| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypertension | D006973 | 115 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
Total
2
Tauroursodeoxycholic acid
Tauroursodeoxycholic acid is a lipid of Sterol Lipids (ST) class. Tauroursodeoxycholic acid is associated with abnormalities such as Hyperglycemia, Obesity, Wiskott-Aldrich Syndrome, neurogenic hypertension and Cholestatic liver disease. The involved functions are known as Cell Death, Apoptosis, Homeostasis, Process and mRNA Expression. Tauroursodeoxycholic acid often locates in Body tissue, Endoplasmic Reticulum, Hepatic, Blood and Protoplasm. The associated genes with Tauroursodeoxycholic acid are Homologous Gene and Mutant Proteins. The related lipids are cholanic acid, taurolithocholic acid 3-sulfate, Sterols, 7-dehydrocholesterol and tauromuricholic acid. The related experimental models are Disease model.
Cross Reference
Introduction
To understand associated biological information of Tauroursodeoxycholic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Tauroursodeoxycholic acid?
Tauroursodeoxycholic acid is suspected in Endothelial dysfunction, Hyperglycemia, Obesity, neurogenic hypertension, Cholestatic liver disease, Heart failure and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Diabetes (3)
- Am. J. Physiol. Heart Circ. Physiol. (1)
- Am. J. Physiol. Lung Cell Mol. Physiol. (1)
- Others (5)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Tauroursodeoxycholic acid
PubChem Associated disorders and diseases
What pathways are associated with Tauroursodeoxycholic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Tauroursodeoxycholic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Tauroursodeoxycholic acid?
Disease model
Disease model are used in the study 'Bile Acids Reduce Prion Conversion, Reduce Neuronal Loss, and Prolong Male Survival in Models of Prion Disease.' (Cortez LM et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Tauroursodeoxycholic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Alvaro D et al. | Functional and ultrastructural features of ethanol/bile salts interaction in the isolated perfused rat liver. | 1995 | Hepatology | pmid:7705787 |
| Dikkers A et al. | Scavenger receptor BI and ABCG5/G8 differentially impact biliary sterol secretion and reverse cholesterol transport in mice. | 2013 | Hepatology | pmid:23401258 |
| Roda A et al. | Taurohyodeoxycholic acid protects against taurochenodeoxycholic acid-induced cholestasis in the rat. | 1998 | Hepatology | pmid:9462652 |
| Azzaroli F et al. | Ursodeoxycholic acid diminishes Fas-ligand-induced apoptosis in mouse hepatocytes. | 2002 | Hepatology | pmid:12085348 |
| Angelico M et al. | N-ethyl-tauroursodeoxycholic acid, a novel deconjugation-resistant bile salt analogue: effects of acute feeding in the rat. | 1995 | Hepatology | pmid:7657297 |
| Hofmann AF | Medical treatment of cholesterol gallstones by bile desaturating agents. | 1984 Sep-Oct | Hepatology | pmid:6384003 |
| Loria P et al. | Effect of taurohyodeoxycholic acid on biliary lipid secretion in humans. | 1997 | Hepatology | pmid:9185744 |
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| Krähenbühl S et al. | Ursodeoxycholate protects oxidative mitochondrial metabolism from bile acid toxicity: dose-response study in isolated rat liver mitochondria. | 1994 | Hepatology | pmid:7982660 |
| Stiehl A et al. | Effect of ursodeoxycholic acid on biliary bile acid and bile lipid composition in gallstone patients. | 1984 Jan-Feb | Hepatology | pmid:6693062 |
| Beuers U | β1 integrin is a long-sought sensor for tauroursodeoxycholic acid. | 2013 | Hepatology | pmid:23456677 |
| Meier PJ et al. | Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver. | 1997 | Hepatology | pmid:9398014 |
| Beuers U et al. | Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C-dependent mechanisms in cholestatic rat liver. | 2001 | Hepatology | pmid:11343250 |
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| Chignard N et al. | Bile acid transport and regulating functions in the human biliary epithelium. | 2001 | Hepatology | pmid:11230727 |
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| Galán M et al. | A novel role for epidermal growth factor receptor tyrosine kinase and its downstream endoplasmic reticulum stress in cardiac damage and microvascular dysfunction in type 1 diabetes mellitus. | 2012 | Hypertension | pmid:22665120 |
| Peterson TC et al. | The inhibitory effect of ursodeoxycholic acid and pentoxifylline on platelet derived growth factor-stimulated proliferation is distinct from an effect by cyclic AMP. | 1998 | Immunopharmacology | pmid:9754904 |
| Fulda S et al. | Cellular stress responses: cell survival and cell death. | 2010 | Int J Cell Biol | pmid:20182529 |
| Dong Y et al. | Neuroprotective effects and impact on caspase-12 expression of tauroursodeoxycholic acid after acute spinal cord injury in rats. | 2015 | Int J Clin Exp Pathol | pmid:26884858 |
| Paridaens A et al. | Modulation of the Unfolded Protein Response by Tauroursodeoxycholic Acid Counteracts Apoptotic Cell Death and Fibrosis in a Mouse Model for Secondary Biliary Liver Fibrosis. | 2017 | Int J Mol Sci | pmid:28117681 |
| Lim SC et al. | Ursodeoxycholic acid switches oxaliplatin-induced necrosis to apoptosis by inhibiting reactive oxygen species production and activating p53-caspase 8 pathway in HepG2 hepatocellular carcinoma. | 2010 | Int. J. Cancer | pmid:19728331 |
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| Fernández-Sánchez L et al. | Tauroursodeoxycholic acid prevents retinal degeneration in transgenic P23H rats. | 2011 | Invest. Ophthalmol. Vis. Sci. | pmid:21508111 |
| Drack AV et al. | TUDCA slows retinal degeneration in two different mouse models of retinitis pigmentosa and prevents obesity in Bardet-Biedl syndrome type 1 mice. | 2012 | Invest. Ophthalmol. Vis. Sci. | pmid:22110077 |
| Phillips MJ et al. | Tauroursodeoxycholic acid preservation of photoreceptor structure and function in the rd10 mouse through postnatal day 30. | 2008 | Invest. Ophthalmol. Vis. Sci. | pmid:18436848 |
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| Yanguas-Casás N et al. | Tauroursodeoxycholic acid reduces glial cell activation in an animal model of acute neuroinflammation. | 2014 | J Neuroinflammation | pmid:24645669 |
| Woo SJ et al. | Ursodeoxycholic acid and tauroursodeoxycholic acid suppress choroidal neovascularization in a laser-treated rat model. | 2010 | J Ocul Pharmacol Ther | pmid:20565307 |
| Simoni P et al. | A new point-of-care portable immunosensor for non-invasive assessment of oro-ileal transit time by oral fluid tauroursodeoxycholate measurement after its oral load. | 2013 Jul-Aug | J Pharm Biomed Anal | pmid:23587552 |
| Higuchi WI et al. | Estimation of cholesterol solubilization by a mixed micelle binding model in aqueous tauroursodeoxycholate:lecithin:cholesterol solutions. | 2008 | J Pharm Sci | pmid:17786967 |
| Fu J et al. | Endoplasmic reticulum stress is involved in 2,4-dichlorophenol-induced hepatotoxicity. | 2016 | J Toxicol Sci | pmid:27853103 |
| Cardoso I et al. | Synergy of combined doxycycline/TUDCA treatment in lowering Transthyretin deposition and associated biomarkers: studies in FAP mouse models. | 2010 | J Transl Med | pmid:20673327 |
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| Amaral JD et al. | p53 is a key molecular target of ursodeoxycholic acid in regulating apoptosis. | 2007 | J. Biol. Chem. | pmid:17881359 |