|
|
|
|
pmid:
|
Eckhardt U et al. |
Polyspecific substrate uptake by the hepatic organic anion transporter Oatp1 in stably transfected CHO cells. |
1999 |
Am. J. Physiol. |
pmid:10198348
|
Funaoka M et al. |
Tauroursodeoxycholic acid enhances phagocytosis of the cultured rat Kupffer cell. |
1999 |
J. Gastroenterol. Hepatol. |
pmid:10440209
|
Hertl M et al. |
Tauroursodeoxycholate ameliorates reperfusion injury after pig liver transplantation. |
1999 |
Transpl. Int. |
pmid:10654358
|
Benz C et al. |
Effect of tauroursodeoxycholic acid on bile acid-induced apoptosis in primary human hepatocytes. |
2000 |
Eur. J. Clin. Invest. |
pmid:10691996
|
Falasca L et al. |
Tauroursodeoxycholate reduces ischemic damage in human allografts: a biochemical and ultrastructural study. |
2000 |
Transplant. Proc. |
pmid:10700964
|
Kurz AK et al. |
Phosphoinositide 3-kinase-dependent Ras activation by tauroursodesoxycholate in rat liver. |
2000 |
Biochem. J. |
pmid:10926845
|
Rodrigues CM et al. |
Tauroursodeoxycholic acid partially prevents apoptosis induced by 3-nitropropionic acid: evidence for a mitochondrial pathway independent of the permeability transition. |
2000 |
J. Neurochem. |
pmid:11080188
|
Rodrigues CM et al. |
Amyloid beta-peptide disrupts mitochondrial membrane lipid and protein structure: protective role of tauroursodeoxycholate. |
2001 |
Biochem. Biophys. Res. Commun. |
pmid:11181071
|
Chignard N et al. |
Bile acid transport and regulating functions in the human biliary epithelium. |
2001 |
Hepatology |
pmid:11230727
|
Milkiewicz P et al. |
Effect of tauroursodeoxycholate and S-adenosyl-L-methionine on 17beta-estradiol glucuronide-induced cholestasis. |
2001 |
J. Hepatol. |
pmid:11281545
|
Ejiri S et al. |
Cellular distribution of thrombomodulin as an early marker for warm ischemic liver injury in porcine liver transplantation: protective effect of prostaglandin I2 analogue and tauroursodeoxycholic acid. |
2001 |
Transplantation |
pmid:11330532
|
Beuers U et al. |
Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C-dependent mechanisms in cholestatic rat liver. |
2001 |
Hepatology |
pmid:11343250
|
Moschetta A et al. |
Hydrophilic bile salts enhance differential distribution of sphingomyelin and phosphatidylcholine between micellar and vesicular phases: potential implications for their effects in vivo. |
2001 |
J. Hepatol. |
pmid:11394647
|
Falasca L et al. |
Protective role of tauroursodeoxycholate during harvesting and cold storage of human liver: a pilot study in transplant recipients. |
2001 |
Transplantation |
pmid:11397961
|
Ishizaki K et al. |
Effect of sodium tauroursodeoxycholate on phalloidin-induced cholestasis in rats. |
2001 |
Eur. J. Pharmacol. |
pmid:11408049
|
Calmus Y and Podevin P |
Tauroursodeoxycholic acid for the cytoprotection of liver grafts during cold storage: a new aspect of its anti-apoptotic properties? |
2001 |
Transplantation |
pmid:11408962
|
Fimognari C et al. |
Micronuclei induction, cell cycle delay and apoptosis as markers of cellular stress caused by ursodeoxycholic acid in human lymphocytes. |
2001 |
Mutat. Res. |
pmid:11448637
|
Crocenzi FA et al. |
Beneficial effects of silymarin on estrogen-induced cholestasis in the rat: a study in vivo and in isolated hepatocyte couplets. |
2001 |
Hepatology |
pmid:11481618
|
Moschetta A et al. |
Cholesterol crystallization in model biles: effects of bile salt and phospholipid species composition. |
2001 |
J. Lipid Res. |
pmid:11483629
|
Danchenko E et al. |
Effect of bile acids on the proliferative activity and apoptosis of rat hepatocytes. |
2001 |
Exp. Toxicol. Pathol. |
pmid:11484843
|
Nathanson MH et al. |
Stimulation of ATP secretion in the liver by therapeutic bile acids. |
2001 |
Biochem. J. |
pmid:11485545
|
Kurz AK et al. |
Tauroursodesoxycholate-induced choleresis involves p38(MAPK) activation and translocation of the bile salt export pump in rats. |
2001 |
Gastroenterology |
pmid:11487550
|
Piazza F et al. |
Competition in liver transport between chenodeoxycholic acid and ursodeoxycholic acid as a mechanism for ursodeoxycholic acid and its amidates' protection of liver damage induced by chenodeoxycholic acid. |
2000 |
Dig Liver Dis |
pmid:11515630
|
Keene CD et al. |
A bile acid protects against motor and cognitive deficits and reduces striatal degeneration in the 3-nitropropionic acid model of Huntington's disease. |
2001 |
Exp. Neurol. |
pmid:11573988
|
Asamoto Y et al. |
Bile-salt hydrophobicity is a key factor regulating rat liver plasma-membrane communication: relation to bilayer structure, fluidity and transporter expression and function. |
2001 |
Biochem. J. |
pmid:11672435
|
Colell A et al. |
Tauroursodeoxycholic acid protects hepatocytes from ethanol-fed rats against tumor necrosis factor-induced cell death by replenishing mitochondrial glutathione. |
2001 |
Hepatology |
pmid:11679967
|
Ishigami F et al. |
Bile salt tauroursodeoxycholic acid modulation of Bax translocation to mitochondria protects the liver from warm ischemia-reperfusion injury in the rat. |
2001 |
Transplantation |
pmid:11740392
|
Rodrigues CM et al. |
Neuroprotection by a bile acid in an acute stroke model in the rat. |
2002 |
J. Cereb. Blood Flow Metab. |
pmid:11919517
|
Carubbi F et al. |
Comparative cytotoxic and cytoprotective effects of taurohyodeoxycholic acid (THDCA) and tauroursodeoxycholic acid (TUDCA) in HepG2 cell line. |
2002 |
Biochim. Biophys. Acta |
pmid:11923098
|
Alpini G et al. |
Ursodeoxycholate and tauroursodeoxycholate inhibit cholangiocyte growth and secretion of BDL rats through activation of PKC alpha. |
2002 |
Hepatology |
pmid:11981754
|
Graf D et al. |
Taurolithocholic acid-3 sulfate induces CD95 trafficking and apoptosis in a c-Jun N-terminal kinase-dependent manner. |
2002 |
Gastroenterology |
pmid:11984527
|
Veggi LM et al. |
Dapsone-induced cholestasis and impairment of bile salt output in the rat. |
2002 |
Biochem. Pharmacol. |
pmid:11996898
|
Pandak WM et al. |
Regulation of oxysterol 7alpha-hydroxylase (CYP7B1) in primary cultures of rat hepatocytes. |
2002 |
Hepatology |
pmid:12029625
|
Glasova H et al. |
Tauroursodeoxycholic acid mobilizes alpha-PKC after uptake in human HepG2 hepatoma cells. |
2002 |
Eur. J. Clin. Invest. |
pmid:12059989
|
Xiao ZL et al. |
Effects of bile acids on the muscle functions of guinea pig gallbladder. |
2002 |
Am. J. Physiol. Gastrointest. Liver Physiol. |
pmid:12065295
|
Duan WM et al. |
Tauroursodeoxycholic acid improves the survival and function of nigral transplants in a rat model of Parkinson's disease. |
2002 |
Cell Transplant |
pmid:12075985
|
Milkiewicz P et al. |
Hepatoprotection with tauroursodeoxycholate and beta muricholate against taurolithocholate induced cholestasis: involvement of signal transduction pathways. |
2002 |
Gut |
pmid:12077103
|
Azzaroli F et al. |
Ursodeoxycholic acid diminishes Fas-ligand-induced apoptosis in mouse hepatocytes. |
2002 |
Hepatology |
pmid:12085348
|
Kim YH and Shin MJ |
Effects of high taurocholate load on activities of hepatic alcohol metabolizing enzymes. |
2002 |
Exp. Mol. Med. |
pmid:12085987
|
Venneman NG et al. |
Effects of hydrophobic and hydrophilic bile salt mixtures on cholesterol crystallization in model biles. |
2002 |
Biochim. Biophys. Acta |
pmid:12117566
|
Keene CD et al. |
Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease. |
2002 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:12149470
|
Yamashita Y et al. |
High metabolic function of primary human and porcine hepatocytes in a polyurethane foam/spheroid culture system in plasma from patients with fulminant hepatic failure. |
2002 |
Cell Transplant |
pmid:12162378
|
Heubi JE et al. |
Tauroursodeoxycholic acid (TUDCA) in the prevention of total parenteral nutrition-associated liver disease. |
2002 |
J. Pediatr. |
pmid:12183720
|
Xie Q et al. |
Effect of tauroursodeoxycholic acid on endoplasmic reticulum stress-induced caspase-12 activation. |
2002 |
Hepatology |
pmid:12198651
|
Piepoli AL et al. |
Tauroursodeoxycholic acid reduces damaging effects of taurodeoxycholic acid on fundus gastric mucosa. |
2002 |
Arch. Physiol. Biochem. |
pmid:12221520
|
Kok T et al. |
Peroxisome proliferator-activated receptor alpha (PPARalpha)-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in mice. |
2003 |
Biochem. J. |
pmid:12381268
|
Noé J et al. |
Functional expression of the canalicular bile salt export pump of human liver. |
2002 |
Gastroenterology |
pmid:12404240
|
Chignard N et al. |
Bile salts potentiate adenylyl cyclase activity and cAMP-regulated secretion in human gallbladder epithelium. |
2003 |
Am. J. Physiol. Gastrointest. Liver Physiol. |
pmid:12421748
|
Lamireau T et al. |
Effects of bile acids on biliary epithelial cells: proliferation, cytotoxicity, and cytokine secretion. |
2003 |
Life Sci. |
pmid:12527037
|
Baiocchi L et al. |
Taurohyodeoxycholate- and tauroursodeoxycholate-induced hypercholeresis is augmented in bile duct ligated rats. |
2003 |
J. Hepatol. |
pmid:12547401
|
Ma J et al. |
Inhibitory effects of ursodeoxycholic acid on the induction of nitric oxide synthase in vascular smooth muscle cells. |
2003 |
Eur. J. Pharmacol. |
pmid:12620498
|
Beuers U et al. |
Taurolithocholic acid exerts cholestatic effects via phosphatidylinositol 3-kinase-dependent mechanisms in perfused rat livers and rat hepatocyte couplets. |
2003 |
J. Biol. Chem. |
pmid:12626520
|
Rodrigues CM et al. |
Tauroursodeoxycholic acid prevents Bax-induced membrane perturbation and cytochrome C release in isolated mitochondria. |
2003 |
Biochemistry |
pmid:12627974
|
Tsuboi K et al. |
Hydrophilic bile salts have a cytoprotective effect against cyclosporine A-induced cholestasis through enhanced canalicular membrane fluidity and transporter activity. |
2003 |
Hepatol. Res. |
pmid:12644037
|
Sánchez Pozzi EJ et al. |
Ursodeoxycholate reduces ethinylestradiol glucuronidation in the rat: role in prevention of estrogen-induced cholestasis. |
2003 |
J. Pharmacol. Exp. Ther. |
pmid:12663690
|
|
|
|
|
pmid:12702047
|
Rodrigues CM et al. |
Tauroursodeoxycholic acid reduces apoptosis and protects against neurological injury after acute hemorrhagic stroke in rats. |
2003 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:12721362
|
Häussinger D et al. |
Involvement of integrins and Src in tauroursodeoxycholate-induced and swelling-induced choleresis. |
2003 |
Gastroenterology |
pmid:12730886
|
|
|
|
|
pmid:12769806
|
Chen W et al. |
Bile acids for viral hepatitis. |
2003 |
Cochrane Database Syst Rev |
pmid:12804455
|
|
|
|
|
pmid:12825132
|
Schoemaker MH et al. |
Resistance of rat hepatocytes against bile acid-induced apoptosis in cholestatic liver injury is due to nuclear factor-kappa B activation. |
2003 |
J. Hepatol. |
pmid:12873810
|
Reinehr R et al. |
Bile salt-induced hepatocyte apoptosis involves epidermal growth factor receptor-dependent CD95 tyrosine phosphorylation. |
2003 |
Gastroenterology |
pmid:12949729
|
Nakai T et al. |
Microtubule-independent choleresis and anti-cholestatic action of tauroursodeoxycholate in colchicine-treated rat liver. |
1992 |
Biochem. J. |
pmid:1361125
|
Liu Y et al. |
Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis. |
2003 |
J. Clin. Invest. |
pmid:14623915
|
Häussinger D et al. |
Cell volume and bile acid excretion. |
1992 |
Biochem. J. |
pmid:1463469
|
Tessier E et al. |
High-performance liquid chromatographic mass spectrometric method for the determination of ursodeoxycholic acid and its glycine and taurine conjugates in human plasma. |
2003 |
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. |
pmid:14643509
|
Alpini G et al. |
Tauroursodeoxycholate inhibits human cholangiocarcinoma growth via Ca2+-, PKC-, and MAPK-dependent pathways. |
2004 |
Am. J. Physiol. Gastrointest. Liver Physiol. |
pmid:14701718
|
Komichi D et al. |
Unique inhibition of bile salt-induced apoptosis by lecithins and cytoprotective bile salts in immortalized mouse cholangiocytes. |
2003 |
Dig. Dis. Sci. |
pmid:14714619
|
Henzel K et al. |
Toxicity of ethanol and acetaldehyde in hepatocytes treated with ursodeoxycholic or tauroursodeoxycholic acid. |
2004 |
Biochim. Biophys. Acta |
pmid:14741743
|
Kubitz R et al. |
Trafficking of the bile salt export pump from the Golgi to the canalicular membrane is regulated by the p38 MAP kinase. |
2004 |
Gastroenterology |
pmid:14762791
|
|
|
|
|
pmid:14965230
|
Rolo AP et al. |
Role of mitochondrial dysfunction in combined bile acid-induced cytotoxicity: the switch between apoptosis and necrosis. |
2004 |
Toxicol. Sci. |
pmid:14976352
|
Lee DK et al. |
[Deoxycholic acid-induced signal transduction in HT-29 cells: role of NF-kappa B and interleukin-8]. |
2004 |
Korean J Gastroenterol |
pmid:15034288
|
Klett EL et al. |
A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol. |
2004 |
BMC Med |
pmid:15040800
|
|
|
|
|
pmid:15057918
|
Schoemaker MH et al. |
Tauroursodeoxycholic acid protects rat hepatocytes from bile acid-induced apoptosis via activation of survival pathways. |
2004 |
Hepatology |
pmid:15185297
|
Castro RE et al. |
The bile acid tauroursodeoxycholic acid modulates phosphorylation and translocation of bad via phosphatidylinositol 3-kinase in glutamate-induced apoptosis of rat cortical neurons. |
2004 |
J. Pharmacol. Exp. Ther. |
pmid:15190125
|
Solá S et al. |
Tauroursodeoxycholic acid prevents amyloid-beta peptide-induced neuronal death via a phosphatidylinositol 3-kinase-dependent signaling pathway. |
2003 Sep-Dec |
Mol. Med. |
pmid:15208744
|
Solá S et al. |
Modulation of nuclear steroid receptors by ursodeoxycholic acid inhibits TGF-beta1-induced E2F-1/p53-mediated apoptosis of rat hepatocytes. |
2004 |
Biochemistry |
pmid:15222754
|
Ramalho RM et al. |
Inhibition of the E2F-1/p53/Bax pathway by tauroursodeoxycholic acid in amyloid beta-peptide-induced apoptosis of PC12 cells. |
2004 |
J. Neurochem. |
pmid:15255934
|
Mita S et al. |
Vectorial transport of bile salts across MDCK cells expressing both rat Na+-taurocholate cotransporting polypeptide and rat bile salt export pump. |
2005 |
Am. J. Physiol. Gastrointest. Liver Physiol. |
pmid:15297262
|
Tachizawa H et al. |
Effects of colchicine on the maximum biliary excretion of cholephilic compounds in rats. |
2004 |
J. Gastroenterol. Hepatol. |
pmid:15304119
|
|
|
|
|
pmid:15312152
|
Zhao XM and Montet JC |
Effects of bile salt supplementation on biliary secretion in estrogen-treated rats. |
1990 |
J. Nutr. Biochem. |
pmid:15539232
|
Marumo T et al. |
Biliary excretion of bile acids and organic anions in rats with dichloroethylene-induced bile canalicular injury. |
2004 |
J. Gastroenterol. |
pmid:15549452
|
Ma J et al. |
Ursodeoxycholic acid inhibits endothelin-1 production in human vascular endothelial cells. |
2004 |
Eur. J. Pharmacol. |
pmid:15556138
|
|
|
|
|
pmid:15652244
|
Pusl T et al. |
Gap junctional intercellular communication is not needed for the anticholestatic effect of tauroursodeoxycholic acid in mouse liver. |
2005 |
J. Hepatol. |
pmid:15763348
|
|
|
|
|
pmid:15810635
|
Crocenzi FA et al. |
Prevention of Mrp2 activity impairment in ethinylestradiol-induced cholestasis by ursodeoxycholate in the rat. |
2005 |
Drug Metab. Dispos. |
pmid:15843489
|
Takayanagi M et al. |
Biliary excretion of olmesartan, an anigotensin II receptor antagonist, in the rat. |
2005 |
J. Gastroenterol. Hepatol. |
pmid:15853995
|
Wang L et al. |
Activation of CREB by tauroursodeoxycholic acid protects cholangiocytes from apoptosis induced by mTOR inhibition. |
2005 |
Hepatology |
pmid:15861431
|
|
|
|
|
pmid:15869421
|
Cai W et al. |
Interferon-alpha-induced modulation of glucocorticoid and serotonin receptors as a mechanism of depression. |
2005 |
J. Hepatol. |
pmid:15885359
|
Castro RE et al. |
A distinct microarray gene expression profile in primary rat hepatocytes incubated with ursodeoxycholic acid. |
2005 |
J. Hepatol. |
pmid:15885361
|
|
|
|
|
pmid:15910498
|
Chen W and Gluud C |
Bile acids for liver-transplanted patients. |
2005 |
Cochrane Database Syst Rev |
pmid:16034975
|
Sokol RJ et al. |
Human hepatic mitochondria generate reactive oxygen species and undergo the permeability transition in response to hydrophobic bile acids. |
2005 |
J. Pediatr. Gastroenterol. Nutr. |
pmid:16056106
|