Glycochenodeoxycholic acid

Glycochenodeoxycholic acid is a lipid of Sterol Lipids (ST) class. Glycochenodeoxycholic acid is associated with abnormalities such as Cholestasis. The involved functions are known as Apoptosis, Process, Cytokinesis and Necrosis. Glycochenodeoxycholic acid often locates in Cell surface. The associated genes with Glycochenodeoxycholic acid are SLC10A1 gene, TNFSF10 gene, AKR1C2 gene and HSPA5 gene. The related lipids are glycoursodeoxycholic acid.

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Introduction

To understand associated biological information of Glycochenodeoxycholic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Glycochenodeoxycholic acid?

Glycochenodeoxycholic acid is suspected in Cholestasis and other diseases in descending order of the highest number of associated sentences.

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No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with Glycochenodeoxycholic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

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What cellular locations are associated with Glycochenodeoxycholic acid?

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What functions are associated with Glycochenodeoxycholic acid?


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What lipids are associated with Glycochenodeoxycholic acid?

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What genes are associated with Glycochenodeoxycholic acid?

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What common seen animal models are associated with Glycochenodeoxycholic acid?

There are no associated biomedical information in the current reference collection.

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All references with Glycochenodeoxycholic acid

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Authors Title Published Journal PubMed Link
pmid:
Fadden K et al. Steroid metabolism along the gastrointestinal tract of the cannulated pig. 1999 Eur. J. Cancer Prev. pmid:10091041
Gumpricht E et al. Glutathione status of isolated rat hepatocytes affects bile acid-induced cellular necrosis but not apoptosis. 2000 Toxicol. Appl. Pharmacol. pmid:10739750
Rust C et al. The bile acid taurochenodeoxycholate activates a phosphatidylinositol 3-kinase-dependent survival signaling cascade. 2000 J. Biol. Chem. pmid:10770953
Sodeman T et al. Bile salts mediate hepatocyte apoptosis by increasing cell surface trafficking of Fas. 2000 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:10859230
Gonzalez B et al. Glycochenodeoxycholic acid (GCDC) induced hepatocyte apoptosis is associated with early modulation of intracellular PKC activity. 2000 Mol. Cell. Biochem. pmid:10888222
Webster CR and Anwer MS Phosphoinositide 3-kinase, but not mitogen-activated protein kinase, pathway is involved in hepatocyte growth factor-mediated protection against bile acid-induced apoptosis in cultured rat hepatocytes. 2001 Hepatology pmid:11230741
Yerushalmi B et al. Bile acid-induced rat hepatocyte apoptosis is inhibited by antioxidants and blockers of the mitochondrial permeability transition. 2001 Hepatology pmid:11230742
Takikawa Y et al. The bile acid-activated phosphatidylinositol 3-kinase pathway inhibits Fas apoptosis upstream of bid in rodent hepatocytes. 2001 Gastroenterology pmid:11375961
Danchenko E et al. Effect of bile acids on the proliferative activity and apoptosis of rat hepatocytes. 2001 Exp. Toxicol. Pathol. pmid:11484843
Higuchi H et al. The bile acid glycochenodeoxycholate induces trail-receptor 2/DR5 expression and apoptosis. 2001 J. Biol. Chem. pmid:11507096
Dilworth C et al. Spontaneous nitric oxide in hepatocyte monolayers and inhibition of compound-induced apoptosis. 2001 Toxicol In Vitro pmid:11698161
Higuchi H et al. Bid antisense attenuates bile acid-induced apoptosis and cholestatic liver injury. 2001 J. Pharmacol. Exp. Ther. pmid:11714870
Zhang F et al. Duodenal reflux induces cyclooxygenase-2 in the esophageal mucosa of rats: evidence for involvement of bile acids. 2001 Gastroenterology pmid:11729118
Li D et al. [Bile salt induces apoptosis of hepatocytes: the mechanism of hepatic function injury during obstructive jaundice]. 1998 Zhonghua Wai Ke Za Zhi pmid:11825482
Gumpricht E et al. Nitric oxide ameliorates hydrophobic bile acid-induced apoptosis in isolated rat hepatocytes by non-mitochondrial pathways. 2002 J. Biol. Chem. pmid:12006578
Yamashita Y et al. High metabolic function of primary human and porcine hepatocytes in a polyurethane foam/spheroid culture system in plasma from patients with fulminant hepatic failure. 2002 Cell Transplant pmid:12162378
pmid:12240947
Graf D et al. Prevention of bile acid-induced apoptosis by betaine in rat liver. 2002 Hepatology pmid:12297830
pmid:12401120
Byrne JA et al. The human bile salt export pump: characterization of substrate specificity and identification of inhibitors. 2002 Gastroenterology pmid:12404239
Higuchi H et al. Bile acids stimulate cFLIP phosphorylation enhancing TRAIL-mediated apoptosis. 2003 J. Biol. Chem. pmid:12407100
Solá S et al. [Release of cytochrome C with the interaction of bilirubin, amyloid beta-peptide and glycochenodeoxycholate from isolated mitochondria]. 2002 Jul-Aug Acta Med Port pmid:12525020
Wang J and Zou S The bcl-2 mRNA expression in GCDC-induced obstructive jaundice in rats and its implication in hepatocellular apoptosis. 2002 J. Huazhong Univ. Sci. Technol. Med. Sci. pmid:12658778
pmid:12734686
Schoemaker MH et al. Resistance of rat hepatocytes against bile acid-induced apoptosis in cholestatic liver injury is due to nuclear factor-kappa B activation. 2003 J. Hepatol. pmid:12873810
Chu SH et al. Roles of reactive oxygen species, NF-kappaB, and peroxiredoxins in glycochenodeoxycholic acid-induced rat hepatocytes death. 2003 Pharmacology pmid:12886025
Reinehr R et al. Bile salt-induced hepatocyte apoptosis involves epidermal growth factor receptor-dependent CD95 tyrosine phosphorylation. 2003 Gastroenterology pmid:12949729
Qiu SM et al. Interaction of bile salts with calcium hydroxyapatite: inhibitors of apatite formation exhibit high-affinity premicellar binding. 1992 Hepatology pmid:1330869
Komichi D et al. Unique inhibition of bile salt-induced apoptosis by lecithins and cytoprotective bile salts in immortalized mouse cholangiocytes. 2003 Dig. Dis. Sci. pmid:14714619
Gumpricht E et al. Beta-carotene prevents bile acid-induced cytotoxicity in the rat hepatocyte: Evidence for an antioxidant and anti-apoptotic role of beta-carotene in vitro. 2004 Pediatr. Res. pmid:14764912
Schoemaker MH et al. Tauroursodeoxycholic acid protects rat hepatocytes from bile acid-induced apoptosis via activation of survival pathways. 2004 Hepatology pmid:15185297
Mita S et al. Vectorial transport of bile salts across MDCK cells expressing both rat Na+-taurocholate cotransporting polypeptide and rat bile salt export pump. 2005 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:15297262
Jaiswal K et al. Bile salt exposure causes phosphatidyl-inositol-3-kinase-mediated proliferation in a Barrett's adenocarcinoma cell line. 2004 Surgery pmid:15300175
pmid:15358635
Baker PR et al. Bile acids influence the growth, oestrogen receptor and oestrogen-regulated proteins of MCF-7 human breast cancer cells. 1992 Br. J. Cancer pmid:1562465
Lepercq P et al. Bifidobacterium animalis strain DN-173 010 hydrolyses bile salts in the gastrointestinal tract of pigs. 2004 Scand. J. Gastroenterol. pmid:15743005
Rust C et al. Phosphatidylinositol 3-kinase-dependent signaling modulates taurochenodeoxycholic acid-induced liver injury and cholestasis in perfused rat livers. 2005 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:15746212
Wang K et al. Reversibility of caspase activation and its role during glycochenodeoxycholate-induced hepatocyte apoptosis. 2005 J. Biol. Chem. pmid:15767249
Hiramatsu K et al. Inhibition of hepatocyte growth factor production in human fibroblasts by ursodeoxycholic acid. 2005 Biol. Pharm. Bull. pmid:15802798
pmid:15810635
Kobak GE et al. Increased susceptibility of fat-laden Zucker-rat hepatocytes to bile acid-induced oncotic necrosis: an in vitro model of steatocholestasis. 2005 J. Lab. Clin. Med. pmid:15902097
Utanohara S et al. The effect of ursodeoxycholic acid on glycochenodeoxycholic acid-induced apoptosis in rat hepatocytes. 2005 Toxicology pmid:16023280
Sokol RJ et al. Human hepatic mitochondria generate reactive oxygen species and undergo the permeability transition in response to hydrophobic bile acids. 2005 J. Pediatr. Gastroenterol. Nutr. pmid:16056106
Zhang R et al. Bile salts inhibit growth and induce apoptosis of human esophageal cancer cell line. 2005 World J. Gastroenterol. pmid:16127738
Wang J et al. Roles of protein kinase C and fructose in hepatic injury caused by obstructive jaundice. 2005 J. Huazhong Univ. Sci. Technol. Med. Sci. pmid:16196296
Komichi D et al. Glycochenodeoxycholate plays a carcinogenic role in immortalized mouse cholangiocytes via oxidative DNA damage. 2005 Free Radic. Biol. Med. pmid:16274877
Rius M et al. Substrate specificity of human ABCC4 (MRP4)-mediated cotransport of bile acids and reduced glutathione. 2006 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:16282361
Dent P et al. Conjugated bile acids promote ERK1/2 and AKT activation via a pertussis toxin-sensitive mechanism in murine and human hepatocytes. 2005 Hepatology pmid:16317705
Rust C et al. Sulfasalazine reduces bile acid induced apoptosis in human hepatoma cells and perfused rat livers. 2006 Gut pmid:16322111
Bernt C et al. The human transcription factor AP-1 is a mediator of bile acid-induced liver cell apoptosis. 2006 Biochem. Biophys. Res. Commun. pmid:16380075
pmid:16411748
Zhang R et al. Bile salts inhibit growth and induce apoptosis of culture human normal esophageal mucosal epithelial cells. 2005 World J. Gastroenterol. pmid:16425417
Yang J et al. High performance liquid chromatography-mass spectrometry for metabonomics: potential biomarkers for acute deterioration of liver function in chronic hepatitis B. 2006 J. Proteome Res. pmid:16512670
Qiu SM et al. Glycochenodeoxycholic acid inhibits calcium phosphate precipitation in vitro by preventing the transformation of amorphous calcium phosphate to calcium hydroxyapatite. 1991 J. Clin. Invest. pmid:1655828
Park EJ et al. Honokiol reduces oxidative stress, c-jun-NH2-terminal kinase phosphorylation and protects against glycochenodeoxycholic acid-induced apoptosis in primary cultured rat hepatocytes. 2006 Planta Med. pmid:16732532
Perez MJ et al. Maternal ethanol consumption during pregnancy enhances bile acid-induced oxidative stress and apoptosis in fetal rat liver. 2006 Toxicology pmid:16824660
Czerny B et al. Effect of tamoxifen and raloxifene on the conjugation of bile acids with taurine and glycine in ovariectomized rats. 2006 May-Jun Pharmacol Rep pmid:16845220
Tsuchiya S et al. Involvement of endoplasmic reticulum in glycochenodeoxycholic acid-induced apoptosis in rat hepatocytes. 2006 Toxicol. Lett. pmid:16860497
pmid:16872555
Hanus M and Zhorov E Bile acid salt binding with colesevelam HCl is not affected by suspension in common beverages. 2006 J Pharm Sci pmid:16937334
Graf D et al. Bile acids inhibit interleukin-6 signaling via gp130 receptor-dependent and -independent pathways in rat liver. 2006 Hepatology pmid:17058237
Zhang R et al. [Bile salts induce differentiation in cultured human normal esophageal mucosal epithelial cells]. 2006 Zhonghua Yi Xue Za Zhi pmid:17156647
Bucher BT et al. Glycochenodeoxycholate (GCDC) inhibits cytokine induced iNOS expression in rat hepatocytes. 2007 J. Surg. Res. pmid:17174337
Becker S et al. Hydrophobic bile salts induce hepatocyte shrinkage via NADPH oxidase activation. 2007 Cell. Physiol. Biochem. pmid:17310103
Alrefai WA et al. Taurodeoxycholate modulates apical Cl-/OH- exchange activity in Caco2 cells. 2007 Dig. Dis. Sci. pmid:17387613
Toke O et al. Kinetic mechanism of ligand binding in human ileal bile acid binding protein as determined by stopped-flow fluorescence analysis. 2007 Biochemistry pmid:17432832
Pan YH and Bahnson BJ Structural basis for bile salt inhibition of pancreatic phospholipase A2. 2007 J. Mol. Biol. pmid:17434532
pmid:17531559
Park EJ et al. PF2401-SF, standardized fraction of Salvia miltiorrhiza and its constituents, tanshinone I, tanshinone IIA, and cryptotanshinone, protect primary cultured rat hepatocytes from bile acid-induced apoptosis by inhibiting JNK phosphorylation. 2007 Food Chem. Toxicol. pmid:17560000
Soden JS et al. Subcutaneous vitamin E ameliorates liver injury in an in vivo model of steatocholestasis. 2007 Hepatology pmid:17659596
Hickman I and Macdonald G Is vitamin E beneficial in chronic liver disease? 2007 Hepatology pmid:17661404
Nonaka M et al. Cytoprotective effect of tauroursodeoxycholate on hepatocyte apoptosis induced by peroxisome proliferator-activated receptor gamma ligand. 2008 J. Gastroenterol. Hepatol. pmid:17868335
Holm R et al. Complexation of tauro- and glyco-conjugated bile salts with three neutral beta-CDs studied by ACE. 2007 Electrophoresis pmid:17893938
Iizaka T et al. Interaction between caspase-8 activation and endoplasmic reticulum stress in glycochenodeoxycholic acid-induced apoptotic HepG2 cells. 2007 Toxicology pmid:17928124
Tamaki N et al. CHOP deficiency attenuates cholestasis-induced liver fibrosis by reduction of hepatocyte injury. 2008 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:18174271
Venglovecz V et al. Effects of bile acids on pancreatic ductal bicarbonate secretion in guinea pig. 2008 Gut pmid:18303091
Pusl T et al. Free fatty acids sensitize hepatocytes to bile acid-induced apoptosis. 2008 Biochem. Biophys. Res. Commun. pmid:18452708
Usechak P et al. Activation of focal adhesion kinase and JNK contributes to the extracellular matrix and cAMP-GEF mediated survival from bile acid induced apoptosis in rat hepatocytes. 2008 J. Hepatol. pmid:18550202
Gumpricht E et al. Resistance of young rat hepatic mitochondria to bile acid-induced permeability transition: potential role of alpha-tocopherol. 2008 Pediatr. Res. pmid:18596569
Gatto M et al. Insulin-like growth factor-1 isoforms in rat hepatocytes and cholangiocytes and their involvement in protection against cholestatic injury. 2008 Lab. Invest. pmid:18607346
Wang WY and Liaw KY Effect of a taurine-supplemented diet on conjugated bile acids in biliary surgical patients. 1991 May-Jun JPEN J Parenter Enteral Nutr pmid:1865551
Vertzoni M et al. Determination of intralumenal individual bile acids by HPLC with charged aerosol detection. 2008 J. Lipid Res. pmid:18693215
Vrenken TE et al. The active metabolite of leflunomide, A77 1726, protects rat hepatocytes against bile acid-induced apoptosis. 2008 J. Hepatol. pmid:18809221
Rust C et al. Bile acid-induced apoptosis in hepatocytes is caspase-6-dependent. 2009 J. Biol. Chem. pmid:19017654
Ijare OB et al. Absence of glycochenodeoxycholic acid (GCDCA) in human bile is an indication of cholestasis: a 1H MRS study. 2009 NMR Biomed pmid:19067402
Lee TY et al. The effect of capillarisin on glycochenodeoxycholic acid-induced apoptosis and heme oxygenase-1 in rat primary hepatocytes. 2009 Mol. Cell. Biochem. pmid:19132499
Gates A et al. cAMP-GEF cytoprotection by Src tyrosine kinase activation of phosphoinositide-3-kinase p110 beta/alpha in rat hepatocytes. 2009 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:19196950
Kis E et al. Effect of membrane cholesterol on BSEP/Bsep activity: species specificity studies for substrates and inhibitors. 2009 Drug Metab. Dispos. pmid:19520776
Goldman A et al. Protective effects of glycoursodeoxycholic acid in Barrett's esophagus cells. 2010 Dis. Esophagus pmid:19549210
Sommerfeld A et al. Bile acid-induced epidermal growth factor receptor activation in quiescent rat hepatic stellate cells can trigger both proliferation and apoptosis. 2009 J. Biol. Chem. pmid:19553664
Holm R et al. Thermodynamics and structure of inclusion compounds of tauro- and glyco-conjugated bile salts and beta-cyclodextrin. 2009 Phys Chem Chem Phys pmid:19562137
Russmann S et al. Current concepts of mechanisms in drug-induced hepatotoxicity. 2009 Curr. Med. Chem. pmid:19689281
Zucchini-Pascal N et al. Pregnane X receptor activation protects rat hepatocytes against deoxycholic acid-induced apoptosis. 2010 Liver Int. pmid:19737350
González-Rubio S et al. Calcium-dependent nitric oxide production is involved in the cytoprotective properties of n-acetylcysteine in glycochenodeoxycholic acid-induced cell death in hepatocytes. 2010 Toxicol. Appl. Pharmacol. pmid:19837105
González-Rubio S et al. Mitochondrial-driven ubiquinone enhances extracellular calcium-dependent nitric oxide production and reduces glycochenodeoxycholic acid-induced cell death in hepatocytes. 2009 Chem. Res. Toxicol. pmid:20020783
Deo RC et al. Interpreting metabolomic profiles using unbiased pathway models. 2010 PLoS Comput. Biol. pmid:20195502
Kalhan SC et al. Plasma metabolomic profile in nonalcoholic fatty liver disease. 2011 Metab. Clin. Exp. pmid:20423748
Borum M and Fromm H Evidence for a direct hepatoprotective action of ursodeoxycholic acid in primary human hepatocytes. 1991 Gastroenterology pmid:2044917
Rust C and Beuers U Learning from the pregnane X receptor: how to fight one aggressor with two strategies. 2010 Liver Int. pmid:20456034