Tauroursodeoxycholic acid

Tauroursodeoxycholic acid is a lipid of Sterol Lipids (ST) class. Tauroursodeoxycholic acid is associated with abnormalities such as Hyperglycemia, Obesity, Wiskott-Aldrich Syndrome, neurogenic hypertension and Cholestatic liver disease. The involved functions are known as Cell Death, Apoptosis, Homeostasis, Process and mRNA Expression. Tauroursodeoxycholic acid often locates in Body tissue, Endoplasmic Reticulum, Hepatic, Blood and Protoplasm. The associated genes with Tauroursodeoxycholic acid are Homologous Gene and Mutant Proteins. The related lipids are cholanic acid, taurolithocholic acid 3-sulfate, Sterols, 7-dehydrocholesterol and tauromuricholic acid. The related experimental models are Disease model.

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Introduction

To understand associated biological information of Tauroursodeoxycholic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Tauroursodeoxycholic acid?

Tauroursodeoxycholic acid is suspected in Endothelial dysfunction, Hyperglycemia, Obesity, neurogenic hypertension, Cholestatic liver disease, Heart failure and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Tauroursodeoxycholic acid

MeSH term MeSH ID Detail
Hypertension D006973 115 associated lipids
Insulin Resistance D007333 99 associated lipids
Total 2

PubChem Associated disorders and diseases

What pathways are associated with Tauroursodeoxycholic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Tauroursodeoxycholic acid?

Related references are published most in these journals:

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What functions are associated with Tauroursodeoxycholic acid?


Related references are published most in these journals:

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What lipids are associated with Tauroursodeoxycholic acid?

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What genes are associated with Tauroursodeoxycholic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Tauroursodeoxycholic acid?

Disease model

Disease model are used in the study 'Bile Acids Reduce Prion Conversion, Reduce Neuronal Loss, and Prolong Male Survival in Models of Prion Disease.' (Cortez LM et al., 2015).

Related references are published most in these journals:

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NCBI Entrez Crosslinks

All references with Tauroursodeoxycholic acid

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Authors Title Published Journal PubMed Link
Guo H et al. Endoplasmic Reticulum Chaperon Tauroursodeoxycholic Acid Attenuates Aldosterone-Infused Renal Injury. 2016 Mediators Inflamm. pmid:27721575
Zhang J et al. Tauroursodeoxycholic Acid Attenuates Renal Tubular Injury in a Mouse Model of Type 2 Diabetes. 2016 Nutrients pmid:27669287
Walsh LK et al. Administration of tauroursodeoxycholic acid prevents endothelial dysfunction caused by an oral glucose load. 2016 Clin. Sci. pmid:27503949
Wei SG et al. Endoplasmic reticulum stress increases brain MAPK signaling, inflammation and renin-angiotensin system activity and sympathetic nerve activity in heart failure. 2016 Am. J. Physiol. Heart Circ. Physiol. pmid:27496879
Groenendyk J et al. Inhibition of the Unfolded Protein Response Mechanism Prevents Cardiac Fibrosis. 2016 PLoS ONE pmid:27441395
Yung HW et al. Placental endoplasmic reticulum stress in gestational diabetes: the potential for therapeutic intervention with chemical chaperones and antioxidants. 2016 Diabetologia pmid:27406815
Flodby P et al. The 78-kD Glucose-Regulated Protein Regulates Endoplasmic Reticulum Homeostasis and Distal Epithelial Cell Survival during Lung Development. 2016 Am. J. Respir. Cell Mol. Biol. pmid:26816051
Ding W et al. Involvement of Endoplasmic Reticulum Stress in Uremic Cardiomyopathy: Protective Effects of Tauroursodeoxycholic Acid. 2016 Cell. Physiol. Biochem. pmid:26765262
Hu J et al. Tauroursodeoxycholic acid prevents hearing loss and hair cell death in Cdh23(erl/erl) mice. 2016 Neuroscience pmid:26748055
Ma H et al. A multicenter, randomized, double-blind trial comparing the efficacy and safety of TUDCA and UDCA in Chinese patients with primary biliary cholangitis. 2016 Medicine (Baltimore) pmid:27893675