lauric acid

lauric acid is a lipid of Fatty Acyls (FA) class. Lauric acid is associated with abnormalities such as Infection, Renal tubular disorder, Hypertensive disease, Obesity and Mycoses. The involved functions are known as Transcription, Genetic, Signal Transduction, Mutation, metaplastic cell transformation and Anabolism. Lauric acid often locates in Skin, Plasma membrane, Cytoplasmic matrix, Body tissue and Palmar surface. The associated genes with lauric acid are Gene Family, SLC33A1 gene, Homologous Gene, Open Reading Frames and P4HTM gene. The related lipids are Fatty Acids, Oleic Acids, Palmitates, Stearates and 9,11-linoleic acid.

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Introduction

To understand associated biological information of lauric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with lauric acid?

lauric acid is suspected in Renal tubular disorder, Hypertensive disease, Infection, Renal vascular disorder, Obesity, Mycoses and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with lauric acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Lung Neoplasms D008175 171 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Body Weight D001835 333 associated lipids
Acne Vulgaris D000152 35 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Thrombosis D013927 49 associated lipids
Per page 10 20 50 | Total 33

PubChem Associated disorders and diseases

What pathways are associated with lauric acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with lauric acid?

Related references are published most in these journals:

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What functions are associated with lauric acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with lauric acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with lauric acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with lauric acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with lauric acid

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Authors Title Published Journal PubMed Link
Lo KW et al. Effects of fatty acids on growth and poly-3-hydroxybutyrate production in bacteria. 2005 Appl. Biochem. Biotechnol. pmid:15920264
Takenaka S et al. Adaptation of Pseudomonas sp. strain 7-6 to quaternary ammonium compounds and their degradation via dual pathways. 2007 Appl. Environ. Microbiol. pmid:17261523
Schallmey A et al. Characterization of cytochrome P450 monooxygenase CYP154H1 from the thermophilic soil bacterium Thermobifida fusca. 2011 Appl. Microbiol. Biotechnol. pmid:21057946
Beyer N et al. P450 fused to phosphite dehydrogenase allows phosphite-driven selective oxidations. 2017 Appl. Microbiol. Biotechnol. pmid:27900443
Ren Q et al. Enatiomerically pure hydroxycarboxylic acids: current approaches and future perspectives. 2010 Appl. Microbiol. Biotechnol. pmid:20393709
Hama S et al. Transesterification of phosphatidylcholine in sn-1 position through direct use of lipase-producing Rhizopus oryzae cells as whole-cell biocatalyst. 2011 Appl. Microbiol. Biotechnol. pmid:21468705
Lu XY et al. Production of poly(3-hydroxybutyrate- co-3-hydroxyhexanoate) with flexible 3-hydroxyhexanoate content in Aeromonas hydrophila CGMCC 0911. 2004 Appl. Microbiol. Biotechnol. pmid:12920488
Chung A et al. Microbial production of 3-hydroxydodecanoic acid by pha operon and fadBA knockout mutant of Pseudomonas putida KT2442 harboring tesB gene. 2009 Appl. Microbiol. Biotechnol. pmid:19271216
Chen GQ et al. Industrial scale production of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate). 2001 Appl. Microbiol. Biotechnol. pmid:11693933
Kojima K et al. A simple method for isolation and construction of markerless cyanobacterial mutants defective in acyl-acyl carrier protein synthetase. 2016 Appl. Microbiol. Biotechnol. pmid:27704180
Sato S et al. Expression and characterization of (R)-specific enoyl coenzyme A hydratases making a channeling route to polyhydroxyalkanoate biosynthesis in Pseudomonas putida. 2011 Appl. Microbiol. Biotechnol. pmid:21327961
Di Bello D et al. Presence and inducibility by beta-naphthoflavone of CYP1A1, CYP1B1 and phase II enzymes in Trematomus bernacchii, an Antarctic fish. 2007 Aquat. Toxicol. pmid:17643506
Nabb DL et al. Comparison of basal level metabolic enzyme activities of freshly isolated hepatocytes from rainbow trout (Oncorhynchus mykiss) and rat. 2006 Aquat. Toxicol. pmid:16935359
Thibaut R et al. Regio-specific hydroxylation of nonylphenol and the involvement of CYP2K- and CYP2M-like iso-enzymes in Atlantic salmon (Salmo salar). 2002 Aquat. Toxicol. pmid:11792434
Dohme F et al. Digestive and metabolic utilization of lauric, myristic and stearic acid in cows, and associated effects on milk fat quality. 2004 Arch Anim Nutr pmid:15195905
Geiger F et al. Trochanteric fractures in the elderly: the influence of primary hip arthroplasty on 1-year mortality. 2007 Arch Orthop Trauma Surg pmid:17899138
Berschauer F et al. [Nutritive physiological effect of dietary fats in growing swine rations. 3. Effect of sunflower and coconut kernels on protein and fat retention, backfat fatty acid pattern and various blood parameters in piglets]. 1983 Arch Tierernahr pmid:6370196
Helali E and Hashem H [Qualitative and quantitative studies on the metabolism of fatty acids, in particular on that of linoleic acid in calves]. 1975 Arch Tierernahr pmid:1233966
Honoré B et al. Cobinding of bilirubin and laurate to human serum albumin: spectroscopic characterization of stoichiometric complexes. 1988 Arch. Biochem. Biophys. pmid:3178221
Kolattukudy PE and Rogers L Biosynthesis of 3-hydroxy fatty acids, the pheromone components of female mallard ducks, by cell-free preparations from the uropygial gland. 1987 Arch. Biochem. Biophys. pmid:3813530
Shet Ms et al. The omega-hydroxlyation of lauric acid: oxidation of 12-hydroxlauric acid to dodecanedioic acid by a purified recombinant fusion protein containing P450 4A1 and NADPH-P450 reductase. 1996 Arch. Biochem. Biophys. pmid:8651697
Brodersen R et al. Cobinding of bilirubin and sulfonamide and of two bilirubin molecules to human serum albumin: a site model. 1987 Arch. Biochem. Biophys. pmid:3813550
Lewis DF Essential requirements for substrate binding affinity and selectivity toward human CYP2 family enzymes. 2003 Arch. Biochem. Biophys. pmid:12464242
Puchkaev AV et al. Aromatic stacking as a determinant of the thermal stability of CYP119 from Sulfolobus solfataricus. 2003 Arch. Biochem. Biophys. pmid:12464244
Rock DA et al. A method for determining two substrates binding in the same active site of cytochrome P450BM3: an explanation of high energy omega product formation. 2003 Arch. Biochem. Biophys. pmid:12859976
Williams DE et al. Regiospecific hydroxylation of lauric acid at the (omega-1) position by hepatic and kidney microsomal cytochromes P-450 from rainbow trout. 1984 Arch. Biochem. Biophys. pmid:6732245
Salaün JP et al. Differential inactivation of plant lauric acid omega- and in-chain-hydroxylases by terminally unsaturated fatty acids. 1988 Arch. Biochem. Biophys. pmid:3341756
Salaun JP et al. Autocatalytic inactivation of plant cytochrome P-450 enzymes: selective inactivation of the lauric acid in-chain hydroxylase from Helianthus tuberosus L. by unsaturated substrate analogs. 1984 Arch. Biochem. Biophys. pmid:6742847
Finlayson MJ et al. Differential expression of cytochrome P-450 1 and related forms in rabbit liver and kidney. 1987 Arch. Biochem. Biophys. pmid:3492962
Kahn RA et al. A conservative amino acid substitution alters the regiospecificity of CYP94A2, a fatty acid hydroxylase from the plant Vicia sativa. 2001 Arch. Biochem. Biophys. pmid:11437349
Loughran PA et al. The kinetic and spectral characterization of the E. coli-expressed mammalian CYP4A7: cytochrome b5 effects vary with substrate. 2001 Arch. Biochem. Biophys. pmid:11368012
Kawashima H et al. Human fatty acid omega-hydroxylase, CYP4A11: determination of complete genomic sequence and characterization of purified recombinant protein. 2000 Arch. Biochem. Biophys. pmid:10860550
Capdevila J et al. Influence of a fibric acid type of hypolipidemic agent on the oxidative metabolism of arachidonic acid by liver microsomal cytochrome P-450. 1985 Arch. Biochem. Biophys. pmid:3933431
Norman HA and Thompson GA Effects of low-temperature stress on the metabolism of phosphatidylglycerol molecular species in Dunaliella salina. 1985 Arch. Biochem. Biophys. pmid:4051499
Wang MH et al. Cloning, sequencing, and cDNA-directed expression of the rat renal CYP4A2: arachidonic acid omega-hydroxylation and 11,12-epoxidation by CYP4A2 protein. 1996 Arch. Biochem. Biophys. pmid:8954571
Sharma P et al. Structural basis of the binding of fatty acids to peptidoglycan recognition protein, PGRP-S through second binding site. 2013 Arch. Biochem. Biophys. pmid:23149273
Arkill KP and Winlove CP Fatty acid transport in articular cartilage. 2006 Arch. Biochem. Biophys. pmid:17084376
Powell PK et al. Identification of CYP4A11 as the major lauric acid omega-hydroxylase in human liver microsomes. 1996 Arch. Biochem. Biophys. pmid:8914854
Lu P et al. Heme-coordinating analogs of lauric acid as inhibitors of fatty acid omega-hydroxylation. 1997 Arch. Biochem. Biophys. pmid:8990261
Okita RT and Okita JR Characterization of a cytochrome P450 from di(2-ethylhexyl) phthalate-treated rats which hydroxylates fatty acids. 1992 Arch. Biochem. Biophys. pmid:1567203
Miranda CL et al. Purification and characterization of hepatic steroid hydroxylases from untreated rainbow trout. 1989 Arch. Biochem. Biophys. pmid:2536262
Girvan HM et al. Flavocytochrome P450 BM3 mutant W1046A is a NADH-dependent fatty acid hydroxylase: implications for the mechanism of electron transfer in the P450 BM3 dimer. 2011 Arch. Biochem. Biophys. pmid:20868649
Chaurasia CS et al. Biochemical characterization of lauric acid omega-hydroxylation by a CYP4A1/NADPH-cytochrome P450 reductase fusion protein. 1995 Arch. Biochem. Biophys. pmid:7872779
Cowart LA et al. Structural determinants of active site binding affinity and metabolism by cytochrome P450 BM-3. 2001 Arch. Biochem. Biophys. pmid:11368173
Duncan T et al. A glycoprotein binding retinoids and fatty acids is present in Drosophila. 1994 Arch. Biochem. Biophys. pmid:8031123
Gilep AA et al. Reconstitution of the enzymatic activities of cytochrome P450s using recombinant flavocytochromes containing rat cytochrome b(5) fused to NADPH--cytochrome P450 reductase with various membrane-binding segments. 2001 Arch. Biochem. Biophys. pmid:11396924
Puchkaev AV and Ortiz de Montellano PR The Sulfolobus solfataricus electron donor partners of thermophilic CYP119: an unusual non-NAD(P)H-dependent cytochrome P450 system. 2005 Arch. Biochem. Biophys. pmid:15629120
Sato H et al. Multiple binding of bilirubin to human serum albumin and cobinding with laurate. 1988 Arch. Biochem. Biophys. pmid:2829743
Kikuta Y et al. Expression and catalytic activity of mouse leukotriene B4 omega-hydroxylase, CYP4F14. 2000 Arch. Biochem. Biophys. pmid:11185557
Straub P et al. Hydrophobic side chain requirements for lauric acid and progesterone hydroxylation at amino acid 113 in cytochrome P450 2C2, a potential determinant of substrate specificity. 1993 Arch. Biochem. Biophys. pmid:8215458