Alpha-muricholic acid

Alpha-muricholic acid is a lipid of Sterol Lipids (ST) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 177 references associated with Alpha-muricholic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Alpha-muricholic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Alpha-muricholic acid

MeSH term MeSH ID Detail
Diabetes Mellitus, Experimental D003921 85 associated lipids
Total 1

PubChem Biomolecular Interactions and Pathways

All references with Alpha-muricholic acid

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Bonde Y et al. Mice Abundant in Muricholic Bile Acids Show Resistance to Dietary Induced Steatosis, Weight Gain, and to Impaired Glucose Metabolism. 2016 PLoS ONE pmid:26824238
Jiang C et al. Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction. 2015 Nat Commun pmid:26670557
Poša M Heuman indices of hydrophobicity of bile acids and their comparison with a newly developed and conventional molecular descriptors. 2014 Biochimie pmid:24076126
Hu X et al. Muricholic bile acids are potent regulators of bile acid synthesis via a positive feedback mechanism. 2014 J. Intern. Med. pmid:24118394
Perreault M et al. The Human UDP-glucuronosyltransferase UGT2A1 and UGT2A2 enzymes are highly active in bile acid glucuronidation. 2013 Drug Metab. Dispos. pmid:23756265
Francis MB et al. Muricholic acids inhibit Clostridium difficile spore germination and growth. 2013 PLoS ONE pmid:24040011
Fu ZD and Klaassen CD Increased bile acids in enterohepatic circulation by short-term calorie restriction in male mice. 2013 Toxicol. Appl. Pharmacol. pmid:24183703
Bhowmik SK et al. Alteration of bile acid metabolism in pseudo germ-free rats [corrected]. 2012 Arch. Pharm. Res. pmid:23212639
Kuribayashi H et al. Enterobacteria-mediated deconjugation of taurocholic acid enhances ileal farnesoid X receptor signaling. 2012 Eur. J. Pharmacol. pmid:23051670
Mizuochi T et al. Characterization of urinary bile acids in a pediatric BRIC-1 patient: effect of rifampicin treatment. 2012 Clin. Chim. Acta pmid:22525741
Hagio M et al. Improved analysis of bile acids in tissues and intestinal contents of rats using LC/ESI-MS. 2009 J. Lipid Res. pmid:18772484
Wooton-Kee CR et al. Increased cholesterol 7alpha-hydroxylase expression and size of the bile acid pool in the lactating rat. 2008 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:18292185
Cuesta de Juan S et al. Ontogenic development-associated changes in the expression of genes involved in rat bile acid homeostasis. 2007 J. Lipid Res. pmid:17332599
Kumagai M et al. Perinatal bile acid metabolism: bile acid analysis of meconium of preterm and full-term infants. 2007 J. Gastroenterol. pmid:18008035
Sehayek E et al. Two loci on chromosome 9 control bile acid composition: evidence that a strong candidate gene, Cyp8b1, is not the culprit. 2006 J. Lipid Res. pmid:16763287
Zelcer N et al. Mice lacking Mrp3 (Abcc3) have normal bile salt transport, but altered hepatic transport of endogenous glucuronides. 2006 J. Hepatol. pmid:16225954
Dongowski G et al. Steroids in the intestinal tract of rats are affected by dietary-fibre-rich barley-based diets. 2003 Br. J. Nutr. pmid:14667183
Lundell K and Wikvall K Gene structure of pig sterol 12alpha-hydroxylase (CYP8B1) and expression in fetal liver: comparison with expression of taurochenodeoxycholic acid 6alpha-hydroxylase (CYP4A21). 2003 Biochim. Biophys. Acta pmid:14643796
Wang DQ and Tazuma S Effect of beta-muricholic acid on the prevention and dissolution of cholesterol gallstones in C57L/J mice. 2002 J. Lipid Res. pmid:12401895
Milkiewicz P et al. Hepatoprotection with tauroursodeoxycholate and beta muricholate against taurolithocholate induced cholestasis: involvement of signal transduction pathways. 2002 Gut pmid:12077103
Nakashima T et al. Differences in the efficacy of ursodeoxycholic acid and bile acid metabolism between viral liver diseases and primary biliary cirrhosis. 2001 J. Gastroenterol. Hepatol. pmid:11350551
Purucker E et al. Metabolism and effects on cholestasis of isoursodeoxycholic and ursodeoxycholic acids in bile duct ligated rats. 2001 Biochim. Biophys. Acta pmid:11287121
Narushima S et al. Absence of cecal secondary bile acids in gnotobiotic mice associated with two human intestinal bacteria with the ability to dehydroxylate bile acids in vitro. 1999 Microbiol. Immunol. pmid:10553682
Eyssen HJ et al. Formation of hyodeoxycholic acid from muricholic acid and hyocholic acid by an unidentified gram-positive rod termed HDCA-1 isolated from rat intestinal microflora. 1999 Appl. Environ. Microbiol. pmid:10388717
Nakashima T et al. A paucity of unusual trihydroxy bile acids in the urine of patients with severe liver diseases. 1999 Hepatology pmid:10216137
Ellis E et al. Bile acid synthesis in primary cultures of rat and human hepatocytes. 1998 Hepatology pmid:9462665
Batta AK et al. Enrichment of the more hydrophilic bile acid ursodeoxycholic acid in the fecal water-soluble fraction after feeding to rats with colon polyps. 1998 Cancer Res. pmid:9563483
Rodrigues CM et al. Formation of delta 22-bile acids in rats is not gender specific and occurs in the peroxisome. 1996 J. Lipid Res. pmid:8728317
Bravo E et al. Differential effects of chylomicron remnants derived from corn oil or palm oil on bile acid synthesis and very low density lipoprotein secretion in cultured rat hepatocytes. 1996 Life Sci. pmid:8761005
Monsma CC et al. Reduced digestibility of beef tallow and cocoa butter affects bile acid excretion and reduces hepatic esterified cholesterol in rats. 1996 J. Nutr. pmid:8759376
Wietholtz H et al. Stimulation of bile acid 6 alpha-hydroxylation by rifampin. 1996 J. Hepatol. pmid:8835747
Scheibner J et al. Deoxycholate and cholate modulate the source of cholesterol substrate for bile acid synthesis in the rat. 1995 Hepatology pmid:7843727
Cohen-Solal C et al. Effects of hyodeoxycholic acid and alpha-hyocholic acid, two 6 alpha-hydroxylated bile acids, on cholesterol and bile acid metabolism in the hamster. 1995 Biochim. Biophys. Acta pmid:7619860
Kimura A et al. Fetal bile acid metabolism during infancy: analysis of 1 beta-hydroxylated bile acids in urine, meconium and feces. 1994 Hepatology pmid:7927221
Iida T et al. Potential bile acid metabolites. 19. The epimeric 3 alpha,6,7 beta-trihydroxy- and 3 alpha,6,7 beta,12 alpha-tetrahydroxy-5 alpha-cholanoic acids. 1993 Steroids pmid:8493703
Twisk J et al. Differential feedback regulation of cholesterol 7 alpha-hydroxylase mRNA and transcriptional activity by rat bile acids in primary monolayer cultures of rat hepatocytes. 1993 Biochem. J. pmid:8457195
Miki S et al. Metabolism of beta-muricholic acid in the hamster and prairie dog. 1993 J. Lipid Res. pmid:8245721
Takahashi A et al. Sulphated bile acid per se inhibits colonic carcinogenesis in mice. 1993 Eur. J. Cancer Prev. pmid:8461867
Scheibner J et al. Bile acid synthesis from newly synthesized vs. preformed cholesterol precursor pools in the rat. 1993 Hepatology pmid:8514259
Katagiri K et al. Tauro-beta-muricholate preserves choleresis and prevents taurocholate-induced cholestasis in colchicine-treated rat liver. 1992 Gastroenterology pmid:1568576
Bravo E et al. The contribution of lipoprotein cholesterol to hepatic precursor pools for bile acid synthesis. 1992 Biochem. Soc. Trans. pmid:1487003
Aranda G et al. Synthesis of 6 alpha-tritiated beta-muricholic acid for use as a molecular probe. 1992 Steroids pmid:1519265
Takikawa H et al. Effects of ursodeoxycholate, its glucuronide and disulfate and beta-muricholate on biliary bicarbonate concentration and biliary lipid excretion. 1992 J. Hepatol. pmid:1506660
Roda A et al. Bile acid structure-activity relationship: evaluation of bile acid lipophilicity using 1-octanol/water partition coefficient and reverse phase HPLC. 1990 J. Lipid Res. pmid:2280184
Parquet M et al. Metabolism and effects on biliary lipid secretion of murocholic acid in the hamster. 1990 J. Hepatol. pmid:2398262
Iida T et al. Potential bile acid metabolites. 14. Hyocholic and muricholic acid stereoisomers. 1989 J. Lipid Res. pmid:2769078
Janssen G et al. By-products in the analysis of beta-muricholic acid in biological samples as methyl ester triacetate. 1989 Steroids pmid:2815149
Okanoue T et al. Changes in serum bile acid composition in relation to histological findings after liver transplantation in piglets. 1989 Eur Surg Res pmid:2806341
Bianchini F et al. Effect of dietary fat, starch and cellulose on fecal bile acids in mice. 1989 J. Nutr. pmid:2600667
Fujino Y et al. Suppression of hepatic HMG-CoA reductase activity by beta-muricholic acid in mice fed a diet containing cholesterol and cholic acid. 1988 Jpn. J. Pharmacol. pmid:3404773

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