| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Birth Weight | D001724 | 23 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Cholestasis | D002779 | 23 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Fetal Resorption | D005327 | 15 associated lipids |
| Gastroesophageal Reflux | D005764 | 10 associated lipids |
| Gastrointestinal Hemorrhage | D006471 | 27 associated lipids |
| Shock, Hemorrhagic | D012771 | 4 associated lipids |
| Short Bowel Syndrome | D012778 | 3 associated lipids |
| Tay-Sachs Disease | D013661 | 2 associated lipids |
| Pancreatitis, Acute Necrotizing | D019283 | 18 associated lipids |
Taurodeoxycholic acid
Taurodeoxycholic acid is a lipid of Sterol Lipids (ST) class. Taurodeoxycholic acid is associated with abnormalities such as Ischemia and Wiskott-Aldrich Syndrome. The involved functions are known as Cell Proliferation, Transcriptional Activation, Phosphorylation, Anabolism and Biochemical Pathway. Taurodeoxycholic acid often locates in Body tissue, Epithelium, Blood, Mucous Membrane and Hepatic. The associated genes with Taurodeoxycholic acid are NOX5 gene, GPBAR1 gene, NR1H4 gene and SLC33A1 gene. The related lipids are cholanic acid, taurolithocholic acid 3-sulfate, Sterols, 7-dehydrocholesterol and tauromuricholic acid.
Cross Reference
Introduction
To understand associated biological information of Taurodeoxycholic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Taurodeoxycholic acid?
Taurodeoxycholic acid is suspected in Ischemia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Taurodeoxycholic acid
PubChem Associated disorders and diseases
What pathways are associated with Taurodeoxycholic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Taurodeoxycholic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Taurodeoxycholic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Taurodeoxycholic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Taurodeoxycholic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Taurodeoxycholic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Taurodeoxycholic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Baiocchi L et al. | Taurohyodeoxycholate- and tauroursodeoxycholate-induced hypercholeresis is augmented in bile duct ligated rats. | 2003 | J. Hepatol. | pmid:12547401 |
| van Erpecum KJ et al. | Phenotypic characterization of Lith genes that determine susceptibility to cholesterol cholelithiasis in inbred mice: soluble pronucleating proteins in gallbladder and hepatic biles. | 2001 | J. Hepatol. | pmid:11682027 |
| Thibault N et al. | Effect of tauroursodeoxycholate on actin filament alteration induced by cholestatic agents. A study in isolated rat hepatocyte couplets. | 1993 | J. Hepatol. | pmid:8151096 |
| Moschetta A et al. | Hydrophilic bile salts enhance differential distribution of sphingomyelin and phosphatidylcholine between micellar and vesicular phases: potential implications for their effects in vivo. | 2001 | J. Hepatol. | pmid:11394647 |
| Baumgartner U et al. | Pattern of bile acid regurgitation and metabolism during perfusion of the bile duct obstructed rat liver. | 1995 | J. Hepatol. | pmid:7790709 |
| Freinkel RK and Traczyk TN | The phospholipases A of epidermis. | 1980 | J. Invest. Dermatol. | pmid:7359009 |
| Paolini M et al. | Mechanism for the prevention of cholestasis involving cytochrome P4503A overexpression. | 2000 | J. Investig. Med. | pmid:10695269 |
| Shekels LL et al. | Tauroursodeoxycholic acid protects in vitro models of human colonic cancer cells from cytotoxic effects of hydrophobic bile acids. | 1996 | J. Lab. Clin. Med. | pmid:8592097 |
| Kidder GW et al. | Evaluation of in vivo measurement of transesophageal electrical resistance as an indicator of early experimental esophageal mucosal injury. | 1983 | J. Lab. Clin. Med. | pmid:6619646 |
| Frijters CM et al. | The role of different P-glycoproteins in hepatobiliary secretion of fluorescently labeled short-chain phospholipids. | 1999 | J. Lipid Res. | pmid:10552998 |
| Watt SM and Simmonds WJ | Effects of four taurine-conjugated bile acids on mucosal uptake and lymphatic absorption of cholesterol in the rat. | 1984 | J. Lipid Res. | pmid:6736779 |
| Campanelli AR et al. | A model for micellar aggregates of a bile salt: crystal structure of sodium taurodeoxycholate monohydrate. | 1987 | J. Lipid Res. | pmid:3598393 |
| Stevens RD et al. | Calcium binding by monosulfate esters of taurochenodeoxycholate. | 1991 | J. Lipid Res. | pmid:1856607 |
| Stevens RD et al. | Proton magnetic resonance studies of the aggregation of taurine-conjugated bile salts. | 1992 | J. Lipid Res. | pmid:1552230 |
| Rao YP et al. | Activation of protein kinase C alpha and delta by bile acids: correlation with bile acid structure and diacylglycerol formation. | 1997 | J. Lipid Res. | pmid:9458268 |
| Momsen WE and Brockman HL | Purification of pancreatic lipase via its affinity for bile salts and apolar surfaces. | 1978 | J. Lipid Res. | pmid:731125 |
| Kosters A et al. | The mechanism of ABCG5/ABCG8 in biliary cholesterol secretion in mice. | 2006 | J. Lipid Res. | pmid:16741293 |
| Eydoux C et al. | Further biochemical characterization of human pancreatic lipase-related protein 2 expressed in yeast cells. | 2007 | J. Lipid Res. | pmid:17401110 |
| Heuman DM et al. | Adsorption of mixtures of bile salt taurine conjugates to lecithin-cholesterol membranes: implications for bile salt toxicity and cytoprotection. | 1996 | J. Lipid Res. | pmid:8728319 |
| Oude Elferink RP et al. | Uncoupling of biliary phospholipid and cholesterol secretion in mice with reduced expression of mdr2 P-glycoprotein. | 1996 | J. Lipid Res. | pmid:8725158 |
| Trawick JD et al. | Rat hepatoma L35 cells, a liver-differentiated cell line, display resistance to bile acid repression of cholesterol 7 alpha-hydroxylase. | 1996 | J. Lipid Res. | pmid:8728321 |
| Ghoos Y et al. | Tauro-7 alpha, 12 alpha-dihydroxy-5 beta-cholanic acid as internal standard in the gas-liquid chromatographic analysis of bile acid methyl ester acetates. | 1983 | J. Lipid Res. | pmid:6644187 |
| Thomson AB | Unidirectional flux rate of cholesterol and fatty acids into the intestine of rats with drug-induced diabetes mellitus: effect of variations in the effective resistance of the unstirred water layer and the bile acid micelle. | 1980 | J. Lipid Res. | pmid:7419982 |
| Batta AK et al. | Thin-layer chromatographic separation of conjugates of ursodeoxycholic acid from those of litho-, chenodeoxy-, deoxy-, and cholic acids. | 1981 | J. Lipid Res. | pmid:7276746 |
| Worku ML et al. | Chemotactic response of Helicobacter pylori to human plasma and bile. | 2004 | J. Med. Microbiol. | pmid:15272070 |
| Charles M et al. | Small-angle neutron scattering study of the association between porcine pancreatic colipase and taurodeoxycholate micelles. | 1980 | J. Mol. Biol. | pmid:7441738 |
| Chalifour R and Kanfer JN | Fatty acid activation and temperature perturbation of rat brain microsomal phospholipase D. | 1982 | J. Neurochem. | pmid:7045286 |
| Glew RH et al. | A case of nonneurologic Gaucher's disease that biochemically resembles the neurologic types. | 1991 | J. Neuropathol. Exp. Neurol. | pmid:1672707 |
| Patton WH and Brigman GP | The use of sodium taurodeoxycholate for excystation of Eimeria tenella sporozoites. | 1979 | J. Parasitol. | pmid:512750 |
| Potter GD et al. | Potassium secretion in response to taurodeoxycholic acid in the newborn rabbit colon. | 1989 | J. Pediatr. Gastroenterol. Nutr. | pmid:2614625 |
| Patton S et al. | Release of membrane from milk fat globules by conjugated bile salts. | 1986 Mar-Apr | J. Pediatr. Gastroenterol. Nutr. | pmid:3754277 |
| Carlos MA et al. | Epidermal growth factor stimulates chloride transport in primary cultures of weanling and adult rabbit colonocytes. | 2007 | J. Pediatr. Gastroenterol. Nutr. | pmid:17325549 |
| Potter GD et al. | Bile acid stimulation of cyclic AMP and ion transport in developing rabbit colon. | 1991 | J. Pediatr. Gastroenterol. Nutr. | pmid:1663997 |
| Perrone EE et al. | Dietary bile acid supplementation improves intestinal integrity and survival in a murine model. | 2010 | J. Pediatr. Surg. | pmid:20620329 |
| Morgan RJ et al. | The protective effect of deglycyrrhinized liquorice against aspirin and aspirin plus bile acid-induced gastric mucosal damage, and its influence on aspirin absorption in rats. | 1983 | J. Pharm. Pharmacol. | pmid:6138416 |
| Morimoto K et al. | Evaluation of permeability enhancement of hydrophilic compounds and macromolecular compounds by bile salts through rabbit corneas in-vitro. | 1987 | J. Pharm. Pharmacol. | pmid:2435884 |
| Miyata M et al. | Enterobacteria modulate intestinal bile acid transport and homeostasis through apical sodium-dependent bile acid transporter (SLC10A2) expression. | 2011 | J. Pharmacol. Exp. Ther. | pmid:20884752 |
| Hartmann G et al. | Inflammatory cytokines, but not bile acids, regulate expression of murine hepatic anion transporters in endotoxemia. | 2002 | J. Pharmacol. Exp. Ther. | pmid:12235261 |
| Sánchez Pozzi EJ et al. | Ursodeoxycholate reduces ethinylestradiol glucuronidation in the rat: role in prevention of estrogen-induced cholestasis. | 2003 | J. Pharmacol. Exp. Ther. | pmid:12663690 |
| Cheng X et al. | Decreased bile-acid synthesis in livers of hepatocyte-conditional NADPH-cytochrome P450 reductase-null mice results in increased bile acids in serum. | 2014 | J. Pharmacol. Exp. Ther. | pmid:25034404 |
| Buchanan CR et al. | Choleretic effects of taurocholate and taurodeoxycholate in the guinea-pig [proceedings]. | 1978 | J. Physiol. (Lond.) | pmid:745096 |
| Voronina S et al. | Bile acids induce calcium signals in mouse pancreatic acinar cells: implications for bile-induced pancreatic pathology. | 2002 | J. Physiol. (Lond.) | pmid:11927668 |
| Dulski PM | Eimeria tenella: incomplete excystation in the presence of EDTA in a taurodeoxycholate-based medium. | 1990 Nov-Dec | J. Protozool. | pmid:2128338 |
| Strauch ED et al. | Bile salt stimulates intestinal epithelial cell migration through TGFbeta after wounding. | 2001 | J. Surg. Res. | pmid:11319879 |
| Baumgartner U et al. | Repetitive short-term bile duct obstruction and relief causes reproducible and reversible bile acid regurgitation. | 2003 | J. Surg. Res. | pmid:12697405 |
| Narain PK et al. | Cholesterol enhances membrane-damaging properties of model bile by increasing the intervesicular-intermixed micellar concentration of hydrophobic bile salts. | 1999 | J. Surg. Res. | pmid:10334899 |
| Perrone EE et al. | Bile salts increase epithelial cell proliferation through HuR-induced c-Myc expression. | 2012 | J. Surg. Res. | pmid:22626558 |
| Alvarez C et al. | Acute effects of bile acids on the pancreatic duct epithelium in vitro. | 1998 | J. Surg. Res. | pmid:9536972 |
| Lim HJ et al. | Isolation of cholesterol-lowering lactic acid bacteria from human intestine for probiotic use. | 2004 | J. Vet. Sci. | pmid:15613825 |
| Lee HK et al. | Bile Acid Inhibition of N-type Calcium Channel Currents from Sympathetic Ganglion Neurons. | 2012 | Korean J. Physiol. Pharmacol. | pmid:22416216 |
| Clouzeau-Girard H et al. | Effects of bile acids on biliary epithelial cell proliferation and portal fibroblast activation using rat liver slices. | 2006 | Lab. Invest. | pmid:16402030 |
| Lamireau T et al. | Effects of bile acids on biliary epithelial cells: proliferation, cytotoxicity, and cytokine secretion. | 2003 | Life Sci. | pmid:12527037 |
| Nagana Gowda GA et al. | Bile acids conjugation in human bile is not random: new insights from (1)H-NMR spectroscopy at 800 MHz. | 2009 | Lipids | pmid:19373503 |
| Ben Bacha A et al. | Biochemical properties of pancreatic colipase from the common stingray Dasyatis pastinaca. | 2011 | Lipids Health Dis | pmid:21549005 |
| Okido M et al. | Influence of phospholipid on bile salt binding to calcium hydroxyapatite and on the poisoning of nascent hydroxyapatite crystals. | 1996 | Liver | pmid:8938633 |
| Hertl M et al. | Hydrophilic bile salts protect bile duct epithelium during cold preservation: a scanning electron microscopy study. | 2000 | Liver Transpl. | pmid:10719022 |
| Dastgheib S et al. | Analyses of glycosphingolipids using clam, Mercenaria mercenaria, ceramide glycanase. | 2000 | Meth. Enzymol. | pmid:11070873 |
| Hu MS et al. | Paracellular phosphate absorption in rat colon: a mechanism for enema-induced hyperphosphatemia. | 1997 | Miner Electrolyte Metab | pmid:9058363 |
| Shah GV et al. | Conformational determinants in receptor recognition of peptide hormones: interaction of parathyroid hormone with the glucagon receptor. | 1987 | Mol. Cell. Endocrinol. | pmid:3030852 |
| Heinen CA et al. | Ion pairing with bile salts modulates intestinal permeability and contributes to food-drug interaction of BCS class III compound trospium chloride. | 2013 | Mol. Pharm. | pmid:23750707 |
| Fang Y et al. | Conjugated bile acids regulate hepatocyte glycogen synthase activity in vitro and in vivo via Galphai signaling. | 2007 | Mol. Pharmacol. | pmid:17200418 |
| Martin FP et al. | A top-down systems biology view of microbiome-mammalian metabolic interactions in a mouse model. | 2007 | Mol. Syst. Biol. | pmid:17515922 |
| Ngamukote S et al. | Cholesterol-lowering activity of the major polyphenols in grape seed. | 2011 | Molecules | pmid:21694670 |
| Murata Y et al. | Properties of an oral preparation containing a chitosan salt. | 2009 | Molecules | pmid:19223823 |
| Shibuya N et al. | Co-mutagenicity of glyco- and tauro-deoxycholic acids in the Ames test. | 1997 | Mutat. Res. | pmid:9465909 |
| van Tilbeurgh H et al. | Interfacial activation of the lipase-procolipase complex by mixed micelles revealed by X-ray crystallography. | 1993 | Nature | pmid:8479519 |
| Binah O et al. | Effects of bile acids on ventricular muscle contraction and electrophysiological properties: studies in rat papillary muscle and isolated ventricular myocytes. | 1987 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:3561530 |
| Zheng ZY and Bernstein C | Bile salt/acid induction of DNA damage in bacterial cells: effect of taurine conjugation. | 1992 | Nutr Cancer | pmid:1437652 |
| Cheng BQ et al. | Ethyl pyruvate improves survival and ameliorates distant organ injury in rats with severe acute pancreatitis. | 2007 | Pancreas | pmid:17895847 |
| Andersson R et al. | Effect of a platelet-activating factor antagonist on pancreatitis-associated gut barrier dysfunction in rats. | 1998 | Pancreas | pmid:9700940 |
| Ben Bacha A et al. | Proteolytic cleavage of ostrich and turkey pancreatic lipases: production of an active N-terminal domain. | 2007 | Pancreas | pmid:17895836 |
| Riepl RL et al. | Effect of intraduodenal bile and taurodeoxycholate on exocrine pancreatic secretion and on plasma levels of vasoactive intestinal polypeptide and somatostatin in man. | 1994 | Pancreas | pmid:7509061 |
| van Minnen LP et al. | Cholesterol crystals enhance and phospholipids protect against pancreatitis induced by hydrophobic bile salts: a rat model study. | 2006 | Pancreas | pmid:16670619 |
| Jin HT et al. | Polyamine catabolism in relation to trypsin activation and apoptosis in experimental acute pancreatitis. | 2011 | Pancreatology | pmid:21525776 |
| Jin HT et al. | Polyamine levels in the pancreas and the blood change according to the severity of pancreatitis. | 2008 | Pancreatology | pmid:18235212 |
| Haraldsen P et al. | Multimodal management - of value in fulminant acute pancreatitis? | 2003 | Pancreatology | pmid:12649560 |
| Xie MQ et al. | A new method for purification of Eimeria tenella merozoites. | 1990 | Parasitol. Res. | pmid:2217116 |
| Buts JP et al. | Intestinal transport of calcium in rat biliary cirrhosis. | 1996 | Pediatr. Res. | pmid:8888279 |
| Chen CC et al. | Effects of high dose octreotide on retrograde bile salt-induced pancreatitis in rats. | 1998 | Peptides | pmid:9533643 |
| Ammon HV et al. | Acid pH enhances the effects of taurodeoxycholate on water and solute transport in the human and rat jejunum. | 1987 | Pflugers Arch. | pmid:3114711 |
| Gasco MR et al. | Ion pairs of beta blockers with taurodeoxycholate. | 1985 | Pharm Acta Helv | pmid:2868463 |
| Song IS et al. | Contribution of ion-pair complexation with bile salts to the transport of organic cations across LLC-PK1 cell monolayers. | 2003 | Pharm. Res. | pmid:12739767 |
| Alvarez FJ and Stella VJ | The role of calcium ions and bile salts on the pancreatic lipase-catalyzed hydrolysis of triglyceride emulsions stabilized with lecithin. | 1989 | Pharm. Res. | pmid:2762220 |
| Song IS et al. | Increased affinity to canalicular P-gp via formation of lipophilic ion-pair complexes with endogenous bile salts is associated with mw threshold in hepatobiliary excretion of quaternary ammonium compounds. | 2010 | Pharm. Res. | pmid:20221674 |
| Scriba GK | Phenytoin-lipid conjugates: chemical, plasma esterase-mediated, and pancreatic lipase-mediated hydrolysis in vitro. | 1993 | Pharm. Res. | pmid:8415405 |
| Karlgren M et al. | In vitro and in silico strategies to identify OATP1B1 inhibitors and predict clinical drug-drug interactions. | 2012 | Pharm. Res. | pmid:21861202 |
| Wiedmann TS et al. | Ionization and solubilization of 4 alkyl benzoic acids and 4 alkyl anilines in sodium taurodeoxycholate solutions. | 1997 | Pharm. Res. | pmid:9434277 |
| Czerny B et al. | Effect of tamoxifen and raloxifene on the conjugation of bile acids with taurine and glycine in ovariectomized rats. | 2006 May-Jun | Pharmacol Rep | pmid:16845220 |
| Jin HT et al. | Association between remote organ injury and tissue polyamine homeostasis in acute experimental pancreatitis - treatment with a polyamine analogue bismethylspermine. | 2011 | Pharmacol Rep | pmid:22001988 |
| Bleske BE et al. | Effect of vehicle on the nasal absorption of epinephrine during cardiopulmonary resuscitation. | 1996 Nov-Dec | Pharmacotherapy | pmid:8947976 |
| Holm R et al. | Thermodynamics and structure of inclusion compounds of tauro- and glyco-conjugated bile salts and beta-cyclodextrin. | 2009 | Phys Chem Chem Phys | pmid:19562137 |
| Abdelkafi S et al. | Carica papaya lipase: a naturally immobilized enzyme with interesting biochemical properties. | 2011 | Plant Foods Hum Nutr | pmid:21267783 |
| Matyash V et al. | Sterol-derived hormone(s) controls entry into diapause in Caenorhabditis elegans by consecutive activation of DAF-12 and DAF-16. | 2004 | PLoS Biol. | pmid:15383841 |
| Trottier J et al. | Profiling circulating and urinary bile acids in patients with biliary obstruction before and after biliary stenting. | 2011 | PLoS ONE | pmid:21760958 |
| Debellis L et al. | The Vibrio cholerae cytolysin promotes chloride secretion from intact human intestinal mucosa. | 2009 | PLoS ONE | pmid:19333391 |
| Renga B et al. | Discovery that theonellasterol a marine sponge sterol is a highly selective FXR antagonist that protects against liver injury in cholestasis. | 2012 | PLoS ONE | pmid:22291955 |
| Lodola A et al. | A catalytic mechanism for cysteine N-terminal nucleophile hydrolases, as revealed by free energy simulations. | 2012 | PLoS ONE | pmid:22389698 |
| James L et al. | Comparison of Bile Acids and Acetaminophen Protein Adducts in Children and Adolescents with Acetaminophen Toxicity. | 2015 | PLoS ONE | pmid:26208104 |
| Zhang Y et al. | Dysfunction of organic anion transporting polypeptide 1a1 alters intestinal bacteria and bile acid metabolism in mice. | 2012 | PLoS ONE | pmid:22496825 |
| Gotoh K et al. | Bile acid-induced virulence gene expression of Vibrio parahaemolyticus reveals a novel therapeutic potential for bile acid sequestrants. | 2010 | PLoS ONE | pmid:20967223 |