Tauroursodeoxycholic acid

Tauroursodeoxycholic acid is a lipid of Sterol Lipids (ST) class. Tauroursodeoxycholic acid is associated with abnormalities such as Hyperglycemia, Obesity, Wiskott-Aldrich Syndrome, neurogenic hypertension and Cholestatic liver disease. The involved functions are known as Cell Death, Apoptosis, Homeostasis, Process and mRNA Expression. Tauroursodeoxycholic acid often locates in Body tissue, Endoplasmic Reticulum, Hepatic, Blood and Protoplasm. The associated genes with Tauroursodeoxycholic acid are Homologous Gene and Mutant Proteins. The related lipids are cholanic acid, taurolithocholic acid 3-sulfate, Sterols, 7-dehydrocholesterol and tauromuricholic acid. The related experimental models are Disease model.

Cross Reference

Introduction

To understand associated biological information of Tauroursodeoxycholic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Tauroursodeoxycholic acid?

Tauroursodeoxycholic acid is suspected in Endothelial dysfunction, Hyperglycemia, Obesity, neurogenic hypertension, Cholestatic liver disease, Heart failure and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Tauroursodeoxycholic acid

MeSH term MeSH ID Detail
Hypertension D006973 115 associated lipids
Insulin Resistance D007333 99 associated lipids
Total 2

PubChem Associated disorders and diseases

What pathways are associated with Tauroursodeoxycholic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Tauroursodeoxycholic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Tauroursodeoxycholic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Tauroursodeoxycholic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Tauroursodeoxycholic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Tauroursodeoxycholic acid?

Disease model

Disease model are used in the study 'Bile Acids Reduce Prion Conversion, Reduce Neuronal Loss, and Prolong Male Survival in Models of Prion Disease.' (Cortez LM et al., 2015).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with Tauroursodeoxycholic acid

Download all related citations
Per page 10 20 50 100 | Total 531
Authors Title Published Journal PubMed Link
pmid:29099865
pmid:28930750
pmid:28821633
pmid:28696246
pmid:12825132
pmid:28573143
pmid:28552716
pmid:28475764
pmid:28332050
pmid:12702047
pmid:28260008
pmid:28249278
pmid:28238527
pmid:28165466
pmid:28155228
pmid:27987324
pmid:27889204
pmid:27729186
pmid:27706903
pmid:27765486
pmid:27596970
pmid:27382986
pmid:27283502
pmid:27277821
pmid:27219292
pmid:27179450
pmid:27106542
pmid:27032713
pmid:26988565
pmid:26892516
pmid:26759227
pmid:26499839
pmid:26427442
pmid:26278107
pmid:26238983
pmid:26234558
pmid:26099855
pmid:26051458
pmid:25841565
pmid:25818106
pmid:25804419
pmid:25791922
pmid:25695629
pmid:25579883
pmid:25499542
pmid:25475860
pmid:25443293
pmid:25100709
pmid:17395011
pmid:29139555
pmid:27588471
pmid:25160872
pmid:23336977
pmid:22201798
pmid:22155234
pmid:26469749
pmid:21971157
pmid:21134703
pmid:16180656
pmid:15869421
pmid:15652244
pmid:15312152
pmid:15057918
pmid:14965230
pmid:12769806
pmid:28285140
pmid:27315604
pmid:27142143
pmid:27580383
pmid:16872555
pmid:15910498
pmid:15810635
pmid:26851371
pmid:28115375
pmid:
Kim KS et al. Taurine may not alleviate hyperglycemia-mediated endoplasmic reticulum stress in human adipocytes. 2013 Adv. Exp. Med. Biol. pmid:23392949
Fu Y and Zhang T Pathophysilogical mechanism and treatment strategies for Leber congenital amaurosis. 2014 Adv. Exp. Med. Biol. pmid:24664772
Cai D and Liu T Inflammatory cause of metabolic syndrome via brain stress and NF-κB. 2012 Aging (Albany NY) pmid:22328600
Larghi A et al. Ursodeoxycholic and tauro-ursodeoxycholic acids for the treatment of primary biliary cirrhosis: a pilot crossover study. 1997 Aliment. Pharmacol. Ther. pmid:9146783
Rivard AL et al. Administration of tauroursodeoxycholic acid (TUDCA) reduces apoptosis following myocardial infarction in rat. 2007 Am. J. Chin. Med. pmid:17436368
Chen Y et al. Effect of taurine-conjugated ursodeoxycholic acid on endoplasmic reticulum stress and apoptosis induced by advanced glycation end products in cultured mouse podocytes. 2008 Am. J. Nephrol. pmid:18648192
Marzioni M et al. Ca2+-dependent cytoprotective effects of ursodeoxycholic and tauroursodeoxycholic acid on the biliary epithelium in a rat model of cholestasis and loss of bile ducts. 2006 Am. J. Pathol. pmid:16436655
Takeda N et al. Altered unfolded protein response is implicated in the age-related exacerbation of proteinuria-induced proximal tubular cell damage. 2013 Am. J. Pathol. pmid:23871833
Stravitz RT et al. Hepatocellular protein kinase C activation by bile acids: implications for regulation of cholesterol 7 alpha-hydroxylase. 1996 Am. J. Physiol. pmid:8770045
Alvaro D et al. Effect of ursodeoxycholic acid on intracellular pH regulation in isolated rat bile duct epithelial cells. 1993 Am. J. Physiol. pmid:8238362
Garcia-Marin JJ et al. Role of H+ transport in ursodeoxycholate-induced biliary HCO-3 secretion in the rat. 1985 Am. J. Physiol. pmid:2994491
Schroeder A et al. Substrate specificity of the rat liver Na(+)-bile salt cotransporter in Xenopus laevis oocytes and in CHO cells. 1998 Am. J. Physiol. pmid:9486191
Farges O et al. Permeability of the rat biliary tree to ursodeoxycholic acid. 1989 Am. J. Physiol. pmid:2705526
Zouboulis-Vafiadis I et al. Conjugation is rate limiting in hepatic transport of ursodeoxycholate in the rat. 1982 Am. J. Physiol. pmid:7114264
Kitani K et al. Tauroursodeoxycholate prevents biliary protein excretion induced by other bile salts in the rat. 1985 Am. J. Physiol. pmid:2984943
Bouscarel B et al. Changes in G protein expression account for impaired modulation of hepatic cAMP formation after BDL. 1998 Am. J. Physiol. pmid:9696716
Deroubaix X et al. Saturation of hepatic transport of taurocholate in rats in vivo. 1991 Am. J. Physiol. pmid:1996639
Eckhardt U et al. Polyspecific substrate uptake by the hepatic organic anion transporter Oatp1 in stably transfected CHO cells. 1999 Am. J. Physiol. pmid:10198348
Kitani K et al. Differing transport maxima values for taurine-conjugated bile salts in rats and hamsters. 1986 Am. J. Physiol. pmid:3789151
Xiao ZL et al. Effects of bile acids on the muscle functions of guinea pig gallbladder. 2002 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:12065295
Chignard N et al. Bile salts potentiate adenylyl cyclase activity and cAMP-regulated secretion in human gallbladder epithelium. 2003 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:12421748
Wang R et al. Defective canalicular transport and toxicity of dietary ursodeoxycholic acid in the abcb11-/- mouse: transport and gene expression studies. 2013 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:23764895
Seyhun E et al. Tauroursodeoxycholic acid reduces endoplasmic reticulum stress, acinar cell damage, and systemic inflammation in acute pancreatitis. 2011 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:21778463
Castro RE et al. Differential regulation of cyclin D1 and cell death by bile acids in primary rat hepatocytes. 2007 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:17431217
Henkel AS et al. Reducing endoplasmic reticulum stress does not improve steatohepatitis in mice fed a methionine- and choline-deficient diet. 2012 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:22556147