Tauroursodeoxycholic acid

Tauroursodeoxycholic acid is a lipid of Sterol Lipids (ST) class. Tauroursodeoxycholic acid is associated with abnormalities such as Hyperglycemia, Obesity, Wiskott-Aldrich Syndrome, neurogenic hypertension and Cholestatic liver disease. The involved functions are known as Cell Death, Apoptosis, Homeostasis, Process and mRNA Expression. Tauroursodeoxycholic acid often locates in Body tissue, Endoplasmic Reticulum, Hepatic, Blood and Protoplasm. The associated genes with Tauroursodeoxycholic acid are Homologous Gene and Mutant Proteins. The related lipids are cholanic acid, taurolithocholic acid 3-sulfate, Sterols, 7-dehydrocholesterol and tauromuricholic acid. The related experimental models are Disease model.

Cross Reference

Introduction

To understand associated biological information of Tauroursodeoxycholic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Tauroursodeoxycholic acid?

Tauroursodeoxycholic acid is suspected in Endothelial dysfunction, Hyperglycemia, Obesity, neurogenic hypertension, Cholestatic liver disease, Heart failure and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Tauroursodeoxycholic acid

MeSH term MeSH ID Detail
Hypertension D006973 115 associated lipids
Insulin Resistance D007333 99 associated lipids
Total 2

PubChem Associated disorders and diseases

What pathways are associated with Tauroursodeoxycholic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Tauroursodeoxycholic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Tauroursodeoxycholic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Tauroursodeoxycholic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Tauroursodeoxycholic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Tauroursodeoxycholic acid?

Disease model

Disease model are used in the study 'Bile Acids Reduce Prion Conversion, Reduce Neuronal Loss, and Prolong Male Survival in Models of Prion Disease.' (Cortez LM et al., 2015).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with Tauroursodeoxycholic acid

Download all related citations
Per page 10 20 50 100 | Total 531
Authors Title Published Journal PubMed Link
Cui H et al. [Experimental study of the permeability of Fel Ursi's in eye]. 2006 Zhonghua Yan Ke Za Zhi pmid:17386143
Shi Z et al. [Tauroursodeoxycholic acid suppresses endoplasmic reticulum stress in pulmonary tissues of intermittent hypoxia mice]. 2015 Zhong Nan Da Xue Xue Bao Yi Xue Ban pmid:26643417
Park JY et al. Bile acid analysis in biliary tract cancer. 2006 Yonsei Med. J. pmid:17191311
Beuers U Effects of bile acids on hepatocellular signaling and secretion. 1997 Jul-Aug Yale J Biol Med pmid:9626754
Roma MG et al. Dynamic localization of hepatocellular transporters in health and disease. 2008 World J. Gastroenterol. pmid:19058304
Roda A et al. A new oral formulation for the release of sodium butyrate in the ileo-cecal region and colon. 2007 World J. Gastroenterol. pmid:17373743
Gnewuch C et al. Serum bile acid profiling reflects enterohepatic detoxification state and intestinal barrier function in inflammatory bowel disease. 2009 World J. Gastroenterol. pmid:19575493
Ramalho RM et al. Bile acids and apoptosis modulation: an emerging role in experimental Alzheimer's disease. 2008 Trends Mol Med pmid:18218342
Ejiri S et al. Cellular distribution of thrombomodulin as an early marker for warm ischemic liver injury in porcine liver transplantation: protective effect of prostaglandin I2 analogue and tauroursodeoxycholic acid. 2001 Transplantation pmid:11330532
Ishigami F et al. Bile salt tauroursodeoxycholic acid modulation of Bax translocation to mitochondria protects the liver from warm ischemia-reperfusion injury in the rat. 2001 Transplantation pmid:11740392
Calmus Y and Podevin P Tauroursodeoxycholic acid for the cytoprotection of liver grafts during cold storage: a new aspect of its anti-apoptotic properties? 2001 Transplantation pmid:11408962
Falasca L et al. Protective role of tauroursodeoxycholate during harvesting and cold storage of human liver: a pilot study in transplant recipients. 2001 Transplantation pmid:11397961
Falasca L et al. Tauroursodeoxycholate reduces ischemic damage in human allografts: a biochemical and ultrastructural study. 2000 Transplant. Proc. pmid:10700964
Baiocchi L et al. TUDCA prevents cholestasis and canalicular damage induced by ischemia-reperfusion injury in the rat, modulating PKCalpha-ezrin pathway. 2008 Transpl. Int. pmid:18435680
Hertl M et al. Tauroursodeoxycholate ameliorates reperfusion injury after pig liver transplantation. 1999 Transpl. Int. pmid:10654358
Crocenzi FA et al. Role of bile salts in colchicine-induced hepatotoxicity. Implications for hepatocellular integrity and function. 1997 Toxicology pmid:9230445
Wong MK et al. Nicotine Directly Induces Endoplasmic Reticulum Stress Response in Rat Placental Trophoblast Giant Cells. 2016 Toxicol. Sci. pmid:26803847
Zhang Y et al. Organic anion transporting polypeptide 1a1 null mice are sensitive to cholestatic liver injury. 2012 Toxicol. Sci. pmid:22461449
Rolo AP et al. Role of mitochondrial dysfunction in combined bile acid-induced cytotoxicity: the switch between apoptosis and necrosis. 2004 Toxicol. Sci. pmid:14976352
Cho JG et al. Tauroursodeoxycholic acid, a bile acid, promotes blood vessel repair by recruiting vasculogenic progenitor cells. 2015 Stem Cells pmid:25407160
Hakim F et al. Chronic sleep fragmentation during the sleep period induces hypothalamic endoplasmic reticulum stress and PTP1b-mediated leptin resistance in male mice. 2015 Sleep pmid:25325461
Hohenester S et al. Primary biliary cirrhosis. 2009 Semin Immunopathol pmid:19603170
Ozcan U et al. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. 2006 Science pmid:16931765
Kawasaki N et al. Obesity-induced endoplasmic reticulum stress causes chronic inflammation in adipose tissue. 2012 Sci Rep pmid:23150771
Muramatsu-Kato K et al. Undernourishment in utero Primes Hepatic Steatosis in Adult Mice Offspring on an Obesogenic Diet; Involvement of Endoplasmic Reticulum Stress. 2015 Sci Rep pmid:26581663
Ishimura S et al. Reduction of endoplasmic reticulum stress inhibits neointima formation after vascular injury. 2014 Sci Rep pmid:25373918
Kim JS et al. Tauroursodeoxycholic acid enhances the pre-implantation embryo development by reducing apoptosis in pigs. 2012 Reprod. Domest. Anim. pmid:22151574
Rodrigues CM et al. Tauroursodeoxycholic acid reduces apoptosis and protects against neurological injury after acute hemorrhagic stroke in rats. 2003 Proc. Natl. Acad. Sci. U.S.A. pmid:12721362
Purkayastha S et al. Neural dysregulation of peripheral insulin action and blood pressure by brain endoplasmic reticulum stress. 2011 Proc. Natl. Acad. Sci. U.S.A. pmid:21282643
Keene CD et al. Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:12149470
Dubrey S et al. The transthyretin amyloidoses: advances in therapy. 2015 Postgrad Med J pmid:26048914
Trottier J et al. Profiling circulating and urinary bile acids in patients with biliary obstruction before and after biliary stenting. 2011 PLoS ONE pmid:21760958
Ma Y et al. Growth hormone secretagogues protect mouse cardiomyocytes from in vitro ischemia/reperfusion injury through regulation of intracellular calcium. 2012 PLoS ONE pmid:22493744
Yang JS et al. Changes in hepatic gene expression upon oral administration of taurine-conjugated ursodeoxycholic acid in ob/ob mice. 2010 PLoS ONE pmid:21079772
Úriz M et al. Ursodeoxycholic acid is conjugated with taurine to promote secretin-stimulated biliary hydrocholeresis in the normal rat. 2011 PLoS ONE pmid:22194894
Sheu ML et al. Honokiol induces calpain-mediated glucose-regulated protein-94 cleavage and apoptosis in human gastric cancer cells and reduces tumor growth. 2007 PLoS ONE pmid:17971859
Nguyen MT et al. Regulation of chemokine and chemokine receptor expression by PPARγ in adipocytes and macrophages. 2012 PLoS ONE pmid:22529965
Mantopoulos D et al. Tauroursodeoxycholic acid (TUDCA) protects photoreceptors from cell death after experimental retinal detachment. 2011 PLoS ONE pmid:21961034
Fernández-Sánchez L et al. Controlled delivery of tauroursodeoxycholic acid from biodegradable microspheres slows retinal degeneration and vision loss in P23H rats. 2017 PLoS ONE pmid:28542454
Zhang JY et al. Inhibition of endoplasmic reticulum stress improves mouse embryo development. 2012 PLoS ONE pmid:22808162
Rani S et al. Tauroursodeoxycholic acid (TUDCA) attenuates pressure overload-induced cardiac remodeling by reducing endoplasmic reticulum stress. 2017 PLoS ONE pmid:28426781
Groenendyk J et al. Inhibition of the Unfolded Protein Response Mechanism Prevents Cardiac Fibrosis. 2016 PLoS ONE pmid:27441395
Fang L et al. Autophagy attenuates diabetic glomerular damage through protection of hyperglycemia-induced podocyte injury. 2013 PLoS ONE pmid:23593240
Turdi S et al. Tauroursodeoxycholic acid mitigates high fat diet-induced cardiomyocyte contractile and intracellular Ca2+ anomalies. 2013 PLoS ONE pmid:23667647
Gómez-Vicente V et al. Neuroprotective Effect of Tauroursodeoxycholic Acid on N-Methyl-D-Aspartate-Induced Retinal Ganglion Cell Degeneration. 2015 PLoS ONE pmid:26379056
Koyama S et al. Gefitinib and Erlotinib Lead to Phosphorylation of Eukaryotic Initiation Factor 2 Alpha Independent of Epidermal Growth Factor Receptor in A549 Cells. 2015 PLoS ONE pmid:26288223
Yao XH et al. Prenatal ethanol exposure causes glucose intolerance with increased hepatic gluconeogenesis and histone deacetylases in adult rat offspring: reversal by tauroursodeoxycholic acid. 2013 PLoS ONE pmid:23544086
Yu KN et al. Titanium Dioxide Nanoparticles Induce Endoplasmic Reticulum Stress-Mediated Autophagic Cell Death via Mitochondria-Associated Endoplasmic Reticulum Membrane Disruption in Normal Lung Cells. 2015 PLoS ONE pmid:26121477
Cheng S et al. Pachymic acid inhibits growth and induces apoptosis of pancreatic cancer in vitro and in vivo by targeting ER stress. 2015 PLoS ONE pmid:25915041
Gupta S et al. Prevention of acute kidney injury by tauroursodeoxycholic acid in rat and cell culture models. 2012 PLoS ONE pmid:23152827
Mališová L et al. Ursodeoxycholic acid but not tauroursodeoxycholic acid inhibits proliferation and differentiation of human subcutaneous adipocytes. 2013 PLoS ONE pmid:24312631
Fang L et al. Involvement of endoplasmic reticulum stress in albuminuria induced inflammasome activation in renal proximal tubular cells. 2013 PLoS ONE pmid:23977286
Ropelle ER et al. IL-6 and IL-10 anti-inflammatory activity links exercise to hypothalamic insulin and leptin sensitivity through IKKbeta and ER stress inhibition. 2010 PLoS Biol. pmid:20808781
Yang X et al. Activation of autophagy by unfolded proteins during endoplasmic reticulum stress. 2016 Plant J. pmid:26616142
Tanaka Y et al. The exacerbating roles of CCAAT/enhancer-binding protein homologous protein (CHOP) in the development of bleomycin-induced pulmonary fibrosis and the preventive effects of tauroursodeoxycholic acid (TUDCA) against pulmonary fibrosis in mice. 2015 Pharmacol. Res. pmid:26005208
Xiang X et al. Effect of SLCO1B1 polymorphism on the plasma concentrations of bile acids and bile acid synthesis marker in humans. 2009 Pharmacogenet. Genomics pmid:19387419
Megaraj V et al. Functional analysis of nonsynonymous single nucleotide polymorphisms of multidrug resistance-associated protein 2 (ABCC2). 2011 Pharmacogenet. Genomics pmid:21691255
Daood MJ et al. Lipid peroxidation is not the primary mechanism of bilirubin-induced neurologic dysfunction in jaundiced Gunn rat pups. 2012 Pediatr. Res. pmid:22902434
Malo A et al. 4-Phenylbutyric acid reduces endoplasmic reticulum stress, trypsin activation, and acinar cell apoptosis while increasing secretion in rat pancreatic acini. 2013 Pancreas pmid:22889983
van Minnen LP et al. Cholesterol crystals enhance and phospholipids protect against pancreatitis induced by hydrophobic bile salts: a rat model study. 2006 Pancreas pmid:16670619
Vandewynckel YP et al. Tauroursodeoxycholic acid dampens oncogenic apoptosis induced by endoplasmic reticulum stress during hepatocarcinogen exposure. 2015 Oncotarget pmid:26293671
Jiao P et al. FFA-induced adipocyte inflammation and insulin resistance: involvement of ER stress and IKKβ pathways. 2011 Obesity (Silver Spring) pmid:20829802
Myronovych A et al. Vertical sleeve gastrectomy reduces hepatic steatosis while increasing serum bile acids in a weight-loss-independent manner. 2014 Obesity (Silver Spring) pmid:23804416
Zhang J et al. Tauroursodeoxycholic Acid Attenuates Renal Tubular Injury in a Mouse Model of Type 2 Diabetes. 2016 Nutrients pmid:27669287
Kim GW et al. Calorie-induced ER stress suppresses uroguanylin satiety signaling in diet-induced obesity. 2016 Nutr Diabetes pmid:27214655
Hu J et al. Tauroursodeoxycholic acid prevents hearing loss and hair cell death in Cdh23(erl/erl) mice. 2016 Neuroscience pmid:26748055
Gaspar JM et al. Tauroursodeoxycholic acid protects retinal neural cells from cell death induced by prolonged exposure to elevated glucose. 2013 Neuroscience pmid:24012838
Yan F et al. Endoplasmic reticulum stress is associated with neuroprotection against apoptosis via autophagy activation in a rat model of subarachnoid hemorrhage. 2014 Neurosci. Lett. pmid:24513235
Lo AC et al. Tauroursodeoxycholic acid (TUDCA) supplementation prevents cognitive impairment and amyloid deposition in APP/PS1 mice. 2013 Neurobiol. Dis. pmid:22974733
Ramalho RM et al. Tauroursodeoxycholic acid suppresses amyloid β-induced synaptic toxicity in vitro and in APP/PS1 mice. 2013 Neurobiol. Aging pmid:22621777
Keestra-Gounder AM et al. NOD1 and NOD2 signalling links ER stress with inflammation. 2016 Nature pmid:27007849
Bracha AL et al. Carbon metabolism-mediated myogenic differentiation. 2010 Nat. Chem. Biol. pmid:20081855
Keune WJ et al. Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling. 2016 Nat Commun pmid:27075612
Fimognari C et al. Micronuclei induction, cell cycle delay and apoptosis as markers of cellular stress caused by ursodeoxycholic acid in human lymphocytes. 2001 Mutat. Res. pmid:11448637
Udawatte C et al. Taurine suppresses the spread of cell death in electrically coupled RPE cells. 2008 Mol. Vis. pmid:18958305
Boatright JH et al. Tool from ancient pharmacopoeia prevents vision loss. 2006 Mol. Vis. pmid:17213800
Qi HP et al. Ursodeoxycholic acid prevents selenite-induced oxidative stress and alleviates cataract formation: In vitro and in vivo studies. 2012 Mol. Vis. pmid:22275806
Zhou L et al. Autophagy-mediated insulin receptor down-regulation contributes to endoplasmic reticulum stress-induced insulin resistance. 2009 Mol. Pharmacol. pmid:19541767
Vaidya SS and Gerk PM Lack of interaction between tauroursodeoxycholate and ATP-binding cassette transporter isoform G2 (ABCG2). 2006 May-Jun Mol. Pharm. pmid:16749862
Castro-Caldas M et al. Tauroursodeoxycholic acid prevents MPTP-induced dopaminergic cell death in a mouse model of Parkinson's disease. 2012 Mol. Neurobiol. pmid:22773138
Nunes AF et al. TUDCA, a bile acid, attenuates amyloid precursor protein processing and amyloid-β deposition in APP/PS1 mice. 2012 Mol. Neurobiol. pmid:22438081
Solá S et al. Tauroursodeoxycholic acid prevents amyloid-beta peptide-induced neuronal death via a phosphatidylinositol 3-kinase-dependent signaling pathway. 2003 Sep-Dec Mol. Med. pmid:15208744
Ramalho RM et al. Apoptosis in transgenic mice expressing the P301L mutated form of human tau. 2008 May-Jun Mol. Med. pmid:18368144
Solá S et al. Functional modulation of nuclear steroid receptors by tauroursodeoxycholic acid reduces amyloid beta-peptide-induced apoptosis. 2006 Mol. Endocrinol. pmid:16728529
Penno CA et al. 11β-Hydroxysteroid dehydrogenase-1 is involved in bile acid homeostasis by modulating fatty acid transport protein-5 in the liver of mice. 2014 Mol Metab pmid:25061560
Nguyen LB et al. Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity in the rat ileum: effects of bile acids and lovastatin. 1994 Metab. Clin. Exp. pmid:7968602
Ma H et al. A multicenter, randomized, double-blind trial comparing the efficacy and safety of TUDCA and UDCA in Chinese patients with primary biliary cholangitis. 2016 Medicine (Baltimore) pmid:27893675
Guo H et al. Endoplasmic Reticulum Chaperon Tauroursodeoxycholic Acid Attenuates Aldosterone-Infused Renal Injury. 2016 Mediators Inflamm. pmid:27721575
Montagnani M et al. A new model for portal protein profile analysis in course of ileal intraluminal bile acid infusion using an in situ perfused rat intestine. 2011 Med Chem pmid:21568879
Anderson CD et al. Endoplasmic reticulum stress is a mediator of posttransplant injury in severely steatotic liver allografts. 2011 Liver Transpl. pmid:21280192
Terry C et al. Preincubation of rat and human hepatocytes with cytoprotectants prior to cryopreservation can improve viability and function upon thawing. 2005 Liver Transpl. pmid:16315306
Terry C et al. Preincubation of rat and human hepatocytes with cytoprotectants prior to cryopreservation can improve viability and function upon thawing. 2006 Liver Transpl. pmid:16382475
Tsukahara K et al. Taurine conjugate of ursodeoxycholate plays a major role in the hepatoprotective effect against cholestasis induced by taurochenodeoxycholate in rats. 1993 Liver pmid:8259039
Bouchard G et al. Influence of oral treatment with ursodeoxycholic and tauroursodeoxycholic acids on estrogen-induced cholestasis in rats: effects on bile formation and liver plasma membranes. 1993 Liver pmid:8377596
Sánchez Pozzi EJ et al. Differential effect of ursodeoxycholate and its taurine conjugate on biliary transport maximum of bilirubin in the rat. 1995 Life Sci. pmid:7643722
Lamireau T et al. Effects of bile acids on biliary epithelial cells: proliferation, cytotoxicity, and cytokine secretion. 2003 Life Sci. pmid:12527037
López-Sánchez LM et al. Inhibition of nitric oxide synthesis during induced cholestasis ameliorates hepatocellular injury by facilitating S-nitrosothiol homeostasis. 2010 Lab. Invest. pmid:19806079
Dombrowski F et al. Tauroursodeoxycholic acid inserts the bile salt export pump into canalicular membranes of cholestatic rat liver. 2006 Lab. Invest. pmid:16344857
Laukens D et al. Tauroursodeoxycholic acid inhibits experimental colitis by preventing early intestinal epithelial cell death. 2014 Lab. Invest. pmid:25310532
Kim HS et al. [Modulation of colon cancer cell invasiveness induced by deoxycholic acid]. 2006 Korean J Gastroenterol pmid:16861876