lauric acid

lauric acid is a lipid of Fatty Acyls (FA) class. Lauric acid is associated with abnormalities such as Infection, Renal tubular disorder, Hypertensive disease, Obesity and Mycoses. The involved functions are known as Transcription, Genetic, Signal Transduction, Mutation, metaplastic cell transformation and Anabolism. Lauric acid often locates in Skin, Plasma membrane, Cytoplasmic matrix, Body tissue and Palmar surface. The associated genes with lauric acid are Gene Family, SLC33A1 gene, Homologous Gene, Open Reading Frames and P4HTM gene. The related lipids are Fatty Acids, Oleic Acids, Palmitates, Stearates and 9,11-linoleic acid.

Cross Reference

Introduction

To understand associated biological information of lauric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with lauric acid?

lauric acid is suspected in Renal tubular disorder, Hypertensive disease, Infection, Renal vascular disorder, Obesity, Mycoses and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with lauric acid

MeSH term MeSH ID Detail
Vascular System Injuries D057772 2 associated lipids
Nephrosis, Lipoid D009402 2 associated lipids
Thromboangiitis Obliterans D013919 4 associated lipids
Bird Diseases D001715 4 associated lipids
Cerebral Infarction D002544 6 associated lipids
Peripheral Arterial Disease D058729 7 associated lipids
Carotid Artery Injuries D020212 8 associated lipids
Obesity, Morbid D009767 8 associated lipids
Liver Diseases, Alcoholic D008108 13 associated lipids
Vasculitis D014657 14 associated lipids
Per page 10 20 50 | Total 33

PubChem Associated disorders and diseases

What pathways are associated with lauric acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with lauric acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with lauric acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with lauric acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with lauric acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with lauric acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with lauric acid

Download all related citations
Per page 10 20 50 100 | Total 1837
Authors Title Published Journal PubMed Link
Hu H et al. A novel class of antagonists for the FFAs receptor GPR40. 2009 Biochem. Biophys. Res. Commun. pmid:19818732
Imaoka S et al. Induction of renal cytochrome P-450 in hepatic microsomes of diabetic rats. 1988 Biochem. Biophys. Res. Commun. pmid:3365247
Roomi MW et al. Decreased expression of cytochrome P-452 in the resistance phenotype characteristic of putative preneoplastic hepatocyte nodules during hepatocarcinogenesis. 1988 Biochem. Biophys. Res. Commun. pmid:3365259
Liu K et al. Isolation and biochemical characterization of two lipases from a metagenomic library of China Holstein cow rumen. 2009 Biochem. Biophys. Res. Commun. pmid:19486892
Alterman MA et al. Heteroatom substitution shifts regioselectivity of lauric acid metabolism from omega-hydroxylation to (omega-1)-oxidation. 1995 Biochem. Biophys. Res. Commun. pmid:7575514
Kiffel L et al. Purification and characterization of a cytochrome P-450 isozyme isolated from the liver of rats pretreated with clofibrate. 1988 Biochem. Biophys. Res. Commun. pmid:3140811
Björkhem I On the mechanism of 11-hydroxylation of lauric acid by rat liver microsomes. 1973 Biochem. Biophys. Res. Commun. pmid:4689066
Björkhem I and Hamberg M On the rate-limiting step in W-hydroxylation of lauric acid. 1972 Biochem. Biophys. Res. Commun. pmid:4662395
Kato A and Arima K Inhibitory effect of sucrose ester of lauric acid on the growth of Escherichia coli. 1971 Biochem. Biophys. Res. Commun. pmid:5543940
Miranda CL et al. Regiospecificity in the hydroxylation of lauric acid by rainbow trout hepatic cytochrome P450 isozymes. 1990 Biochem. Biophys. Res. Commun. pmid:2403346
Amet Y et al. Evidence that cytochrome P450 2E1 is involved in the (omega-1)-hydroxylation of lauric acid in rat liver microsomes. 1994 Biochem. Biophys. Res. Commun. pmid:8093035
Imaoka S et al. A transgenic mouse expressing human CYP4B1 in the liver. 2001 Biochem. Biophys. Res. Commun. pmid:11396967
Helvig C et al. Drosophila melanogaster CYP6A8, an insect P450 that catalyzes lauric acid (omega-1)-hydroxylation. 2004 Biochem. Biophys. Res. Commun. pmid:15555597
Tanaka T et al. Saturated and trans-unsaturated fatty acids elicit high levels of superoxide generation in intact and cell-free preparations of neutrophils. 1987 Biochem. Biophys. Res. Commun. pmid:3034258
Pinot F et al. New cytochrome P450-dependent reactions from wheat: terminal and sub-terminal hydroxylation of oleic acid by microsomes from naphthalic acid anhydride and phenobarbital induced wheat seedlings. 1994 Biochem. Biophys. Res. Commun. pmid:8297392
Yoshimoto M et al. Purification and characterization of two forms of cytochrome P-450 from rat kidney cortex microsomes. 1986 Biochem. Int. pmid:3814156
Takahashi K et al. Ester synthesis at extraordinarily low temperature of -3 degrees C by modified lipase in benzene. 1985 Biochem. Int. pmid:3927919
Tambo F et al. Auto-oxidation of Lingula unguis and Siphonosoma cumanense hemerythrins induced by some perturbants. 1989 Biochem. Int. pmid:2764951
Imaoka S et al. Omega- and (omega-1)-hydroxylation of lauric acid and arachidonic acid by rat renal cytochrome P-450. 1989 Biochem. Int. pmid:2504167
Dahlbäck H and Wikvall K 25-Hydroxylation of vitamin D3 by a cytochrome P-450 from rabbit liver mitochondria. 1988 Biochem. J. pmid:2844144
Rottensteiner H et al. The peroxisomal transporter gene ANT1 is regulated by a deviant oleate response element (ORE): characterization of the signal for fatty acid induction. 2002 Biochem. J. pmid:12071844
Whiting P and Dinan L Formation of apolar ecdysteroid conjugates by ovaries of the house cricket Acheta domesticus in vitro. 1988 Biochem. J. pmid:3421912
Girvan HM et al. Novel haem co-ordination variants of flavocytochrome P450BM3. 2009 Biochem. J. pmid:18721129
Gibson GG et al. Cytochrome P-450 induction by clofibrate. Purification and properties of a hepatic cytochrome P-450 relatively specific for the 12- and 11-hydroxylation of dodecanoic acid (lauric acid). 1982 Biochem. J. pmid:7103935
Hasegawa K et al. Growth of beta(2)-microglobulin-related amyloid fibrils by non-esterified fatty acids at a neutral pH. 2008 Biochem. J. pmid:18637792
Radom J et al. Influence of chain length of pyrene fatty acids on their uptake and metabolism by Epstein-Barr-virus-transformed lymphoid cell lines from a patient with multisystemic lipid storage myopathy and from control subjects. 1990 Biochem. J. pmid:2165389
Sandercock SP and Russell NJ The elongation of exogenous fatty acids and the control of phospholipid acyl chain length in Micrococcus cryophilus. 1980 Biochem. J. pmid:7470022
VAN DE KAMER JH et al. Gas-liquid partition chromatography: the separation and micro-estimation of volatile fatty acids from formic acid to dodecanoic acid. 1955 Biochem. J. pmid:13260193
Sohlenius AK et al. The effects of perfluoro-octanoic acid on hepatic peroxisome proliferation and related parameters show no sex-related differences in mice. 1992 Biochem. J. pmid:1497616
JAMES AT and MARTIN AJ Gas-liquid partition chromatography; the separation and micro-estimation of volatile fatty acids from formic acid to dodecanoic acid. 1952 Biochem. J. pmid:14934673
Girvan HM et al. Glutamate-haem ester bond formation is disfavoured in flavocytochrome P450 BM3: characterization of glutamate substitution mutants at the haem site of P450 BM3. 2010 Biochem. J. pmid:20180779
Lind KE and Moller JV Ligand-apomyoglobin interactions. Configurational adaptability of the haem-binding site. 1976 Biochem. J. pmid:949328
Muller DN et al. Mouse Cyp4a isoforms: enzymatic properties, gender- and strain-specific expression, and role in renal 20-hydroxyeicosatetraenoic acid formation. 2007 Biochem. J. pmid:17112342
Kragh-Hansen U et al. High-affinity binding of laurate to naturally occurring mutants of human serum albumin and proalbumin. 1996 Biochem. J. pmid:9003380
Bergman T and Postlind H Characterization of pig kidney microsomal cytochrome P-450 catalysing 25-hydroxylation of vitamin D3 and C27 steroids. 1990 Biochem. J. pmid:2169238
Cunningham VJ et al. The binding of L-tryptophan to serum albumins in the presence of non-esterified fatty acids. 1975 Biochem. J. pmid:1147909
Benveniste I et al. Immunochemical characterization of NADPH-cytochrome P-450 reductase from Jerusalem artichoke and other higher plants. 1989 Biochem. J. pmid:2499315
Lundell K Cloning and expression of two novel pig liver and kidney fatty acid hydroxylases [cytochrome P450 (CYP)4A24 and CYP4A25]. 2002 Biochem. J. pmid:11931657
Magdalou J et al. Effect of 1-benzylimidazole on cytochromes P-450 induction and on the activities of epoxide hydrolases and UDP-glucuronosyltransferases in rat liver. 1988 Biochem. Pharmacol. pmid:2840913
Amet Y et al. Validation of the (omega-1)-hydroxylation of lauric acid as an in vitro substrate probe for human liver CYP2E1. 1995 Biochem. Pharmacol. pmid:8615855
Williams DE et al. Sex differences in cytochrome P-450 isozyme composition and activity in kidney microsomes of mature rainbow trout. 1986 Biochem. Pharmacol. pmid:3718543
Pons N et al. Interaction of polyhalogenated compounds of appropriate configuration with mammalian or bacterial CYP enzymes. Increased bilirubin and uroporphyrinogen oxidation in vitro. 2003 Biochem. Pharmacol. pmid:12907239
Ronis MJ et al. Induction, suppression and inhibition of multiple hepatic cytochrome P450 isozymes in the male rat and bobwhite quail (Colinus virginianus) by ergosterol biosynthesis inhibiting fungicides (EBIFs). 1994 Biochem. Pharmacol. pmid:7986207
Sharma R et al. Co-induction of microsomal cytochrome P-452 and the peroxisomal fatty acid beta-oxidation pathway in the rat by clofibrate and di-(2-ethylhexyl)phthalate. Dose-response studies. 1988 Biochem. Pharmacol. pmid:3355594
Kikuta Y et al. Expression and induction of cytochrome P450s in rabbit parotid glands. 2001 Biochem. Pharmacol. pmid:11389885
Past MR and Cook DE Effect of diabetes on rat liver cytochrome P-450. Evidence for a unique diabetes-dependent rat liver cytochrome P-450. 1982 Biochem. Pharmacol. pmid:7150359
Kocarek TA and Feller DR Induction of peroxisomal fatty acyl-CoA oxidase and microsomal laurate hydroxylase activities by beclobric acid and two metabolites in primary cultures of rat hepatocytes. 1987 Biochem. Pharmacol. pmid:3632723
De Matteis F et al. Peroxidase-like activity of uncoupled cytochrome P450: studies with bilirubin and toxicological implications of uncoupling. 2012 Biochem. Pharmacol. pmid:22564776
Bains SK et al. Immunochemical study on the contribution of hypolipidaemic-induced cytochrome P-452 to the metabolism of lauric acid and arachidonic acid. 1985 Biochem. Pharmacol. pmid:3929789
Hornung B et al. Medium chain length fatty acids stimulate triacylglycerol synthesis in tissue culture cells. 1992 Biochem. Pharmacol. pmid:1739406
Knickle LC et al. The suppression of hepatic cytochrome P4504A mRNA mediated by the interferon inducer polyinosinic acid.polycytidylic acid. 1992 Biochem. Pharmacol. pmid:1380810
Rodríguez-Penas D et al. Aliskiren affects fatty-acid uptake and lipid-related genes in rodent and human cardiomyocytes. 2011 Biochem. Pharmacol. pmid:21640714
Sivapathasundaram S et al. A study of the expression of the xenobiotic-metabolising cytochrome P450 proteins and of testosterone metabolism in bovine liver. 2001 Biochem. Pharmacol. pmid:11585060
Amet Y et al. Cytochrome P450 4A and 2E1 expression in human kidney microsomes. 1997 Biochem. Pharmacol. pmid:9113097
Okita RT et al. Lauric acid hydroxylation in human liver and kidney cortex microsomes. 1979 Biochem. Pharmacol. pmid:533546
Imaoka S et al. Mutagenic activation of urinary bladder carcinogens by CYP4B1 and the presence of CYP4B1 in bladder mucosa. 1997 Biochem. Pharmacol. pmid:9310344
Hvattum E et al. Microsomal oxidation of dodecylthioacetic acid (a 3-thia fatty acid) in rat liver. 1991 Mar 15-Apr 1 Biochem. Pharmacol. pmid:1672593
Sharma RK et al. Role of hepatic and renal cytochrome P-450 IVA1 in the metabolism of lipid substrates. 1989 Biochem. Pharmacol. pmid:2554928
Kocarek TA and Feller DR Quantitative assessment of enzyme induction by peroxisome proliferators and application to determination of effects on triglyceride biosynthesis in primary cultures of rat hepatocytes. 1989 Biochem. Pharmacol. pmid:2597188
Kitagawa S et al. Effects of alkyl gallates on P-glycoprotein function. 2005 Biochem. Pharmacol. pmid:16139251
Pham MA et al. Characterization of distinct forms of cytochromes P-450, epoxide metabolizing enzymes and UDP-glucuronosyltransferases in rat skin. 1989 Biochem. Pharmacol. pmid:2500129
Swinney DC et al. A novel rat hepatic clofibrate-inducible cytochrome P450 that is not a lauric acid hydroxylase. 1991 Biochem. Pharmacol. pmid:1662512
Lundgren B et al. Effects of dietary treatment with 11 dicarboxylic acids, diethylcarboxylic esters and fatty acids on peroxisomal fatty acid beta-oxidation, epoxide hydrolases and lauric acid omega-hydroxylation in mouse liver. 1992 Biochem. Pharmacol. pmid:1540233
Thomas H et al. Effect of hypolipidemic compounds on lauric acid hydroxylation and phase II enzymes. 1989 Biochem. Pharmacol. pmid:2500933
Raza H and Levine WG Effect of hypolipidemic drugs on the metabolism of lauric acid and dimethylaminoazobenzene by rat liver microsomes. 1987 Biochem. Pharmacol. pmid:3103631
Nakamura M et al. Induction of cytochrome P450 isozymes in rat renal microsomes by cyclosporin A. 1994 Biochem. Pharmacol. pmid:7980643
Byard J et al. Novel approaches to the purification and identification of cytochrome P450 enzymes in the equine. 1996 Biochem. Soc. Trans. pmid:8736866
Gibson GG and Bains SK Cytochrome P-450 isoenzymes involved in fatty acid metabolism. 1985 Biochem. Soc. Trans. pmid:4065418
Makowska JM et al. Species differences in the hepatic response to a potent peroxisome proliferator. 1989 Biochem. Soc. Trans. pmid:2628085
Sherrington EJ et al. Lack of effect of different dietary saturated fatty acids on adipose tissue deposition in the rat. 1996 Biochem. Soc. Trans. pmid:8736816
Abigor RD et al. Lipase-catalysed production of biodiesel fuel from some Nigerian lauric oils. 2000 Biochem. Soc. Trans. pmid:11171279
Zheng YM et al. Covalent heme binding to CYP4B1 via Glu310 and a carbocation porphyrin intermediate. 2003 Biochemistry pmid:12693958
Narayanan VS and Storch J Fatty acid transfer in taurodeoxycholate mixed micelles. 1996 Biochemistry pmid:8652524
Raner GM et al. Regioselective peroxo-dependent heme alkylation in P450(BM3)-F87G by aromatic aldehydes: effects of alkylation on cataysis. 2002 Biochemistry pmid:12135382
Six DA et al. Purification and mutagenesis of LpxL, the lauroyltransferase of Escherichia coli lipid A biosynthesis. 2008 Biochemistry pmid:18656959
Cheng XL et al. The biosynthetic incorporation of short-chain linear saturated fatty acids by Acholeplasma laidlawii B may suppress cell growth by perturbing membrane lipid polar headgroup distribution. 2002 Biochemistry pmid:12093284
Straub P et al. Differential effects of mutations in substrate recognition site 1 of cytochrome P450 2C2 on lauric acid and progesterone hydroxylation. 1994 Biochemistry pmid:8025107
Ost TW et al. Phenylalanine 393 exerts thermodynamic control over the heme of flavocytochrome P450 BM3. 2001 Biochemistry pmid:11695888
Loughran PA et al. Identification of unique amino acids that modulate CYP4A7 activity. 2000 Biochemistry pmid:11106489
Hamilton SE et al. Identification of the high-affinity lipid binding site in Escherichia coli pyruvate oxidase. 1986 Biochemistry pmid:3545288
Modi S et al. NMR studies of substrate binding to cytochrome P450 BM3: comparisons to cytochrome P450 cam. 1995 Biochemistry pmid:7619797
Yeom H et al. The role of Thr268 in oxygen activation of cytochrome P450BM-3. 1995 Biochemistry pmid:7578081
Haines DC et al. Crystal structure of inhibitor-bound P450BM-3 reveals open conformation of substrate access channel. 2008 Biochemistry pmid:18298086
Gasymov OK et al. Ligand binding site of tear lipocalin: contribution of a trigonal cluster of charged residues probed by 8-anilino-1-naphthalenesulfonic acid. 2008 Biochemistry pmid:18179255
Kim D et al. Kinetic analysis of lauric acid hydroxylation by human cytochrome P450 4A11. 2014 Biochemistry pmid:25203493
Murataliev MB and Feyereisen R Functional interactions in cytochrome P450BM3. Fatty acid substrate binding alters electron-transfer properties of the flavoprotein domain. 1996 Biochemistry pmid:8942669
Murataliev MB et al. Functional interactions in cytochrome P450BM3: flavin semiquinone intermediates, role of NADP(H), and mechanism of electron transfer by the flavoprotein domain. 1997 Biochemistry pmid:9204888
Winkler E et al. Identification of the pH sensor for nucleotide binding in the uncoupling protein from brown adipose tissue. 1997 Biochemistry pmid:8993328
Kantor HL and Prestegard JH Fusion of fatty acid containing lecithin vesicles. 1975 Biochemistry pmid:1125198
Poli-Scaife S et al. The substrate binding site of human liver cytochrome P450 2C9: an NMR study. 1997 Biochemistry pmid:9335524
Zheng YM et al. Identification of a meander region proline residue critical for heme binding to cytochrome P450: implications for the catalytic function of human CYP4B1. 1998 Biochemistry pmid:9737862
Davis JH 2H nuclear magnetic resonance of exchange-labeled gramicidin in an oriented lyotropic nematic phase. 1988 Biochemistry pmid:2450569
Haining RL et al. Enzymatic determinants of the substrate specificity of CYP2C9: role of B'-C loop residues in providing the pi-stacking anchor site for warfarin binding. 1999 Biochemistry pmid:10079071
Makovitzki A and Shai Y pH-dependent antifungal lipopeptides and their plausible mode of action. 2005 Biochemistry pmid:16008362
Richieri GV et al. Binding kinetics of engineered mutants provide insight about the pathway for entering and exiting the intestinal fatty acid binding protein. 1999 Biochemistry pmid:10231541
Noble MA et al. Imidazolyl carboxylic acids as mechanistic probes of flavocytochrome P-450 BM3. 1998 Biochemistry pmid:9843385
Lawson RJ et al. Expression and characterization of the two flavodoxin proteins of Bacillus subtilis, YkuN and YkuP: biophysical properties and interactions with cytochrome P450 BioI. 2004 Biochemistry pmid:15449930
Echtay KS et al. Role of intrahelical arginine residues in functional properties of uncoupling protein (UCP1). 2001 Biochemistry pmid:11318647
Reynolds CM and Raetz CR Replacement of lipopolysaccharide with free lipid A molecules in Escherichia coli mutants lacking all core sugars. 2009 Biochemistry pmid:19754149
Sanghani PC et al. Human glutathione-dependent formaldehyde dehydrogenase. Structures of apo, binary, and inhibitory ternary complexes. 2002 Biochemistry pmid:12196016