Varanic acid

Varanic acid is a lipid of Sterol Lipids (ST) class. Varanic acid is associated with abnormalities such as Protein Deficiency and 3-hydroxyacyl-coa dehydrogenase deficiency. The involved functions are known as Diastasis, Mass-to-Charge Ratio and enoyl-CoA hydratase activity. The associated genes with Varanic acid are HSD17B4 gene, EHHADH gene and HADH gene. The related lipids are 3,7,12,24-tetrahydroxycholestanoic acid.

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Introduction

To understand associated biological information of Varanic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Varanic acid?

Varanic acid is suspected in Protein Deficiency, 3-hydroxyacyl-coa dehydrogenase deficiency and other diseases in descending order of the highest number of associated sentences.

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No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with Varanic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

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What cellular locations are associated with Varanic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Varanic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Varanic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Varanic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Varanic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Varanic acid

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Total 10
Authors Title Published Journal PubMed Link
Hagey LR et al. A novel varanic acid epimer--(24R,25S)-3α,7α,12α,24-tetrahydroxy-5β-cholestan-27-oic acid--is a major biliary bile acid in two varanid lizards and the Gila monster. 2012 Steroids pmid:22986074
Vreken P et al. Sensitive analysis of serum 3alpha, 7alpha, 12alpha,24-tetrahydroxy- 5beta-cholestan-26-oic acid diastereomers using gas chromatography-mass spectrometry and its application in peroxisomal D-bifunctional protein deficiency. 1998 J. Lipid Res. pmid:9831634
Kurosawa T et al. Synthesis of diastereomers of 3 alpha,7 alpha,12 alpha, 24-tetrahydroxy- and 3 alpha,7 alpha,24-trihydroxy-5 beta-cholestan- 26-oic acids and their structures. 1996 Steroids pmid:8837295
Une M et al. Formation of varanic acid, 3 alpha, 7 alpha, 12 alpha, 24-tetrahydroxy-5 beta-cholestanoic acid from 3 alpha, 7 alpha, 12 alpha-trihydroxy-5 beta-cholestanoic acid in Bombina orientalis. 1996 Steroids pmid:8916357
Une M et al. Stereospecific formation of (24E)-3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholest-24-en-26-oic acid and (24R,25S)-3 alpha,7 alpha,12 alpha,24-tetrahydroxy-5 beta-cholestan-26-oic acid from either (25R)- or (25S)-3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholestan-26-oic acid by rat liver homogenate. 1984 J. Biochem. pmid:6520115
Gustafsson J et al. Zellweger's cerebro-hepato-renal syndrome--variations in expressivity and in defects of bile acid synthesis. 1983 Clin. Genet. pmid:6652941
Une M et al. Synthesis of four diastereoisomers at carbons 24 and 25 of 3 alpha,7 alpha,12 alpha,24-tetrahydroxy-5 beta-cholestan-26-oic acid, intermediates of bile acid biosynthesis. 1983 J. Lipid Res. pmid:6631226
Batta AK et al. Improved synthesis of 3 alpha, 7 alpha, 12 alpha, 24 = xi-tetrahydroxy-5 beta-cholestan-26-oic acid. 1982 Steroids pmid:7157440
Swell L et al. Biosynthesis of bile acids in man. An in vivo evaluation of the conversion of R and S 3 alpha, 7 alpha, 12 alpha-trihydroxy-5 beta-cholestanoic and 3 alpha, 7 alpha, 12 alpha-24 xi-tetrahydroxy-5 beta-cholestanoic acids to cholic acid. 1981 J. Biol. Chem. pmid:7005227
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