Tauroursodeoxycholic acid

Tauroursodeoxycholic acid is a lipid of Sterol Lipids (ST) class. Tauroursodeoxycholic acid is associated with abnormalities such as Hyperglycemia, Obesity, Wiskott-Aldrich Syndrome, neurogenic hypertension and Cholestatic liver disease. The involved functions are known as Cell Death, Apoptosis, Homeostasis, Process and mRNA Expression. Tauroursodeoxycholic acid often locates in Body tissue, Endoplasmic Reticulum, Hepatic, Blood and Protoplasm. The associated genes with Tauroursodeoxycholic acid are Homologous Gene and Mutant Proteins. The related lipids are cholanic acid, taurolithocholic acid 3-sulfate, Sterols, 7-dehydrocholesterol and tauromuricholic acid. The related experimental models are Disease model.

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Introduction

To understand associated biological information of Tauroursodeoxycholic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Tauroursodeoxycholic acid?

Tauroursodeoxycholic acid is suspected in Endothelial dysfunction, Hyperglycemia, Obesity, neurogenic hypertension, Cholestatic liver disease, Heart failure and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Tauroursodeoxycholic acid

MeSH term MeSH ID Detail
Insulin Resistance D007333 99 associated lipids
Hypertension D006973 115 associated lipids
Total 2

PubChem Associated disorders and diseases

What pathways are associated with Tauroursodeoxycholic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Tauroursodeoxycholic acid?

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Location Cross reference Weighted score Related literatures
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What functions are associated with Tauroursodeoxycholic acid?


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What lipids are associated with Tauroursodeoxycholic acid?

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What genes are associated with Tauroursodeoxycholic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Tauroursodeoxycholic acid?

Disease model

Disease model are used in the study 'Bile Acids Reduce Prion Conversion, Reduce Neuronal Loss, and Prolong Male Survival in Models of Prion Disease.' (Cortez LM et al., 2015).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Tauroursodeoxycholic acid

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Authors Title Published Journal PubMed Link
Chen W et al. Bile acids for viral hepatitis. 2003 Cochrane Database Syst Rev pmid:12804455
pmid:12769806
Häussinger D et al. Involvement of integrins and Src in tauroursodeoxycholate-induced and swelling-induced choleresis. 2003 Gastroenterology pmid:12730886
Rodrigues CM et al. Tauroursodeoxycholic acid reduces apoptosis and protects against neurological injury after acute hemorrhagic stroke in rats. 2003 Proc. Natl. Acad. Sci. U.S.A. pmid:12721362
pmid:12702047
Sánchez Pozzi EJ et al. Ursodeoxycholate reduces ethinylestradiol glucuronidation in the rat: role in prevention of estrogen-induced cholestasis. 2003 J. Pharmacol. Exp. Ther. pmid:12663690
Tsuboi K et al. Hydrophilic bile salts have a cytoprotective effect against cyclosporine A-induced cholestasis through enhanced canalicular membrane fluidity and transporter activity. 2003 Hepatol. Res. pmid:12644037
Rodrigues CM et al. Tauroursodeoxycholic acid prevents Bax-induced membrane perturbation and cytochrome C release in isolated mitochondria. 2003 Biochemistry pmid:12627974
Beuers U et al. Taurolithocholic acid exerts cholestatic effects via phosphatidylinositol 3-kinase-dependent mechanisms in perfused rat livers and rat hepatocyte couplets. 2003 J. Biol. Chem. pmid:12626520
Ma J et al. Inhibitory effects of ursodeoxycholic acid on the induction of nitric oxide synthase in vascular smooth muscle cells. 2003 Eur. J. Pharmacol. pmid:12620498