Malo A et al. |
Tauroursodeoxycholic acid reduces endoplasmic reticulum stress, trypsin activation, and acinar cell apoptosis while increasing secretion in rat pancreatic acini. |
2010 |
Am. J. Physiol. Gastrointest. Liver Physiol. |
pmid:20671193
|
Guo R et al. |
Metallothionein alleviates oxidative stress-induced endoplasmic reticulum stress and myocardial dysfunction. |
2009 |
J. Mol. Cell. Cardiol. |
pmid:19344729
|
Xiang X et al. |
Effect of SLCO1B1 polymorphism on the plasma concentrations of bile acids and bile acid synthesis marker in humans. |
2009 |
Pharmacogenet. Genomics |
pmid:19387419
|
Fimognari C et al. |
Apoptosis and modulation of cell cycle control by bile acids in human leukemia T cells. |
2009 |
Ann. N. Y. Acad. Sci. |
pmid:19723064
|
Feng Y et al. |
Bear bile: dilemma of traditional medicinal use and animal protection. |
2009 |
J Ethnobiol Ethnomed |
pmid:19138420
|
Dreger SC et al. |
Killing of rat basophilic leukemia cells by lethal toxin from Clostridium sordellii: critical role of phosphatidylinositide 3'-OH kinase/Akt signaling. |
2009 |
Biochemistry |
pmid:19199813
|
Viana RJ et al. |
Tauroursodeoxycholic acid prevents E22Q Alzheimer's Abeta toxicity in human cerebral endothelial cells. |
2009 |
Cell. Mol. Life Sci. |
pmid:19189048
|
Schulz F et al. |
Prevention of Clostridium sordellii lethal toxin-induced apoptotic cell death by tauroursodeoxycholic acid. |
2009 |
Biochemistry |
pmid:19691300
|
Miki T et al. |
Endoplasmic reticulum stress in diabetic hearts abolishes erythropoietin-induced myocardial protection by impairment of phospho-glycogen synthase kinase-3beta-mediated suppression of mitochondrial permeability transition. |
2009 |
Diabetes |
pmid:19755525
|
Ozcan L et al. |
Endoplasmic reticulum stress plays a central role in development of leptin resistance. |
2009 |
Cell Metab. |
pmid:19117545
|
Hohenester S et al. |
Primary biliary cirrhosis. |
2009 |
Semin Immunopathol |
pmid:19603170
|
Zhou L et al. |
Autophagy-mediated insulin receptor down-regulation contributes to endoplasmic reticulum stress-induced insulin resistance. |
2009 |
Mol. Pharmacol. |
pmid:19541767
|
Gnewuch C et al. |
Serum bile acid profiling reflects enterohepatic detoxification state and intestinal barrier function in inflammatory bowel disease. |
2009 |
World J. Gastroenterol. |
pmid:19575493
|
Sommerfeld A et al. |
Bile acid-induced epidermal growth factor receptor activation in quiescent rat hepatic stellate cells can trigger both proliferation and apoptosis. |
2009 |
J. Biol. Chem. |
pmid:19553664
|
Ramalho RM et al. |
Apoptosis in transgenic mice expressing the P301L mutated form of human tau. |
2008 May-Jun |
Mol. Med. |
pmid:18368144
|
Udawatte C et al. |
Taurine suppresses the spread of cell death in electrically coupled RPE cells. |
2008 |
Mol. Vis. |
pmid:18958305
|
Roma MG et al. |
Dynamic localization of hepatocellular transporters in health and disease. |
2008 |
World J. Gastroenterol. |
pmid:19058304
|
Watanabe N and Lam E |
BAX inhibitor-1 modulates endoplasmic reticulum stress-mediated programmed cell death in Arabidopsis. |
2008 |
J. Biol. Chem. |
pmid:18039663
|
Higuchi WI et al. |
Estimation of cholesterol solubilization by a mixed micelle binding model in aqueous tauroursodeoxycholate:lecithin:cholesterol solutions. |
2008 |
J Pharm Sci |
pmid:17786967
|
Monte MJ et al. |
Cytosol-nucleus traffic and colocalization with FXR of conjugated bile acids in rat hepatocytes. |
2008 |
Am. J. Physiol. Gastrointest. Liver Physiol. |
pmid:18467501
|
Wei H et al. |
ER and oxidative stresses are common mediators of apoptosis in both neurodegenerative and non-neurodegenerative lysosomal storage disorders and are alleviated by chemical chaperones. |
2008 |
Hum. Mol. Genet. |
pmid:17989065
|
Ramalho RM et al. |
Bile acids and apoptosis modulation: an emerging role in experimental Alzheimer's disease. |
2008 |
Trends Mol Med |
pmid:18218342
|
Mannack G et al. |
Taurolithocholic acid-3 sulfate impairs insulin signaling in cultured rat hepatocytes and perfused rat liver. |
2008 |
Cell. Physiol. Biochem. |
pmid:18209481
|
Lawless MW et al. |
Tauroursodeoxycholic acid: relieving the pathogenesis of HFE C282Y hereditary hemochromatosis. |
2008 |
Hepatology |
pmid:18203149
|
Colak A et al. |
Tauroursodeoxycholic acid and secondary damage after spinal cord injury in rats. |
2008 |
J Clin Neurosci |
pmid:18343118
|
Baiocchi L et al. |
TUDCA prevents cholestasis and canalicular damage induced by ischemia-reperfusion injury in the rat, modulating PKCalpha-ezrin pathway. |
2008 |
Transpl. Int. |
pmid:18435680
|
Phillips MJ et al. |
Tauroursodeoxycholic acid preservation of photoreceptor structure and function in the rd10 mouse through postnatal day 30. |
2008 |
Invest. Ophthalmol. Vis. Sci. |
pmid:18436848
|
Nonaka M et al. |
Cytoprotective effect of tauroursodeoxycholate on hepatocyte apoptosis induced by peroxisome proliferator-activated receptor gamma ligand. |
2008 |
J. Gastroenterol. Hepatol. |
pmid:17868335
|
Macedo B et al. |
Anti-apoptotic treatment reduces transthyretin deposition in a transgenic mouse model of Familial Amyloidotic Polyneuropathy. |
2008 |
Biochim. Biophys. Acta |
pmid:18572024
|
Wimmer R et al. |
Tauroursodeoxycholic acid exerts anticholestatic effects by a cooperative cPKC alpha-/PKA-dependent mechanism in rat liver. |
2008 |
Gut |
pmid:18583398
|
Pusl T et al. |
Tauroursodeoxycholic acid reduces bile acid-induced apoptosis by modulation of AP-1. |
2008 |
Biochem. Biophys. Res. Commun. |
pmid:18164257
|
Chen Y et al. |
Effect of taurine-conjugated ursodeoxycholic acid on endoplasmic reticulum stress and apoptosis induced by advanced glycation end products in cultured mouse podocytes. |
2008 |
Am. J. Nephrol. |
pmid:18648192
|
Park IH et al. |
Ursodeoxycholic acid prevents apoptosis of mouse sensory neurons induced by cisplatin by reducing P53 accumulation. |
2008 |
Biochem. Biophys. Res. Commun. |
pmid:18558085
|
Sheu ML et al. |
Honokiol induces calpain-mediated glucose-regulated protein-94 cleavage and apoptosis in human gastric cancer cells and reduces tumor growth. |
2007 |
PLoS ONE |
pmid:17971859
|
Xie Y et al. |
Conditional intestinal lipotoxicity in Apobec-1-/- Mttp-IKO mice: a survival advantage for mammalian intestinal apolipoprotein B mRNA editing. |
2007 |
J. Biol. Chem. |
pmid:17855359
|
Taffetani S et al. |
Prolactin stimulates the proliferation of normal female cholangiocytes by differential regulation of Ca2+-dependent PKC isoforms. |
2007 |
BMC Physiol. |
pmid:17640386
|
de Almeida SF et al. |
Chemical chaperones reduce endoplasmic reticulum stress and prevent mutant HFE aggregate formation. |
2007 |
J. Biol. Chem. |
pmid:17626021
|
Sabeva NS et al. |
Defects in the leptin axis reduce abundance of the ABCG5-ABCG8 sterol transporter in liver. |
2007 |
J. Biol. Chem. |
pmid:17561514
|
Roda A et al. |
A new oral formulation for the release of sodium butyrate in the ileo-cecal region and colon. |
2007 |
World J. Gastroenterol. |
pmid:17373743
|
Gerk PM et al. |
Human multidrug resistance protein 2 transports the therapeutic bile salt tauroursodeoxycholate. |
2007 |
J. Pharmacol. Exp. Ther. |
pmid:17108237
|
Lawless MW et al. |
Expression of hereditary hemochromatosis C282Y HFE protein in HEK293 cells activates specific endoplasmic reticulum stress responses. |
2007 |
BMC Cell Biol. |
pmid:17650303
|
Castro RE et al. |
Differential regulation of cyclin D1 and cell death by bile acids in primary rat hepatocytes. |
2007 |
Am. J. Physiol. Gastrointest. Liver Physiol. |
pmid:17431217
|
Rivard AL et al. |
Administration of tauroursodeoxycholic acid (TUDCA) reduces apoptosis following myocardial infarction in rat. |
2007 |
Am. J. Chin. Med. |
pmid:17436368
|
Amaral JD et al. |
p53 is a key molecular target of ursodeoxycholic acid in regulating apoptosis. |
2007 |
J. Biol. Chem. |
pmid:17881359
|
Gregor MF and Hotamisligil GS |
Thematic review series: Adipocyte Biology. Adipocyte stress: the endoplasmic reticulum and metabolic disease. |
2007 |
J. Lipid Res. |
pmid:17699733
|
Miller SD et al. |
Tauroursodeoxycholic acid inhibits apoptosis induced by Z alpha-1 antitrypsin via inhibition of Bad. |
2007 |
Hepatology |
pmid:17559149
|
Vaidya SS and Gerk PM |
Lack of interaction between tauroursodeoxycholate and ATP-binding cassette transporter isoform G2 (ABCG2). |
2006 May-Jun |
Mol. Pharm. |
pmid:16749862
|
Kanazawa I |
Therapeutic Strategies in Huntington's Disease. |
2006 |
J Clin Neurol |
pmid:20396523
|
Kim HS et al. |
[Modulation of colon cancer cell invasiveness induced by deoxycholic acid]. |
2006 |
Korean J Gastroenterol |
pmid:16861876
|
Zhang W et al. |
Binding studies of bile acids using the native fluorescence of the tryptophan residue Of Bax protein. |
2006 |
Biosci. Rep. |
pmid:16850250
|
Boost KA et al. |
c-Met responsiveness of isolated hepatocytes evaluated in an in vitro de-differentiation model. |
2006 |
Int. J. Mol. Med. |
pmid:16465395
|
Marzioni M et al. |
Ca2+-dependent cytoprotective effects of ursodeoxycholic and tauroursodeoxycholic acid on the biliary epithelium in a rat model of cholestasis and loss of bile ducts. |
2006 |
Am. J. Pathol. |
pmid:16436655
|
Crocenzi FA et al. |
Galactosamine prevents ethinylestradiol-induced cholestasis. |
2006 |
Drug Metab. Dispos. |
pmid:16554370
|
Plösch T et al. |
Abcg5/Abcg8-independent pathways contribute to hepatobiliary cholesterol secretion in mice. |
2006 |
Am. J. Physiol. Gastrointest. Liver Physiol. |
pmid:16614371
|
Cui H et al. |
[Experimental study of the permeability of Fel Ursi's in eye]. |
2006 |
Zhonghua Yan Ke Za Zhi |
pmid:17386143
|
Dombrowski F et al. |
Tauroursodeoxycholic acid inserts the bile salt export pump into canalicular membranes of cholestatic rat liver. |
2006 |
Lab. Invest. |
pmid:16344857
|
Kosters A et al. |
The mechanism of ABCG5/ABCG8 in biliary cholesterol secretion in mice. |
2006 |
J. Lipid Res. |
pmid:16741293
|
Powell AA et al. |
Resistance to ursodeoxycholic acid-induced growth arrest can also result in resistance to deoxycholic acid-induced apoptosis and increased tumorgenicity. |
2006 |
BMC Cancer |
pmid:16948850
|
Ramalho RM et al. |
Tauroursodeoxycholic acid modulates p53-mediated apoptosis in Alzheimer's disease mutant neuroblastoma cells. |
2006 |
J. Neurochem. |
pmid:16923170
|
Ozcan U et al. |
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. |
2006 |
Science |
pmid:16931765
|
Petruzzelli M et al. |
Indomethacin enhances bile salt detergent activity: relevance for NSAIDs-induced gastrointestinal mucosal injury. |
2006 |
Dig. Dis. Sci. |
pmid:16615001
|
Solá S et al. |
Functional modulation of nuclear steroid receptors by tauroursodeoxycholic acid reduces amyloid beta-peptide-induced apoptosis. |
2006 |
Mol. Endocrinol. |
pmid:16728529
|
Boatright JH et al. |
Tool from ancient pharmacopoeia prevents vision loss. |
2006 |
Mol. Vis. |
pmid:17213800
|
Barth A et al. |
Bile acid transport and metabolism in rat liver slices. |
2006 |
Exp. Toxicol. Pathol. |
pmid:16413764
|
Park JY et al. |
Bile acid analysis in biliary tract cancer. |
2006 |
Yonsei Med. J. |
pmid:17191311
|
van Minnen LP et al. |
Cholesterol crystals enhance and phospholipids protect against pancreatitis induced by hydrophobic bile salts: a rat model study. |
2006 |
Pancreas |
pmid:16670619
|
Terry C et al. |
Preincubation of rat and human hepatocytes with cytoprotectants prior to cryopreservation can improve viability and function upon thawing. |
2006 |
Liver Transpl. |
pmid:16382475
|
Mrówczynska L et al. |
Inhibition of MRP1-mediated efflux in human erythrocytes by mono-anionic bile salts. |
2005 Sep-Oct |
Anticancer Res. |
pmid:16101123
|
Castro RE et al. |
A distinct microarray gene expression profile in primary rat hepatocytes incubated with ursodeoxycholic acid. |
2005 |
J. Hepatol. |
pmid:15885361
|
Ved R et al. |
Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans. |
2005 |
J. Biol. Chem. |
pmid:16239214
|
Pusl T et al. |
Gap junctional intercellular communication is not needed for the anticholestatic effect of tauroursodeoxycholic acid in mouse liver. |
2005 |
J. Hepatol. |
pmid:15763348
|
Cai W et al. |
Interferon-alpha-induced modulation of glucocorticoid and serotonin receptors as a mechanism of depression. |
2005 |
J. Hepatol. |
pmid:15885359
|
Terry C et al. |
Preincubation of rat and human hepatocytes with cytoprotectants prior to cryopreservation can improve viability and function upon thawing. |
2005 |
Liver Transpl. |
pmid:16315306
|
Mita S et al. |
Vectorial transport of bile salts across MDCK cells expressing both rat Na+-taurocholate cotransporting polypeptide and rat bile salt export pump. |
2005 |
Am. J. Physiol. Gastrointest. Liver Physiol. |
pmid:15297262
|
Dent P et al. |
Conjugated bile acids promote ERK1/2 and AKT activation via a pertussis toxin-sensitive mechanism in murine and human hepatocytes. |
2005 |
Hepatology |
pmid:16317705
|
Crocenzi FA et al. |
Prevention of Mrp2 activity impairment in ethinylestradiol-induced cholestasis by ursodeoxycholate in the rat. |
2005 |
Drug Metab. Dispos. |
pmid:15843489
|
Sokol RJ et al. |
Human hepatic mitochondria generate reactive oxygen species and undergo the permeability transition in response to hydrophobic bile acids. |
2005 |
J. Pediatr. Gastroenterol. Nutr. |
pmid:16056106
|
Chen W and Gluud C |
Bile acids for liver-transplanted patients. |
2005 |
Cochrane Database Syst Rev |
pmid:16034975
|
Takayanagi M et al. |
Biliary excretion of olmesartan, an anigotensin II receptor antagonist, in the rat. |
2005 |
J. Gastroenterol. Hepatol. |
pmid:15853995
|
Wang L et al. |
Activation of CREB by tauroursodeoxycholic acid protects cholangiocytes from apoptosis induced by mTOR inhibition. |
2005 |
Hepatology |
pmid:15861431
|
Castro RE et al. |
The bile acid tauroursodeoxycholic acid modulates phosphorylation and translocation of bad via phosphatidylinositol 3-kinase in glutamate-induced apoptosis of rat cortical neurons. |
2004 |
J. Pharmacol. Exp. Ther. |
pmid:15190125
|
Ramalho RM et al. |
Inhibition of the E2F-1/p53/Bax pathway by tauroursodeoxycholic acid in amyloid beta-peptide-induced apoptosis of PC12 cells. |
2004 |
J. Neurochem. |
pmid:15255934
|
Kubitz R et al. |
Trafficking of the bile salt export pump from the Golgi to the canalicular membrane is regulated by the p38 MAP kinase. |
2004 |
Gastroenterology |
pmid:14762791
|
Alpini G et al. |
Tauroursodeoxycholate inhibits human cholangiocarcinoma growth via Ca2+-, PKC-, and MAPK-dependent pathways. |
2004 |
Am. J. Physiol. Gastrointest. Liver Physiol. |
pmid:14701718
|
Solá S et al. |
Modulation of nuclear steroid receptors by ursodeoxycholic acid inhibits TGF-beta1-induced E2F-1/p53-mediated apoptosis of rat hepatocytes. |
2004 |
Biochemistry |
pmid:15222754
|
Klett EL et al. |
A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol. |
2004 |
BMC Med |
pmid:15040800
|
Schoemaker MH et al. |
Tauroursodeoxycholic acid protects rat hepatocytes from bile acid-induced apoptosis via activation of survival pathways. |
2004 |
Hepatology |
pmid:15185297
|
Lee DK et al. |
[Deoxycholic acid-induced signal transduction in HT-29 cells: role of NF-kappa B and interleukin-8]. |
2004 |
Korean J Gastroenterol |
pmid:15034288
|
Henzel K et al. |
Toxicity of ethanol and acetaldehyde in hepatocytes treated with ursodeoxycholic or tauroursodeoxycholic acid. |
2004 |
Biochim. Biophys. Acta |
pmid:14741743
|
Ma J et al. |
Ursodeoxycholic acid inhibits endothelin-1 production in human vascular endothelial cells. |
2004 |
Eur. J. Pharmacol. |
pmid:15556138
|
Marumo T et al. |
Biliary excretion of bile acids and organic anions in rats with dichloroethylene-induced bile canalicular injury. |
2004 |
J. Gastroenterol. |
pmid:15549452
|
Rolo AP et al. |
Role of mitochondrial dysfunction in combined bile acid-induced cytotoxicity: the switch between apoptosis and necrosis. |
2004 |
Toxicol. Sci. |
pmid:14976352
|
Tachizawa H et al. |
Effects of colchicine on the maximum biliary excretion of cholephilic compounds in rats. |
2004 |
J. Gastroenterol. Hepatol. |
pmid:15304119
|
Solá S et al. |
Tauroursodeoxycholic acid prevents amyloid-beta peptide-induced neuronal death via a phosphatidylinositol 3-kinase-dependent signaling pathway. |
2003 Sep-Dec |
Mol. Med. |
pmid:15208744
|
Rodrigues CM et al. |
Tauroursodeoxycholic acid reduces apoptosis and protects against neurological injury after acute hemorrhagic stroke in rats. |
2003 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:12721362
|
Häussinger D et al. |
Involvement of integrins and Src in tauroursodeoxycholate-induced and swelling-induced choleresis. |
2003 |
Gastroenterology |
pmid:12730886
|
Chen W et al. |
Bile acids for viral hepatitis. |
2003 |
Cochrane Database Syst Rev |
pmid:12804455
|
Beuers U et al. |
Taurolithocholic acid exerts cholestatic effects via phosphatidylinositol 3-kinase-dependent mechanisms in perfused rat livers and rat hepatocyte couplets. |
2003 |
J. Biol. Chem. |
pmid:12626520
|
Sánchez Pozzi EJ et al. |
Ursodeoxycholate reduces ethinylestradiol glucuronidation in the rat: role in prevention of estrogen-induced cholestasis. |
2003 |
J. Pharmacol. Exp. Ther. |
pmid:12663690
|
Liu Y et al. |
Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis. |
2003 |
J. Clin. Invest. |
pmid:14623915
|