Diosgenin

Diosgenin is a lipid of Sterol Lipids (ST) class. Diosgenin is associated with abnormalities such as Diabetes, PARAGANGLIOMAS 3, Osteoporosis, estrogen deficiency and Bone Diseases. The involved functions are known as Process, inhibitors, Metabolic Inhibition, Diastasis and Inflammation. Diosgenin often locates in Hepatic, Extracellular, Body tissue, Entire bony skeleton and Cytoplasmic matrix. The associated genes with Diosgenin are SLC2A1 gene, Operator gene, CFB gene, IMPACT gene and iberiotoxin. The related lipids are Saponins, Saponin, Steroids, Sapogenins and yamogenin.

Cross Reference

Introduction

To understand associated biological information of Diosgenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Diosgenin?

Diosgenin is suspected in Osteoporosis, Vascular Diseases, Anemia, Sickle Cell, Diabetes, Dyslipidemias, PARAGANGLIOMAS 3 and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Diosgenin

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Total 1

PubChem Associated disorders and diseases

What pathways are associated with Diosgenin

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Diosgenin through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Diosgenin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Diosgenin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Diosgenin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Diosgenin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Diosgenin?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Diosgenin

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Authors Title Published Journal PubMed Link
Kim M et al. Optimal Fermentation Conditions of Hyaluronidase Inhibition Activity on Asparagus cochinchinensis Merrill by Weissella cibaria. 2017 J. Microbiol. Biotechnol. pmid:28189140
Pi WX et al. Combination of Morroniside and Diosgenin Prevents High Glucose-Induced Cardiomyocytes Apoptosis. 2017 Molecules pmid:28106847
Junchao Y et al. Anti- trachea inflammatory effects of diosgenin from Dioscorea nipponica through interactions with glucocorticoid receptor α. 2017 J. Int. Med. Res. pmid:27913746
Zhang Y et al. Protective effects of dioscin against doxorubicin-induced nephrotoxicity via adjusting FXR-mediated oxidative stress and inflammation. 2017 Toxicology pmid:28082111
Ciura J et al. Next-generation sequencing of representational difference analysis products for identification of genes involved in diosgenin biosynthesis in fenugreek (Trigonella foenum-graecum). 2017 Planta pmid:28161815
Reshma PL et al. Mitochondrial dysfunction in H9c2 cells during ischemia and amelioration with Tribulus terrestris L. 2016 Life Sci. pmid:27049116
Janicka K et al. The Equilibria of Diosgenin-Phosphatidylcholine and Diosgenin-Cholesterol in Monolayers at the Air/Water Interface. 2016 J. Membr. Biol. pmid:27350149
Zhao X et al. Dioscin Induces Apoptosis in Human Cervical Carcinoma HeLa and SiHa Cells through ROS-Mediated DNA Damage and the Mitochondrial Signaling Pathway. 2016 Molecules pmid:27271587
Folwarczna J et al. Effect of diosgenin, a steroidal sapogenin, on the rat skeletal system. 2016 Acta Biochim. Pol. pmid:27119728
Zhang X et al. A new quantitation method of protodioscin by HPLC-ESI-MS/MS in rat plasma and its application to the pharmacokinetic study. 2016 Steroids pmid:26703445