bilirubin and sulfonamide and of two bilirubin molecules to human serum albumin: a site model. | 1987 | Arch. Biochem. Biophys. | pmid:3813550 |
| Lewis DF | Essential requirements for substrate binding affinity and selectivity toward human CYP2 family enzymes. | 2003 | Arch. Biochem. Biophys. | pmid:12464242 |
| Puchkaev AV et al. | Aromatic stacking as a determinant of the thermal stability of CYP119 from Sulfolobus solfataricus. | 2003 | Arch. Biochem. Biophys. | pmid:12464244 |
| Rock DA et al. | A method for determining two substrates binding in the same active site of cytochrome P450BM3: an explanation of high energy omega product formation. | 2003 | Arch. Biochem. Biophys. | pmid:12859976 |
| Cheesman MJ et al. | Rabbit CYP4B1 engineered for high-level expression in Escherichia coli: ligand stabilization and processing of the N-terminus and heme prosthetic group. | 2003 | Arch. Biochem. Biophys. | pmid:12859977 |
| Hoch U et al. | Structural determination of the substrate specificities and regioselectivities of the rat and human fatty acid omega-hydroxylases. | 2000 | Arch. Biochem. Biophys. | pmid:10620324 |
| Williams DE et al. | Regiospecific hydroxylation of lauric acid at the (omega-1) position by hepatic and kidney microsomal cytochromes P-450 from rainbow trout. | 1984 | Arch. Biochem. Biophys. | pmid:6732245 |
| Salaün JP et al. | Differential inactivation of plant lauric acid omega- and in-chain-hydroxylases by terminally unsaturated fatty acids. | 1988 | Arch. Biochem. Biophys. | pmid:3341756 |
| Salaun JP et al. | Autocatalytic inactivation of plant cytochrome P-450 enzymes: selective inactivation of the lauric acid in-chain hydroxylase from Helianthus tuberosus L. by unsaturated substrate analogs. | 1984 | Arch. Biochem. Biophys. | pmid:6742847 |
| Finlayson MJ et al. | Differential expression of cytochrome P-450 1 and related forms in rabbit liver and kidney. | 1987 | Arch. Biochem. Biophys. | pmid:3492962 |
| Kahn RA et al. | A conservative amino acid substitution alters the regiospecificity of CYP94A2, a fatty acid hydroxylase from the plant Vicia sativa. | 2001 | Arch. Biochem. Biophys. | pmid:11437349 |
| Loughran PA et al. | The kinetic and spectral characterization of the E. coli-expressed mammalian CYP4A7: cytochrome b5 effects vary with substrate. | 2001 | Arch. Biochem. Biophys. | pmid:11368012 |
| Kawashima H et al. | Human fatty acid omega-hydroxylase, CYP4A11: determination of complete genomic sequence and characterization of purified recombinant protein. | 2000 | Arch. Biochem. Biophys. | pmid:10860550 |
| Capdevila J et al. | Influence of a fibric acid type of hypolipidemic agent on the oxidative metabolism of arachidonic acid by liver microsomal cytochrome P-450. | 1985 | Arch. Biochem. Biophys. | pmid:3933431 |
| Norman HA and Thompson GA | Effects of low-temperature stress on the metabolism of phosphatidylglycerol molecular species in Dunaliella salina. | 1985 | Arch. Biochem. Biophys. | pmid:4051499 |
| Wang MH et al. | Cloning, sequencing, and cDNA-directed expression of the rat renal CYP4A2: arachidonic acid omega-hydroxylation and 11,12-epoxidation by CYP4A2 protein. | 1996 | Arch. Biochem. Biophys. | pmid:8954571 |
| Sharma P et al. | Structural basis of the binding of fatty acids to peptidoglycan recognition protein, PGRP-S through second binding site. | 2013 | Arch. Biochem. Biophys. | pmid:23149273 |
| Arkill KP and Winlove CP | Fatty acid transport in articular cartilage. | 2006 | Arch. Biochem. Biophys. | pmid:17084376 |
| Powell PK et al. | Identification of CYP4A11 as the major lauric acid omega-hydroxylase in human liver microsomes. | 1996 | Arch. Biochem. Biophys. | pmid:8914854 |
| Lu P et al. | Heme-coordinating analogs of lauric acid as inhibitors of fatty acid omega-hydroxylation. | 1997 | Arch. Biochem. Biophys. | pmid:8990261 |
| Okita RT and Okita JR | Characterization of a cytochrome P450 from di(2-ethylhexyl) phthalate-treated rats which hydroxylates fatty acids. | 1992 | Arch. Biochem. Biophys. | pmid:1567203 |
| Miranda CL et al. | Purification and characterization of hepatic steroid hydroxylases from untreated rainbow trout. | 1989 | Arch. Biochem. Biophys. | pmid:2536262 |
| Girvan HM et al. | Flavocytochrome P450 BM3 mutant W1046A is a NADH-dependent fatty acid hydroxylase: implications for the mechanism of electron transfer in the P450 BM3 dimer. | 2011 | Arch. Biochem. Biophys. | pmid:20868649 |
| Jeffery B et al. | Peroxisome proliferator activated receptor alpha regulates a male-specific cytochrome P450 in mouse liver. | 2004 | Arch. Biochem. Biophys. | pmid:15313227 |
| Chaurasia CS et al. | Biochemical characterization of lauric acid omega-hydroxylation by a CYP4A1/NADPH-cytochrome P450 reductase fusion protein. | 1995 | Arch. Biochem. Biophys. | pmid:7872779 |
| Cowart LA et al. | Structural determinants of active site binding affinity and metabolism by cytochrome P450 BM-3. | 2001 | Arch. Biochem. Biophys. | pmid:11368173 |
| Duncan T et al. | A glycoprotein binding retinoids and fatty acids is present in Drosophila. | 1994 | Arch. Biochem. Biophys. | pmid:8031123 |
| Gilep AA et al. | Reconstitution of the enzymatic activities of cytochrome P450s using recombinant flavocytochromes containing rat cytochrome b(5) fused to NADPH--cytochrome P450 reductase with various membrane-binding segments. | 2001 | Arch. Biochem. Biophys. | pmid:11396924 |
| Puchkaev AV and Ortiz de Montellano PR | The Sulfolobus solfataricus electron donor partners of thermophilic CYP119: an unusual non-NAD(P)H-dependent cytochrome P450 system. | 2005 | Arch. Biochem. Biophys. | pmid:15629120 |
| Sato H et al. | Multiple binding of bilirubin to human serum albumin and cobinding with laurate. | 1988 | Arch. Biochem. Biophys. | pmid:2829743 |
| Kikuta Y et al. | Expression and catalytic activity of mouse leukotriene B4 omega-hydroxylase, CYP4F14. | 2000 | Arch. Biochem. Biophys. | pmid:11185557 |
| Straub P et al. | Hydrophobic side chain requirements for lauric acid and progesterone hydroxylation at amino acid 113 in cytochrome P450 2C2, a potential determinant of substrate specificity. | 1993 | Arch. Biochem. Biophys. | pmid:8215458 |
| Chavez JA and Summers SA | Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes. | 2003 | Arch. Biochem. Biophys. | pmid:14592453 |
| Stodtmeister W et al. | [Fatty acid composition of lipids from the hair in psoriasis vulgaris (author's transl)]. | 1979 | Arch. Dermatol. Res. | pmid:464651 |
| Que Hee SS and Zainal H | Permeation of herbicidal dichlobenil from a Casoron formulation through nitrile gloves. | 2010 | Arch. Environ. Contam. Toxicol. | pmid:19855916 |
| Green PR and Geer BW | Changes in the fatty acid composition of Drosophila melanogaster during development and ageing. | 1979 | Arch. Int. Physiol. Biochim. | pmid:93438 |
| Demarne Y et al. | Comparison of long term lipogenic effects of two different medium-chain triglycerides (tri C8: O and tri C12 : O) in the growing rat. | 1978 | Arch. Int. Physiol. Biochim. | pmid:80196 |
| Demarne Y et al. | Effects of two different medium-chain triglycerides (tri C8:O and tri C12:O) on liver lipids in the growing rat. | 1978 | Arch. Int. Physiol. Biochim. | pmid:80984 |
| Laurila H et al. | The cytochrome P450-containing monooxygenase of Trichosporon cutaneum: occurrence and properties. | 1984 | Arch. Microbiol. | pmid:6397156 |
| Jenkins CL et al. | Fatty acid composition of Simonsiella strains. | 1977 | Arch. Microbiol. | pmid:560178 |
| Huang CB et al. | Short- and medium-chain fatty acids exhibit antimicrobial activity for oral microorganisms. | 2011 | Arch. Oral Biol. | pmid:21333271 |
| Kim SG | A special issue edited by Dr. Louis J. Ignarro, A Nobel Prize Laureate. | 2009 | Arch. Pharm. Res. | pmid:19727600 |
| Gwak HS et al. | Effect of vehicles and enhancers on the in vitro permeation of melatonin through hairless mouse skin. | 2002 | Arch. Pharm. Res. | pmid:12135116 |
| Bani-Jaber A et al. | The synthesis and characterization of fatty acid salts of chitosan as novel matrices for prolonged intragastric drug delivery. | 2012 | Arch. Pharm. Res. | pmid:22864738 |
| Kim HW et al. | The effect of vehicles and pressure sensitive adhesives on the percutaneous absorption of quercetin through the hairless mouse skin. | 2004 | Arch. Pharm. Res. | pmid:15357005 |
| Shin SC and Cho CW | Enhanced transdermal delivery of pranoprofen from the bioadhesive gels. | 2006 | Arch. Pharm. Res. | pmid:17121190 |
| Nannelli A et al. | Effects of the anticancer dehydrotarplatin on cytochrome P450 and antioxidant enzymes in male rat tissues. | 2007 | Arch. Toxicol. | pmid:17364183 |
| Alam MS et al. | Influence of di-butyltin dilaurate on brain neurotransmitter systems and behavior in rats. | 1988 | Arch. Toxicol. | pmid:2899427 |
| Bartolotta S et al. | Effect of fatty acids on arenavirus replication: inhibition of virus production by lauric acid. | 2001 | Arch. Virol. | pmid:11402863 |
| Zhou X et al. | The effect of saturated fatty acids on methanogenesis and cell viability of Methanobrevibacter ruminantium. | 2013 | Archaea | pmid:23710130 |
| Costello PB and Green FA | The extracellular control of intracellular aspirin hydrolysis. | 1987 | Arthritis Rheum. | pmid:3580009 |
| Alemparte J et al. | Patellofemoral evaluation with radiographs and computed tomography scans in 60 knees of asymptomatic subjects. | 2007 | Arthroscopy | pmid:17276225 |
| Karadeniz F et al. | Kinetic resolution of racemic 1-phenyl 1-propanol by lipase catalyzed enantioselective esterification reaction. | 2010 | Artif Cells Blood Substit Immobil Biotechnol | pmid:20831353 |
| Karahaliloglu Z et al. | Antibacterial chitosan/silk sericin 3D porous scaffolds as a wound dressing material. | 2017 | Artif Cells Nanomed Biotechnol | pmid:27396677 |
| Schlieper P and Tawfik H | Antiarrhythmic activity of alpha-tocopherol nicotinate and related compounds and their physico-chemical properties. | 1987 | Arzneimittelforschung | pmid:3675687 |
| Kawamura K et al. | Effect of cilostazol, a new antithrombotic drug, on an experimental model of peripheral circulation insufficiency. | 1985 | Arzneimittelforschung | pmid:4074428 |
| Murai T et al. | Effect of beraprost sodium on peripheral circulation insufficiency in rats and rabbits. | 1989 | Arzneimittelforschung | pmid:2510741 |
| Hara H et al. | Effect of (+/-)-2-(dimethylamino)-1-[[o-(m-methoxyphenethyl)phenoxy] methyl]ethyl hydrogen succinate on experimental models of peripheral obstructive disease. | 1991 | Arzneimittelforschung | pmid:1930349 |
| Aoki T et al. | Cholesterol-lowering effect of NK-104, a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, in guinea pig model of hyperlipidemia. | 2001 | Arzneimittelforschung | pmid:11304935 |
| Imamura T et al. | Effect of ozagrel, a selective thromboxane A2-synthetase inhibitor, on cerebral infarction in rats. Comparative study with norphenazone, a free-radical scavenger. | 2003 | Arzneimittelforschung | pmid:14650360 |
| Idris CA and Sundram K | Effect of dietary cholesterol, trans and saturated fatty acids on serum lipoproteins in non-human primates. | 2002 | Asia Pac J Clin Nutr | pmid:12492627 |
| Serra I et al. | Effect of dietary intake on the levels of biliary unsaturated free Fatty acids having inhibitory activity on mutagens. | 2009 | Asian Pac. J. Cancer Prev. | pmid:20104986 |
| Hanley K et al. | Development of a plant viral-vector-based gene expression assay for the screening of yeast cytochrome p450 monooxygenases. | 2003 | Assay Drug Dev Technol | pmid:15090141 |
| HÃ¥versen L et al. | Induction of proinflammatory cytokines by long-chain saturated fatty acids in human macrophages. | 2009 | Atherosclerosis | pmid:18599066 |
| Yoshida H et al. | A phosphodiesterase 3 inhibitor, K-134, improves hindlimb skeletal muscle circulation in rat models of peripheral arterial disease. | 2012 | Atherosclerosis | pmid:22269153 |
| Arrol S et al. | The effects of fatty acids on apolipoprotein B secretion by human hepatoma cells (HEP G2). | 2000 | Atherosclerosis | pmid:10856517 |
| Redgrave TG and Dunne KB | Chylomicron formation and composition in unanaesthetised rabbits. | 1975 Nov-Dec | Atherosclerosis | pmid:173354 |
| Lagrost L et al. | Variations in serum cholesteryl ester transfer and phospholipid transfer activities in healthy women and men consuming diets enriched in lauric, palmitic or oleic acids. | 1999 | Atherosclerosis | pmid:10030391 |
| Timbermont L et al. | Control of Clostridium perfringens-induced necrotic enteritis in broilers by target-released butyric acid, fatty acids and essential oils. | 2010 | Avian Pathol. | pmid:20390546 |
| Alves NF et al. | Acute Treatment with Lauric Acid Reduces Blood Pressure and Oxidative Stress in Spontaneously Hypertensive Rats. | 2017 | Basic Clin. Pharmacol. Toxicol. | pmid:28054477 |
| Stark K et al. | Expression of CYP4F12 in gastrointestinal and urogenital epithelia. | 2004 | Basic Clin. Pharmacol. Toxicol. | pmid:15078342 |
| Russell VA et al. | Animal models of attention-deficit hyperactivity disorder. | 2005 | Behav Brain Funct | pmid:16022733 |
| Imaoka S and Funae Y | Purification and NH2-terminal sequence of cytochrome P-450 from kidney microsomes of untreated male rats. | 1986 | Biochem. Biophys. Res. Commun. | pmid:3801020 |
| Liu K et al. | Isolation and biochemical characterization of two lipases from a metagenomic library of China Holstein cow rumen. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19486892 |
| Leighton F et al. | Peroxisomal fatty acid oxidation is selectively inhibited by phenothiazines in isolated hepatocytes. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6732769 |
| Imai Y and Nakamura M | Point mutations at threonine-301 modify substrate specificity of rabbit liver microsomal cytochromes P-450 (laurate (omega-1)-hydroxylase and testosterone 16 alpha-hydroxylase). | 1989 | Biochem. Biophys. Res. Commun. | pmid:2493247 |
| Miranda CL et al. | Regiospecificity in the hydroxylation of lauric acid by rainbow trout hepatic cytochrome P450 isozymes. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2403346 |
| Imaoka S et al. | A transgenic mouse expressing human CYP4B1 in the liver. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11396967 |
| Pinot F et al. | New cytochrome P450-dependent reactions from wheat: terminal and sub-terminal hydroxylation of oleic acid by microsomes from naphthalic acid anhydride and phenobarbital induced wheat seedlings. | 1994 | Biochem. Biophys. Res. Commun. | pmid:8297392 |