| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypertension | D006973 | 115 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
Total
2
Tauroursodeoxycholic acid
Tauroursodeoxycholic acid is a lipid of Sterol Lipids (ST) class. Tauroursodeoxycholic acid is associated with abnormalities such as Hyperglycemia, Obesity, Wiskott-Aldrich Syndrome, neurogenic hypertension and Cholestatic liver disease. The involved functions are known as Cell Death, Apoptosis, Homeostasis, Process and mRNA Expression. Tauroursodeoxycholic acid often locates in Body tissue, Endoplasmic Reticulum, Hepatic, Blood and Protoplasm. The associated genes with Tauroursodeoxycholic acid are Homologous Gene and Mutant Proteins. The related lipids are cholanic acid, taurolithocholic acid 3-sulfate, Sterols, 7-dehydrocholesterol and tauromuricholic acid. The related experimental models are Disease model.
Cross Reference
Introduction
To understand associated biological information of Tauroursodeoxycholic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Tauroursodeoxycholic acid?
Tauroursodeoxycholic acid is suspected in Endothelial dysfunction, Hyperglycemia, Obesity, neurogenic hypertension, Cholestatic liver disease, Heart failure and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Tauroursodeoxycholic acid
PubChem Associated disorders and diseases
What pathways are associated with Tauroursodeoxycholic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Tauroursodeoxycholic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Tauroursodeoxycholic acid?
Disease model
Disease model are used in the study 'Bile Acids Reduce Prion Conversion, Reduce Neuronal Loss, and Prolong Male Survival in Models of Prion Disease.' (Cortez LM et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Tauroursodeoxycholic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mrówczynska L et al. | Inhibition of MRP1-mediated efflux in human erythrocytes by mono-anionic bile salts. | 2005 Sep-Oct | Anticancer Res. | pmid:16101123 |
| pmid:16180656 | ||||
| Ved R et al. | Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans. | 2005 | J. Biol. Chem. | pmid:16239214 |
| Terry C et al. | Preincubation of rat and human hepatocytes with cytoprotectants prior to cryopreservation can improve viability and function upon thawing. | 2005 | Liver Transpl. | pmid:16315306 |
| Dent P et al. | Conjugated bile acids promote ERK1/2 and AKT activation via a pertussis toxin-sensitive mechanism in murine and human hepatocytes. | 2005 | Hepatology | pmid:16317705 |
| Dombrowski F et al. | Tauroursodeoxycholic acid inserts the bile salt export pump into canalicular membranes of cholestatic rat liver. | 2006 | Lab. Invest. | pmid:16344857 |
| Terry C et al. | Preincubation of rat and human hepatocytes with cytoprotectants prior to cryopreservation can improve viability and function upon thawing. | 2006 | Liver Transpl. | pmid:16382475 |
| Barth A et al. | Bile acid transport and metabolism in rat liver slices. | 2006 | Exp. Toxicol. Pathol. | pmid:16413764 |
| Marzioni M et al. | Ca2+-dependent cytoprotective effects of ursodeoxycholic and tauroursodeoxycholic acid on the biliary epithelium in a rat model of cholestasis and loss of bile ducts. | 2006 | Am. J. Pathol. | pmid:16436655 |
| Boost KA et al. | c-Met responsiveness of isolated hepatocytes evaluated in an in vitro de-differentiation model. | 2006 | Int. J. Mol. Med. | pmid:16465395 |
| Crocenzi FA et al. | Galactosamine prevents ethinylestradiol-induced cholestasis. | 2006 | Drug Metab. Dispos. | pmid:16554370 |
| Plösch T et al. | Abcg5/Abcg8-independent pathways contribute to hepatobiliary cholesterol secretion in mice. | 2006 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:16614371 |
| Petruzzelli M et al. | Indomethacin enhances bile salt detergent activity: relevance for NSAIDs-induced gastrointestinal mucosal injury. | 2006 | Dig. Dis. Sci. | pmid:16615001 |
| van Minnen LP et al. | Cholesterol crystals enhance and phospholipids protect against pancreatitis induced by hydrophobic bile salts: a rat model study. | 2006 | Pancreas | pmid:16670619 |
| Solá S et al. | Functional modulation of nuclear steroid receptors by tauroursodeoxycholic acid reduces amyloid beta-peptide-induced apoptosis. | 2006 | Mol. Endocrinol. | pmid:16728529 |
| Kosters A et al. | The mechanism of ABCG5/ABCG8 in biliary cholesterol secretion in mice. | 2006 | J. Lipid Res. | pmid:16741293 |
| Vaidya SS and Gerk PM | Lack of interaction between tauroursodeoxycholate and ATP-binding cassette transporter isoform G2 (ABCG2). | 2006 May-Jun | Mol. Pharm. | pmid:16749862 |
| Zhang W et al. | Binding studies of bile acids using the native fluorescence of the tryptophan residue Of Bax protein. | 2006 | Biosci. Rep. | pmid:16850250 |
| Kim HS et al. | [Modulation of colon cancer cell invasiveness induced by deoxycholic acid]. | 2006 | Korean J Gastroenterol | pmid:16861876 |
| pmid:16872555 | ||||
| Ramalho RM et al. | Tauroursodeoxycholic acid modulates p53-mediated apoptosis in Alzheimer's disease mutant neuroblastoma cells. | 2006 | J. Neurochem. | pmid:16923170 |
| Ozcan U et al. | Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. | 2006 | Science | pmid:16931765 |
| Powell AA et al. | Resistance to ursodeoxycholic acid-induced growth arrest can also result in resistance to deoxycholic acid-induced apoptosis and increased tumorgenicity. | 2006 | BMC Cancer | pmid:16948850 |
| Gerk PM et al. | Human multidrug resistance protein 2 transports the therapeutic bile salt tauroursodeoxycholate. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17108237 |
| Park JY et al. | Bile acid analysis in biliary tract cancer. | 2006 | Yonsei Med. J. | pmid:17191311 |
| Boatright JH et al. | Tool from ancient pharmacopoeia prevents vision loss. | 2006 | Mol. Vis. | pmid:17213800 |
| Roda A et al. | A new oral formulation for the release of sodium butyrate in the ileo-cecal region and colon. | 2007 | World J. Gastroenterol. | pmid:17373743 |
| Cui H et al. | [Experimental study of the permeability of Fel Ursi's in eye]. | 2006 | Zhonghua Yan Ke Za Zhi | pmid:17386143 |
| pmid:17395011 | ||||
| Castro RE et al. | Differential regulation of cyclin D1 and cell death by bile acids in primary rat hepatocytes. | 2007 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:17431217 |
| Rivard AL et al. | Administration of tauroursodeoxycholic acid (TUDCA) reduces apoptosis following myocardial infarction in rat. | 2007 | Am. J. Chin. Med. | pmid:17436368 |
| Miller SD et al. | Tauroursodeoxycholic acid inhibits apoptosis induced by Z alpha-1 antitrypsin via inhibition of Bad. | 2007 | Hepatology | pmid:17559149 |
| Sabeva NS et al. | Defects in the leptin axis reduce abundance of the ABCG5-ABCG8 sterol transporter in liver. | 2007 | J. Biol. Chem. | pmid:17561514 |
| de Almeida SF et al. | Chemical chaperones reduce endoplasmic reticulum stress and prevent mutant HFE aggregate formation. | 2007 | J. Biol. Chem. | pmid:17626021 |
| Taffetani S et al. | Prolactin stimulates the proliferation of normal female cholangiocytes by differential regulation of Ca2+-dependent PKC isoforms. | 2007 | BMC Physiol. | pmid:17640386 |
| Lawless MW et al. | Expression of hereditary hemochromatosis C282Y HFE protein in HEK293 cells activates specific endoplasmic reticulum stress responses. | 2007 | BMC Cell Biol. | pmid:17650303 |
| Gregor MF and Hotamisligil GS | Thematic review series: Adipocyte Biology. Adipocyte stress: the endoplasmic reticulum and metabolic disease. | 2007 | J. Lipid Res. | pmid:17699733 |
| Higuchi WI et al. | Estimation of cholesterol solubilization by a mixed micelle binding model in aqueous tauroursodeoxycholate:lecithin:cholesterol solutions. | 2008 | J Pharm Sci | pmid:17786967 |
| Xie Y et al. | Conditional intestinal lipotoxicity in Apobec-1-/- Mttp-IKO mice: a survival advantage for mammalian intestinal apolipoprotein B mRNA editing. | 2007 | J. Biol. Chem. | pmid:17855359 |
| Nonaka M et al. | Cytoprotective effect of tauroursodeoxycholate on hepatocyte apoptosis induced by peroxisome proliferator-activated receptor gamma ligand. | 2008 | J. Gastroenterol. Hepatol. | pmid:17868335 |
| Amaral JD et al. | p53 is a key molecular target of ursodeoxycholic acid in regulating apoptosis. | 2007 | J. Biol. Chem. | pmid:17881359 |
| Sheu ML et al. | Honokiol induces calpain-mediated glucose-regulated protein-94 cleavage and apoptosis in human gastric cancer cells and reduces tumor growth. | 2007 | PLoS ONE | pmid:17971859 |
| Wei H et al. | ER and oxidative stresses are common mediators of apoptosis in both neurodegenerative and non-neurodegenerative lysosomal storage disorders and are alleviated by chemical chaperones. | 2008 | Hum. Mol. Genet. | pmid:17989065 |
| Watanabe N and Lam E | BAX inhibitor-1 modulates endoplasmic reticulum stress-mediated programmed cell death in Arabidopsis. | 2008 | J. Biol. Chem. | pmid:18039663 |
| Chazouillères O et al. | Effect of bile acids on ischemia-reperfusion liver injury. | 1991 | J. Hepatol. | pmid:1808225 |
| Pusl T et al. | Tauroursodeoxycholic acid reduces bile acid-induced apoptosis by modulation of AP-1. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18164257 |
| Lawless MW et al. | Tauroursodeoxycholic acid: relieving the pathogenesis of HFE C282Y hereditary hemochromatosis. | 2008 | Hepatology | pmid:18203149 |
| Mannack G et al. | Taurolithocholic acid-3 sulfate impairs insulin signaling in cultured rat hepatocytes and perfused rat liver. | 2008 | Cell. Physiol. Biochem. | pmid:18209481 |
| Ramalho RM et al. | Bile acids and apoptosis modulation: an emerging role in experimental Alzheimer's disease. | 2008 | Trends Mol Med | pmid:18218342 |
| Colak A et al. | Tauroursodeoxycholic acid and secondary damage after spinal cord injury in rats. | 2008 | J Clin Neurosci | pmid:18343118 |