| MeSH term | MeSH ID | Detail |
|---|---|---|
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Cholestasis | D002779 | 23 associated lipids |
| Birth Weight | D001724 | 23 associated lipids |
| Shock, Hemorrhagic | D012771 | 4 associated lipids |
| Gastrointestinal Hemorrhage | D006471 | 27 associated lipids |
| Tay-Sachs Disease | D013661 | 2 associated lipids |
| Fetal Resorption | D005327 | 15 associated lipids |
| Pancreatitis, Acute Necrotizing | D019283 | 18 associated lipids |
| Short Bowel Syndrome | D012778 | 3 associated lipids |
| Gastroesophageal Reflux | D005764 | 10 associated lipids |
Taurodeoxycholic acid
Taurodeoxycholic acid is a lipid of Sterol Lipids (ST) class. Taurodeoxycholic acid is associated with abnormalities such as Ischemia and Wiskott-Aldrich Syndrome. The involved functions are known as Cell Proliferation, Transcriptional Activation, Phosphorylation, Anabolism and Biochemical Pathway. Taurodeoxycholic acid often locates in Body tissue, Epithelium, Blood, Mucous Membrane and Hepatic. The associated genes with Taurodeoxycholic acid are NOX5 gene, GPBAR1 gene, NR1H4 gene and SLC33A1 gene. The related lipids are cholanic acid, taurolithocholic acid 3-sulfate, Sterols, 7-dehydrocholesterol and tauromuricholic acid.
Cross Reference
Introduction
To understand associated biological information of Taurodeoxycholic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Taurodeoxycholic acid?
Taurodeoxycholic acid is suspected in Ischemia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Taurodeoxycholic acid
PubChem Associated disorders and diseases
What pathways are associated with Taurodeoxycholic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Taurodeoxycholic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Taurodeoxycholic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Taurodeoxycholic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Taurodeoxycholic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Taurodeoxycholic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Taurodeoxycholic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lim HJ et al. | Isolation of cholesterol-lowering lactic acid bacteria from human intestine for probiotic use. | 2004 | J. Vet. Sci. | pmid:15613825 |
| Strauch ED et al. | Bile salt stimulates intestinal epithelial cell migration through TGFbeta after wounding. | 2001 | J. Surg. Res. | pmid:11319879 |
| Baumgartner U et al. | Repetitive short-term bile duct obstruction and relief causes reproducible and reversible bile acid regurgitation. | 2003 | J. Surg. Res. | pmid:12697405 |
| Narain PK et al. | Cholesterol enhances membrane-damaging properties of model bile by increasing the intervesicular-intermixed micellar concentration of hydrophobic bile salts. | 1999 | J. Surg. Res. | pmid:10334899 |
| Perrone EE et al. | Bile salts increase epithelial cell proliferation through HuR-induced c-Myc expression. | 2012 | J. Surg. Res. | pmid:22626558 |
| Alvarez C et al. | Acute effects of bile acids on the pancreatic duct epithelium in vitro. | 1998 | J. Surg. Res. | pmid:9536972 |
| Dulski PM | Eimeria tenella: incomplete excystation in the presence of EDTA in a taurodeoxycholate-based medium. | 1990 Nov-Dec | J. Protozool. | pmid:2128338 |
| Buchanan CR et al. | Choleretic effects of taurocholate and taurodeoxycholate in the guinea-pig [proceedings]. | 1978 | J. Physiol. (Lond.) | pmid:745096 |
| Voronina S et al. | Bile acids induce calcium signals in mouse pancreatic acinar cells: implications for bile-induced pancreatic pathology. | 2002 | J. Physiol. (Lond.) | pmid:11927668 |
| Miyata M et al. | Enterobacteria modulate intestinal bile acid transport and homeostasis through apical sodium-dependent bile acid transporter (SLC10A2) expression. | 2011 | J. Pharmacol. Exp. Ther. | pmid:20884752 |
| Hartmann G et al. | Inflammatory cytokines, but not bile acids, regulate expression of murine hepatic anion transporters in endotoxemia. | 2002 | J. Pharmacol. Exp. Ther. | pmid:12235261 |
| Sánchez Pozzi EJ et al. | Ursodeoxycholate reduces ethinylestradiol glucuronidation in the rat: role in prevention of estrogen-induced cholestasis. | 2003 | J. Pharmacol. Exp. Ther. | pmid:12663690 |
| Cheng X et al. | Decreased bile-acid synthesis in livers of hepatocyte-conditional NADPH-cytochrome P450 reductase-null mice results in increased bile acids in serum. | 2014 | J. Pharmacol. Exp. Ther. | pmid:25034404 |
| Morgan RJ et al. | The protective effect of deglycyrrhinized liquorice against aspirin and aspirin plus bile acid-induced gastric mucosal damage, and its influence on aspirin absorption in rats. | 1983 | J. Pharm. Pharmacol. | pmid:6138416 |
| Morimoto K et al. | Evaluation of permeability enhancement of hydrophilic compounds and macromolecular compounds by bile salts through rabbit corneas in-vitro. | 1987 | J. Pharm. Pharmacol. | pmid:2435884 |
| Perrone EE et al. | Dietary bile acid supplementation improves intestinal integrity and survival in a murine model. | 2010 | J. Pediatr. Surg. | pmid:20620329 |
| Potter GD et al. | Potassium secretion in response to taurodeoxycholic acid in the newborn rabbit colon. | 1989 | J. Pediatr. Gastroenterol. Nutr. | pmid:2614625 |
| Patton S et al. | Release of membrane from milk fat globules by conjugated bile salts. | 1986 Mar-Apr | J. Pediatr. Gastroenterol. Nutr. | pmid:3754277 |
| Carlos MA et al. | Epidermal growth factor stimulates chloride transport in primary cultures of weanling and adult rabbit colonocytes. | 2007 | J. Pediatr. Gastroenterol. Nutr. | pmid:17325549 |
| Potter GD et al. | Bile acid stimulation of cyclic AMP and ion transport in developing rabbit colon. | 1991 | J. Pediatr. Gastroenterol. Nutr. | pmid:1663997 |
| Patton WH and Brigman GP | The use of sodium taurodeoxycholate for excystation of Eimeria tenella sporozoites. | 1979 | J. Parasitol. | pmid:512750 |
| Glew RH et al. | A case of nonneurologic Gaucher's disease that biochemically resembles the neurologic types. | 1991 | J. Neuropathol. Exp. Neurol. | pmid:1672707 |
| Chalifour R and Kanfer JN | Fatty acid activation and temperature perturbation of rat brain microsomal phospholipase D. | 1982 | J. Neurochem. | pmid:7045286 |
| Charles M et al. | Small-angle neutron scattering study of the association between porcine pancreatic colipase and taurodeoxycholate micelles. | 1980 | J. Mol. Biol. | pmid:7441738 |
| Worku ML et al. | Chemotactic response of Helicobacter pylori to human plasma and bile. | 2004 | J. Med. Microbiol. | pmid:15272070 |
| Frijters CM et al. | The role of different P-glycoproteins in hepatobiliary secretion of fluorescently labeled short-chain phospholipids. | 1999 | J. Lipid Res. | pmid:10552998 |
| Watt SM and Simmonds WJ | Effects of four taurine-conjugated bile acids on mucosal uptake and lymphatic absorption of cholesterol in the rat. | 1984 | J. Lipid Res. | pmid:6736779 |
| Campanelli AR et al. | A model for micellar aggregates of a bile salt: crystal structure of sodium taurodeoxycholate monohydrate. | 1987 | J. Lipid Res. | pmid:3598393 |
| Stevens RD et al. | Calcium binding by monosulfate esters of taurochenodeoxycholate. | 1991 | J. Lipid Res. | pmid:1856607 |
| Stevens RD et al. | Proton magnetic resonance studies of the aggregation of taurine-conjugated bile salts. | 1992 | J. Lipid Res. | pmid:1552230 |
| Rao YP et al. | Activation of protein kinase C alpha and delta by bile acids: correlation with bile acid structure and diacylglycerol formation. | 1997 | J. Lipid Res. | pmid:9458268 |
| Momsen WE and Brockman HL | Purification of pancreatic lipase via its affinity for bile salts and apolar surfaces. | 1978 | J. Lipid Res. | pmid:731125 |
| Kosters A et al. | The mechanism of ABCG5/ABCG8 in biliary cholesterol secretion in mice. | 2006 | J. Lipid Res. | pmid:16741293 |
| Eydoux C et al. | Further biochemical characterization of human pancreatic lipase-related protein 2 expressed in yeast cells. | 2007 | J. Lipid Res. | pmid:17401110 |
| Heuman DM et al. | Adsorption of mixtures of bile salt taurine conjugates to lecithin-cholesterol membranes: implications for bile salt toxicity and cytoprotection. | 1996 | J. Lipid Res. | pmid:8728319 |
| Oude Elferink RP et al. | Uncoupling of biliary phospholipid and cholesterol secretion in mice with reduced expression of mdr2 P-glycoprotein. | 1996 | J. Lipid Res. | pmid:8725158 |
| Trawick JD et al. | Rat hepatoma L35 cells, a liver-differentiated cell line, display resistance to bile acid repression of cholesterol 7 alpha-hydroxylase. | 1996 | J. Lipid Res. | pmid:8728321 |
| Ghoos Y et al. | Tauro-7 alpha, 12 alpha-dihydroxy-5 beta-cholanic acid as internal standard in the gas-liquid chromatographic analysis of bile acid methyl ester acetates. | 1983 | J. Lipid Res. | pmid:6644187 |
| Thomson AB | Unidirectional flux rate of cholesterol and fatty acids into the intestine of rats with drug-induced diabetes mellitus: effect of variations in the effective resistance of the unstirred water layer and the bile acid micelle. | 1980 | J. Lipid Res. | pmid:7419982 |
| Batta AK et al. | Thin-layer chromatographic separation of conjugates of ursodeoxycholic acid from those of litho-, chenodeoxy-, deoxy-, and cholic acids. | 1981 | J. Lipid Res. | pmid:7276746 |
| Shekels LL et al. | Tauroursodeoxycholic acid protects in vitro models of human colonic cancer cells from cytotoxic effects of hydrophobic bile acids. | 1996 | J. Lab. Clin. Med. | pmid:8592097 |
| Kidder GW et al. | Evaluation of in vivo measurement of transesophageal electrical resistance as an indicator of early experimental esophageal mucosal injury. | 1983 | J. Lab. Clin. Med. | pmid:6619646 |
| Paolini M et al. | Mechanism for the prevention of cholestasis involving cytochrome P4503A overexpression. | 2000 | J. Investig. Med. | pmid:10695269 |
| Freinkel RK and Traczyk TN | The phospholipases A of epidermis. | 1980 | J. Invest. Dermatol. | pmid:7359009 |
| Baiocchi L et al. | Taurohyodeoxycholate- and tauroursodeoxycholate-induced hypercholeresis is augmented in bile duct ligated rats. | 2003 | J. Hepatol. | pmid:12547401 |
| van Erpecum KJ et al. | Phenotypic characterization of Lith genes that determine susceptibility to cholesterol cholelithiasis in inbred mice: soluble pronucleating proteins in gallbladder and hepatic biles. | 2001 | J. Hepatol. | pmid:11682027 |
| Thibault N et al. | Effect of tauroursodeoxycholate on actin filament alteration induced by cholestatic agents. A study in isolated rat hepatocyte couplets. | 1993 | J. Hepatol. | pmid:8151096 |
| Moschetta A et al. | Hydrophilic bile salts enhance differential distribution of sphingomyelin and phosphatidylcholine between micellar and vesicular phases: potential implications for their effects in vivo. | 2001 | J. Hepatol. | pmid:11394647 |
| Baumgartner U et al. | Pattern of bile acid regurgitation and metabolism during perfusion of the bile duct obstructed rat liver. | 1995 | J. Hepatol. | pmid:7790709 |
| Alvarez C and Bass BL | Role of transforming growth factor-beta in growth and injury response of the pancreatic duct epithelium in vitro. | 1999 Mar-Apr | J. Gastrointest. Surg. | pmid:10457343 |
| Funaoka M et al. | Tauroursodeoxycholic acid enhances phagocytosis of the cultured rat Kupffer cell. | 1999 | J. Gastroenterol. Hepatol. | pmid:10440209 |
| Bani D et al. | The vasorelaxant hormone relaxin induces changes in liver sinusoid microcirculation: a morphologic study in the rat. | 2001 | J. Endocrinol. | pmid:11739020 |
| Girardet JM et al. | Study of mechanism of lipolysis inhibition by bovine milk proteose-peptone component 3. | 1993 | J. Dairy Sci. | pmid:8408864 |
| Meira SM et al. | Probiotic potential of Lactobacillus spp. isolated from Brazilian regional ovine cheese. | 2012 | J. Dairy Res. | pmid:23171587 |
| Stange EF et al. | Role of primary and secondary bile acids as feedback inhibitors of bile acid synthesis in the rat in vivo. | 1989 | J. Clin. Invest. | pmid:2738150 |
| Reichen J | Role of the hepatic artery in canalicular bile formation by the perfused rat liver. A multiple indicator dilution study. | 1988 | J. Clin. Invest. | pmid:3284914 |
| Devor DC et al. | Taurodeoxycholate activates potassium and chloride conductances via an IP3-mediated release of calcium from intracellular stores in a colonic cell line (T84) | 1993 | J. Clin. Invest. | pmid:7693758 |
| Dharmsathaphorn K et al. | Cl- secretion induced by bile salts. A study of the mechanism of action based on a cultured colonic epithelial cell line. | 1989 | J. Clin. Invest. | pmid:2547841 |
| Gaskin KJ et al. | Colipase and maximally activated pancreatic lipase in normal subjects and patients with steatorrhea. | 1982 | J. Clin. Invest. | pmid:7056854 |
| Field M | Bile salt-induced diarrhea: the cellular mechanism. | 1993 | J. Clin. Invest. | pmid:8227323 |
| Johnson LF and Harmon JW | Experimental esophagitis in a rabbit model. Clinical relevance. | 1986 | J. Clin. Gastroenterol. | pmid:3090135 |
| Aumatell A and Wells RJ | Determination of a cardiac antiarrhythmic, tricyclic antipsychotics and antidepressants in human and animal urine by micellar electrokinetic capillary chromatography using a bile salt. | 1995 | J. Chromatogr. B, Biomed. Appl. | pmid:7581909 |
| Burkard I et al. | Differentiated quantification of human bile acids in serum by high-performance liquid chromatography-tandem mass spectrometry. | 2005 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:16182619 |
| Naoi M et al. | Microassay for GM1 ganglioside beta-galactosidase activity using high-performance liquid chromatography. | 1988 | J. Chromatogr. | pmid:3133384 |
| Carsberg CJ et al. | Ultraviolet radiation-induced melanogenesis in human melanocytes. Effects of modulating protein kinase C. | 1994 | J. Cell. Sci. | pmid:7531203 |
| Raufman JP et al. | Deoxycholyltaurine rescues human colon cancer cells from apoptosis by activating EGFR-dependent PI3K/Akt signaling. | 2008 | J. Cell. Physiol. | pmid:18064605 |
| Keating N et al. | Physiological concentrations of bile acids down-regulate agonist induced secretion in colonic epithelial cells. | 2009 | J. Cell. Mol. Med. | pmid:19583809 |
| Martoni C et al. | Investigation of microencapsulated BSH active lactobacillus in the simulated human GI tract. | 2007 | J. Biomed. Biotechnol. | pmid:18273409 |
| Crandall WV and Lowe ME | Colipase residues Glu64 and Arg65 are essential for normal lipase-mediated fat digestion in the presence of bile salt micelles. | 2001 | J. Biol. Chem. | pmid:11278590 |
| Aubert E et al. | Site-directed mutagenesis of the basic N-terminal cluster of pancreatic bile salt-dependent lipase. Functional significance. | 2002 | J. Biol. Chem. | pmid:12110666 |
| Pignol D et al. | Critical role of micelles in pancreatic lipase activation revealed by small angle neutron scattering. | 2000 | J. Biol. Chem. | pmid:10660587 |
| Kispal G et al. | Isolation and characterization of 3-hydroxyacyl coenzyme A dehydrogenase-binding protein from pig heart inner mitochondrial membrane. | 1986 | J. Biol. Chem. | pmid:3771531 |
| Murakami K and Okuda K | Purification and characterization of taurodeoxycholate 7 alpha-monooxygenase in rat liver. | 1981 | J. Biol. Chem. | pmid:7263676 |
| Freie AB et al. | Val-407 and Ile-408 in the beta5'-loop of pancreatic lipase mediate lipase-colipase interactions in the presence of bile salt micelles. | 2006 | J. Biol. Chem. | pmid:16431912 |
| Momsen WE et al. | Interfacial structure and lipase action. Characterization of taurodeoxycholate-didecanoylglycerol monolayers by physical and kinetic methods. | 1979 | J. Biol. Chem. | pmid:479165 |
| Patton JS et al. | Binding of porcine pancreatic lipase and colipase in the absence of substrate studies by two-phase partition and affinity chromatography. | 1978 | J. Biol. Chem. | pmid:659413 |
| Campbell CH and Rome LH | Coated vesicles from rat liver and calf brain contain lysosomal enzymes bound to mannose 6-phosphate receptors. | 1983 | J. Biol. Chem. | pmid:6138357 |
| Shefer S et al. | Metabolism of iso-bile acids in the rat. | 1982 | J. Biol. Chem. | pmid:7035450 |
| Schmidt DR et al. | Regulation of bile acid synthesis by fat-soluble vitamins A and D. | 2010 | J. Biol. Chem. | pmid:20233723 |
| Voronina SG et al. | Effects of secretagogues and bile acids on mitochondrial membrane potential of pancreatic acinar cells: comparison of different modes of evaluating DeltaPsim. | 2004 | J. Biol. Chem. | pmid:15084611 |
| Camarota LM et al. | Carboxyl ester lipase cofractionates with scavenger receptor BI in hepatocyte lipid rafts and enhances selective uptake and hydrolysis of cholesteryl esters from HDL3. | 2004 | J. Biol. Chem. | pmid:15105424 |
| Bourbon-Freie A et al. | Trp-107 and trp-253 account for the increased steady state fluorescence that accompanies the conformational change in human pancreatic triglyceride lipase induced by tetrahydrolipstatin and bile salt. | 2009 | J. Biol. Chem. | pmid:19346257 |
| Li SC et al. | A protein activator for the enzymic hydrolysis of GM2 ganglioside. | 1981 | J. Biol. Chem. | pmid:7240201 |
| Kobayashi T and Suzuki K | A taurodeoxycholate-activated galactosylceramidase in the murine intestine. | 1981 | J. Biol. Chem. | pmid:7451495 |
| Figge A et al. | Hepatic overexpression of murine Abcb11 increases hepatobiliary lipid secretion and reduces hepatic steatosis. | 2004 | J. Biol. Chem. | pmid:14570929 |
| Hino A et al. | Effects of deoxycholic acid and its epimers on lipid peroxidation in isolated rat hepatocytes. | 2001 | J. Biochem. | pmid:11328589 |
| Kupper J et al. | The flagellar bundle of Halobacterium salinarium is inserted into a distinct polar cap structure. | 1994 | J. Bacteriol. | pmid:8051038 |
| Strauch ED et al. | Bile salts regulate intestinal epithelial cell migration by nuclear factor-kappa B-induced expression of transforming growth factor-beta. | 2003 | J. Am. Coll. Surg. | pmid:14644286 |
| Helgason T et al. | Impact of surfactant properties on oxidative stability of beta-carotene encapsulated within solid lipid nanoparticles. | 2009 | J. Agric. Food Chem. | pmid:19691283 |
| Xu Y et al. | Freeze-dried grape powder attenuates mitochondria- and oxidative stress-mediated apoptosis in liver cells. | 2009 | J. Agric. Food Chem. | pmid:19754144 |
| Orioni B et al. | Polymorphic behavior in protein-surfactant mixtures: the water-bovine serum albumin-sodium taurodeoxycholate system. | 2006 | J Phys Chem B | pmid:16800527 |
| Hanus M and Zhorov E | Bile acid salt binding with colesevelam HCl is not affected by suspension in common beverages. | 2006 | J Pharm Sci | pmid:16937334 |
| Roda A et al. | Effect of basic cholane derivatives on intestinal cholic acid metabolism: in vitro and in vivo activity. | 1992 | J Pharm Sci | pmid:1640360 |
| Selvam S et al. | A photophysical study on the role of bile salt hydrophobicity in solubilizing amphotericin B aggregates. | 2009 | J Pharm Sci | pmid:19283765 |
| Dai J et al. | Impact of bile acids on the growth of human cholangiocarcinoma via FXR. | 2011 | J Hematol Oncol | pmid:21988803 |
| Khafagy el-S et al. | Effect of cell-penetrating peptides on the nasal absorption of insulin. | 2009 | J Control Release | pmid:18930084 |
| Aguirre TAS et al. | Coated minispheres of salmon calcitonin target rat intestinal regions to achieve systemic bioavailability: Comparison between intestinal instillation and oral gavage. | 2016 | J Control Release | pmid:27480451 |
| Song KH et al. | Enhanced intestinal absorption of salmon calcitonin (sCT) from proliposomes containing bile salts. | 2005 | J Control Release | pmid:15979756 |
| Borné J et al. | Vesicle formation and other structures in aqueous dispersions of monoolein and sodium oleate. | 2003 | J Colloid Interface Sci | pmid:16256485 |
| Asaro F et al. | 23Na and 35/37Cl as NMR probes of growth and shape of sodium taurodeoxycholate micellar aggregates in the presence of NaCl. | 2013 | J Colloid Interface Sci | pmid:23127873 |