lauric acid

lauric acid is a lipid of Fatty Acyls (FA) class. Lauric acid is associated with abnormalities such as Infection, Renal tubular disorder, Hypertensive disease, Obesity and Mycoses. The involved functions are known as Transcription, Genetic, Signal Transduction, Mutation, metaplastic cell transformation and Anabolism. Lauric acid often locates in Skin, Plasma membrane, Cytoplasmic matrix, Body tissue and Palmar surface. The associated genes with lauric acid are Gene Family, SLC33A1 gene, Homologous Gene, Open Reading Frames and P4HTM gene. The related lipids are Fatty Acids, Oleic Acids, Palmitates, Stearates and 9,11-linoleic acid.

Cross Reference

Introduction

To understand associated biological information of lauric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with lauric acid?

lauric acid is suspected in Renal tubular disorder, Hypertensive disease, Infection, Renal vascular disorder, Obesity, Mycoses and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with lauric acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Lung Neoplasms D008175 171 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Body Weight D001835 333 associated lipids
Acne Vulgaris D000152 35 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Thrombosis D013927 49 associated lipids
Prostatic Hyperplasia D011470 20 associated lipids
Brain Infarction D020520 17 associated lipids
Stroke D020521 32 associated lipids
Starvation D013217 47 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Seizures D012640 87 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Cerebrovascular Disorders D002561 25 associated lipids
Cerebral Infarction D002544 6 associated lipids
Liver Diseases, Alcoholic D008108 13 associated lipids
Per page 10 20 50 | Total 33

PubChem Associated disorders and diseases

What pathways are associated with lauric acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with lauric acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with lauric acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with lauric acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with lauric acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with lauric acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with lauric acid

Download all related citations
Per page 10 20 50 100 | Total 1837
Authors Title Published Journal PubMed Link
Dahlbäck H and Wikvall K 25-Hydroxylation of vitamin D3 by a cytochrome P-450 from rabbit liver mitochondria. 1988 Biochem. J. pmid:2844144
Rottensteiner H et al. The peroxisomal transporter gene ANT1 is regulated by a deviant oleate response element (ORE): characterization of the signal for fatty acid induction. 2002 Biochem. J. pmid:12071844
Whiting P and Dinan L Formation of apolar ecdysteroid conjugates by ovaries of the house cricket Acheta domesticus in vitro. 1988 Biochem. J. pmid:3421912
Girvan HM et al. Novel haem co-ordination variants of flavocytochrome P450BM3. 2009 Biochem. J. pmid:18721129
Gibson GG et al. Cytochrome P-450 induction by clofibrate. Purification and properties of a hepatic cytochrome P-450 relatively specific for the 12- and 11-hydroxylation of dodecanoic acid (lauric acid). 1982 Biochem. J. pmid:7103935
Hasegawa K et al. Growth of beta(2)-microglobulin-related amyloid fibrils by non-esterified fatty acids at a neutral pH. 2008 Biochem. J. pmid:18637792
Radom J et al. Influence of chain length of pyrene fatty acids on their uptake and metabolism by Epstein-Barr-virus-transformed lymphoid cell lines from a patient with multisystemic lipid storage myopathy and from control subjects. 1990 Biochem. J. pmid:2165389
Sandercock SP and Russell NJ The elongation of exogenous fatty acids and the control of phospholipid acyl chain length in Micrococcus cryophilus. 1980 Biochem. J. pmid:7470022
VAN DE KAMER JH et al. Gas-liquid partition chromatography: the separation and micro-estimation of volatile fatty acids from formic acid to dodecanoic acid. 1955 Biochem. J. pmid:13260193
Sohlenius AK et al. The effects of perfluoro-octanoic acid on hepatic peroxisome proliferation and related parameters show no sex-related differences in mice. 1992 Biochem. J. pmid:1497616
JAMES AT and MARTIN AJ Gas-liquid partition chromatography; the separation and micro-estimation of volatile fatty acids from formic acid to dodecanoic acid. 1952 Biochem. J. pmid:14934673
Girvan HM et al. Glutamate-haem ester bond formation is disfavoured in flavocytochrome P450 BM3: characterization of glutamate substitution mutants at the haem site of P450 BM3. 2010 Biochem. J. pmid:20180779
Lind KE and Moller JV Ligand-apomyoglobin interactions. Configurational adaptability of the haem-binding site. 1976 Biochem. J. pmid:949328
Muller DN et al. Mouse Cyp4a isoforms: enzymatic properties, gender- and strain-specific expression, and role in renal 20-hydroxyeicosatetraenoic acid formation. 2007 Biochem. J. pmid:17112342
Kragh-Hansen U et al. High-affinity binding of laurate to naturally occurring mutants of human serum albumin and proalbumin. 1996 Biochem. J. pmid:9003380
Bergman T and Postlind H Characterization of pig kidney microsomal cytochrome P-450 catalysing 25-hydroxylation of vitamin D3 and C27 steroids. 1990 Biochem. J. pmid:2169238
Benveniste I et al. Immunochemical characterization of NADPH-cytochrome P-450 reductase from Jerusalem artichoke and other higher plants. 1989 Biochem. J. pmid:2499315
Lundell K Cloning and expression of two novel pig liver and kidney fatty acid hydroxylases [cytochrome P450 (CYP)4A24 and CYP4A25]. 2002 Biochem. J. pmid:11931657
Yoshimoto M et al. Purification and characterization of two forms of cytochrome P-450 from rat kidney cortex microsomes. 1986 Biochem. Int. pmid:3814156
Takahashi K et al. Ester synthesis at extraordinarily low temperature of -3 degrees C by modified lipase in benzene. 1985 Biochem. Int. pmid:3927919
Tambo F et al. Auto-oxidation of Lingula unguis and Siphonosoma cumanense hemerythrins induced by some perturbants. 1989 Biochem. Int. pmid:2764951
Imaoka S et al. Omega- and (omega-1)-hydroxylation of lauric acid and arachidonic acid by rat renal cytochrome P-450. 1989 Biochem. Int. pmid:2504167
Hu H et al. A novel class of antagonists for the FFAs receptor GPR40. 2009 Biochem. Biophys. Res. Commun. pmid:19818732
Bambal RB and Hanzlik RP Active site structure and substrate specificity of cytochrome P450 4A1: steric control of ligand approach perpendicular to heme plane. 1996 Biochem. Biophys. Res. Commun. pmid:8605007
Imaoka S and Funae Y Purification and NH2-terminal sequence of cytochrome P-450 from kidney microsomes of untreated male rats. 1986 Biochem. Biophys. Res. Commun. pmid:3801020
Imaoka S et al. Induction of renal cytochrome P-450 in hepatic microsomes of diabetic rats. 1988 Biochem. Biophys. Res. Commun. pmid:3365247
Roomi MW et al. Decreased expression of cytochrome P-452 in the resistance phenotype characteristic of putative preneoplastic hepatocyte nodules during hepatocarcinogenesis. 1988 Biochem. Biophys. Res. Commun. pmid:3365259
Liu K et al. Isolation and biochemical characterization of two lipases from a metagenomic library of China Holstein cow rumen. 2009 Biochem. Biophys. Res. Commun. pmid:19486892
Leighton F et al. Peroxisomal fatty acid oxidation is selectively inhibited by phenothiazines in isolated hepatocytes. 1984 Biochem. Biophys. Res. Commun. pmid:6732769
Okita R and Chance C Induction of laurate omega-hydroxylase by di (2-ethylhexyl)phthalate in rat liver microsomes. 1984 Biochem. Biophys. Res. Commun. pmid:6732809
Han S et al. Structural insights into the binding of lauric acid to CYP107L2 from Streptomyces avermitilis. 2017 Biochem. Biophys. Res. Commun. pmid:27890614
Alterman MA et al. Heteroatom substitution shifts regioselectivity of lauric acid metabolism from omega-hydroxylation to (omega-1)-oxidation. 1995 Biochem. Biophys. Res. Commun. pmid:7575514
Kiffel L et al. Purification and characterization of a cytochrome P-450 isozyme isolated from the liver of rats pretreated with clofibrate. 1988 Biochem. Biophys. Res. Commun. pmid:3140811
Björkhem I On the mechanism of 11-hydroxylation of lauric acid by rat liver microsomes. 1973 Biochem. Biophys. Res. Commun. pmid:4689066
Murakami K et al. Evidence for direct binding of fatty acids and eicosanoids to human peroxisome proliferators-activated receptor alpha. 1999 Biochem. Biophys. Res. Commun. pmid:10403814
Imai Y and Nakamura M Point mutations at threonine-301 modify substrate specificity of rabbit liver microsomal cytochromes P-450 (laurate (omega-1)-hydroxylase and testosterone 16 alpha-hydroxylase). 1989 Biochem. Biophys. Res. Commun. pmid:2493247
Björkhem I and Hamberg M On the rate-limiting step in W-hydroxylation of lauric acid. 1972 Biochem. Biophys. Res. Commun. pmid:4662395
Kato A and Arima K Inhibitory effect of sucrose ester of lauric acid on the growth of Escherichia coli. 1971 Biochem. Biophys. Res. Commun. pmid:5543940
Miranda CL et al. Regiospecificity in the hydroxylation of lauric acid by rainbow trout hepatic cytochrome P450 isozymes. 1990 Biochem. Biophys. Res. Commun. pmid:2403346
Amet Y et al. Evidence that cytochrome P450 2E1 is involved in the (omega-1)-hydroxylation of lauric acid in rat liver microsomes. 1994 Biochem. Biophys. Res. Commun. pmid:8093035
Imaoka S et al. A transgenic mouse expressing human CYP4B1 in the liver. 2001 Biochem. Biophys. Res. Commun. pmid:11396967
Helvig C et al. Drosophila melanogaster CYP6A8, an insect P450 that catalyzes lauric acid (omega-1)-hydroxylation. 2004 Biochem. Biophys. Res. Commun. pmid:15555597
Tanaka T et al. Saturated and trans-unsaturated fatty acids elicit high levels of superoxide generation in intact and cell-free preparations of neutrophils. 1987 Biochem. Biophys. Res. Commun. pmid:3034258
Pinot F et al. New cytochrome P450-dependent reactions from wheat: terminal and sub-terminal hydroxylation of oleic acid by microsomes from naphthalic acid anhydride and phenobarbital induced wheat seedlings. 1994 Biochem. Biophys. Res. Commun. pmid:8297392
Russell VA et al. Animal models of attention-deficit hyperactivity disorder. 2005 Behav Brain Funct pmid:16022733
Alves NF et al. Acute Treatment with Lauric Acid Reduces Blood Pressure and Oxidative Stress in Spontaneously Hypertensive Rats. 2017 Basic Clin. Pharmacol. Toxicol. pmid:28054477
Stark K et al. Expression of CYP4F12 in gastrointestinal and urogenital epithelia. 2004 Basic Clin. Pharmacol. Toxicol. pmid:15078342
Timbermont L et al. Control of Clostridium perfringens-induced necrotic enteritis in broilers by target-released butyric acid, fatty acids and essential oils. 2010 Avian Pathol. pmid:20390546
HÃ¥versen L et al. Induction of proinflammatory cytokines by long-chain saturated fatty acids in human macrophages. 2009 Atherosclerosis pmid:18599066
Yoshida H et al. A phosphodiesterase 3 inhibitor, K-134, improves hindlimb skeletal muscle circulation in rat models of peripheral arterial disease. 2012 Atherosclerosis pmid:22269153
Arrol S et al. The effects of fatty acids on apolipoprotein B secretion by human hepatoma cells (HEP G2). 2000 Atherosclerosis pmid:10856517
Redgrave TG and Dunne KB Chylomicron formation and composition in unanaesthetised rabbits. 1975 Nov-Dec Atherosclerosis pmid:173354
Lagrost L et al. Variations in serum cholesteryl ester transfer and phospholipid transfer activities in healthy women and men consuming diets enriched in lauric, palmitic or oleic acids. 1999 Atherosclerosis pmid:10030391
Hanley K et al. Development of a plant viral-vector-based gene expression assay for the screening of yeast cytochrome p450 monooxygenases. 2003 Assay Drug Dev Technol pmid:15090141
Serra I et al. Effect of dietary intake on the levels of biliary unsaturated free Fatty acids having inhibitory activity on mutagens. 2009 Asian Pac. J. Cancer Prev. pmid:20104986
Idris CA and Sundram K Effect of dietary cholesterol, trans and saturated fatty acids on serum lipoproteins in non-human primates. 2002 Asia Pac J Clin Nutr pmid:12492627
Schlieper P and Tawfik H Antiarrhythmic activity of alpha-tocopherol nicotinate and related compounds and their physico-chemical properties. 1987 Arzneimittelforschung pmid:3675687
Kawamura K et al. Effect of cilostazol, a new antithrombotic drug, on an experimental model of peripheral circulation insufficiency. 1985 Arzneimittelforschung pmid:4074428
Murai T et al. Effect of beraprost sodium on peripheral circulation insufficiency in rats and rabbits. 1989 Arzneimittelforschung pmid:2510741
Hara H et al. Effect of (+/-)-2-(dimethylamino)-1-[[o-(m-methoxyphenethyl)phenoxy] methyl]ethyl hydrogen succinate on experimental models of peripheral obstructive disease. 1991 Arzneimittelforschung pmid:1930349
Aoki T et al. Cholesterol-lowering effect of NK-104, a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, in guinea pig model of hyperlipidemia. 2001 Arzneimittelforschung pmid:11304935
Imamura T et al. Effect of ozagrel, a selective thromboxane A2-synthetase inhibitor, on cerebral infarction in rats. Comparative study with norphenazone, a free-radical scavenger. 2003 Arzneimittelforschung pmid:14650360
Karahaliloglu Z et al. Antibacterial chitosan/silk sericin 3D porous scaffolds as a wound dressing material. 2017 Artif Cells Nanomed Biotechnol pmid:27396677
Karadeniz F et al. Kinetic resolution of racemic 1-phenyl 1-propanol by lipase catalyzed enantioselective esterification reaction. 2010 Artif Cells Blood Substit Immobil Biotechnol pmid:20831353
Alemparte J et al. Patellofemoral evaluation with radiographs and computed tomography scans in 60 knees of asymptomatic subjects. 2007 Arthroscopy pmid:17276225
Costello PB and Green FA The extracellular control of intracellular aspirin hydrolysis. 1987 Arthritis Rheum. pmid:3580009
Zhou X et al. The effect of saturated fatty acids on methanogenesis and cell viability of Methanobrevibacter ruminantium. 2013 Archaea pmid:23710130
Bartolotta S et al. Effect of fatty acids on arenavirus replication: inhibition of virus production by lauric acid. 2001 Arch. Virol. pmid:11402863
Nannelli A et al. Effects of the anticancer dehydrotarplatin on cytochrome P450 and antioxidant enzymes in male rat tissues. 2007 Arch. Toxicol. pmid:17364183
Alam MS et al. Influence of di-butyltin dilaurate on brain neurotransmitter systems and behavior in rats. 1988 Arch. Toxicol. pmid:2899427
Kim SG A special issue edited by Dr. Louis J. Ignarro, A Nobel Prize Laureate. 2009 Arch. Pharm. Res. pmid:19727600
Gwak HS et al. Effect of vehicles and enhancers on the in vitro permeation of melatonin through hairless mouse skin. 2002 Arch. Pharm. Res. pmid:12135116
Bani-Jaber A et al. The synthesis and characterization of fatty acid salts of chitosan as novel matrices for prolonged intragastric drug delivery. 2012 Arch. Pharm. Res. pmid:22864738
Kim HW et al. The effect of vehicles and pressure sensitive adhesives on the percutaneous absorption of quercetin through the hairless mouse skin. 2004 Arch. Pharm. Res. pmid:15357005
Shin SC and Cho CW Enhanced transdermal delivery of pranoprofen from the bioadhesive gels. 2006 Arch. Pharm. Res. pmid:17121190
Huang CB et al. Short- and medium-chain fatty acids exhibit antimicrobial activity for oral microorganisms. 2011 Arch. Oral Biol. pmid:21333271
Laurila H et al. The cytochrome P450-containing monooxygenase of Trichosporon cutaneum: occurrence and properties. 1984 Arch. Microbiol. pmid:6397156
Jenkins CL et al. Fatty acid composition of Simonsiella strains. 1977 Arch. Microbiol. pmid:560178
Green PR and Geer BW Changes in the fatty acid composition of Drosophila melanogaster during development and ageing. 1979 Arch. Int. Physiol. Biochim. pmid:93438
Demarne Y et al. Comparison of long term lipogenic effects of two different medium-chain triglycerides (tri C8: O and tri C12 : O) in the growing rat. 1978 Arch. Int. Physiol. Biochim. pmid:80196
Demarne Y et al. Effects of two different medium-chain triglycerides (tri C8:O and tri C12:O) on liver lipids in the growing rat. 1978 Arch. Int. Physiol. Biochim. pmid:80984
Que Hee SS and Zainal H Permeation of herbicidal dichlobenil from a Casoron formulation through nitrile gloves. 2010 Arch. Environ. Contam. Toxicol. pmid:19855916
Stodtmeister W et al. [Fatty acid composition of lipids from the hair in psoriasis vulgaris (author's transl)]. 1979 Arch. Dermatol. Res. pmid:464651
Shet Ms et al. The omega-hydroxlyation of lauric acid: oxidation of 12-hydroxlauric acid to dodecanedioic acid by a purified recombinant fusion protein containing P450 4A1 and NADPH-P450 reductase. 1996 Arch. Biochem. Biophys. pmid:8651697
Lewis DF Essential requirements for substrate binding affinity and selectivity toward human CYP2 family enzymes. 2003 Arch. Biochem. Biophys. pmid:12464242
Puchkaev AV et al. Aromatic stacking as a determinant of the thermal stability of CYP119 from Sulfolobus solfataricus. 2003 Arch. Biochem. Biophys. pmid:12464244
Salaün JP et al. Differential inactivation of plant lauric acid omega- and in-chain-hydroxylases by terminally unsaturated fatty acids. 1988 Arch. Biochem. Biophys. pmid:3341756
Kahn RA et al. A conservative amino acid substitution alters the regiospecificity of CYP94A2, a fatty acid hydroxylase from the plant Vicia sativa. 2001 Arch. Biochem. Biophys. pmid:11437349
Loughran PA et al. The kinetic and spectral characterization of the E. coli-expressed mammalian CYP4A7: cytochrome b5 effects vary with substrate. 2001 Arch. Biochem. Biophys. pmid:11368012
Norman HA and Thompson GA Effects of low-temperature stress on the metabolism of phosphatidylglycerol molecular species in Dunaliella salina. 1985 Arch. Biochem. Biophys. pmid:4051499
Sharma P et al. Structural basis of the binding of fatty acids to peptidoglycan recognition protein, PGRP-S through second binding site. 2013 Arch. Biochem. Biophys. pmid:23149273
Arkill KP and Winlove CP Fatty acid transport in articular cartilage. 2006 Arch. Biochem. Biophys. pmid:17084376
Lu P et al. Heme-coordinating analogs of lauric acid as inhibitors of fatty acid omega-hydroxylation. 1997 Arch. Biochem. Biophys. pmid:8990261
Miranda CL et al. Purification and characterization of hepatic steroid hydroxylases from untreated rainbow trout. 1989 Arch. Biochem. Biophys. pmid:2536262
Girvan HM et al. Flavocytochrome P450 BM3 mutant W1046A is a NADH-dependent fatty acid hydroxylase: implications for the mechanism of electron transfer in the P450 BM3 dimer. 2011 Arch. Biochem. Biophys. pmid:20868649
Cowart LA et al. Structural determinants of active site binding affinity and metabolism by cytochrome P450 BM-3. 2001 Arch. Biochem. Biophys. pmid:11368173
Duncan T et al. A glycoprotein binding retinoids and fatty acids is present in Drosophila. 1994 Arch. Biochem. Biophys. pmid:8031123
Gilep AA et al. Reconstitution of the enzymatic activities of cytochrome P450s using recombinant flavocytochromes containing rat cytochrome b(5) fused to NADPH--cytochrome P450 reductase with various membrane-binding segments. 2001 Arch. Biochem. Biophys. pmid:11396924
Puchkaev AV and Ortiz de Montellano PR The Sulfolobus solfataricus electron donor partners of thermophilic CYP119: an unusual non-NAD(P)H-dependent cytochrome P450 system. 2005 Arch. Biochem. Biophys. pmid:15629120
Straub P et al. Hydrophobic side chain requirements for lauric acid and progesterone hydroxylation at amino acid 113 in cytochrome P450 2C2, a potential determinant of substrate specificity. 1993 Arch. Biochem. Biophys. pmid:8215458