Trihydroxycoprostane

Trihydroxycoprostane is a lipid of Sterol Lipids (ST) class. The involved functions are known as Uptake, Enterohepatic Circulation, Metabolic Inhibition and Ionization. Trihydroxycoprostane often locates in Hepatic, Entire gastrointestinal tract and Abdominal Cavity. The related lipids are 3,7,12-trihydroxycoprostane, (3beta,5beta,7alpha,12alpha)-isomer, Cholestanes and scymnol.

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Introduction

To understand associated biological information of Trihydroxycoprostane, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Trihydroxycoprostane?

There are no associated biomedical information in the current reference collection.

No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with Trihydroxycoprostane

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Trihydroxycoprostane?

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What functions are associated with Trihydroxycoprostane?


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What lipids are associated with Trihydroxycoprostane?

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What genes are associated with Trihydroxycoprostane?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with Trihydroxycoprostane?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Trihydroxycoprostane

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Authors Title Published Journal PubMed Link
Furster C and Wikvall K Identification of CYP3A4 as the major enzyme responsible for 25-hydroxylation of 5beta-cholestane-3alpha,7alpha,12alpha-triol in human liver microsomes. 1999 Biochim. Biophys. Acta pmid:9931427
Suzuki Y [Other peroxisomal diseases]. 1998 Ryoikibetsu Shokogun Shirizu pmid:9645078
Fricker G et al. Enterohepatic circulation of scymnol sulfate in an elasmobranch, the little skate (Raja erinacea). 1997 Am. J. Physiol. pmid:9374698
Pikuleva IA et al. Expression, purification, and enzymatic properties of recombinant human cytochrome P450c27 (CYP27). 1997 Arch. Biochem. Biophys. pmid:9210654
Une M et al. Comparative studies on omega-hydroxylation of 5 beta-cholestane-3 alpha, 7 alpha, 12 alpha-triol in the mitochondrial and microsomal fraction of the liver from several vertebrates. 1997 Steroids pmid:9185292
Ikegawa S et al. Stereoisomeric inversion of (25R)- and (25S)-3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholestanoic acids in rat liver peroxisome. 1995 Biol. Pharm. Bull. pmid:7581245
Betsholtz IH and Wikvall K Cytochrome P450 CYP27-catalyzed oxidation of C27-steroid into C27-acid. 1995 J. Steroid Biochem. Mol. Biol. pmid:7577714
Dueland S et al. 26-hydroxylation of 5 beta-cholestane-3 alpha,7 alpha,12 alpha-triol by isolated nonparenchymal cells and hepatocytes from rat liver. 1982 J. Lipid Res. pmid:7161561
Noshiro M et al. The involvement of cytochrome b5 in 5 beta-cholestane-3 alpha, 7 alpha, 12 alpha-triol 25-hydroxylation and taurodeoxycholate 7 alpha-hydroxylation of rat liver. 1982 Biochem. Biophys. Res. Commun. pmid:7115387
Björkhem I et al. Assay of intermediates in bile acid biosynthesis using isotope dilution--mass spectrometry: hepatic levels in the normal state and in cerebrotendinous xanthomatosis. 1981 J. Lipid Res. pmid:7017048