Norethindrone

Norethindrone is a lipid of Sterol Lipids (ST) class. Norethindrone is associated with abnormalities such as Endometriosis, site unspecified, Wiskott-Aldrich Syndrome and Estrogenic effect. The involved functions are known as Hemorrhage, Phosphorylation, Apoptosis, DNA Repair and Cell Cycle. Norethindrone often locates in Blood, Back, Body tissue, Nucleolar and Human tissue. The associated genes with Norethindrone are MMP gene, NR3C1 gene and Genes, Reporter. The related lipids are Steroids, 4,17 beta-dihydroxy-4-androstene-3-one, 4-estren-3,17-diol and Estranes.

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Introduction

To understand associated biological information of Norethindrone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Norethindrone?

Norethindrone is suspected in Endometriosis, site unspecified, Estrogenic effect and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Norethindrone

MeSH term MeSH ID Detail
Pancreatic Neoplasms D010190 77 associated lipids
Body Weight D001835 333 associated lipids
Arteriosclerosis D001161 86 associated lipids
Total 3

PubChem Associated disorders and diseases

What pathways are associated with Norethindrone

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Norethindrone?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Norethindrone?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Norethindrone?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Norethindrone?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Norethindrone?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Norethindrone

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Authors Title Published Journal PubMed Link
Verhoeven CH et al. In vitro and in vivo metabolism of the progestagen Org 30659 in several species. 1998 Drug Metab. Dispos. pmid:9806953
Moore B Sequential mestranol and morethisterone in the treatment of the climacteric syndrome. 1976 Postgrad Med J pmid:981118
Burnett D et al. Plasma protein changes in post-menopausal women receiving mestranol-norethisterone hormone replacement therapy. 1976 Postgrad Med J pmid:981119
Sturdee DW et al. Glucose tolerance and hormone replacement therapy. A preliminary study. 1976 Postgrad Med J pmid:981120
LeBel M et al. Effects of rifabutin and rifampicin on the pharmacokinetics of ethinylestradiol and norethindrone. 1998 J Clin Pharmacol pmid:9824786
Lamble JW and Lamble AP Some effects of progestogens, oestrogens and androgens on the ocular tension of rabbits and owl monkeys. 1978 Exp. Eye Res. pmid:98336
Yadava HS et al. Effect of low dose norethindrone acetate released through subdermal silastic implant on lipid metabolism in female rhesus monkeys. 1978 Indian J. Exp. Biol. pmid:98430
Hägglund H et al. Norethisterone treatment, a major risk-factor for veno-occlusive disease in the liver after allogeneic bone marrow transplantation. 1998 Blood pmid:9845522
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Ladinsky H et al. Lack of influence of the phase of estrus cycle or treatment with steroid contraceptive drugs on cholinergic parameters in mouse and rat brain. 1976 Pharmacology pmid:986656
Trapnell CB et al. Thalidomide does not alter the pharmacokinetics of ethinyl estradiol and norethindrone. 1998 Clin. Pharmacol. Ther. pmid:9871424
Raudaskoski T et al. Plasma insulin-like growth factor-I and its binding proteins 1 and 3 during continuous nonoral and oral combined hormone replacement therapy. 1998 Menopause pmid:9872487
Briatico G et al. Effects of contraceptive agents on drug metabolism in various animal species. 1976 Br. J. Pharmacol. pmid:987822
Rowlands SC and Dakin L Twelve years of injectable contraceptive use in a general practice. 1998 Br J Fam Plann pmid:9882767
Weiner E and Johansson ED The influence of norethisterone oenanthate on ovarian function. 1976 Acta Endocrinol. pmid:989667
Ohman L et al. Topical administration of progestational steroids in the eye and nose--a rapid absorption to the blood. 1978 Contraception pmid:99284
Al-Azzawi F et al. Continuous combined hormone replacement therapy compared with tibolone. 1999 Obstet Gynecol pmid:9932566
Mills TM et al. Metabolism of oral contraceptive drugs. The formation and disappearance of metabolites of norethindrone and mestranol after intravenous and oral administration. 1976 Am. J. Obstet. Gynecol. pmid:998688
Rowan JP "Estrophasic" dosing: A new concept in oral contraceptive therapy. 1999 Am. J. Obstet. Gynecol. pmid:9988834