MeSH term | MeSH ID | Detail |
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Body Weight | D001835 | 333 associated lipids |
Diosgenin is a lipid of Sterol Lipids (ST) class. Diosgenin is associated with abnormalities such as Diabetes, PARAGANGLIOMAS 3, Osteoporosis, estrogen deficiency and Bone Diseases. The involved functions are known as Process, inhibitors, Metabolic Inhibition, Diastasis and Inflammation. Diosgenin often locates in Hepatic, Extracellular, Body tissue, Entire bony skeleton and Cytoplasmic matrix. The associated genes with Diosgenin are SLC2A1 gene, Operator gene, CFB gene, IMPACT gene and iberiotoxin. The related lipids are Saponins, Saponin, Steroids, Sapogenins and yamogenin.
To understand associated biological information of Diosgenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Diosgenin is suspected in Osteoporosis, Vascular Diseases, Anemia, Sickle Cell, Diabetes, Dyslipidemias, PARAGANGLIOMAS 3 and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Diosgenin
MeSH term | MeSH ID | Detail |
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Body Weight | D001835 | 333 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Diosgenin through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Kim M et al. | Optimal Fermentation Conditions of Hyaluronidase Inhibition Activity on Asparagus cochinchinensis Merrill by Weissella cibaria. | 2017 | J. Microbiol. Biotechnol. | pmid:28189140 |
Pi WX et al. | Combination of Morroniside and Diosgenin Prevents High Glucose-Induced Cardiomyocytes Apoptosis. | 2017 | Molecules | pmid:28106847 |
Junchao Y et al. | Anti- trachea inflammatory effects of diosgenin from Dioscorea nipponica through interactions with glucocorticoid receptor α. | 2017 | J. Int. Med. Res. | pmid:27913746 |
Zhang Y et al. | Protective effects of dioscin against doxorubicin-induced nephrotoxicity via adjusting FXR-mediated oxidative stress and inflammation. | 2017 | Toxicology | pmid:28082111 |
Ciura J et al. | Next-generation sequencing of representational difference analysis products for identification of genes involved in diosgenin biosynthesis in fenugreek (Trigonella foenum-graecum). | 2017 | Planta | pmid:28161815 |
Reshma PL et al. | Mitochondrial dysfunction in H9c2 cells during ischemia and amelioration with Tribulus terrestris L. | 2016 | Life Sci. | pmid:27049116 |
Janicka K et al. | The Equilibria of Diosgenin-Phosphatidylcholine and Diosgenin-Cholesterol in Monolayers at the Air/Water Interface. | 2016 | J. Membr. Biol. | pmid:27350149 |
Zhao X et al. | Dioscin Induces Apoptosis in Human Cervical Carcinoma HeLa and SiHa Cells through ROS-Mediated DNA Damage and the Mitochondrial Signaling Pathway. | 2016 | Molecules | pmid:27271587 |
Folwarczna J et al. | Effect of diosgenin, a steroidal sapogenin, on the rat skeletal system. | 2016 | Acta Biochim. Pol. | pmid:27119728 |
Zhang X et al. | A new quantitation method of protodioscin by HPLC-ESI-MS/MS in rat plasma and its application to the pharmacokinetic study. | 2016 | Steroids | pmid:26703445 |