| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypertension | D006973 | 115 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
Total
2
Tauroursodeoxycholic acid
Tauroursodeoxycholic acid is a lipid of Sterol Lipids (ST) class. Tauroursodeoxycholic acid is associated with abnormalities such as Hyperglycemia, Obesity, Wiskott-Aldrich Syndrome, neurogenic hypertension and Cholestatic liver disease. The involved functions are known as Cell Death, Apoptosis, Homeostasis, Process and mRNA Expression. Tauroursodeoxycholic acid often locates in Body tissue, Endoplasmic Reticulum, Hepatic, Blood and Protoplasm. The associated genes with Tauroursodeoxycholic acid are Homologous Gene and Mutant Proteins. The related lipids are cholanic acid, taurolithocholic acid 3-sulfate, Sterols, 7-dehydrocholesterol and tauromuricholic acid. The related experimental models are Disease model.
Cross Reference
Introduction
To understand associated biological information of Tauroursodeoxycholic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Tauroursodeoxycholic acid?
Tauroursodeoxycholic acid is suspected in Endothelial dysfunction, Hyperglycemia, Obesity, neurogenic hypertension, Cholestatic liver disease, Heart failure and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Diabetes (3)
- Am. J. Physiol. Heart Circ. Physiol. (1)
- Am. J. Physiol. Lung Cell Mol. Physiol. (1)
- Others (5)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Tauroursodeoxycholic acid
PubChem Associated disorders and diseases
What pathways are associated with Tauroursodeoxycholic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Tauroursodeoxycholic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Tauroursodeoxycholic acid?
Disease model
Disease model are used in the study 'Bile Acids Reduce Prion Conversion, Reduce Neuronal Loss, and Prolong Male Survival in Models of Prion Disease.' (Cortez LM et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Tauroursodeoxycholic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Castro-Caldas M et al. | Tauroursodeoxycholic acid prevents MPTP-induced dopaminergic cell death in a mouse model of Parkinson's disease. | 2012 | Mol. Neurobiol. | pmid:22773138 |
| Nunes AF et al. | TUDCA, a bile acid, attenuates amyloid precursor protein processing and amyloid-β deposition in APP/PS1 mice. | 2012 | Mol. Neurobiol. | pmid:22438081 |
| Vaidya SS and Gerk PM | Lack of interaction between tauroursodeoxycholate and ATP-binding cassette transporter isoform G2 (ABCG2). | 2006 May-Jun | Mol. Pharm. | pmid:16749862 |
| Zhou L et al. | Autophagy-mediated insulin receptor down-regulation contributes to endoplasmic reticulum stress-induced insulin resistance. | 2009 | Mol. Pharmacol. | pmid:19541767 |
| Udawatte C et al. | Taurine suppresses the spread of cell death in electrically coupled RPE cells. | 2008 | Mol. Vis. | pmid:18958305 |
| Boatright JH et al. | Tool from ancient pharmacopoeia prevents vision loss. | 2006 | Mol. Vis. | pmid:17213800 |
| Qi HP et al. | Ursodeoxycholic acid prevents selenite-induced oxidative stress and alleviates cataract formation: In vitro and in vivo studies. | 2012 | Mol. Vis. | pmid:22275806 |
| Fimognari C et al. | Micronuclei induction, cell cycle delay and apoptosis as markers of cellular stress caused by ursodeoxycholic acid in human lymphocytes. | 2001 | Mutat. Res. | pmid:11448637 |
| Keune WJ et al. | Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling. | 2016 | Nat Commun | pmid:27075612 |
| Bracha AL et al. | Carbon metabolism-mediated myogenic differentiation. | 2010 | Nat. Chem. Biol. | pmid:20081855 |
| Keestra-Gounder AM et al. | NOD1 and NOD2 signalling links ER stress with inflammation. | 2016 | Nature | pmid:27007849 |
| Ramalho RM et al. | Tauroursodeoxycholic acid suppresses amyloid β-induced synaptic toxicity in vitro and in APP/PS1 mice. | 2013 | Neurobiol. Aging | pmid:22621777 |
| Lo AC et al. | Tauroursodeoxycholic acid (TUDCA) supplementation prevents cognitive impairment and amyloid deposition in APP/PS1 mice. | 2013 | Neurobiol. Dis. | pmid:22974733 |
| Yan F et al. | Endoplasmic reticulum stress is associated with neuroprotection against apoptosis via autophagy activation in a rat model of subarachnoid hemorrhage. | 2014 | Neurosci. Lett. | pmid:24513235 |
| Hu J et al. | Tauroursodeoxycholic acid prevents hearing loss and hair cell death in Cdh23(erl/erl) mice. | 2016 | Neuroscience | pmid:26748055 |
| Gaspar JM et al. | Tauroursodeoxycholic acid protects retinal neural cells from cell death induced by prolonged exposure to elevated glucose. | 2013 | Neuroscience | pmid:24012838 |
| Kim GW et al. | Calorie-induced ER stress suppresses uroguanylin satiety signaling in diet-induced obesity. | 2016 | Nutr Diabetes | pmid:27214655 |
| Zhang J et al. | Tauroursodeoxycholic Acid Attenuates Renal Tubular Injury in a Mouse Model of Type 2 Diabetes. | 2016 | Nutrients | pmid:27669287 |
| Jiao P et al. | FFA-induced adipocyte inflammation and insulin resistance: involvement of ER stress and IKKβ pathways. | 2011 | Obesity (Silver Spring) | pmid:20829802 |
| Myronovych A et al. | Vertical sleeve gastrectomy reduces hepatic steatosis while increasing serum bile acids in a weight-loss-independent manner. | 2014 | Obesity (Silver Spring) | pmid:23804416 |
| Vandewynckel YP et al. | Tauroursodeoxycholic acid dampens oncogenic apoptosis induced by endoplasmic reticulum stress during hepatocarcinogen exposure. | 2015 | Oncotarget | pmid:26293671 |
| Malo A et al. | 4-Phenylbutyric acid reduces endoplasmic reticulum stress, trypsin activation, and acinar cell apoptosis while increasing secretion in rat pancreatic acini. | 2013 | Pancreas | pmid:22889983 |
| van Minnen LP et al. | Cholesterol crystals enhance and phospholipids protect against pancreatitis induced by hydrophobic bile salts: a rat model study. | 2006 | Pancreas | pmid:16670619 |
| Daood MJ et al. | Lipid peroxidation is not the primary mechanism of bilirubin-induced neurologic dysfunction in jaundiced Gunn rat pups. | 2012 | Pediatr. Res. | pmid:22902434 |
| Xiang X et al. | Effect of SLCO1B1 polymorphism on the plasma concentrations of bile acids and bile acid synthesis marker in humans. | 2009 | Pharmacogenet. Genomics | pmid:19387419 |
| Megaraj V et al. | Functional analysis of nonsynonymous single nucleotide polymorphisms of multidrug resistance-associated protein 2 (ABCC2). | 2011 | Pharmacogenet. Genomics | pmid:21691255 |
| Tanaka Y et al. | The exacerbating roles of CCAAT/enhancer-binding protein homologous protein (CHOP) in the development of bleomycin-induced pulmonary fibrosis and the preventive effects of tauroursodeoxycholic acid (TUDCA) against pulmonary fibrosis in mice. | 2015 | Pharmacol. Res. | pmid:26005208 |
| Yang X et al. | Activation of autophagy by unfolded proteins during endoplasmic reticulum stress. | 2016 | Plant J. | pmid:26616142 |
| Ropelle ER et al. | IL-6 and IL-10 anti-inflammatory activity links exercise to hypothalamic insulin and leptin sensitivity through IKKbeta and ER stress inhibition. | 2010 | PLoS Biol. | pmid:20808781 |
| Trottier J et al. | Profiling circulating and urinary bile acids in patients with biliary obstruction before and after biliary stenting. | 2011 | PLoS ONE | pmid:21760958 |
| Ma Y et al. | Growth hormone secretagogues protect mouse cardiomyocytes from in vitro ischemia/reperfusion injury through regulation of intracellular calcium. | 2012 | PLoS ONE | pmid:22493744 |
| Yang JS et al. | Changes in hepatic gene expression upon oral administration of taurine-conjugated ursodeoxycholic acid in ob/ob mice. | 2010 | PLoS ONE | pmid:21079772 |
| Úriz M et al. | Ursodeoxycholic acid is conjugated with taurine to promote secretin-stimulated biliary hydrocholeresis in the normal rat. | 2011 | PLoS ONE | pmid:22194894 |
| Sheu ML et al. | Honokiol induces calpain-mediated glucose-regulated protein-94 cleavage and apoptosis in human gastric cancer cells and reduces tumor growth. | 2007 | PLoS ONE | pmid:17971859 |
| Nguyen MT et al. | Regulation of chemokine and chemokine receptor expression by PPARγ in adipocytes and macrophages. | 2012 | PLoS ONE | pmid:22529965 |
| Mantopoulos D et al. | Tauroursodeoxycholic acid (TUDCA) protects photoreceptors from cell death after experimental retinal detachment. | 2011 | PLoS ONE | pmid:21961034 |
| Fernández-Sánchez L et al. | Controlled delivery of tauroursodeoxycholic acid from biodegradable microspheres slows retinal degeneration and vision loss in P23H rats. | 2017 | PLoS ONE | pmid:28542454 |
| Zhang JY et al. | Inhibition of endoplasmic reticulum stress improves mouse embryo development. | 2012 | PLoS ONE | pmid:22808162 |
| Rani S et al. | Tauroursodeoxycholic acid (TUDCA) attenuates pressure overload-induced cardiac remodeling by reducing endoplasmic reticulum stress. | 2017 | PLoS ONE | pmid:28426781 |
| Groenendyk J et al. | Inhibition of the Unfolded Protein Response Mechanism Prevents Cardiac Fibrosis. | 2016 | PLoS ONE | pmid:27441395 |
| Fang L et al. | Autophagy attenuates diabetic glomerular damage through protection of hyperglycemia-induced podocyte injury. | 2013 | PLoS ONE | pmid:23593240 |
| Turdi S et al. | Tauroursodeoxycholic acid mitigates high fat diet-induced cardiomyocyte contractile and intracellular Ca2+ anomalies. | 2013 | PLoS ONE | pmid:23667647 |
| Gómez-Vicente V et al. | Neuroprotective Effect of Tauroursodeoxycholic Acid on N-Methyl-D-Aspartate-Induced Retinal Ganglion Cell Degeneration. | 2015 | PLoS ONE | pmid:26379056 |
| Koyama S et al. | Gefitinib and Erlotinib Lead to Phosphorylation of Eukaryotic Initiation Factor 2 Alpha Independent of Epidermal Growth Factor Receptor in A549 Cells. | 2015 | PLoS ONE | pmid:26288223 |
| Yao XH et al. | Prenatal ethanol exposure causes glucose intolerance with increased hepatic gluconeogenesis and histone deacetylases in adult rat offspring: reversal by tauroursodeoxycholic acid. | 2013 | PLoS ONE | pmid:23544086 |
| Yu KN et al. | Titanium Dioxide Nanoparticles Induce Endoplasmic Reticulum Stress-Mediated Autophagic Cell Death via Mitochondria-Associated Endoplasmic Reticulum Membrane Disruption in Normal Lung Cells. | 2015 | PLoS ONE | pmid:26121477 |
| Cheng S et al. | Pachymic acid inhibits growth and induces apoptosis of pancreatic cancer in vitro and in vivo by targeting ER stress. | 2015 | PLoS ONE | pmid:25915041 |
| Gupta S et al. | Prevention of acute kidney injury by tauroursodeoxycholic acid in rat and cell culture models. | 2012 | PLoS ONE | pmid:23152827 |
| Mališová L et al. | Ursodeoxycholic acid but not tauroursodeoxycholic acid inhibits proliferation and differentiation of human subcutaneous adipocytes. | 2013 | PLoS ONE | pmid:24312631 |
| Fang L et al. | Involvement of endoplasmic reticulum stress in albuminuria induced inflammasome activation in renal proximal tubular cells. | 2013 | PLoS ONE | pmid:23977286 |