MeSH term | MeSH ID | Detail |
---|---|---|
Hemolysis | D006461 | 131 associated lipids |
Metabolism, Inborn Errors | D008661 | 46 associated lipids |
Rocky Mountain Spotted Fever | D012373 | 3 associated lipids |
Digitonin is a lipid of Sterol Lipids (ST) class. Digitonin is associated with abnormalities such as SCHOPF-SCHULZ-PASSARGE SYNDROME (disorder), Infection, BOSLEY-SALIH-ALORAINY SYNDROME, Hyperostosis, Diffuse Idiopathic Skeletal and FRONTOTEMPORAL DEMENTIA, CHROMOSOME 3-LINKED. The involved functions are known as Coprecipitation, establishment and maintenance of localization, Mutation, protein thiol-disulfide exchange and Receptor Binding. Digitonin often locates in Protoplasm, Cytoplasm, Membrane, Cytoplasmic matrix and Cytoplasmic Domain. The associated genes with Digitonin are Integral Membrane Proteins, Polypeptides, GOLPH3 gene, GAS1 gene and TRAF3IP2 gene. The related lipids are Promega, Sterols, 1,2-dihexadecyl-sn-glycero-3-phosphocholine, proteoliposomes and Lysophosphatidylcholines.
To understand associated biological information of Digitonin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Digitonin is suspected in CONE-ROD DYSTROPHY 1 (disorder), BOSLEY-SALIH-ALORAINY SYNDROME, protrusion, Infection, NOONAN SYNDROME 3, SCHOPF-SCHULZ-PASSARGE SYNDROME (disorder) and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Digitonin
MeSH term | MeSH ID | Detail |
---|---|---|
Hemolysis | D006461 | 131 associated lipids |
Metabolism, Inborn Errors | D008661 | 46 associated lipids |
Rocky Mountain Spotted Fever | D012373 | 3 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Digitonin through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Malabed R et al. | Sterol-recognition ability and membrane-disrupting activity of Ornithogalum saponin OSW-1 and usual 3-O-glycosyl saponins. | 2017 | Biochim. Biophys. Acta | pmid:28947142 |
Zholobenko AV et al. | On the causes and consequences of the uncoupler-like effects of quercetin and dehydrosilybin in H9c2 cells. | 2017 | PLoS ONE | pmid:28977033 |
Wheeler JR et al. | Distinct stages in stress granule assembly and disassembly. | 2016 | Elife | pmid:27602576 |
Au S et al. | A new mechanism for nuclear import by actin-based propulsion used by a baculovirus nucleocapsid. | 2016 | J. Cell. Sci. | pmid:27284005 |
Jäger F et al. | Membrane interactions and self-association of components of the Ess/Type VII secretion system of Staphylococcus aureus. | 2016 | FEBS Lett. | pmid:26785823 |
Shinzawa-Itoh K et al. | Purification of Active Respiratory Supercomplex from Bovine Heart Mitochondria Enables Functional Studies. | 2016 | J. Biol. Chem. | pmid:26698328 |
Mito M et al. | Simultaneous multicolor detection of RNA and proteins using super-resolution microscopy. | 2016 | Methods | pmid:26564236 |
Berger ML | Soaping the NMDA receptor: Various types of detergents influence differently [(3)H]MK-801 binding to rat brain membranes. | 2016 | Biochim. Biophys. Acta | pmid:26518518 |
Sudji IR et al. | Membrane Disintegration Caused by the Steroid Saponin Digitonin Is Related to the Presence of Cholesterol. | 2015 | Molecules | pmid:26569199 |
Pinnola A et al. | Light-Harvesting Complex Stress-Related Proteins Catalyze Excess Energy Dissipation in Both Photosystems of Physcomitrella patens. | 2015 | Plant Cell | pmid:26508763 |