Digitonin

Digitonin is a lipid of Sterol Lipids (ST) class. Digitonin is associated with abnormalities such as SCHOPF-SCHULZ-PASSARGE SYNDROME (disorder), Infection, BOSLEY-SALIH-ALORAINY SYNDROME, Hyperostosis, Diffuse Idiopathic Skeletal and FRONTOTEMPORAL DEMENTIA, CHROMOSOME 3-LINKED. The involved functions are known as Coprecipitation, establishment and maintenance of localization, Mutation, protein thiol-disulfide exchange and Receptor Binding. Digitonin often locates in Protoplasm, Cytoplasm, Membrane, Cytoplasmic matrix and Cytoplasmic Domain. The associated genes with Digitonin are Integral Membrane Proteins, Polypeptides, GOLPH3 gene, GAS1 gene and TRAF3IP2 gene. The related lipids are Promega, Sterols, 1,2-dihexadecyl-sn-glycero-3-phosphocholine, proteoliposomes and Lysophosphatidylcholines.

Cross Reference

Introduction

To understand associated biological information of Digitonin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Digitonin?

Digitonin is suspected in CONE-ROD DYSTROPHY 1 (disorder), BOSLEY-SALIH-ALORAINY SYNDROME, protrusion, Infection, NOONAN SYNDROME 3, SCHOPF-SCHULZ-PASSARGE SYNDROME (disorder) and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Digitonin

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Rocky Mountain Spotted Fever D012373 3 associated lipids
Total 3

PubChem Associated disorders and diseases

What pathways are associated with Digitonin

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Digitonin through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Digitonin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Digitonin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Digitonin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Digitonin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Digitonin?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Digitonin

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Authors Title Published Journal PubMed Link
Malabed R et al. Sterol-recognition ability and membrane-disrupting activity of Ornithogalum saponin OSW-1 and usual 3-O-glycosyl saponins. 2017 Biochim. Biophys. Acta pmid:28947142
Zholobenko AV et al. On the causes and consequences of the uncoupler-like effects of quercetin and dehydrosilybin in H9c2 cells. 2017 PLoS ONE pmid:28977033
Wheeler JR et al. Distinct stages in stress granule assembly and disassembly. 2016 Elife pmid:27602576
Au S et al. A new mechanism for nuclear import by actin-based propulsion used by a baculovirus nucleocapsid. 2016 J. Cell. Sci. pmid:27284005
Jäger F et al. Membrane interactions and self-association of components of the Ess/Type VII secretion system of Staphylococcus aureus. 2016 FEBS Lett. pmid:26785823
Shinzawa-Itoh K et al. Purification of Active Respiratory Supercomplex from Bovine Heart Mitochondria Enables Functional Studies. 2016 J. Biol. Chem. pmid:26698328
Mito M et al. Simultaneous multicolor detection of RNA and proteins using super-resolution microscopy. 2016 Methods pmid:26564236
Berger ML Soaping the NMDA receptor: Various types of detergents influence differently [(3)H]MK-801 binding to rat brain membranes. 2016 Biochim. Biophys. Acta pmid:26518518
Sudji IR et al. Membrane Disintegration Caused by the Steroid Saponin Digitonin Is Related to the Presence of Cholesterol. 2015 Molecules pmid:26569199
Pinnola A et al. Light-Harvesting Complex Stress-Related Proteins Catalyze Excess Energy Dissipation in Both Photosystems of Physcomitrella patens. 2015 Plant Cell pmid:26508763