Norethindrone

Norethindrone is a lipid of Sterol Lipids (ST) class. Norethindrone is associated with abnormalities such as Endometriosis, site unspecified, Wiskott-Aldrich Syndrome and Estrogenic effect. The involved functions are known as Hemorrhage, Phosphorylation, Apoptosis, DNA Repair and Cell Cycle. Norethindrone often locates in Blood, Back, Body tissue, Nucleolar and Human tissue. The associated genes with Norethindrone are MMP gene, NR3C1 gene and Genes, Reporter. The related lipids are Steroids, 4,17 beta-dihydroxy-4-androstene-3-one, 4-estren-3,17-diol and Estranes.

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Introduction

To understand associated biological information of Norethindrone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Norethindrone?

Norethindrone is suspected in Endometriosis, site unspecified, Estrogenic effect and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Norethindrone

MeSH term MeSH ID Detail
Arteriosclerosis D001161 86 associated lipids
Body Weight D001835 333 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Total 3

PubChem Associated disorders and diseases

What pathways are associated with Norethindrone

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Norethindrone?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Norethindrone?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Norethindrone?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Norethindrone?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Norethindrone?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Norethindrone

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Authors Title Published Journal PubMed Link
Christensen JM and Zupon MA Norethindrone disposition following x-ionizing radiation in rats. 1985 Res. Commun. Chem. Pathol. Pharmacol. pmid:3909274
Watanabe H et al. Identification of hydrazone of norethindrone, a metabolic product resulting from the interaction between isoniazid and norethindrone. 1981 Res. Commun. Chem. Pathol. Pharmacol. pmid:7255877
Ho-Ngoc A et al. Quantitation of delta 4-reduced metabolite of norethindrone in human plasma by HPLC-RIA. 1984 Res. Commun. Chem. Pathol. Pharmacol. pmid:6739957
Beck LR and Pope VZ Long-acting injectable norethisterone contraceptive system: review of clinical studies. 1984 Res Front Fertil Regul pmid:12179635
Wistuba J et al. Experimental endocrine manipulation by contraceptive regimen in the male marmoset (Callithrix jacchus). 2013 Reproduction pmid:23431271
García-Becerra R et al. Comparison of 7α-methyl-19-nortestosterone effectiveness alone or combined with progestins on androgen receptor mediated-transactivation. 2012 Reproduction pmid:22065861
Ramachandra SG et al. Effect of chronic administration of 7alpha-methyl-19-nortestosterone on serum testosterone, number of spermatozoa and fertility in adult male bonnet monkeys (Macaca radiata). 2002 Reproduction pmid:12141943
Ferrero S et al. Letrozole and norethisterone acetate versus letrozole and triptorelin in the treatment of endometriosis related pain symptoms: a randomized controlled trial. 2011 Reprod. Biol. Endocrinol. pmid:21693037
Filannino A et al. Dose-response effects of estrogenic mycotoxins (zearalenone, alpha- and beta-zearalenol) on motility, hyperactivation and the acrosome reaction of stallion sperm. 2011 Reprod. Biol. Endocrinol. pmid:21970729
Thongtip N et al. Successful artificial insemination in the Asian elephant (Elephas maximus) using chilled and frozen-thawed semen. 2009 Reprod. Biol. Endocrinol. pmid:19615097
Ferrero S et al. Use of aromatase inhibitors to treat endometriosis-related pain symptoms: a systematic review. 2011 Reprod. Biol. Endocrinol. pmid:21693038
Nothnick WB The emerging use of aromatase inhibitors for endometriosis treatment. 2011 Reprod. Biol. Endocrinol. pmid:21693036
Nutu M et al. Distribution and hormonal regulation of membrane progesterone receptors beta and gamma in ciliated epithelial cells of mouse and human fallopian tubes. 2009 Reprod. Biol. Endocrinol. pmid:19715581
Chwalisz K et al. The hormonal profile of norethindrone acetate: rationale for add-back therapy with gonadotropin-releasing hormone agonists in women with endometriosis. 2012 Reprod Sci pmid:22457429
Hofmeyr GJ et al. Effects of the copper intrauterine device versus injectable progestin contraception on pregnancy rates and method discontinuation among women attending termination of pregnancy services in South Africa: a pragmatic randomized controlled trial. 2016 Reprod Health pmid:27091008
Norethisterone. 2011 Rep Carcinog pmid:21860523
Norethisterone. 2004 Rep Carcinog pmid:21105253
Norethisterone. 2002 Rep Carcinog pmid:15328588
Maier WE and Herman JR Pharmacology and toxicology of ethinyl estradiol and norethindrone acetate in experimental animals. 2001 Regul. Toxicol. Pharmacol. pmid:11502156
Rugarn O et al. Progesterone and norethisterone have different effects on tachykinin-like immunoreactivity in rat cortex and striatum. 2001 Regul. Pept. pmid:11495683