| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypertension | D006973 | 115 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
Total
2
Tauroursodeoxycholic acid
Tauroursodeoxycholic acid is a lipid of Sterol Lipids (ST) class. Tauroursodeoxycholic acid is associated with abnormalities such as Hyperglycemia, Obesity, Wiskott-Aldrich Syndrome, neurogenic hypertension and Cholestatic liver disease. The involved functions are known as Cell Death, Apoptosis, Homeostasis, Process and mRNA Expression. Tauroursodeoxycholic acid often locates in Body tissue, Endoplasmic Reticulum, Hepatic, Blood and Protoplasm. The associated genes with Tauroursodeoxycholic acid are Homologous Gene and Mutant Proteins. The related lipids are cholanic acid, taurolithocholic acid 3-sulfate, Sterols, 7-dehydrocholesterol and tauromuricholic acid. The related experimental models are Disease model.
Cross Reference
Introduction
To understand associated biological information of Tauroursodeoxycholic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Tauroursodeoxycholic acid?
Tauroursodeoxycholic acid is suspected in Endothelial dysfunction, Hyperglycemia, Obesity, neurogenic hypertension, Cholestatic liver disease, Heart failure and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Diabetes (3)
- Am. J. Physiol. Heart Circ. Physiol. (1)
- Am. J. Physiol. Lung Cell Mol. Physiol. (1)
- Others (5)
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Tauroursodeoxycholic acid
PubChem Associated disorders and diseases
What pathways are associated with Tauroursodeoxycholic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Tauroursodeoxycholic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Tauroursodeoxycholic acid?
Disease model
Disease model are used in the study 'Bile Acids Reduce Prion Conversion, Reduce Neuronal Loss, and Prolong Male Survival in Models of Prion Disease.' (Cortez LM et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with Tauroursodeoxycholic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| van Heumen BW et al. | Celecoxib and tauro-ursodeoxycholic acid co-treatment inhibits cell growth in familial adenomatous polyposis derived LT97 colon adenoma cells. | 2012 | Exp. Cell Res. | pmid:22366264 |
| Achard CS and Laybutt DR | Lipid-induced endoplasmic reticulum stress in liver cells results in two distinct outcomes: adaptation with enhanced insulin signaling or insulin resistance. | 2012 | Endocrinology | pmid:22374970 |
| Tang C et al. | Glucose-induced beta cell dysfunction in vivo in rats: link between oxidative stress and endoplasmic reticulum stress. | 2012 | Diabetologia | pmid:22396011 |
| Nunes AF et al. | TUDCA, a bile acid, attenuates amyloid precursor protein processing and amyloid-β deposition in APP/PS1 mice. | 2012 | Mol. Neurobiol. | pmid:22438081 |
| Zhang Y et al. | Organic anion transporting polypeptide 1a1 null mice are sensitive to cholestatic liver injury. | 2012 | Toxicol. Sci. | pmid:22461449 |
| Beriault DR and Werstuck GH | The role of glucosamine-induced ER stress in diabetic atherogenesis. | 2012 | Exp Diabetes Res | pmid:22474416 |
| Ma Y et al. | Growth hormone secretagogues protect mouse cardiomyocytes from in vitro ischemia/reperfusion injury through regulation of intracellular calcium. | 2012 | PLoS ONE | pmid:22493744 |
| Elanchezhian R et al. | Low glucose under hypoxic conditions induces unfolded protein response and produces reactive oxygen species in lens epithelial cells. | 2012 | Cell Death Dis | pmid:22513875 |
| Nguyen MT et al. | Regulation of chemokine and chemokine receptor expression by PPARγ in adipocytes and macrophages. | 2012 | PLoS ONE | pmid:22529965 |
| Cursio R and Gugenheim J | Ischemia-Reperfusion Injury and Ischemic-Type Biliary Lesions following Liver Transplantation. | 2012 | J Transplant | pmid:22530107 |
| Zhang T et al. | Chemical chaperone TUDCA preserves cone photoreceptors in a mouse model of Leber congenital amaurosis. | 2012 | Invest. Ophthalmol. Vis. Sci. | pmid:22531707 |
| Cheng F et al. | Refined Qingkailing Protects MCAO Mice from Endoplasmic Reticulum Stress-Induced Apoptosis with a Broad Time Window. | 2012 | Evid Based Complement Alternat Med | pmid:22536287 |
| Perez Barriocanal F et al. | Influence of backward perfusion on ursodeoxycholate-induced choleresis in isolated in situ rat liver. | 1990 | J. Hepatol. | pmid:2254627 |
| Lenin R et al. | Amelioration of glucolipotoxicity-induced endoplasmic reticulum stress by a "chemical chaperone" in human THP-1 monocytes. | 2012 | Exp Diabetes Res | pmid:22550476 |
| Obici L et al. | Doxycycline plus tauroursodeoxycholic acid for transthyretin amyloidosis: a phase II study. | 2012 | Amyloid | pmid:22551192 |
| Henkel AS et al. | Reducing endoplasmic reticulum stress does not improve steatohepatitis in mice fed a methionine- and choline-deficient diet. | 2012 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:22556147 |
| Farrell GC et al. | NASH is an Inflammatory Disorder: Pathogenic, Prognostic and Therapeutic Implications. | 2012 | Gut Liver | pmid:22570745 |
| Ramalho RM et al. | Tauroursodeoxycholic acid suppresses amyloid β-induced synaptic toxicity in vitro and in APP/PS1 mice. | 2013 | Neurobiol. Aging | pmid:22621777 |
| Brandes V et al. | Protection from Clostridium difficile toxin B-catalysed Rac1/Cdc42 glucosylation by tauroursodeoxycholic acid-induced Rac1/Cdc42 phosphorylation. | 2012 | Biol. Chem. | pmid:22628301 |
| Brites D | The evolving landscape of neurotoxicity by unconjugated bilirubin: role of glial cells and inflammation. | 2012 | Front Pharmacol | pmid:22661946 |
| Galán M et al. | A novel role for epidermal growth factor receptor tyrosine kinase and its downstream endoplasmic reticulum stress in cardiac damage and microvascular dysfunction in type 1 diabetes mellitus. | 2012 | Hypertension | pmid:22665120 |
| Balasubramanyam M et al. | Molecular intricacies and the role of ER stress in diabetes. | 2012 | Exp Diabetes Res | pmid:22701473 |
| Cash JG et al. | Apolipoprotein E4 impairs macrophage efferocytosis and potentiates apoptosis by accelerating endoplasmic reticulum stress. | 2012 | J. Biol. Chem. | pmid:22730380 |
| Younce C and Kolattukudy P | MCP-1 induced protein promotes adipogenesis via oxidative stress, endoplasmic reticulum stress and autophagy. | 2012 | Cell. Physiol. Biochem. | pmid:22739135 |
| Castro-Caldas M et al. | Tauroursodeoxycholic acid prevents MPTP-induced dopaminergic cell death in a mouse model of Parkinson's disease. | 2012 | Mol. Neurobiol. | pmid:22773138 |
| Mühlfeld S et al. | Short-term feedback regulation of bile salt uptake by bile salts in rodent liver. | 2012 | Hepatology | pmid:22806967 |
| Zhang JY et al. | Inhibition of endoplasmic reticulum stress improves mouse embryo development. | 2012 | PLoS ONE | pmid:22808162 |
| Roy A and Kolattukudy PE | Monocyte chemotactic protein-induced protein (MCPIP) promotes inflammatory angiogenesis via sequential induction of oxidative stress, endoplasmic reticulum stress and autophagy. | 2012 | Cell. Signal. | pmid:22820500 |
| Gohlke H et al. | α5 β1-integrins are sensors for tauroursodeoxycholic acid in hepatocytes. | 2013 | Hepatology | pmid:22865233 |
| Malo A et al. | 4-Phenylbutyric acid reduces endoplasmic reticulum stress, trypsin activation, and acinar cell apoptosis while increasing secretion in rat pancreatic acini. | 2013 | Pancreas | pmid:22889983 |
| Daood MJ et al. | Lipid peroxidation is not the primary mechanism of bilirubin-induced neurologic dysfunction in jaundiced Gunn rat pups. | 2012 | Pediatr. Res. | pmid:22902434 |
| Zhu Q et al. | Tauroursodeoxycholate, a chemical chaperone, prevents palmitate-induced apoptosis in pancreatic β-cells by reducing ER stress. | 2013 | Exp. Clin. Endocrinol. Diabetes | pmid:22972029 |
| Lo AC et al. | Tauroursodeoxycholic acid (TUDCA) supplementation prevents cognitive impairment and amyloid deposition in APP/PS1 mice. | 2013 | Neurobiol. Dis. | pmid:22974733 |
| Jiménez-Castro MB et al. | Tauroursodeoxycholic acid affects PPARγ and TLR4 in Steatotic liver transplantation. | 2012 | Am. J. Transplant. | pmid:22994543 |
| Matsubara T et al. | TGF-β-SMAD3 signaling mediates hepatic bile acid and phospholipid metabolism following lithocholic acid-induced liver injury. | 2012 | J. Lipid Res. | pmid:23034213 |
| Young CN et al. | ER stress in the brain subfornical organ mediates angiotensin-dependent hypertension. | 2012 | J. Clin. Invest. | pmid:23064361 |
| Dromparis P et al. | Attenuating endoplasmic reticulum stress as a novel therapeutic strategy in pulmonary hypertension. | 2013 | Circulation | pmid:23149668 |
| Kawasaki N et al. | Obesity-induced endoplasmic reticulum stress causes chronic inflammation in adipose tissue. | 2012 | Sci Rep | pmid:23150771 |
| Gupta S et al. | Prevention of acute kidney injury by tauroursodeoxycholic acid in rat and cell culture models. | 2012 | PLoS ONE | pmid:23152827 |
| Panzhinskiy E et al. | Endoplasmic reticulum stress upregulates protein tyrosine phosphatase 1B and impairs glucose uptake in cultured myotubes. | 2013 | Diabetologia | pmid:23178931 |
| Liang B et al. | Aberrant endoplasmic reticulum stress in vascular smooth muscle increases vascular contractility and blood pressure in mice deficient of AMP-activated protein kinase-α2 in vivo. | 2013 | Arterioscler. Thromb. Vasc. Biol. | pmid:23288166 |
| pmid:23336977 | ||||
| Kim KS et al. | Taurine may not alleviate hyperglycemia-mediated endoplasmic reticulum stress in human adipocytes. | 2013 | Adv. Exp. Med. Biol. | pmid:23392949 |
| Dikkers A et al. | Scavenger receptor BI and ABCG5/G8 differentially impact biliary sterol secretion and reverse cholesterol transport in mice. | 2013 | Hepatology | pmid:23401258 |
| Omura T et al. | Sodium tauroursodeoxycholate prevents paraquat-induced cell death by suppressing endoplasmic reticulum stress responses in human lung epithelial A549 cells. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23416354 |
| Beuers U | β1 integrin is a long-sought sensor for tauroursodeoxycholic acid. | 2013 | Hepatology | pmid:23456677 |
| Utili R et al. | Estradiol-17 beta-D-glucuronide (E-17G) cholestasis in perfused rat liver: fate of E-17G and choleretic responses to bile salts. | 1990 | Hepatology | pmid:2347547 |
| Hamano M et al. | Lipid overloading during liver regeneration causes delayed hepatocyte DNA replication by increasing ER stress in mice with simple hepatic steatosis. | 2014 | J. Gastroenterol. | pmid:23512345 |
| Yao XH et al. | Prenatal ethanol exposure causes glucose intolerance with increased hepatic gluconeogenesis and histone deacetylases in adult rat offspring: reversal by tauroursodeoxycholic acid. | 2013 | PLoS ONE | pmid:23544086 |
| Zhang J et al. | Autophagy is involved in endoplasmic reticulum stress-induced cell death of rat hepatocytes. | 2013 | J. Surg. Res. | pmid:23548375 |