| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Horváth G et al. | Structural determinants of ligand binding in the ternary complex of human ileal bile acid binding protein with glycocholate and glycochenodeoxycholate obtained from solution NMR. | 2016 | FEBS J. | pmid:26613247 |
| González-Rubio S et al. | AP-1 Inhibition by SR 11302 Protects Human Hepatoma HepG2 Cells from Bile Acid-Induced Cytotoxicity by Restoring the NOS-3 Expression. | 2016 | PLoS ONE | pmid:27490694 |
| Lang E et al. | Bile Acid-Induced Suicidal Erythrocyte Death. | 2016 | Cell. Physiol. Biochem. | pmid:27050423 |
| Webster CR and Anwer MS | Hydrophobic bile acid apoptosis is regulated by sphingosine-1-phosphate receptor 2 in rat hepatocytes and human hepatocellular carcinoma cells. | 2016 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:26999807 |
| Woolbright BL et al. | Bile Acid-Induced Toxicity in HepaRG Cells Recapitulates the Response in Primary Human Hepatocytes. | 2016 | Basic Clin. Pharmacol. Toxicol. | pmid:26176423 |
| Sellinger M et al. | Ursodeoxycholyl lysophosphatidylethanolamide inhibits cholestasis- and hypoxia-induced apoptosis by upregulating antiapoptosis proteins. | 2015 | Exp. Biol. Med. (Maywood) | pmid:25125499 |
| James L et al. | Comparison of Bile Acids and Acetaminophen Protein Adducts in Children and Adolescents with Acetaminophen Toxicity. | 2015 | PLoS ONE | pmid:26208104 |
| Sommerfeld A et al. | Tauroursodeoxycholate Protects Rat Hepatocytes from Bile Acid-Induced Apoptosis via β1-Integrin- and Protein Kinase A-Dependent Mechanisms. | 2015 | Cell. Physiol. Biochem. | pmid:26044599 |
| Woolbright BL et al. | Bile acid-induced necrosis in primary human hepatocytes and in patients with obstructive cholestasis. | 2015 | Toxicol. Appl. Pharmacol. | pmid:25636263 |
| Kowal JM et al. | Bile acid effects are mediated by ATP release and purinergic signalling in exocrine pancreatic cells. | 2015 | Cell Commun. Signal | pmid:26050734 |
| Webster CR et al. | Protein kinase Cδ protects against bile acid apoptosis by suppressing proapoptotic JNK and BIM pathways in human and rat hepatocytes. | 2014 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:25359536 |
| Yu T et al. | Decreasing mitochondrial fission prevents cholestatic liver injury. | 2014 | J. Biol. Chem. | pmid:25342755 |
| Lozano E et al. | Cocarcinogenic effects of intrahepatic bile acid accumulation in cholangiocarcinoma development. | 2014 | Mol. Cancer Res. | pmid:24255171 |
| Cross AJ et al. | A prospective study of serum metabolites and colorectal cancer risk. | 2014 | Cancer | pmid:24894841 |
| Penno CA et al. | 11β-Hydroxysteroid dehydrogenase-1 is involved in bile acid homeostasis by modulating fatty acid transport protein-5 in the liver of mice. | 2014 | Mol Metab | pmid:25061560 |
| Karimian G et al. | Sphingosine kinase-1 inhibition protects primary rat hepatocytes against bile salt-induced apoptosis. | 2013 | Biochim. Biophys. Acta | pmid:23816565 |
| Zhang JH et al. | Potent stimulation of fibroblast growth factor 19 expression in the human ileum by bile acids. | 2013 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:23518683 |
| Wang K et al. | Hepatic apoptosis can modulate liver fibrosis through TIMP1 pathway. | 2013 | Apoptosis | pmid:23456624 |
| Schulz S et al. | Progressive stages of mitochondrial destruction caused by cell toxic bile salts. | 2013 | Biochim. Biophys. Acta | pmid:23685124 |
| Tian Z et al. | Cytochrome P450 107U1 is required for sporulation and antibiotic production in Streptomyces coelicolor. | 2013 | Arch. Biochem. Biophys. | pmid:23357279 |
| Chen Y et al. | Mitofusin 2 protects hepatocyte mitochondrial function from damage induced by GCDCA. | 2013 | PLoS ONE | pmid:23755235 |
| Woudenberg-Vrenken TE et al. | Metformin protects rat hepatocytes against bile acid-induced apoptosis. | 2013 | PLoS ONE | pmid:23951244 |
| Bajpai M et al. | High resolution integrative analysis reveals widespread genetic and epigenetic changes after chronic in-vitro acid and bile exposure in Barrett's epithelium cells. | 2013 | Genes Chromosomes Cancer | pmid:24123713 |
| Heinen CA et al. | Ion pairing with bile salts modulates intestinal permeability and contributes to food-drug interaction of BCS class III compound trospium chloride. | 2013 | Mol. Pharm. | pmid:23750707 |
| Liang S et al. | Effect of quercetin 7-rhamnoside on glycochenodeoxycholic acid-induced L-02 human normal liver cell apoptosis. | 2013 | Int. J. Mol. Med. | pmid:23756642 |
| Horváth G et al. | Internal motions and exchange processes in human ileal bile acid binding protein as studied by backbone (15)N nuclear magnetic resonance spectroscopy. | 2012 | Biochemistry | pmid:22329738 |
| Karimian G et al. | Angiotensin II protects primary rat hepatocytes against bile salt-induced apoptosis. | 2012 | PLoS ONE | pmid:23300732 |
| Brites D | The evolving landscape of neurotoxicity by unconjugated bilirubin: role of glial cells and inflammation. | 2012 | Front Pharmacol | pmid:22661946 |
| Karlgren M et al. | In vitro and in silico strategies to identify OATP1B1 inhibitors and predict clinical drug-drug interactions. | 2012 | Pharm. Res. | pmid:21861202 |
| Zhangxue H et al. | Glycochenodeoxycholate induces rat alveolar epithelial type II cell death and inhibits surfactant secretion in vitro. | 2012 | Free Radic. Biol. Med. | pmid:22569305 |
| Denk GU et al. | Tauro-β-muricholic acid restricts bile acid-induced hepatocellular apoptosis by preserving the mitochondrial membrane potential. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22809502 |
| Ishizuka S et al. | Glycochenodeoxycholic acid promotes proliferation of intestinal epithelia via reduction of cyclic AMP and increase in H2AX phosphorylation after exposure to γ-rays. | 2012 | Biomed. Res. | pmid:22790215 |
| Karimian G et al. | Pertussis toxin, an inhibitor of G(αi) PCR, inhibits bile acid- and cytokine-induced apoptosis in primary rat hepatocytes. | 2012 | PLoS ONE | pmid:22900098 |
| Woolbright BL and Jaeschke H | Novel insight into mechanisms of cholestatic liver injury. | 2012 | World J. Gastroenterol. | pmid:23049206 |
| Tolosa L et al. | Development of a multiparametric cell-based protocol to screen and classify the hepatotoxicity potential of drugs. | 2012 | Toxicol. Sci. | pmid:22331495 |
| Perez MJ et al. | Mitochondrial genome depletion dysregulates bile acid- and paracetamol-induced expression of the transporters Mdr1, Mrp1 and Mrp4 in liver cells. | 2011 | Br. J. Pharmacol. | pmid:21175587 |
| Maléth J et al. | Non-conjugated chenodeoxycholate induces severe mitochondrial damage and inhibits bicarbonate transport in pancreatic duct cells. | 2011 | Gut | pmid:20732916 |
| Kalhan SC et al. | Plasma metabolomic profile in nonalcoholic fatty liver disease. | 2011 | Metab. Clin. Exp. | pmid:20423748 |
| Bhogal RH and Afford SC | Anti-oxidants do not prevent bile acid-induced cell death in rat hepatocytes. | 2011 | Liver Int. | pmid:21073650 |
| González R et al. | Nitric oxide mimics transcriptional and post-translational regulation during α-tocopherol cytoprotection against glycochenodeoxycholate-induced cell death in hepatocytes. | 2011 | J. Hepatol. | pmid:21145864 |
| Wang K et al. | iNOS/NO signaling regulates apoptosis induced by glycochenodeoxycholate in hepatocytes. | 2011 | Cell. Signal. | pmid:21693187 |
| Wang K et al. | C/EBPα and C/EBPβ binding proteins modulate hepatocyte apoptosis through iNOS signaling pathway. | 2011 | Biochim. Biophys. Acta | pmid:21539866 |
| Liao M et al. | Role of bile salt in regulating Mcl-1 phosphorylation and chemoresistance in hepatocellular carcinoma cells. | 2011 | Mol. Cancer | pmid:21507240 |
| González R et al. | Cytoprotective properties of rifampicin are related to the regulation of detoxification system and bile acid transporter expression during hepatocellular injury induced by hydrophobic bile acids. | 2011 | J Hepatobiliary Pancreat Sci | pmid:21526375 |
| Johnston A et al. | cAMP-guanine exchange factor protection from bile acid-induced hepatocyte apoptosis involves glycogen synthase kinase regulation of c-Jun NH2-terminal kinase. | 2011 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:21546580 |
| Ehlken H et al. | Hepatocyte IKK2 protects Mdr2-/- mice from chronic liver failure. | 2011 | PLoS ONE | pmid:22022477 |
| Roberts RE et al. | The relationship between postprandial bile acid concentration, GLP-1, PYY and ghrelin. | 2011 | Clin. Endocrinol. (Oxf) | pmid:21039722 |
| Zanzoni S et al. | Structural requirements for cooperativity in ileal bile acid-binding proteins. | 2011 | J. Biol. Chem. | pmid:21917914 |
| Goldman A et al. | Protective effects of glycoursodeoxycholic acid in Barrett's esophagus cells. | 2010 | Dis. Esophagus | pmid:19549210 |
| Woudenberg-Vrenken TE et al. | Anti-oxidants do not prevent bile acid-induced cell death in rat hepatocytes. | 2010 | Liver Int. | pmid:20825559 |
| Deo RC et al. | Interpreting metabolomic profiles using unbiased pathway models. | 2010 | PLoS Comput. Biol. | pmid:20195502 |
| Hohenester S et al. | Phosphatidylinositol-3-kinase p110γ contributes to bile salt-induced apoptosis in primary rat hepatocytes and human hepatoma cells. | 2010 | J. Hepatol. | pmid:20675006 |
| Wang K et al. | Survivin signaling is regulated through nuclear factor-kappa B pathway during glycochenodeoxycholate-induced hepatocyte apoptosis. | 2010 | Biochim. Biophys. Acta | pmid:20816704 |
| Graf D et al. | Inhibition of interferon-α-induced signaling by hyperosmolarity and hydrophobic bile acids. | 2010 | Biol. Chem. | pmid:21028968 |
| Zucchini-Pascal N et al. | Pregnane X receptor activation protects rat hepatocytes against deoxycholic acid-induced apoptosis. | 2010 | Liver Int. | pmid:19737350 |
| Gille C et al. | HepatoNet1: a comprehensive metabolic reconstruction of the human hepatocyte for the analysis of liver physiology. | 2010 | Mol. Syst. Biol. | pmid:20823849 |
| González-Rubio S et al. | Calcium-dependent nitric oxide production is involved in the cytoprotective properties of n-acetylcysteine in glycochenodeoxycholic acid-induced cell death in hepatocytes. | 2010 | Toxicol. Appl. Pharmacol. | pmid:19837105 |
| Rust C and Beuers U | Learning from the pregnane X receptor: how to fight one aggressor with two strategies. | 2010 | Liver Int. | pmid:20456034 |
| Denk GU et al. | Glycochenodeoxycholate-induced apoptosis is not reduced by augmenter of liver regeneration in the human hepatoma cell line HuH-7. | 2010 | Digestion | pmid:20588045 |
| Gotoh K et al. | Bile acid-induced virulence gene expression of Vibrio parahaemolyticus reveals a novel therapeutic potential for bile acid sequestrants. | 2010 | PLoS ONE | pmid:20967223 |
| Russmann S et al. | Current concepts of mechanisms in drug-induced hepatotoxicity. | 2009 | Curr. Med. Chem. | pmid:19689281 |
| Gates A et al. | cAMP-GEF cytoprotection by Src tyrosine kinase activation of phosphoinositide-3-kinase p110 beta/alpha in rat hepatocytes. | 2009 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:19196950 |
| Ijare OB et al. | Absence of glycochenodeoxycholic acid (GCDCA) in human bile is an indication of cholestasis: a 1H MRS study. | 2009 | NMR Biomed | pmid:19067402 |
| Rust C et al. | Bile acid-induced apoptosis in hepatocytes is caspase-6-dependent. | 2009 | J. Biol. Chem. | pmid:19017654 |
| Lee TY et al. | The effect of capillarisin on glycochenodeoxycholic acid-induced apoptosis and heme oxygenase-1 in rat primary hepatocytes. | 2009 | Mol. Cell. Biochem. | pmid:19132499 |
| Sommerfeld A et al. | Bile acid-induced epidermal growth factor receptor activation in quiescent rat hepatic stellate cells can trigger both proliferation and apoptosis. | 2009 | J. Biol. Chem. | pmid:19553664 |
| González-Rubio S et al. | Mitochondrial-driven ubiquinone enhances extracellular calcium-dependent nitric oxide production and reduces glycochenodeoxycholic acid-induced cell death in hepatocytes. | 2009 | Chem. Res. Toxicol. | pmid:20020783 |
| Kis E et al. | Effect of membrane cholesterol on BSEP/Bsep activity: species specificity studies for substrates and inhibitors. | 2009 | Drug Metab. Dispos. | pmid:19520776 |
| Holm R et al. | Thermodynamics and structure of inclusion compounds of tauro- and glyco-conjugated bile salts and beta-cyclodextrin. | 2009 | Phys Chem Chem Phys | pmid:19562137 |
| Vrenken TE et al. | The active metabolite of leflunomide, A77 1726, protects rat hepatocytes against bile acid-induced apoptosis. | 2008 | J. Hepatol. | pmid:18809221 |
| Gatto M et al. | Insulin-like growth factor-1 isoforms in rat hepatocytes and cholangiocytes and their involvement in protection against cholestatic injury. | 2008 | Lab. Invest. | pmid:18607346 |
| Usechak P et al. | Activation of focal adhesion kinase and JNK contributes to the extracellular matrix and cAMP-GEF mediated survival from bile acid induced apoptosis in rat hepatocytes. | 2008 | J. Hepatol. | pmid:18550202 |
| Tamaki N et al. | CHOP deficiency attenuates cholestasis-induced liver fibrosis by reduction of hepatocyte injury. | 2008 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:18174271 |
| Nonaka M et al. | Cytoprotective effect of tauroursodeoxycholate on hepatocyte apoptosis induced by peroxisome proliferator-activated receptor gamma ligand. | 2008 | J. Gastroenterol. Hepatol. | pmid:17868335 |
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| Gumpricht E et al. | Resistance of young rat hepatic mitochondria to bile acid-induced permeability transition: potential role of alpha-tocopherol. | 2008 | Pediatr. Res. | pmid:18596569 |
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Glycochenodeoxycholic acid
Glycochenodeoxycholic acid is a lipid of Sterol Lipids (ST) class. Glycochenodeoxycholic acid is associated with abnormalities such as Cholestasis. The involved functions are known as Apoptosis, Process, Cytokinesis and Necrosis. Glycochenodeoxycholic acid often locates in Cell surface. The associated genes with Glycochenodeoxycholic acid are SLC10A1 gene, TNFSF10 gene, AKR1C2 gene and HSPA5 gene. The related lipids are glycoursodeoxycholic acid.
Cross Reference
Introduction
To understand associated biological information of Glycochenodeoxycholic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Glycochenodeoxycholic acid?
Glycochenodeoxycholic acid is suspected in Cholestasis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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No disease MeSH terms mapped to the current reference collection.
PubChem Associated disorders and diseases
What pathways are associated with Glycochenodeoxycholic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Glycochenodeoxycholic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Glycochenodeoxycholic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Glycochenodeoxycholic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Glycochenodeoxycholic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Glycochenodeoxycholic acid?
There are no associated biomedical information in the current reference collection.