MeSH term | MeSH ID | Detail |
---|---|---|
Insulin Resistance | D007333 | 99 associated lipids |
Hypertension | D006973 | 115 associated lipids |
Tauroursodeoxycholic acid is a lipid of Sterol Lipids (ST) class. Tauroursodeoxycholic acid is associated with abnormalities such as Hyperglycemia, Obesity, Wiskott-Aldrich Syndrome, neurogenic hypertension and Cholestatic liver disease. The involved functions are known as Cell Death, Apoptosis, Homeostasis, Process and mRNA Expression. Tauroursodeoxycholic acid often locates in Body tissue, Endoplasmic Reticulum, Hepatic, Blood and Protoplasm. The associated genes with Tauroursodeoxycholic acid are Homologous Gene and Mutant Proteins. The related lipids are cholanic acid, taurolithocholic acid 3-sulfate, Sterols, 7-dehydrocholesterol and tauromuricholic acid. The related experimental models are Disease model.
To understand associated biological information of Tauroursodeoxycholic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Tauroursodeoxycholic acid is suspected in Endothelial dysfunction, Hyperglycemia, Obesity, neurogenic hypertension, Cholestatic liver disease, Heart failure and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Tauroursodeoxycholic acid
MeSH term | MeSH ID | Detail |
---|---|---|
Insulin Resistance | D007333 | 99 associated lipids |
Hypertension | D006973 | 115 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Disease model are used in the study 'Bile Acids Reduce Prion Conversion, Reduce Neuronal Loss, and Prolong Male Survival in Models of Prion Disease.' (Cortez LM et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Chen W et al. | Bile acids for viral hepatitis. | 2003 | Cochrane Database Syst Rev | pmid:12804455 |
pmid:12769806 | ||||
Häussinger D et al. | Involvement of integrins and Src in tauroursodeoxycholate-induced and swelling-induced choleresis. | 2003 | Gastroenterology | pmid:12730886 |
Rodrigues CM et al. | Tauroursodeoxycholic acid reduces apoptosis and protects against neurological injury after acute hemorrhagic stroke in rats. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12721362 |
pmid:12702047 | ||||
Sánchez Pozzi EJ et al. | Ursodeoxycholate reduces ethinylestradiol glucuronidation in the rat: role in prevention of estrogen-induced cholestasis. | 2003 | J. Pharmacol. Exp. Ther. | pmid:12663690 |
Tsuboi K et al. | Hydrophilic bile salts have a cytoprotective effect against cyclosporine A-induced cholestasis through enhanced canalicular membrane fluidity and transporter activity. | 2003 | Hepatol. Res. | pmid:12644037 |
Rodrigues CM et al. | Tauroursodeoxycholic acid prevents Bax-induced membrane perturbation and cytochrome C release in isolated mitochondria. | 2003 | Biochemistry | pmid:12627974 |
Beuers U et al. | Taurolithocholic acid exerts cholestatic effects via phosphatidylinositol 3-kinase-dependent mechanisms in perfused rat livers and rat hepatocyte couplets. | 2003 | J. Biol. Chem. | pmid:12626520 |
Ma J et al. | Inhibitory effects of ursodeoxycholic acid on the induction of nitric oxide synthase in vascular smooth muscle cells. | 2003 | Eur. J. Pharmacol. | pmid:12620498 |