| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypertension | D006973 | 115 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
Total
2
Tauroursodeoxycholic acid
Tauroursodeoxycholic acid is a lipid of Sterol Lipids (ST) class. Tauroursodeoxycholic acid is associated with abnormalities such as Hyperglycemia, Obesity, Wiskott-Aldrich Syndrome, neurogenic hypertension and Cholestatic liver disease. The involved functions are known as Cell Death, Apoptosis, Homeostasis, Process and mRNA Expression. Tauroursodeoxycholic acid often locates in Body tissue, Endoplasmic Reticulum, Hepatic, Blood and Protoplasm. The associated genes with Tauroursodeoxycholic acid are Homologous Gene and Mutant Proteins. The related lipids are cholanic acid, taurolithocholic acid 3-sulfate, Sterols, 7-dehydrocholesterol and tauromuricholic acid. The related experimental models are Disease model.
Cross Reference
Introduction
To understand associated biological information of Tauroursodeoxycholic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Tauroursodeoxycholic acid?
Tauroursodeoxycholic acid is suspected in Endothelial dysfunction, Hyperglycemia, Obesity, neurogenic hypertension, Cholestatic liver disease, Heart failure and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Diabetes (3)
- Am. J. Physiol. Heart Circ. Physiol. (1)
- Am. J. Physiol. Lung Cell Mol. Physiol. (1)
- Others (5)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Tauroursodeoxycholic acid
PubChem Associated disorders and diseases
What pathways are associated with Tauroursodeoxycholic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Tauroursodeoxycholic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Tauroursodeoxycholic acid?
Disease model
Disease model are used in the study 'Bile Acids Reduce Prion Conversion, Reduce Neuronal Loss, and Prolong Male Survival in Models of Prion Disease.' (Cortez LM et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Tauroursodeoxycholic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Xiao ZL et al. | Effects of bile acids on the muscle functions of guinea pig gallbladder. | 2002 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12065295 |
| Monte MJ et al. | Cytosol-nucleus traffic and colocalization with FXR of conjugated bile acids in rat hepatocytes. | 2008 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:18467501 |
| Wang R et al. | Defective canalicular transport and toxicity of dietary ursodeoxycholic acid in the abcb11-/- mouse: transport and gene expression studies. | 2013 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:23764895 |
| Plösch T et al. | Abcg5/Abcg8-independent pathways contribute to hepatobiliary cholesterol secretion in mice. | 2006 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:16614371 |
| Seyhun E et al. | Tauroursodeoxycholic acid reduces endoplasmic reticulum stress, acinar cell damage, and systemic inflammation in acute pancreatitis. | 2011 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:21778463 |
| Mita S et al. | Vectorial transport of bile salts across MDCK cells expressing both rat Na+-taurocholate cotransporting polypeptide and rat bile salt export pump. | 2005 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:15297262 |
| Henkel AS et al. | Reducing endoplasmic reticulum stress does not improve steatohepatitis in mice fed a methionine- and choline-deficient diet. | 2012 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:22556147 |
| Spitler KM et al. | Suppression of endoplasmic reticulum stress improves endothelium-dependent contractile responses in aorta of the spontaneously hypertensive rat. | 2013 | Am. J. Physiol. Heart Circ. Physiol. | pmid:23709602 |
| Wei SG et al. | Endoplasmic reticulum stress increases brain MAPK signaling, inflammation and renin-angiotensin system activity and sympathetic nerve activity in heart failure. | 2016 | Am. J. Physiol. Heart Circ. Physiol. | pmid:27496879 |
| Shi Z et al. | Vasonatrin peptide attenuates myocardial ischemia-reperfusion injury in diabetic rats and underlying mechanisms. | 2015 | Am. J. Physiol. Heart Circ. Physiol. | pmid:25485902 |
| Siddesha JM et al. | Effect of a chemical chaperone, tauroursodeoxycholic acid, on HDM-induced allergic airway disease. | 2016 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:27154200 |
| Xia H et al. | Brain ACE2 overexpression reduces DOCA-salt hypertension independently of endoplasmic reticulum stress. | 2015 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:25519733 |
| Memme JM et al. | Chronology of UPR activation in skeletal muscle adaptations to chronic contractile activity. | 2016 | Am. J. Physiol., Cell Physiol. | pmid:27122157 |
| Flodby P et al. | The 78-kD Glucose-Regulated Protein Regulates Endoplasmic Reticulum Homeostasis and Distal Epithelial Cell Survival during Lung Development. | 2016 | Am. J. Respir. Cell Mol. Biol. | pmid:26816051 |
| Eto T and Tompkins RK | Inhibition of pepsin activity by ursodeoxycholic acids and chenodeoxycholic acids. | 1985 | Am. J. Surg. | pmid:3933371 |
| Jiménez-Castro MB et al. | Tauroursodeoxycholic acid affects PPARγ and TLR4 in Steatotic liver transplantation. | 2012 | Am. J. Transplant. | pmid:22994543 |
| Obici L et al. | Doxycycline plus tauroursodeoxycholic acid for transthyretin amyloidosis: a phase II study. | 2012 | Amyloid | pmid:22551192 |
| Fimognari C et al. | Apoptosis and modulation of cell cycle control by bile acids in human leukemia T cells. | 2009 | Ann. N. Y. Acad. Sci. | pmid:19723064 |
| Mrówczynska L et al. | Inhibition of MRP1-mediated efflux in human erythrocytes by mono-anionic bile salts. | 2005 Sep-Oct | Anticancer Res. | pmid:16101123 |
| Zhang Y et al. | Activation of Akt rescues endoplasmic reticulum stress-impaired murine cardiac contractile function via glycogen synthase kinase-3β-mediated suppression of mitochondrial permeation pore opening. | 2011 | Antioxid. Redox Signal. | pmid:21542787 |
| Xu LH et al. | Critical Role of Endoplasmic Reticulum Stress in Chronic Intermittent Hypoxia-Induced Deficits in Synaptic Plasticity and Long-Term Memory. | 2015 | Antioxid. Redox Signal. | pmid:25843188 |
| Liu Y et al. | Quercetin induces protective autophagy and apoptosis through ER stress via the p-STAT3/Bcl-2 axis in ovarian cancer. | 2017 | Apoptosis | pmid:28188387 |
| Piepoli AL et al. | Tauroursodeoxycholic acid reduces damaging effects of taurodeoxycholic acid on fundus gastric mucosa. | 2002 | Arch. Physiol. Biochem. | pmid:12221520 |
| Liang B et al. | Aberrant endoplasmic reticulum stress in vascular smooth muscle increases vascular contractility and blood pressure in mice deficient of AMP-activated protein kinase-α2 in vivo. | 2013 | Arterioscler. Thromb. Vasc. Biol. | pmid:23288166 |
| Cai Z et al. | Endoplasmic reticulum stress participates in aortic valve calcification in hypercholesterolemic animals. | 2013 | Arterioscler. Thromb. Vasc. Biol. | pmid:23928865 |
| Gao X et al. | The nephroprotective effect of tauroursodeoxycholic acid on ischaemia/reperfusion-induced acute kidney injury by inhibiting endoplasmic reticulum stress. | 2012 | Basic Clin. Pharmacol. Toxicol. | pmid:22212133 |
| Belaidi E et al. | Endoplasmic reticulum stress contributes to heart protection induced by cyclophilin D inhibition. | 2013 | Basic Res. Cardiol. | pmid:23744057 |
| Basseri S and Austin RC | Endoplasmic reticulum stress and lipid metabolism: mechanisms and therapeutic potential. | 2012 | Biochem Res Int | pmid:22195283 |
| Berger E and Haller D | Structure-function analysis of the tertiary bile acid TUDCA for the resolution of endoplasmic reticulum stress in intestinal epithelial cells. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21605547 |
| Lee YY et al. | Tauroursodeoxycholate (TUDCA), chemical chaperone, enhances function of islets by reducing ER stress. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20541525 |
| Lee ES et al. | Chemical chaperones reduce ionizing radiation-induced endoplasmic reticulum stress and cell death in IEC-6 cells. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24973711 |
| Pusl T et al. | Tauroursodeoxycholic acid reduces bile acid-induced apoptosis by modulation of AP-1. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18164257 |
| Rieusset J et al. | Reduction of endoplasmic reticulum stress using chemical chaperones or Grp78 overexpression does not protect muscle cells from palmitate-induced insulin resistance. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22177958 |
| Park IH et al. | Ursodeoxycholic acid prevents apoptosis of mouse sensory neurons induced by cisplatin by reducing P53 accumulation. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18558085 |
| Omura T et al. | Sodium tauroursodeoxycholate prevents paraquat-induced cell death by suppressing endoplasmic reticulum stress responses in human lung epithelial A549 cells. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23416354 |
| Bellentani S et al. | Chronic administration of ursodeoxycholic and tauroursodeoxycholic acid changes microsomal membrane lipid content and fatty acid compositions in rats. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8607791 |
| Rodrigues CM et al. | Amyloid beta-peptide disrupts mitochondrial membrane lipid and protein structure: protective role of tauroursodeoxycholate. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11181071 |
| Beuers U et al. | Tauroursodeoxycholic acid inhibits the cytosolic Ca++ increase in human neutrophils stimulated by formyl-methionyl-leucyl-phenylalanine. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2222431 |
| Kok T et al. | Peroxisome proliferator-activated receptor alpha (PPARalpha)-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in mice. | 2003 | Biochem. J. | pmid:12381268 |
| Kurz AK et al. | Phosphoinositide 3-kinase-dependent Ras activation by tauroursodesoxycholate in rat liver. | 2000 | Biochem. J. | pmid:10926845 |
| Nakai T et al. | Microtubule-independent choleresis and anti-cholestatic action of tauroursodeoxycholate in colchicine-treated rat liver. | 1992 | Biochem. J. | pmid:1361125 |
| Asamoto Y et al. | Bile-salt hydrophobicity is a key factor regulating rat liver plasma-membrane communication: relation to bilayer structure, fluidity and transporter expression and function. | 2001 | Biochem. J. | pmid:11672435 |
| Nathanson MH et al. | Stimulation of ATP secretion in the liver by therapeutic bile acids. | 2001 | Biochem. J. | pmid:11485545 |
| Häussinger D et al. | Cell volume and bile acid excretion. | 1992 | Biochem. J. | pmid:1463469 |
| Klinkspoor JH et al. | Bile salts stimulate mucin secretion by cultured dog gallbladder epithelial cells independent of their detergent effect. | 1998 | Biochem. J. | pmid:9576876 |
| Klinkspoor JH et al. | Mechanism of bile salt-induced mucin secretion by cultured dog gallbladder epithelial cells. | 1996 | Biochem. J. | pmid:8670165 |
| Barnwell SG et al. | Effect of taurochenodeoxycholate or tauroursodeoxycholate upon biliary output of phospholipids and plasma-membrane enzymes, and the extent of cell damage, in isolated perfused rat livers. | 1983 | Biochem. J. | pmid:6316931 |
| Thibault N and Ballet F | Effect of bile acids on intracellular calcium in isolated rat hepatocyte couplets. | 1993 | Biochem. Pharmacol. | pmid:8435088 |
| Veggi LM et al. | Dapsone-induced cholestasis and impairment of bile salt output in the rat. | 2002 | Biochem. Pharmacol. | pmid:11996898 |
| Gilani SS et al. | Use of 1H NMR spectroscopy (T2 relaxation times) to examine the effects of conjugated ursodeoxycholic acid on phospholipid fluidity of human gallbladder bile. | 1997 | Biochem. Soc. Trans. | pmid:9056921 |