Ursodeoxycholic acid is a lipid of Sterol Lipids (ST) class. Ursodeoxycholic acid is associated with abnormalities such as Liver diseases, Cirrhosis, Hypertension, Portal, Cholestatic liver disease and Cholangitis, Sclerosing. The involved functions are known as protein expression, Fibrosis, Apoptosis, Metabolic Inhibition and Signal Transduction. Ursodeoxycholic acid often locates in Membrane, Clone, Tissue membrane, Protoplasm and Hepatic. The associated genes with Ursodeoxycholic acid are ABCC2 gene, ABCB4 gene, IMPACT gene, Alleles and PTGS2 wt Allele. The related lipids are Micelles, Steroids, cholanic acid, glycoursodeoxycholic acid and taurolithocholic acid 3-sulfate. The related experimental models are Disease model.
To understand associated biological information of Ursodeoxycholic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Ursodeoxycholic acid is suspected in Primary biliary cirrhosis, Cholestasis, Cholestatic liver disease, Liver diseases, cholesterol gallstones, Primary sclerosing cholangitis and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Ursodeoxycholic acid
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Crohn Disease | D003424 | 12 associated lipids |
| Cholelithiasis | D002769 | 16 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Disease model are used in the study 'Bile Acids Reduce Prion Conversion, Reduce Neuronal Loss, and Prolong Male Survival in Models of Prion Disease.' (Cortez LM et al., 2015).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Melchor-Mendoza YK et al. | Ursodeoxycholic Acid Therapy in Patients with Primary Biliary Cholangitis with Limited Liver Transplantation Availability. | 2017 May - Jun | Ann Hepatol | pmid:28425413 |
| Stremmel W et al. | The overall fatty acid absorption controlled by basolateral chylomicron excretion under regulation of p-JNK1. | 2017 | Biochim. Biophys. Acta | pmid:28602806 |
| Adeyemi O et al. | Ursodeoxycholic acid prevents ventricular conduction slowing and arrhythmia by restoring T-type calcium current in fetuses during cholestasis. | 2017 | PLoS ONE | pmid:28934223 |
| Kim EK et al. | Ursodeoxycholic acid inhibits the proliferation of colon cancer cells by regulating oxidative stress and cancer stem-like cell growth. | 2017 | PLoS ONE | pmid:28708871 |
| Ko WK et al. | Anti-inflammatory effects of ursodeoxycholic acid by lipopolysaccharide-stimulated inflammatory responses in RAW 264.7 macrophages. | 2017 | PLoS ONE | pmid:28665991 |
| Joshita S et al. | Genetic Contribution to the Pathogenesis of Primary Biliary Cholangitis. | 2017 | J Immunol Res | pmid:28255561 |
| Igarashi G et al. | Two Cases of Primary Sclerosing Cholangitis Overlapping with Autoimmune Hepatitis in Adults. | 2017 | Intern. Med. | pmid:28250296 |
| Chung YR et al. | Ursodeoxycholic Acid Attenuates Endoplasmic Reticulum Stress-Related Retinal Pericyte Loss in Streptozotocin-Induced Diabetic Mice. | 2017 | J Diabetes Res | pmid:28127564 |
| Nam JY et al. | Oral Medications Enhance Adherence to Surveillance for Hepatocellular Carcinoma and Survival in Chronic Hepatitis B Patients. | 2017 | PLoS ONE | pmid:28099520 |
| Hatano R et al. | Ursodeoxycholic Acid Ameliorates Intrahepatic Cholestasis Independent of Biliary Bicarbonate Secretion in Vil2kd/kd Mice. | 2017 | Biol. Pharm. Bull. | pmid:28049946 |