3alpha,12beta-dihydroxy-5alpha-cholan-24-oic acid is a lipid of Sterol Lipids (ST) class. 3alpha,12beta-dihydroxy-5alpha-cholan-24-oic acid is associated with abnormalities such as Cholestasis and Little's Disease. The involved functions are known as inhibitors, Signal Transduction, Phosphorylation, Cell Survival and Detergents. 3alpha,12beta-dihydroxy-5alpha-cholan-24-oic acid often locates in Protoplasm. The related lipids are Promega.
To understand associated biological information of 3alpha,12beta-dihydroxy-5alpha-cholan-24-oic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
3alpha,12beta-dihydroxy-5alpha-cholan-24-oic acid is suspected in Cholestasis, Little's Disease and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 3alpha,12beta-dihydroxy-5alpha-cholan-24-oic acid
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lung Neoplasms | D008175 | 171 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Crohn Disease | D003424 | 12 associated lipids |
| Cholelithiasis | D002769 | 16 associated lipids |
| Blastomycosis | D001759 | 5 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Borges MM et al. | Efficacy and safety of amphotericin B deoxycholate versus N-methylglucamine antimoniate in pediatric visceral leishmaniasis: an open-label, randomized, and controlled pilot trial in Brazil. | 2017 Jan-Feb | Rev. Soc. Bras. Med. Trop. | pmid:28327804 |
| Oliveira MME et al. | Fungemia associated with Schizophyllum commune in Brazil. | 2017 | PLoS Negl Trop Dis | pmid:28662024 |
| Menotti J et al. | A cell impedance-based real-time in vitro assay to assess the toxicity of amphotericin B formulations. | 2017 | Toxicol. Appl. Pharmacol. | pmid:28865757 |
| Fraenza CC and Anoardo E | Dynamical regimes of lipids in additivated liposomes with enhanced elasticity: A field-cycling NMR relaxometry approach. | 2017 | Biophys. Chem. | pmid:28697447 |
| Alvarez C et al. | Antifungal Efficacy of an Intravenous Formulation Containing Monomeric Amphotericin B, 5-Fluorocytosine, and Saline for Sodium Supplementation. | 2017 | Pharm. Res. | pmid:28205003 |
| Rolón M et al. | Engineering Oral and Parenteral Amorphous Amphotericin B Formulations against Experimental Trypanosoma cruzi Infections. | 2017 | Mol. Pharm. | pmid:28198632 |
| Grisin T et al. | Supramolecular Chitosan Micro-Platelets Synergistically Enhance Anti-Candida albicans Activity of Amphotericin B Using an Immunocompetent Murine Model. | 2017 | Pharm. Res. | pmid:28168390 |
| Grisin T et al. | Cyclodextrin-mediated self-associating chitosan micro-platelets act as a drug booster against Candida glabrata mucosal infection in immunocompetent mice. | 2017 | Int J Pharm | pmid:28130196 |
| Liu H et al. | Reduction-sensitive micelles self-assembled from amphiphilic chondroitin sulfate A-deoxycholic acid conjugate for triggered release of doxorubicin. | 2017 | Mater Sci Eng C Mater Biol Appl | pmid:28415498 |
| Khattab SN et al. | Study of antileishmanial activity of 2-aminobenzoyl amino acid hydrazides and their quinazoline derivatives. | 2017 | Bioorg. Med. Chem. Lett. | pmid:28087274 |
| Lovero G et al. | Invitro antifungal susceptibilities of Candida species to liposomal amphotericin B, determined using CLSI broth microdilution, and amphotericin B deoxycholate, measured using the Etest. | 2017 | J. Med. Microbiol. | pmid:27959780 |
| Wang RY et al. | Cryptococcosis in patients with hematological diseases: a 14-year retrospective clinical analysis in a Chinese tertiary hospital. | 2017 | BMC Infect. Dis. | pmid:28673256 |
| Le T et al. | A Trial of Itraconazole or Amphotericin B for HIV-Associated Talaromycosis. | 2017 | N. Engl. J. Med. | pmid:28614691 |
| Kim JY et al. | Selective effect of phosphatidylcholine on the lysis of adipocytes. | 2017 | PLoS ONE | pmid:28463991 |
| Shridharani SM | Early Experience in 100 Consecutive Patients With Injection Adipocytolysis for Neck Contouring With ATX-101 (Deoxycholic Acid). | 2017 | Dermatol Surg | pmid:28448317 |
| Song Y et al. | Mucormycosis in renal transplant recipients: review of 174 reported cases. | 2017 | BMC Infect. Dis. | pmid:28420334 |
| Concha-Velasco F et al. | Factors associated with early mycological clearance in HIV-associated cryptococcal meningitis. | 2017 | PLoS ONE | pmid:28355252 |
| Zhao C et al. | Discovery and Synthesis of Amino Acids Modified Deoxycholic Acid Derivatives and in Vitro Antiproliferative Evaluation. | 2017 | Chem. Pharm. Bull. | pmid:28090067 |
| Duran MI et al. | Synthesis of Five Known Brassinosteroid Analogs from Hyodeoxycholic Acid and Their Activities as Plant-Growth Regulators. | 2017 | Int J Mol Sci | pmid:28282853 |
| Miyamoto N et al. | A two-component micelle with emergent pH responsiveness by mixing dilauroyl phosphocholine and deoxycholic acid and its delivery of proteins into the cytosol. | 2017 | Colloids Surf B Biointerfaces | pmid:28347946 |
| Hsu CY et al. | Anti-MRSA malleable liposomes carrying chloramphenicol for ameliorating hair follicle targeting. | 2017 | Int J Nanomedicine | pmid:29184410 |
| Bhari N et al. | Histoplasmosis mimicking non-Hodgkin lymphoma in a 40-year-old man with AIDS. | 2017 | Int J STD AIDS | pmid:27535728 |
| Kobayashi Y et al. | The Associations between Circulating Bile Acids and the Muscle Volume in Patients with Non-alcoholic Fatty Liver Disease (NAFLD). | 2017 | Intern. Med. | pmid:28381740 |
| Chen L et al. | Biocompatible cationic pullulan-g-desoxycholic acid-g-PEI micelles used to co-deliver drug and gene for cancer therapy. | 2017 | Mater Sci Eng C Mater Biol Appl | pmid:27770912 |
| Abdel-Latif MM et al. | Factors regulating nuclear factor-kappa B activation in esophageal cancer cells: Role of bile acids and acid. | 2016 Jan-Mar | J Cancer Res Ther | pmid:27072265 |
| Tang Y et al. | Autophagy induced by exogenous bile acids is therapeutic in a model of α-1-AT deficiency liver disease. | 2016 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:27102560 |
| Sun P et al. | Influence of 5% dextrose volume on amphotericin B deoxycholate preparation. | 2016 | J. Pharm. Pharmacol. | pmid:26992126 |
| Xiong XH et al. | Absorption mechanism of oxymatrine in cultured Madin-Darby canine kidney cell monolayers. | 2016 | Pharm Biol | pmid:26983455 |
| Smits MM et al. | Biliary effects of liraglutide and sitagliptin, a 12-week randomized placebo-controlled trial in type 2 diabetes patients. | 2016 | Diabetes Obes Metab | pmid:27451030 |
| Djanic M et al. | Docking-based preliminary study on the interactions of bile acids with drugs at the transporter level in intestinal bacteria. | 2016 | Eur Rev Med Pharmacol Sci | pmid:26914133 |
| Dossa AY et al. | Bile acids regulate intestinal cell proliferation by modulating EGFR and FXR signaling. | 2016 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:26608185 |
| Zheng H et al. | A retrospective research of HIV-negative cryptococcal meningoencephalitis patients with acute/subacute onset. | 2016 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:26792138 |
| Farhana L et al. | Bile acid: a potential inducer of colon cancer stem cells. | 2016 | Stem Cell Res Ther | pmid:27908290 |
| Zia Q et al. | Super aggregated form of Amphotericin B: a novel way to increase its therapeutic index. | 2016 | Curr. Pharm. Des. | pmid:26648472 |
| Serafim C et al. | Lipoamino acid-based micelles as promising delivery vehicles for monomeric amphotericin B. | 2016 | Int J Pharm | pmid:26617315 |
| Zhang Y et al. | [Clinical comparative analysis for pulmonary histoplasmosis and progressive disseminated histoplasmosis]. | 2016 | Zhong Nan Da Xue Xue Bao Yi Xue Ban | pmid:28070050 |
| El-Nabarawi MA et al. | Transbuccal delivery of betahistine dihydrochloride from mucoadhesive tablets with a unidirectional drug flow: in vitro, ex vivo and in vivo evaluation. | 2016 | Drug Des Devel Ther | pmid:28008227 |
| Hwang SR et al. | Preparation and in vivo evaluation of an orally available enteric-microencapsulated parathyroid hormone (1-34)-deoxycholic acid nanocomplex. | 2016 | Int J Nanomedicine | pmid:27621618 |
| Herrera H et al. | Structural Modifications of Deoxycholic Acid to Obtain Three Known Brassinosteroid Analogues and Full NMR Spectroscopic Characterization. | 2016 | Molecules | pmid:27618889 |
| Humphrey S et al. | Sodium Deoxycholate for Submental Contouring. | 2016 | Skin Therapy Lett. | pmid:27603325 |
| Abeijon C et al. | Novel Antigen Detection Assay to Monitor Therapeutic Efficacy of Visceral Leishmaniasis. | 2016 | Am. J. Trop. Med. Hyg. | pmid:27481058 |
| Meiring S et al. | Prevalence and Hospital Management of Amphotericin B Deoxycholate-Related Toxicities during Treatment of HIV-Associated Cryptococcal Meningitis in South Africa. | 2016 | PLoS Negl Trop Dis | pmid:27467556 |
| Humphrey S et al. | ATX-101 for reduction of submental fat: A phase III randomized controlled trial. | 2016 | J. Am. Acad. Dermatol. | pmid:27430612 |
| Barker JH et al. | Evidence Suggesting That Francisella tularensis O-Antigen Capsule Contains a Lipid A-Like Molecule That Is Structurally Distinct from the More Abundant Free Lipid A. | 2016 | PLoS ONE | pmid:27326857 |
| Xie G et al. | Dysregulated hepatic bile acids collaboratively promote liver carcinogenesis. | 2016 | Int. J. Cancer | pmid:27273788 |
| Paredes K et al. | Virulence and Experimental Treatment of Trichoderma longibrachiatum, a Fungus Refractory to Treatment. | 2016 | Antimicrob. Agents Chemother. | pmid:27216056 |
| Coelho AC et al. | A Luciferase-Expressing Leishmania braziliensis Line That Leads to Sustained Skin Lesions in BALB/c Mice and Allows Monitoring of Miltefosine Treatment Outcome. | 2016 | PLoS Negl Trop Dis | pmid:27144739 |
| Nalwanga D and Henning L | If It Looks Like a Duck, Swims Like a Duck, and Quacks Like a Duck--Does It Have to Be a Duck? | 2016 | PLoS Negl Trop Dis | pmid:27124154 |
| Shen C et al. | Deoxycholic acid (DCA) confers an intestinal phenotype on esophageal squamous epithelium via induction of the stemness-associated reprogramming factors OCT4 and SOX2. | 2016 | Cell Cycle | pmid:27096226 |
| Centuori SM et al. | Deoxycholic acid mediates non-canonical EGFR-MAPK activation through the induction of calcium signaling in colon cancer cells. | 2016 | Biochim. Biophys. Acta | pmid:27086143 |
| Merry M and Boulware DR | Cryptococcal Meningitis Treatment Strategies Affected by the Explosive Cost of Flucytosine in the United States: A Cost-effectiveness Analysis. | 2016 | Clin. Infect. Dis. | pmid:27009249 |
| Ridlon JM et al. | Taurocholic acid metabolism by gut microbes and colon cancer. | 2016 | Gut Microbes | pmid:27003186 |
| Moore SM et al. | Extraction, Enrichment, Solubilization, and Digestion Techniques for Membrane Proteomics. | 2016 | J. Proteome Res. | pmid:26979493 |
| Yasugi M et al. | Transcriptional Profile during Deoxycholate-Induced Sporulation in a Clostridium perfringens Isolate Causing Foodborne Illness. | 2016 | Appl. Environ. Microbiol. | pmid:26969700 |
| Nascimento E et al. | Refractory and/or Relapsing Cryptococcosis Associated with Acquired Immune Deficiency Syndrome: Clinical Features, Genotype, and Virulence Factors of Cryptococcus spp. Isolates. | 2016 | Am. J. Trop. Med. Hyg. | pmid:26928832 |
| Thapa S et al. | Persistent Fever and Skin Lesions Due to Histoplasmosis in a Boy from Rural Nepal. | 2016 | Am. J. Trop. Med. Hyg. | pmid:26843610 |
| Stone NR et al. | Liposomal Amphotericin B (AmBisome(®)): A Review of the Pharmacokinetics, Pharmacodynamics, Clinical Experience and Future Directions. | 2016 | Drugs | pmid:26818726 |
| Pardon NA et al. | A weakly acidic solution containing deoxycholic acid induces esophageal epithelial apoptosis and impairs integrity in an in vivo perfusion rabbit model. | 2016 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:26797397 |
| Fu Y et al. | Decellularization of porcine skeletal muscle extracellular matrix for the formulation of a matrix hydrogel: a preliminary study. | 2016 | J. Cell. Mol. Med. | pmid:26781342 |
| Mahmoud RY et al. | The Multivalent Adhesion Molecule SSO1327 plays a key role in Shigella sonnei pathogenesis. | 2016 | Mol. Microbiol. | pmid:26481305 |
| Kiggundu R et al. | Brief Report: Effects of Tenofovir and Amphotericin B Deoxycholate Coadministration on Kidney Function in Patients Treated for Cryptococcal Meningitis. | 2016 | J. Acquir. Immune Defic. Syndr. | pmid:26334743 |
| Adhikari K et al. | Factors Affecting Enhanced Permeation of Amphotericin B Across Cell Membranes and Safety of Formulation. | 2016 | AAPS PharmSciTech | pmid:26349688 |
| Surampalli G et al. | Safety evaluation of naringenin upon experimental exposure on rat gastrointestinal epithelium for novel optimal drug delivery. | 2016 | Drug Deliv | pmid:24937377 |
| Rocheblave L et al. | Deoxycholic acid derivatives as inhibitors of P-glycoprotein-mediated multidrug efflux. | 2016 | Steroids | pmid:27697501 |
| Fan J et al. | Shear rheology and in-vitro release kinetic study of apigenin from lyotropic liquid crystal. | 2016 | Int J Pharm | pmid:26657272 |
| Mei L et al. | Antitumor and Antimetastasis Activities of Heparin-based Micelle Served As Both Carrier and Drug. | 2016 | ACS Appl Mater Interfaces | pmid:27058058 |
| Alvarez C et al. | Reformulation of Fungizone by PEG-DSPE Micelles: Deaggregation and Detoxification of Amphotericin B. | 2016 | Pharm. Res. | pmid:27198671 |
| Berger ML | Soaping the NMDA receptor: Various types of detergents influence differently [(3)H]MK-801 binding to rat brain membranes. | 2016 | Biochim. Biophys. Acta | pmid:26518518 |
| Yan JK et al. | Self-aggregated nanoparticles of carboxylic curdlan-deoxycholic acid conjugates as a carrier of doxorubicin. | 2015 | Int. J. Biol. Macromol. | pmid:25193095 |
| Souza AC et al. | Activity and in vivo tracking of Amphotericin B loaded PLGA nanoparticles. | 2015 | Eur J Med Chem | pmid:25827397 |
| Martinez Mdel C et al. | Experimental protoporphyria: effect of bile acids on liver damage induced by griseofulvin. | 2015 | Biomed Res Int | pmid:25945334 |
| Saracut C et al. | Secondary bile acids effects in colon pathology. Experimental mice study. | 2015 | Acta Cir Bras | pmid:26465107 |
| Botero Aguirre JP and Restrepo Hamid AM | Amphotericin B deoxycholate versus liposomal amphotericin B: effects on kidney function. | 2015 | Cochrane Database Syst Rev | pmid:26595825 |
| Wade KC and Monk HM | New antifungal and antiviral dosing. | 2015 | Clin Perinatol | pmid:25678004 |
| Chaturvedi K et al. | Oral insulin delivery using deoxycholic acid conjugated PEGylated polyhydroxybutyrate co-polymeric nanoparticles. | 2015 | Nanomedicine (Lond) | pmid:26008194 |
| Iatta R et al. | In vitro activity of two amphotericin B formulations against Malassezia furfur strains recovered from patients with bloodstream infections. | 2015 | Med. Mycol. | pmid:25631480 |
| Falci DR et al. | Hematological toxicities associated with amphotericin B formulations. | 2015 | Leuk. Lymphoma | pmid:25629990 |
| Wang CS et al. | Bile acids cycle disruption in patients with nasopharyngeal carcinoma promotes the elevation of interleukin-10 secretion. | 2015 | Afr Health Sci | pmid:26958021 |
| Trifilio SM et al. | Amphotericin B deoxycholate nasal spray administered to hematopoietic stem cell recipients with prior fungal colonization of the upper airway passages is associated with low rates of invasive fungal infection. | 2015 | Transpl Infect Dis | pmid:25620386 |
| Rodrigues PM et al. | Inhibition of NF-κB by deoxycholic acid induces miR-21/PDCD4-dependent hepatocelular apoptosis. | 2015 | Sci Rep | pmid:26621219 |
| Sousa T et al. | Deoxycholic acid modulates cell death signaling through changes in mitochondrial membrane properties. | 2015 | J. Lipid Res. | pmid:26351365 |
| Bicanic T et al. | Toxicity of Amphotericin B Deoxycholate-Based Induction Therapy in Patients with HIV-Associated Cryptococcal Meningitis. | 2015 | Antimicrob. Agents Chemother. | pmid:26349818 |
| Rocha PN et al. | Role of urine neutrophil gelatinase-associated lipocalin in the early diagnosis of amphotericin B-induced acute kidney injury. | 2015 | Antimicrob. Agents Chemother. | pmid:26303800 |
| Scheerlinck E et al. | Minimizing technical variation during sample preparation prior to label-free quantitative mass spectrometry. | 2015 | Anal. Biochem. | pmid:26302362 |
| Kim DH and Larson AC | Deoxycholate bile acid directed synthesis of branched Au nanostructures for near infrared photothermal ablation. | 2015 | Biomaterials | pmid:25934288 |
| Peng KW et al. | Ethnic variability in the expression of hepatic drug transporters: absolute quantification by an optimized targeted quantitative proteomic approach. | 2015 | Drug Metab. Dispos. | pmid:25926430 |
| Barnes R et al. | Economic Comparison of an Empirical Versus Diagnostic-Driven Strategy for Treating Invasive Fungal Disease in Immunocompromised Patients. | 2015 | Clin Ther | pmid:25891805 |
| Falci DR et al. | Comparison of nephrotoxicity associated to different lipid formulations of amphotericin B: a real-life study. | 2015 | Mycoses | pmid:25590436 |
| Jiang J et al. | Mechanism of enhanced antiosteoporosis effect of circinal-icaritin by self-assembled nanomicelles in vivo with suet oil and sodium deoxycholate. | 2015 | Int J Nanomedicine | pmid:25848257 |
| Dayal D et al. | Outcome of Rhino-Sinus Mucormycosis in Children with Type 1 Diabetes. | 2015 | Indian J Pediatr | pmid:25589195 |
| Botero-Calderon L et al. | Advances in the treatment of invasive neonatal candidiasis. | 2015 | Expert Opin Pharmacother | pmid:25842986 |
| Wei WH et al. | In vitro investigation of self-assembled nanoparticles based on hyaluronic acid-deoxycholic acid conjugates for controlled release doxorubicin: effect of degree of substitution of deoxycholic acid. | 2015 | Int J Mol Sci | pmid:25837468 |
| Zhang JW et al. | Therapeutic effect of Qingyi decoction in severe acute pancreatitis-induced intestinal barrier injury. | 2015 | World J. Gastroenterol. | pmid:25834318 |
| Miller AO et al. | Successful treatment of Candida osteoarticular infections with limited duration of antifungal therapy and orthopedic surgical intervention. | 2015 | Infect Dis (Lond) | pmid:25539148 |
| Esteves M et al. | Interaction of Cytotoxic and Cytoprotective Bile Acids with Model Membranes: Influence of the Membrane Composition. | 2015 | Langmuir | pmid:26218497 |
| Lee JY et al. | Bile acid-conjugated chondroitin sulfate A-based nanoparticles for tumor-targeted anticancer drug delivery. | 2015 | Eur J Pharm Biopharm | pmid:26149228 |
| Moreno-RodrÃguez AC et al. | Efficacy and toxicity evaluation of new amphotericin B micelle systems for brain fungal infections. | 2015 | Int J Pharm | pmid:26256151 |
| Yang Y et al. | Enhancing vitamin E bioaccessibility: factors impacting solubilization and hydrolysis of α-tocopherol acetate encapsulated in emulsion-based delivery systems. | 2015 | Food Funct | pmid:25312787 |
| Houdek MT et al. | Elution of High Dose Amphotericin B Deoxycholate From Polymethylmethacrylate. | 2015 | J Arthroplasty | pmid:26162513 |
| Kevric I et al. | New World and Old World Leishmania Infections: A Practical Review. | 2015 | Dermatol Clin | pmid:26143433 |