| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypertension | D006973 | 115 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
Total
2
Tauroursodeoxycholic acid
Tauroursodeoxycholic acid is a lipid of Sterol Lipids (ST) class. Tauroursodeoxycholic acid is associated with abnormalities such as Hyperglycemia, Obesity, Wiskott-Aldrich Syndrome, neurogenic hypertension and Cholestatic liver disease. The involved functions are known as Cell Death, Apoptosis, Homeostasis, Process and mRNA Expression. Tauroursodeoxycholic acid often locates in Body tissue, Endoplasmic Reticulum, Hepatic, Blood and Protoplasm. The associated genes with Tauroursodeoxycholic acid are Homologous Gene and Mutant Proteins. The related lipids are cholanic acid, taurolithocholic acid 3-sulfate, Sterols, 7-dehydrocholesterol and tauromuricholic acid. The related experimental models are Disease model.
Cross Reference
Introduction
To understand associated biological information of Tauroursodeoxycholic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Tauroursodeoxycholic acid?
Tauroursodeoxycholic acid is suspected in Endothelial dysfunction, Hyperglycemia, Obesity, neurogenic hypertension, Cholestatic liver disease, Heart failure and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Diabetes (3)
- Am. J. Physiol. Heart Circ. Physiol. (1)
- Am. J. Physiol. Lung Cell Mol. Physiol. (1)
- Others (5)
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Tauroursodeoxycholic acid
PubChem Associated disorders and diseases
What pathways are associated with Tauroursodeoxycholic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Tauroursodeoxycholic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Tauroursodeoxycholic acid?
Disease model
Disease model are used in the study 'Bile Acids Reduce Prion Conversion, Reduce Neuronal Loss, and Prolong Male Survival in Models of Prion Disease.' (Cortez LM et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with Tauroursodeoxycholic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Aranha MM et al. | Apoptosis-associated microRNAs are modulated in mouse, rat and human neural differentiation. | 2010 | BMC Genomics | pmid:20868483 |
| Ge W et al. | Cardiac-specific overexpression of catalase attenuates paraquat-induced myocardial geometric and contractile alteration: role of ER stress. | 2010 | Free Radic. Biol. Med. | pmid:20937379 |
| Ceylan-Isik AF et al. | Endoplasmic reticulum chaperon tauroursodeoxycholic acid alleviates obesity-induced myocardial contractile dysfunction. | 2011 | J. Mol. Cell. Cardiol. | pmid:21035453 |
| Oveson BC et al. | Constituents of bile, bilirubin and TUDCA, protect against oxidative stress-induced retinal degeneration. | 2011 | J. Neurochem. | pmid:21054389 |
| Ishiyama J et al. | Unsaturated FAs prevent palmitate-induced LOX-1 induction via inhibition of ER stress in macrophages. | 2011 | J. Lipid Res. | pmid:21078775 |
| Yang JS et al. | Changes in hepatic gene expression upon oral administration of taurine-conjugated ursodeoxycholic acid in ob/ob mice. | 2010 | PLoS ONE | pmid:21079772 |
| Qiao X et al. | Differentiation of various traditional Chinese medicines derived from animal bile and gallstone: simultaneous determination of bile acids by liquid chromatography coupled with triple quadrupole mass spectrometry. | 2011 | J Chromatogr A | pmid:21111425 |
| pmid:21134703 | ||||
| da-Silva WS et al. | The chemical chaperones tauroursodeoxycholic and 4-phenylbutyric acid accelerate thyroid hormone activation and energy expenditure. | 2011 | FEBS Lett. | pmid:21237159 |
| Xiao C et al. | Sodium phenylbutyrate, a drug with known capacity to reduce endoplasmic reticulum stress, partially alleviates lipid-induced insulin resistance and beta-cell dysfunction in humans. | 2011 | Diabetes | pmid:21270237 |
| Anderson CD et al. | Endoplasmic reticulum stress is a mediator of posttransplant injury in severely steatotic liver allografts. | 2011 | Liver Transpl. | pmid:21280192 |
| Purkayastha S et al. | Neural dysregulation of peripheral insulin action and blood pressure by brain endoplasmic reticulum stress. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:21282643 |
| Ben Mosbah I et al. | Endoplasmic reticulum stress inhibition protects steatotic and non-steatotic livers in partial hepatectomy under ischemia-reperfusion. | 2010 | Cell Death Dis | pmid:21364657 |
| Yeo J et al. | Effects of a multi-herbal extract on type 2 diabetes. | 2011 | Chin Med | pmid:21375727 |
| Song S et al. | Cholesterol-derived bile acids enhance the chaperone activity of α-crystallins. | 2011 | Cell Stress Chaperones | pmid:21380614 |
| Fernández-Sánchez L et al. | Tauroursodeoxycholic acid prevents retinal degeneration in transgenic P23H rats. | 2011 | Invest. Ophthalmol. Vis. Sci. | pmid:21508111 |
| Zhang Y et al. | Activation of Akt rescues endoplasmic reticulum stress-impaired murine cardiac contractile function via glycogen synthase kinase-3β-mediated suppression of mitochondrial permeation pore opening. | 2011 | Antioxid. Redox Signal. | pmid:21542787 |
| Montagnani M et al. | A new model for portal protein profile analysis in course of ileal intraluminal bile acid infusion using an in situ perfused rat intestine. | 2011 | Med Chem | pmid:21568879 |
| Luoma PV | Gene-activation mechanisms in the regression of atherosclerosis, elimination of diabetes type 2, and prevention of dementia. | 2011 | Curr. Mol. Med. | pmid:21568932 |
| Berger E and Haller D | Structure-function analysis of the tertiary bile acid TUDCA for the resolution of endoplasmic reticulum stress in intestinal epithelial cells. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21605547 |
| Megaraj V et al. | Functional analysis of nonsynonymous single nucleotide polymorphisms of multidrug resistance-associated protein 2 (ABCC2). | 2011 | Pharmacogenet. Genomics | pmid:21691255 |
| Viana RJ et al. | Amyloid-β peptide-induced secretion of endoplasmic reticulum chaperone glycoprotein GRP94. | 2011 | J. Alzheimers Dis. | pmid:21750376 |
| Trottier J et al. | Profiling circulating and urinary bile acids in patients with biliary obstruction before and after biliary stenting. | 2011 | PLoS ONE | pmid:21760958 |
| Seyhun E et al. | Tauroursodeoxycholic acid reduces endoplasmic reticulum stress, acinar cell damage, and systemic inflammation in acute pancreatitis. | 2011 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:21778463 |
| Kirkpatrick CL et al. | Hepatic nuclear factor 1alpha (HNF1alpha) dysfunction down-regulates X-box-binding protein 1 (XBP1) and sensitizes beta-cells to endoplasmic reticulum stress. | 2011 | J. Biol. Chem. | pmid:21784843 |
| Sökmen HM et al. | Situs inversus totalis and secondary biliary cirrhosis: a case report. | 2011 | Comp Hepatol | pmid:21813017 |
| Kim SY et al. | Tauroursodeoxycholate (TUDCA) inhibits neointimal hyperplasia by suppression of ERK via PKCα-mediated MKP-1 induction. | 2011 | Cardiovasc. Res. | pmid:21840882 |
| Studer E et al. | Conjugated bile acids activate the sphingosine-1-phosphate receptor 2 in primary rodent hepatocytes. | 2012 | Hepatology | pmid:21932398 |
| Mantopoulos D et al. | Tauroursodeoxycholic acid (TUDCA) protects photoreceptors from cell death after experimental retinal detachment. | 2011 | PLoS ONE | pmid:21961034 |
| pmid:21971157 | ||||
| Fonseca MB et al. | c-Jun regulates the stability of anti-apoptotic ΔNp63 in amyloid-β-induced apoptosis. | 2012 | J. Alzheimers Dis. | pmid:22045494 |
| Amin A et al. | Chronic inhibition of endoplasmic reticulum stress and inflammation prevents ischaemia-induced vascular pathology in type II diabetic mice. | 2012 | J. Pathol. | pmid:22081301 |
| Drack AV et al. | TUDCA slows retinal degeneration in two different mouse models of retinitis pigmentosa and prevents obesity in Bardet-Biedl syndrome type 1 mice. | 2012 | Invest. Ophthalmol. Vis. Sci. | pmid:22110077 |
| Leong ML et al. | Neuronal loss in the rostral ventromedial medulla in a rat model of neuropathic pain. | 2011 | J. Neurosci. | pmid:22114272 |
| Xu J et al. | Endoplasmic reticulum stress and diabetic cardiomyopathy. | 2012 | Exp Diabetes Res | pmid:22144992 |
| Kim JS et al. | Tauroursodeoxycholic acid enhances the pre-implantation embryo development by reducing apoptosis in pigs. | 2012 | Reprod. Domest. Anim. | pmid:22151574 |
| pmid:22155234 | ||||
| Rieusset J et al. | Reduction of endoplasmic reticulum stress using chemical chaperones or Grp78 overexpression does not protect muscle cells from palmitate-induced insulin resistance. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22177958 |
| Zhang JY et al. | Effect of endoplasmic reticulum stress on porcine oocyte maturation and parthenogenetic embryonic development in vitro. | 2012 | Biol. Reprod. | pmid:22190710 |
| Hassan IH et al. | Influenza A viral replication is blocked by inhibition of the inositol-requiring enzyme 1 (IRE1) stress pathway. | 2012 | J. Biol. Chem. | pmid:22194594 |
| Úriz M et al. | Ursodeoxycholic acid is conjugated with taurine to promote secretin-stimulated biliary hydrocholeresis in the normal rat. | 2011 | PLoS ONE | pmid:22194894 |
| Basseri S and Austin RC | Endoplasmic reticulum stress and lipid metabolism: mechanisms and therapeutic potential. | 2012 | Biochem Res Int | pmid:22195283 |
| pmid:22201798 | ||||
| Gao X et al. | The nephroprotective effect of tauroursodeoxycholic acid on ischaemia/reperfusion-induced acute kidney injury by inhibiting endoplasmic reticulum stress. | 2012 | Basic Clin. Pharmacol. Toxicol. | pmid:22212133 |
| Beuers U et al. | Tauroursodeoxycholic acid inhibits the cytosolic Ca++ increase in human neutrophils stimulated by formyl-methionyl-leucyl-phenylalanine. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2222431 |
| Qi HP et al. | Ursodeoxycholic acid prevents selenite-induced oxidative stress and alleviates cataract formation: In vitro and in vivo studies. | 2012 | Mol. Vis. | pmid:22275806 |
| Schmucker DL et al. | Hepatic injury induced by bile salts: correlation between biochemical and morphological events. | 1990 | Hepatology | pmid:2227821 |
| Bodewes FA et al. | Ursodeoxycholate modulates bile flow and bile salt pool independently from the cystic fibrosis transmembrane regulator (Cftr) in mice. | 2012 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:22301109 |
| Min JH et al. | Oral solubilized ursodeoxycholic acid therapy in amyotrophic lateral sclerosis: a randomized cross-over trial. | 2012 | J. Korean Med. Sci. | pmid:22323869 |
| Cai D and Liu T | Inflammatory cause of metabolic syndrome via brain stress and NF-κB. | 2012 | Aging (Albany NY) | pmid:22328600 |