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Proscillaridin A is cytotoxic for glioblastoma cell lines and controls tumor xenograft growth in vivo. |
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2010 Nov-Dec |
Acta Pol Pharm |
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Synthesis and cytotoxic activity of G3 PAMAM-NH(2) dendrimer-modified digoxin and proscillaridin A conjugates in breast cancer cells. |
2010 Mar-Apr |
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2010 |
Nat. Prod. Res. |
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Cytotoxic effects of cardiac glycosides in colon cancer cells, alone and in combination with standard chemotherapeutic drugs. |
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Antiproliferative activity of derivatives of ouabain, digoxin and proscillaridin A in human MCF-7 and MDA-MB-231 breast cancer cells. |
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Apoptosis-mediated cytotoxicity of ouabain, digoxin and proscillaridin A in the estrogen independent MDA-MB-231 breast cancer cells. |
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Inhibition of DNA topoisomerases I and II, and growth inhibition of breast cancer MCF-7 cells by ouabain, digoxin and proscillaridin A. |
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Exquisitely small amounts of nonglucocorticoid natural steroids suppress the human allogeneic T-cell response. |
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[An elderly case of idiopathic dilatation of the right atrium in which right-sided heart failure was exacerbated by drug-induced bradyarrhythmia]. |
2001 |
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The T-cell suppressive effect of bufadienolides: structural requirements for their immunoregulatory activity. |
2001 |
Int. Immunopharmacol. |
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Proscillaridin A immunoreactivity: its purification, transport in blood by a specific binding protein and its correlation with blood pressure. |
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1996 |
Am. J. Hypertens. |
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Pulse pressure correlates in humans with a proscillaridin A immunoreactive compound. |
1996 |
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Cardiac glycoside-induced elevation of intracellular Na+ ion concentration in human erythrocytes studied by 23Na NMR spectroscopy: relationship between inotropy speed and elevation rate of intracellular Na+ ion concentration. |
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Okamoto M and Tsukahara T |
[Preparation of phenylpropylsilica and its application to high performance liquid chromatographic analysis of proscillaridin]. |
1993 |
Yakugaku Zasshi |
pmid:8387581
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Studies on cardiac ingredients of plants. IX. Chemical transformation of proscillaridin by utilizing its 1,4-cycloadducts as key compounds and biological activities of their derivatives. |
1992 |
Chem. Pharm. Bull. |
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[Studies on cardiac ingredients of plants. X. Preparation of nitrates of tetrahydroproscillaridin and their pharmacological activities]. |
1992 |
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1991 |
Yakugaku Zasshi |
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Studies on cardiac ingredients of plants. VII: Chemical transformation of proscillaridin by means of the Diels-Alder reaction and biological activities of its derivatives. |
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Chem. Pharm. Bull. |
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Specific anti-digoxin Fab fragments: an available antidote for proscillaridin and scilliroside poisoning? |
1990 |
Hum Exp Toxicol |
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Studies on cardiac ingredients of plants. V. Chemical transformation of proscillaridin and biological activities of derivatives. |
1988 |
Chem. Pharm. Bull. |
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Hemodynamic effect of methylepoxyproscillaridin (P35) in patients with congestive myocardiopathy. |
1988 |
Int J Clin Pharmacol Ther Toxicol |
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The bioavailability of methylepoxyproscillaridin (P35): a new semisynthetic cardiac glycoside. |
1988 |
Int J Clin Pharmacol Ther Toxicol |
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Studies on cardiac ingredients of plants. III. Structural confirmation and biological activity of reduced proscillaridins. |
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Chem. Pharm. Bull. |
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1987 |
Nippon Yakurigaku Zasshi |
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Determination of proscillaridin in plasma by radioimmunoassay. |
1986 |
J. Pharmacobio-dyn. |
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[Potential radiopharmaceutical for adrenal gland scintigraphy. 1. Radioiodination of tyramine derivatives of some derivatives of digitoxigenin and scillarenin]. |
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Arch. Pharm. (Weinheim) |
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[Use of a cardiotonic agent in the ventricular pre-excitation syndrome. Report of a case]. |
1985 |
Arq. Bras. Cardiol. |
pmid:4096667
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A comparative dose-effect study with cardiac glycosides assessing cardiac and extracardiac responses in normal subjects. |
1984 Jul-Aug |
J. Cardiovasc. Pharmacol. |
pmid:6206318
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Burkert K and Beckmann H |
[Plasma concentration and elimination behavior of the cardiac glycoside meproscillarin in patients with liver cirrhosis]. |
1983 |
Z Gastroenterol |
pmid:6845784
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Lüllmann H et al. |
Electrophysiological studies of some semisynthetic cardiac glycoside derivatives in isolated papillary muscle of the guinea-pig. |
1983 |
Br. J. Pharmacol. |
pmid:6652355
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Brock N et al. |
Studies on the urotoxicity of oxazaphosphorine cytostatics and its prevention--III. Profile of action of sodium 2-mercaptoethane sulfonate (mesna). |
1982 |
Eur J Cancer Clin Oncol |
pmid:6819957
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Tytman B |
[Evaluation of the practical use of mathematical methods and computer technics for the control of treatment with selected digitalis glycosides]. |
1981 |
Pol Tyg Lek |
pmid:7335534
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[Densitometric determination of proscillaridin A, scillaren A and scilliroside]. |
1980 |
Farmaco Prat |
pmid:7449933
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Belz GG and Aust PE |
[Threshold of action of meproscillarin following intravenous administration]. |
1980 |
Med Klin |
pmid:7001203
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Lindner E et al. |
[14,15-beta-oxido analog of proscillaridin (HOE 040). A new cardiac glycoside with low arrhythmic activity and greater absorption ratio]. |
1979 |
Arzneimittelforschung |
pmid:109100
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Beckmann H et al. |
[Meproscillarin in patients with renal failure and concomitant heart failure (author's transl)]. |
1979 |
Med Klin |
pmid:522817
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Tytman B |
[Construction of tables facilitating daily control of treatment with proscillaridin A]. |
1979 |
Pol Tyg Lek |
pmid:575563
|
Bergdahl B |
Disposition rate of proscillaridin A in man after multiple oral doses. |
1979 |
Arzneimittelforschung |
pmid:582147
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Regal DS and Waginger H |
[Effect of proscillaridin on specific adenosine triphosphatases in heart muscle of rats. Electron optical demonstration and significance for calcium metabolism]. |
1978 |
Zentralbl Veterinarmed A |
pmid:212903
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Regal DS |
[Effect of proscillaridin on adenosine triphosphatase in kidney tissue in the rat. Electron microscopy demonstration and significance for calcium metabolism]. |
1978 |
Zentralbl Veterinarmed A |
pmid:153691
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Kubinyi H |
[Meproscillarin, a new semisynthetic cardiac glycoside/chemistry and physical properties (author's transl)]. |
1978 |
Arzneimittelforschung |
pmid:580577
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Friedrich L et al. |
[Studies on extracardiac effects of the cardiac glycoside meproscillarin in animal experiments (author's transl)]. |
1978 |
Arzneimittelforschung |
pmid:580579
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Andersson KE et al. |
Biliary excretion and enterochepatic recycling of proscillaridin A after oral adminstration to man. |
1977 |
Eur. J. Clin. Pharmacol. |
pmid:862647
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Andersson KE et al. |
Proscillaridin activity in portal and peripheral venous blood after oral administration to man. |
1977 |
Eur. J. Clin. Pharmacol. |
pmid:862648
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Bergdahl B and Andersson KE |
Stability in vitro of methylproscillaridin. |
1977 |
Eur. J. Clin. Pharmacol. |
pmid:16755
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Stauch M et al. |
[Effect of proscillaridin-4'-methylether on pressure rise velocity in the left ventricle of patients with coronary heart disease (author's transl)]. |
1977 |
Klin. Wochenschr. |
pmid:330937
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Stefan G |
[Echocardiography during the therapy of cardiovascular diseases]. |
1977 |
MMW Munch Med Wochenschr |
pmid:401936
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Wójcicki J and Stanosz S |
[Comparative studies of action in cats of intraintestinally administered digoxin, proscillardin and K- strophantoside]. |
1977 |
Acta Pol Pharm |
pmid:930618
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Garcia Casado P et al. |
Proscillaridin A yield from squill bulbs. |
1977 |
Pharm Acta Helv |
pmid:565519
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Andersson KE et al. |
On the absorption of proscillaridin A after single oral doses to normal and achlorhydric subjects. |
1977 |
Acta Pharmacol Toxicol (Copenh) |
pmid:576356
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Andersson KE et al. |
Activities of proscillaridin A in thoracic duct lymph after single oral doses in man. |
1977 |
Acta Pharmacol Toxicol (Copenh) |
pmid:576557
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Neugebauer G |
[Influence of high intravenous doses of D-penicillamine on toxic actions of cardiac glycosides in the guinea pig. Short communication (author's transl)]. |
1977 |
Arzneimittelforschung |
pmid:580003
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Belz GG et al. |
Pharmacokinetics and pharmacodynamics of methyl proscillaridin in healthy man. |
1976 |
Eur. J. Clin. Pharmacol. |
pmid:786669
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Einig H |
[Investigations on the Stability of Proscillaridine, Proscillaridine-3'-methylether and Proscillaridine-4'-methylether in Artificial Gastric and Intestinal Fluids (author's transl)]. |
1976 |
Arzneimittelforschung |
pmid:12764
|
Belz GG et al. |
Plasma concentrations during repeated intravenous and oral methyl-proscillaridin application in man. |
1976 |
Arzneimittelforschung |
pmid:947212
|
Krämer KD and Hochrein H |
[Enteral availability and therapeutic activity of proscillaridin-4'-methyl ether (author's transl)]. |
1976 |
Arzneimittelforschung |
pmid:989015
|
Bellardo G and Pichierri U |
[Trial of a combination of proscillaridin A, thioridazine and Cori ester in the ambulatory treatment of some cardiopathies, especially senile types]. |
1976 |
Minerva Med. |
pmid:967364
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Stefan G |
[Echocardiographic evaluation of left ventricular function during therapy with cardiovascularly effective drugs]. |
1976 |
Z Kardiol |
pmid:969820
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Krämer KD and Hochrein H |
[Enteral availability and suggested dosages for methyl proscillaridin in decompensated heart patients]. |
1975 |
Verh Dtsch Ges Inn Med |
pmid:1227053
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Andersson KE et al. |
On the pharmacokinetics of proscillaridin A in man. |
1975 |
Eur. J. Clin. Pharmacol. |
pmid:1233243
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Rietbrock N and Staud R |
Metabolism and excretion of methylproscillaridin by man. |
1975 |
Eur. J. Clin. Pharmacol. |
pmid:1233244
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Staud R et al. |
Excretion of methylproscillaridin in patients with a biliary fistula. |
1975 |
Eur. J. Clin. Pharmacol. |
pmid:1233271
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Andersson KE et al. |
In vitro stability of proscillaridin A. |
1975 |
Eur. J. Clin. Pharmacol. |
pmid:9294
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Zalar S et al. |
[Relationship between binding to the myocardium and effects of proscillaridin on isolated perfused heart of the guinea pig]. |
1975 |
Boll Chim Farm |
pmid:1131317
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Nishida H et al. |
[Effect of proscillaridin on active cation transport across human red cell membrane (author's transl)]. |
1974 |
Hokkaido Igaku Zasshi |
pmid:4477138
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Nishida H |
[Studies on direct effects of proscillaridin A on the electrolyte excretion and transport ATPase in dog kidneys (author's transl)]. |
1974 |
Hokkaido Igaku Zasshi |
pmid:4281758
|
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