| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Qaiser MZ et al. | Uptake and metabolism of sulphated steroids by the blood-brain barrier in the adult male rat. | 2017 | J. Neurochem. | pmid:28665486 |
| Nguyen T et al. | Impaired calcium mobilization in natural killer cells from chronic fatigue syndrome/myalgic encephalomyelitis patients is associated with transient receptor potential melastatin 3 ion channels. | 2017 | Clin. Exp. Immunol. | pmid:27727448 |
| Rubil S and Thiel G | Activation of gene transcription via CIM0216, a synthetic ligand of transient receptor potential melastatin-3 (TRPM3) channels. | 2017 | Channels (Austin) | pmid:27356187 |
| Wilding TJ et al. | Chimeric Glutamate Receptor Subunits Reveal the Transmembrane Domain Is Sufficient for NMDA Receptor Pore Properties but Some Positive Allosteric Modulators Require Additional Domains. | 2016 | J. Neurosci. | pmid:27559165 |
| Kang EJ et al. | Pregnenolone sulfate regulates prolactin production in the rat pituitary. | 2016 | J. Endocrinol. | pmid:27507676 |
| Malafoglia V et al. | Transient Receptor Potential Melastatin-3 (TRPM3) Mediates Nociceptive-Like Responses in Hydra vulgaris. | 2016 | PLoS ONE | pmid:26974325 |
| Uchida K et al. | Stimulation-dependent gating of TRPM3 channel in planar lipid bilayers. | 2016 | FASEB J. | pmid:26655382 |
| Wilkins ME et al. | Murine startle mutant Nmf11 affects the structural stability of the glycine receptor and increases deactivation. | 2016 | J. Physiol. (Lond.) | pmid:27028707 |
| Chopra DA et al. | Bidirectional Effect of Pregnenolone Sulfate on GluN1/GluN2A N-Methyl-D-Aspartate Receptor Gating Depending on Extracellular Calcium and Intracellular Milieu. | 2015 | Mol. Pharmacol. | pmid:26162866 |
| Tóth BI et al. | Regulation of the transient receptor potential channel TRPM3 by phosphoinositides. | 2015 | J. Gen. Physiol. | pmid:26123194 |
| Wong P et al. | Pregnenolone sulfate normalizes schizophrenia-like behaviors in dopamine transporter knockout mice through the AKT/GSK3β pathway. | 2015 | Transl Psychiatry | pmid:25781227 |
| Held K et al. | Activation of TRPM3 by a potent synthetic ligand reveals a role in peptide release. | 2015 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25733887 |
| Brown RL et al. | TRPM3 expression in mouse retina. | 2015 | PLoS ONE | pmid:25679224 |
| Lesch A et al. | Transient receptor potential melastatin-3 (TRPM3)-induced activation of AP-1 requires Ca2+ ions and the transcription factors c-Jun, ATF2, and ternary complex factor. | 2015 | Mol. Pharmacol. | pmid:25576487 |
| Son GY et al. | Hypotonic stress induces RANKL via transient receptor potential melastatin 3 (TRPM3) and vaniloid 4 (TRPV4) in human PDL cells. | 2015 | J. Dent. Res. | pmid:25595364 |
| Emnett CM et al. | Interaction between positive allosteric modulators and trapping blockers of the NMDA receptor channel. | 2015 | Br. J. Pharmacol. | pmid:25377730 |
| Gonzalez-Usano A et al. | Pregnenolone sulfate restores the glutamate-nitric-oxide-cGMP pathway and extracellular GABA in cerebellum and learning and motor coordination in hyperammonemic rats. | 2014 | ACS Chem Neurosci | pmid:24256194 |
| Plescia F et al. | Pregnenolone sulphate enhances spatial orientation and object discrimination in adult male rats: evidence from a behavioural and electrophysiological study. | 2014 | Behav. Brain Res. | pmid:24149069 |
| Drews A et al. | Structural requirements of steroidal agonists of transient receptor potential melastatin 3 (TRPM3) cation channels. | 2014 | Br. J. Pharmacol. | pmid:24251620 |
| Smith CC et al. | A role for picomolar concentrations of pregnenolone sulfate in synaptic activity-dependent Ca2+ signaling and CREB activation. | 2014 | Mol. Pharmacol. | pmid:25057049 |
| Schuler G et al. | Free and sulfated steroids secretion in postpubertal boars (Sus scrofa domestica). | 2014 | Reproduction | pmid:24961601 |
| Lesch A et al. | Activation and inhibition of transient receptor potential TRPM3-induced gene transcription. | 2014 | Br. J. Pharmacol. | pmid:24895737 |
| El Bitar F et al. | Neuroprotection by the synthetic neurosteroid enantiomers ent-PREGS and ent-DHEAS against Aβ₂₅₋₃₅ peptide-induced toxicity in vitro and in vivo in mice. | 2014 | Psychopharmacology (Berl.) | pmid:24481566 |
| Hong JS et al. | Pregnenolone sulfate modulates glycinergic transmission in rat medullary dorsal horn neurons. | 2013 | Eur. J. Pharmacol. | pmid:23665111 |
| Burel D et al. | Gonadotropin-releasing hormone stimulates the biosynthesis of pregnenolone sulfate and dehydroepiandrosterone sulfate in the hypothalamus. | 2013 | Endocrinology | pmid:23554453 |
| Kostakis E et al. | The neuroactive steroid pregnenolone sulfate stimulates trafficking of functional N-methyl D-aspartate receptors to the cell surface via a noncanonical, G protein, and Ca2+-dependent mechanism. | 2013 | Mol. Pharmacol. | pmid:23716622 |
| Plescia F et al. | The role of pregnenolone sulphate in spatial orientation-acquisition and retention: an interplay between cognitive potentiation and mood regulation. | 2013 | Behav. Processes | pmid:23860279 |
| Adamusová E et al. | Pregnenolone sulfate activates NMDA receptor channels. | 2013 | Physiol Res | pmid:24359434 |
| Harteneck C | Pregnenolone sulfate: from steroid metabolite to TRP channel ligand. | 2013 | Molecules | pmid:24084011 |
| Straub I et al. | Flavanones that selectively inhibit TRPM3 attenuate thermal nociception in vivo. | 2013 | Mol. Pharmacol. | pmid:24006495 |
| Rustichelli C et al. | Simultaneous determination of pregnenolone sulphate, dehydroepiandrosterone and allopregnanolone in rat brain areas by liquid chromatography-electrospray tandem mass spectrometry. | 2013 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:23727868 |
| Alpizar YA et al. | Lack of correlation between the amplitudes of TRP channel-mediated responses to weak and strong stimuli in intracellular Ca(2+) imaging experiments. | 2013 | Cell Calcium | pmid:24079971 |
| Grosser G et al. | Cloning and functional characterization of the mouse sodium-dependent organic anion transporter Soat (Slc10a6). | 2013 | J. Steroid Biochem. Mol. Biol. | pmid:23562556 |
| Straub I et al. | Citrus fruit and fabacea secondary metabolites potently and selectively block TRPM3. | 2013 | Br. J. Pharmacol. | pmid:23190005 |
| Mathew J et al. | Decreased GABA receptor in the cerebral cortex of epileptic rats: effect of Bacopa monnieri and Bacoside-A. | 2012 | J. Biomed. Sci. | pmid:22364254 |
| Horishita T et al. | Inhibition by pregnenolone sulphate, a metabolite of the neurosteroid pregnenolone, of voltage-gated sodium channels expressed in Xenopus oocytes. | 2012 | J. Pharmacol. Sci. | pmid:22878600 |
| Freichel M et al. | The Role of TRP Proteins in Mast Cells. | 2012 | Front Immunol | pmid:22701456 |
| Do Rego JL et al. | Regulation of neurosteroid biosynthesis by neurotransmitters and neuropeptides. | 2012 | Front Endocrinol (Lausanne) | pmid:22654849 |
| Mani SK and Oyola MG | Progesterone signaling mechanisms in brain and behavior. | 2012 | Front Endocrinol (Lausanne) | pmid:22649404 |
| Helms CM et al. | Neurosteroid influences on sensitivity to ethanol. | 2012 | Front Endocrinol (Lausanne) | pmid:22654852 |
| Majeed Y et al. | Pregnenolone sulphate-independent inhibition of TRPM3 channels by progesterone. | 2012 | Cell Calcium | pmid:22000496 |
| Sun X et al. | Pregnenolone sulfate decreases intraocular pressure and changes expression of sigma receptor in a model of chronic ocular hypertension. | 2012 | Mol. Biol. Rep. | pmid:22311017 |
| Darbra S et al. | Allopregnanolone infused into the dorsal (CA1) hippocampus increases prepulse inhibition of startle response in Wistar rats. | 2012 | Psychoneuroendocrinology | pmid:21871738 |
| Cameron K et al. | Neurosteroid binding to the amino terminal and glutamate binding domains of ionotropic glutamate receptors. | 2012 | Steroids | pmid:22504555 |
| Haccard O et al. | Naturally occurring steroids in Xenopus oocyte during meiotic maturation. Unexpected presence and role of steroid sulfates. | 2012 | Mol. Cell. Endocrinol. | pmid:22687883 |
| Scullin CS and Partridge LD | Modulation by pregnenolone sulfate of filtering properties in the hippocampal trisynaptic circuit. | 2012 | Hippocampus | pmid:22648992 |
| Yang R et al. | Anti-amnesic effect of neurosteroid PREGS in Aβ25-35-injected mice through σ1 receptor- and α7nAChR-mediated neuroprotection. | 2012 | Neuropharmacology | pmid:22884465 |
| Xu B et al. | Neurosteroid PREGS protects neurite growth and survival of newborn neurons in the hippocampal dentate gyrus of APPswe/PS1dE9 mice. | 2012 | Curr Alzheimer Res | pmid:22272612 |
| Yang R et al. | Pregnenolone sulfate enhances survival of adult-generated hippocampal granule cells via sustained presynaptic potentiation. | 2011 Feb-Mar | Neuropharmacology | pmid:21111750 |
| Kumar A | Long-Term Potentiation at CA3-CA1 Hippocampal Synapses with Special Emphasis on Aging, Disease, and Stress. | 2011 | Front Aging Neurosci | pmid:21647396 |
| Tsutsui K et al. | Biosynthesis, mode of action, and functional significance of neurosteroids in the purkinje cell. | 2011 | Front Endocrinol (Lausanne) | pmid:22654818 |
| Longone P et al. | Neurosteroids as neuromodulators in the treatment of anxiety disorders. | 2011 | Front Endocrinol (Lausanne) | pmid:22654814 |
| Borowicz KK et al. | Neuroprotective actions of neurosteroids. | 2011 | Front Endocrinol (Lausanne) | pmid:22649375 |
| Tsutsui K | Neurosteroid biosynthesis and function in the brain of domestic birds. | 2011 | Front Endocrinol (Lausanne) | pmid:22645509 |
| Haraguchi S et al. | Mode of action and functional significance of 7α-hydroxypregnenolone stimulating locomotor activity. | 2011 | Front Endocrinol (Lausanne) | pmid:22645507 |
| Ossewaarde L et al. | Changes in functioning of mesolimbic incentive processing circuits during the premenstrual phase. | 2011 | Soc Cogn Affect Neurosci | pmid:20817665 |
| Kasperska-Zajac A | Does dehydroepiandrosterone influence the expression of urticaria?-a mini review. | 2011 | Inflammation | pmid:20686829 |
| Rammouz G et al. | Oxidative Stress-Mediated Brain Dehydroepiandrosterone (DHEA) Formation in Alzheimer's Disease Diagnosis. | 2011 | Front Endocrinol (Lausanne) | pmid:22654823 |
| Kancheva R et al. | Neuroactive steroids in periphery and cerebrospinal fluid. | 2011 | Neuroscience | pmid:21641969 |
| Cauli O et al. | Differential modulation of the glutamate-nitric oxide-cyclic GMP pathway by distinct neurosteroids in cerebellum in vivo. | 2011 | Neuroscience | pmid:21703332 |
| Raphemot R et al. | Discovery, characterization, and structure-activity relationships of an inhibitor of inward rectifier potassium (Kir) channels with preference for Kir2.3, Kir3.x, and Kir7.1. | 2011 | Front Pharmacol | pmid:22275899 |
| Petit GH et al. | Pregnenolone sulfate and its enantiomer: differential modulation of memory in a spatial discrimination task using forebrain NMDA receptor deficient mice. | 2011 | Eur Neuropsychopharmacol | pmid:21036556 |
| Zamudio-Bulcock PA and Valenzuela CF | Pregnenolone sulfate increases glutamate release at neonatal climbing fiber-to-Purkinje cell synapses. | 2011 | Neuroscience | pmid:21130844 |
| Arterbery AS et al. | Evolution of ligand specificity in vertebrate corticosteroid receptors. | 2011 | BMC Evol. Biol. | pmid:21232159 |
| Taves MD et al. | Measurement of steroid concentrations in brain tissue: methodological considerations. | 2011 | Front Endocrinol (Lausanne) | pmid:22654806 |
| Chisari M et al. | Hydrophobic anions potently and uncompetitively antagonize GABA(A) receptor function in the absence of a conventional binding site. | 2011 | Br. J. Pharmacol. | pmid:21457224 |
| Mòdol L et al. | Neurosteroids infusion into the CA1 hippocampal region on exploration, anxiety-like behaviour and aversive learning. | 2011 | Behav. Brain Res. | pmid:21463656 |
| Darbra S and Pallarès M | Interaction between early postnatal neurosteroid manipulations and adult infusion of neurosteroids into CA1 hippocampal region on the open field behaviour. | 2011 | Behav. Brain Res. | pmid:20920532 |
| Beaumont M and Maccaferri G | Is connexin36 critical for GABAergic hypersynchronization in the hippocampus? | 2011 | J. Physiol. (Lond.) | pmid:21300748 |
| Mayer SI et al. | Signal transduction of pregnenolone sulfate in insulinoma cells: activation of Egr-1 expression involving TRPM3, voltage-gated calcium channels, ERK, and ternary complex factors. | 2011 | J. Biol. Chem. | pmid:21257751 |
| Wirth MM | Beyond the HPA Axis: Progesterone-Derived Neuroactive Steroids in Human Stress and Emotion. | 2011 | Front Endocrinol (Lausanne) | pmid:22649366 |
| Vriens J et al. | TRPM3 is a nociceptor channel involved in the detection of noxious heat. | 2011 | Neuron | pmid:21555074 |
| Chao A et al. | Combined liquid and solid-phase extraction improves quantification of brain estrogen content. | 2011 | Front Neuroanat | pmid:21909323 |
| Lambert S et al. | Transient receptor potential melastatin 1 (TRPM1) is an ion-conducting plasma membrane channel inhibited by zinc ions. | 2011 | J. Biol. Chem. | pmid:21278253 |
| Druzin M et al. | Mechanism of estradiol-induced block of voltage-gated K+ currents in rat medial preoptic neurons. | 2011 | PLoS ONE | pmid:21625454 |
| Reddy DS | Role of anticonvulsant and antiepileptogenic neurosteroids in the pathophysiology and treatment of epilepsy. | 2011 | Front Endocrinol (Lausanne) | pmid:22654805 |
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| Vaudry H et al. | Neurosteroid biosynthesis in the brain of amphibians. | 2011 | Front Endocrinol (Lausanne) | pmid:22649387 |
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pregnenolone sulfate
Pregnenolone sulfate is a lipid of Sterol Lipids (ST) class. Pregnenolone sulfate is associated with abnormalities such as Wiskott-Aldrich Syndrome. The involved functions are known as Anabolism, Transcriptional Activation, Stimulus, Exocytosis and inhibitors. Pregnenolone sulfate often locates in Extracellular, Membrane, Protoplasm, Cell membrane and Cytoplasmic. The associated genes with pregnenolone sulfate are TRPM3 gene, JUN gene, MAPK1 gene, ATF2 gene and Genes, Reporter. The related lipids are Steroids, pregnenolone sulfate, estradiol 17-sulfate, 16-androstene and steroid sulfate.
Cross Reference
Introduction
To understand associated biological information of pregnenolone sulfate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with pregnenolone sulfate?
pregnenolone sulfate is suspected in and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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No disease MeSH terms mapped to the current reference collection.
PubChem Associated disorders and diseases
What pathways are associated with pregnenolone sulfate
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with pregnenolone sulfate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with pregnenolone sulfate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with pregnenolone sulfate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with pregnenolone sulfate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with pregnenolone sulfate?
There are no associated biomedical information in the current reference collection.