Glycocholic Acid

Glycocholic acid is a lipid of Sterol Lipids (ST) class. Glycocholic acid is associated with abnormalities such as Gastric ulcer, Kissing ulcers, Liver Cirrhosis, Hepatitis and Wiskott-Aldrich Syndrome. The involved functions are known as Stimulus, Ulcer, Pressure- physical agent, Regulation and Uptake. Glycocholic acid often locates in Mucous Membrane, Gastric mucosa, Hepatic and Blood. The associated genes with Glycocholic Acid are AGXT gene, FABP6 gene and glycine methyl ester hydrochloride. The related lipids are Sterols.

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Introduction

To understand associated biological information of Glycocholic Acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Glycocholic Acid?

Glycocholic Acid is suspected in Liver Cirrhosis, Hepatitis, Gastric ulcer, Kissing ulcers, Cholestasis and other diseases in descending order of the highest number of associated sentences.

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No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with Glycocholic Acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Glycocholic Acid?

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What functions are associated with Glycocholic Acid?


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What lipids are associated with Glycocholic Acid?

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What genes are associated with Glycocholic Acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Glycocholic Acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Glycocholic Acid

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Authors Title Published Journal PubMed Link
Mansour HM et al. Nanomedicine in pulmonary delivery. 2009 Int J Nanomedicine pmid:20054434
Hildebrandt E and McGee DJ Helicobacter pylori lipopolysaccharide modification, Lewis antigen expression, and gastric colonization are cholesterol-dependent. 2009 BMC Microbiol. pmid:20003432
Jose M and Thomas SV Role of multidrug transporters in neurotherapeutics. 2009 Ann Indian Acad Neurol pmid:20142853
Brown A Analysis of cooperativity by isothermal titration calorimetry. 2009 Int J Mol Sci pmid:20111687
Kaushik JK et al. Functional and probiotic attributes of an indigenous isolate of Lactobacillus plantarum. 2009 PLoS ONE pmid:19956615
Oh SW et al. Blending effects on adsorption and micellization of different membrane protein solubilizers II. A thermodynamic study on a mixed system of CHAPS with a bile salt in pH 7.4 phosphate buffer solution. 2008 Colloids Surf B Biointerfaces pmid:17997082
Sorg JA and Sonenshein AL Bile salts and glycine as cogerminants for Clostridium difficile spores. 2008 J. Bacteriol. pmid:18245298
Jain AK et al. Effective insulin delivery using starch nanoparticles as a potential trans-nasal mucoadhesive carrier. 2008 Eur J Pharm Biopharm pmid:18295464
Xu Z et al. [Study on relationship between expression of familial intrahepatic cholestasis 1 mRNA in placenta and Intrahepatic cholestasis of pregnancy]. 2008 Sichuan Da Xue Xue Bao Yi Xue Ban pmid:18575333
Lo YL et al. Inhibit multidrug resistance and induce apoptosis by using glycocholic acid and epirubicin. 2008 Eur J Pharm Sci pmid:18606222
Martin FP et al. Probiotic modulation of symbiotic gut microbial-host metabolic interactions in a humanized microbiome mouse model. 2008 Mol. Syst. Biol. pmid:18197175
Mariette C et al. Activation of MUC1 mucin expression by bile acids in human esophageal adenocarcinomatous cells and tissues is mediated by the phosphatidylinositol 3-kinase. 2008 Surgery pmid:18154934
Terasaki M et al. Detection of endogenous DNA adducts, O-carboxymethyl-2'-deoxyguanosine and 3-ethanesulfonic acid-2'-deoxycytidine, in the rat stomach after duodenal reflux. 2008 Cancer Sci. pmid:18549406
Sahni J et al. Design and in vitro characterization of buccoadhesive drug delivery system of insulin. 2008 Indian J Pharm Sci pmid:20390082
González P and Polli JE Impact of impurity on kinetic estimates from transport and inhibition studies. 2008 J. Pharmacol. Exp. Ther. pmid:18443216
Smola M et al. Nanocarriers as pulmonary drug delivery systems to treat and to diagnose respiratory and non respiratory diseases. 2008 Int J Nanomedicine pmid:18488412
Vertzoni M et al. Determination of intralumenal individual bile acids by HPLC with charged aerosol detection. 2008 J. Lipid Res. pmid:18693215
Shaham O et al. Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity. 2008 Mol. Syst. Biol. pmid:18682704
Chen J et al. Adaptive responses of renal organic anion transporter 3 (OAT3) during cholestasis. 2008 Am. J. Physiol. Renal Physiol. pmid:18480179
Reed JR et al. Physical incorporation of NADPH-cytochrome P450 reductase and cytochrome P450 into phospholipid vesicles using glycocholate and Bio-Beads. 2008 Drug Metab. Dispos. pmid:18048487
Stålberg O et al. Structure-interaction relationships between the bile acid GCA and pharmaceuticals using multivariate data analysis and capillary electrophoresis. 2007 J Pharm Sci pmid:17286289
Vicens M et al. Novel cationic and neutral glycocholic acid and polyamine conjugates able to inhibit transporters involved in hepatic and intestinal bile acid uptake. 2007 Bioorg. Med. Chem. pmid:17276074
Roman-Nunez M et al. Influence of sodium glycocholate on production of conjugated linoleic acid by cells of Lactobacillus reuteri ATCC 55739. 2007 J. Food Sci. pmid:17995782
Gunnarsson M et al. Long-term biokinetics and radiation exposure of patients undergoing 14C-glycocholic acid and 14C-xylose breath tests. 2007 Cancer Biother. Radiopharm. pmid:18158767
Toke O et al. Kinetic mechanism of ligand binding in human ileal bile acid binding protein as determined by stopped-flow fluorescence analysis. 2007 Biochemistry pmid:17432832
Delpino MV et al. A bile salt hydrolase of Brucella abortus contributes to the establishment of a successful infection through the oral route in mice. 2007 Infect. Immun. pmid:17088355
Shen LJ and Wu FL Nanomedicines in renal transplant rejection--focus on sirolimus. 2007 Int J Nanomedicine pmid:17722509
Lamb K et al. Luminal stimuli acutely sensitize visceromotor responses to distension of the rat stomach. 2007 Dig. Dis. Sci. pmid:17216335
Reschly EJ et al. Functional evolution of the vitamin D and pregnane X receptors. 2007 BMC Evol. Biol. pmid:17997857
Martins S et al. Lipid-based colloidal carriers for peptide and protein delivery--liposomes versus lipid nanoparticles. 2007 Int J Nanomedicine pmid:18203427
Kim D et al. Biosynthesis of bile acids in a variety of marine bacterial taxa. 2007 J. Microbiol. Biotechnol. pmid:18050942
Cai SY et al. The farnesoid X receptor FXRalpha/NR1H4 acquired ligand specificity for bile salts late in vertebrate evolution. 2007 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:17567710
Ung CY et al. In silico prediction of pregnane X receptor activators by machine learning approaches. 2007 Mol. Pharmacol. pmid:17003167
Martoni C et al. Investigation of microencapsulated BSH active lactobacillus in the simulated human GI tract. 2007 J. Biomed. Biotechnol. pmid:18273409
Mahalingam R et al. Transbuccal delivery of 5-aza-2 -deoxycytidine: effects of drug concentration, buffer solution, and bile salts on permeation. 2007 AAPS PharmSciTech pmid:17915805
Hao Y et al. Gene expression changes associated with Barrett's esophagus and Barrett's-associated adenocarcinoma cell lines after acid or bile salt exposure. 2007 BMC Gastroenterol pmid:17597535
Kumar RS et al. Bile salt hydrolase, the member of Ntn-hydrolase family: differential modes of structural and functional transitions during denaturation. 2007 IUBMB Life pmid:17454305
Morita SY et al. Bile salt-dependent efflux of cellular phospholipids mediated by ATP binding cassette protein B4. 2007 Hepatology pmid:17523162
Robinson DM and Keating GM Colesevelam: a review of its use in hypercholesterolemia. 2007 Am J Cardiovasc Drugs pmid:18076213
Pan YH and Bahnson BJ Structural basis for bile salt inhibition of pancreatic phospholipase A2. 2007 J. Mol. Biol. pmid:17434532
Holm R et al. Complexation of tauro- and glyco-conjugated bile salts with three neutral beta-CDs studied by ACE. 2007 Electrophoresis pmid:17893938
Martin FP et al. A top-down systems biology view of microbiome-mammalian metabolic interactions in a mouse model. 2007 Mol. Syst. Biol. pmid:17515922
Czerny B et al. Effect of tamoxifen and raloxifene on the conjugation of bile acids with taurine and glycine in ovariectomized rats. 2006 May-Jun Pharmacol Rep pmid:16845220
Katsuma M et al. Effects of absorption promoters on insulin absorption through colon-targeted delivery. 2006 Int J Pharm pmid:16289574
Murata Y et al. Adsorption of bile acid by chitosan salts prepared with cinnamic acid and analogue compounds. 2006 J Biomater Sci Polym Ed pmid:16909945
Hanus M and Zhorov E Bile acid salt binding with colesevelam HCl is not affected by suspension in common beverages. 2006 J Pharm Sci pmid:16937334
Zhang R et al. [Bile salts induce differentiation in cultured human normal esophageal mucosal epithelial cells]. 2006 Zhonghua Yi Xue Za Zhi pmid:17156647
Shi DY et al. [Clinical and experimental study on wuling pill in treating gestation period intrahepatic cholestasis]. 2006 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:16548349
Rifai K et al. Repeated administration of a vitamin preparation containing glycocholic acid in patients with hepatobiliary disease. 2006 Aliment. Pharmacol. Ther. pmid:16629939
Ilardia-Arana D et al. Biorelevant dissolution media: aggregation of amphiphiles and solubility of estradiol. 2006 J Pharm Sci pmid:16374874
Pedrini P et al. Xanthomonas maltophilia CBS 897.97 as a source of new 7beta- and 7alpha-hydroxysteroid dehydrogenases and cholylglycine hydrolase: improved biotransformations of bile acids. 2006 Steroids pmid:16307764
Rius M et al. Substrate specificity of human ABCC4 (MRP4)-mediated cotransport of bile acids and reduced glutathione. 2006 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:16282361
Fetih G et al. Excellent absorption enhancing characteristics of NO donors for improving the intestinal absorption of poorly absorbable compound compared with conventional absorption enhancers. 2006 Drug Metab. Pharmacokinet. pmid:16858126
Prieto AI et al. Repair of DNA damage induced by bile salts in Salmonella enterica. 2006 Genetics pmid:16888329
Mrówczynska L et al. Inhibition of MRP1-mediated efflux in human erythrocytes by mono-anionic bile salts. 2005 Sep-Oct Anticancer Res. pmid:16101123
Czerny B et al. Effect of tibolone on turnover of cholesterol to bile acids in ovariectomized rats. 2005 Sep-Oct Menopause pmid:16145315
Bottari E and Festa MR Composition of aqueous solutions containing sodium glycocholate and glycodeoxycholate. 2005 Nov-Dec Ann Chim pmid:16398343
Bottari E et al. The influence of the ionic medium on the behaviour of sodium glycocholate and cholate aqueous solutions. 2005 Jan-Feb Ann Chim pmid:15801173
Hayashi H et al. Two common PFIC2 mutations are associated with the impaired membrane trafficking of BSEP/ABCB11. 2005 Hepatology pmid:15791618
Dimova S et al. High-speed digital imaging method for ciliary beat frequency measurement. 2005 J. Pharm. Pharmacol. pmid:15831215
Leggio C et al. Small-angle X-ray scattering and light scattering on lysozyme and sodium glycocholate micelles. 2005 J Phys Chem B pmid:16375371
Olivares J et al. Micellar electrokinetic chromatography of bilirubin, related compounds, and selected drugs with mixtures of binary bile salts. 2005 Electrophoresis pmid:15714544
Dimova S et al. Stable ciliary activity in human nasal epithelial cells grown in a perfusion system. 2005 Int J Pharm pmid:15725562
Fetih G et al. Improvement of absorption enhancing effects of n-dodecyl-beta-D-maltopyranoside by its colon-specific delivery using chitosan capsules. 2005 Int J Pharm pmid:15778050
Suchodolski JS et al. Development of a 13C-glycocholic acid blood test to assess bacterial metabolic activity of the small intestine in canines. 2005 Can. J. Vet. Res. pmid:16479732
Monte MJ et al. Proapoptotic effect on normal and tumor intestinal cells of cytostatic drugs with enterohepatic organotropism. 2005 J. Pharmacol. Exp. Ther. pmid:15985617
Yoneda M et al. [Cholyl glycine (CG)]. 2005 Nippon Rinsho pmid:16149646
Lane ME et al. Quantitative estimation of the effects of bile salt surfactant systems on insulin stability and permeability in the rat intestine using a mass balance model. 2005 J. Pharm. Pharmacol. pmid:15720779
Bunjes H and Koch MH Saturated phospholipids promote crystallization but slow down polymorphic transitions in triglyceride nanoparticles. 2005 J Control Release pmid:16023752
Zhang R et al. Bile salts inhibit growth and induce apoptosis of culture human normal esophageal mucosal epithelial cells. 2005 World J. Gastroenterol. pmid:16425417
Mita S et al. Vectorial transport of bile salts across MDCK cells expressing both rat Na+-taurocholate cotransporting polypeptide and rat bile salt export pump. 2005 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:15297262
Dent P et al. Conjugated bile acids promote ERK1/2 and AKT activation via a pertussis toxin-sensitive mechanism in murine and human hepatocytes. 2005 Hepatology pmid:16317705
Nakahara M et al. Ileal bile acid-binding protein, functionally associated with the farnesoid X receptor or the ileal bile acid transporter, regulates bile acid activity in the small intestine. 2005 J. Biol. Chem. pmid:16230354
Xuan B et al. Alternative delivery of insulin via eye drops. 2005 Diabetes Technol. Ther. pmid:16241870
Chen ZS et al. Transport of bile acids, sulfated steroids, estradiol 17-beta-D-glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11). 2005 Mol. Pharmacol. pmid:15537867
Zhang R et al. Bile salts inhibit growth and induce apoptosis of human esophageal cancer cell line. 2005 World J. Gastroenterol. pmid:16127738
Thomas LA et al. Octreotide induced prolongation of colonic transit increases faecal anaerobic bacteria, bile acid metabolising enzymes, and serum deoxycholic acid in patients with acromegaly. 2005 Gut pmid:15831907
Cameron NS et al. Poly(N,N,N-trimethylammoniumalkyl acrylamide chloride) based hydrogels for serum cholesterol reduction. 2004 Jan-Feb Biomacromolecules pmid:14715004
Reis S et al. Noninvasive methods to determine the critical micelle concentration of some bile acid salts. 2004 Anal. Biochem. pmid:15464960
Kelly S et al. Functional assessment of bacterial colonization in patients with ileal pouch-anal anastomosis and Brooke ileostomy. 2004 Dis. Colon Rectum pmid:15484354
Murata Y et al. Adsorption of bile acid by chitosan-orotic acid salt and its application as an oral preparation. 2004 Chem. Pharm. Bull. pmid:15467231
Mariette C et al. Transcriptional regulation of human mucin MUC4 by bile acids in oesophageal cancer cells is promoter-dependent and involves activation of the phosphatidylinositol 3-kinase signalling pathway. 2004 Biochem. J. pmid:14583090
Mims D and Hercules D Quantification of bile acids directly from plasma by MALDI-TOF-MS. 2004 Anal Bioanal Chem pmid:14747894
Agu RU et al. Metabolism and absorption enhancement of methionine enkephalin in human nasal epithelium. 2004 Peptides pmid:15165710
Bidlack JE and Silverman PM An active type IV secretion system encoded by the F plasmid sensitizes Escherichia coli to bile salts. 2004 J. Bacteriol. pmid:15292121
Zhao YJ et al. [Study on relationship between serum cholylglycine and placental apoptosis in patients with intrahepatic cholestasis of pregnancy]. 2004 Zhonghua Fu Chan Ke Za Zhi pmid:15347465
Eirheim HU et al. Evaluation of different toxicity assays applied to proliferating cells and to stratified epithelium in relation to permeability enhancement with glycocholate. 2004 Toxicol In Vitro pmid:15251183
Liu H et al. [Effects of protease inhibitors on intestinal absorption of insulin]. 2004 Yao Xue Xue Bao pmid:15127624
Kang YM et al. Sensitization of mechanosensitive gastric vagal afferent fibers in the rat by thermal and chemical stimuli and gastric ulcers. 2004 J. Neurophysiol. pmid:15069095
Dussault I et al. Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance. 2003 Proc. Natl. Acad. Sci. U.S.A. pmid:12569201
Serrano MA et al. Effect of ursodeoxycholic acid on the impairment induced by maternal cholestasis in the rat placenta-maternal liver tandem excretory pathway. 2003 J. Pharmacol. Exp. Ther. pmid:12606635
Tochtrop GP et al. Steroid ring hydroxylation patterns govern cooperativity in human bile acid binding protein. 2003 Biochemistry pmid:14529265
Chang HY et al. Determination of ursodeoxycholic acid in pharmaceutical preparations by capillary electrophoresis with indirect UV detection. 2003 J Pharm Biomed Anal pmid:12899981
Hata S et al. Substrate specificities of rat oatp1 and ntcp: implications for hepatic organic anion uptake. 2003 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:12842829
Rius M et al. Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane. 2003 Hepatology pmid:12883481
Carter D et al. Differential effects of metformin on bile salt absorption from the jejunum and ileum. 2003 Diabetes Obes Metab pmid:12630937
Marin JJ et al. Sensitivity of bile acid transport by organic anion-transporting polypeptides to intracellular pH. 2003 Biochim. Biophys. Acta pmid:12659967
Lorenzo-Zúñiga V et al. Oral bile acids reduce bacterial overgrowth, bacterial translocation, and endotoxemia in cirrhotic rats. 2003 Hepatology pmid:12601352
Lindhardt K and Bechgaard E Sodium glycocholate transport across Caco-2 cell monolayers, and the enhancement of mannitol transport relative to transepithelial electrical resistance. 2003 Int J Pharm pmid:12550793
Ellis E et al. Feedback regulation of bile acid synthesis in primary human hepatocytes: evidence that CDCA is the strongest inhibitor. 2003 Hepatology pmid:14512880