| MeSH term | MeSH ID | Detail |
|---|---|---|
| Insulin Resistance | D007333 | 99 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
Total
2
Tauroursodeoxycholic acid
Tauroursodeoxycholic acid is a lipid of Sterol Lipids (ST) class. Tauroursodeoxycholic acid is associated with abnormalities such as Hyperglycemia, Obesity, Wiskott-Aldrich Syndrome, neurogenic hypertension and Cholestatic liver disease. The involved functions are known as Cell Death, Apoptosis, Homeostasis, Process and mRNA Expression. Tauroursodeoxycholic acid often locates in Body tissue, Endoplasmic Reticulum, Hepatic, Blood and Protoplasm. The associated genes with Tauroursodeoxycholic acid are Homologous Gene and Mutant Proteins. The related lipids are cholanic acid, taurolithocholic acid 3-sulfate, Sterols, 7-dehydrocholesterol and tauromuricholic acid. The related experimental models are Disease model.
Cross Reference
Introduction
To understand associated biological information of Tauroursodeoxycholic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Tauroursodeoxycholic acid?
Tauroursodeoxycholic acid is suspected in Endothelial dysfunction, Hyperglycemia, Obesity, neurogenic hypertension, Cholestatic liver disease, Heart failure and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Tauroursodeoxycholic acid
PubChem Associated disorders and diseases
What pathways are associated with Tauroursodeoxycholic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Tauroursodeoxycholic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Tauroursodeoxycholic acid?
Disease model
Disease model are used in the study 'Bile Acids Reduce Prion Conversion, Reduce Neuronal Loss, and Prolong Male Survival in Models of Prion Disease.' (Cortez LM et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Tauroursodeoxycholic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Dikkers A et al. | Scavenger receptor BI and ABCG5/G8 differentially impact biliary sterol secretion and reverse cholesterol transport in mice. | 2013 | Hepatology | pmid:23401258 |
| Pandak WM et al. | Regulation of oxysterol 7alpha-hydroxylase (CYP7B1) in primary cultures of rat hepatocytes. | 2002 | Hepatology | pmid:12029625 |
| Azzaroli F et al. | Ursodeoxycholic acid diminishes Fas-ligand-induced apoptosis in mouse hepatocytes. | 2002 | Hepatology | pmid:12085348 |
| Gohlke H et al. | α5 β1-integrins are sensors for tauroursodeoxycholic acid in hepatocytes. | 2013 | Hepatology | pmid:22865233 |
| Cruz LN et al. | Regulation of multidrug resistance-associated protein 2 by calcium signaling in mouse liver. | 2010 | Hepatology | pmid:20578149 |
| Lawless MW et al. | Tauroursodeoxycholic acid: relieving the pathogenesis of HFE C282Y hereditary hemochromatosis. | 2008 | Hepatology | pmid:18203149 |
| Schoemaker MH et al. | Tauroursodeoxycholic acid protects rat hepatocytes from bile acid-induced apoptosis via activation of survival pathways. | 2004 | Hepatology | pmid:15185297 |
| Mühlfeld S et al. | Short-term feedback regulation of bile salt uptake by bile salts in rodent liver. | 2012 | Hepatology | pmid:22806967 |
| Kitani K et al. | Tauro alpha-muricholate is as effective as tauro beta-muricholate and tauroursodeoxycholate in preventing taurochenodeoxycholate-induced liver damage in the rat. | 1994 | Hepatology | pmid:8138240 |
| Loria P et al. | Effect of taurohyodeoxycholic acid on biliary lipid secretion in humans. | 1997 | Hepatology | pmid:9185744 |
| Krähenbühl S et al. | Ursodeoxycholate protects oxidative mitochondrial metabolism from bile acid toxicity: dose-response study in isolated rat liver mitochondria. | 1994 | Hepatology | pmid:7982660 |
| Pak JM and Lee SS | Vasoactive effects of bile salts in cirrhotic rats: in vivo and in vitro studies. | 1993 | Hepatology | pmid:8225224 |
| Ohiwa T et al. | Tauroursodeoxycholate and tauro-beta-muricholate exert cytoprotection by reducing intrahepatocyte taurochenodeoxycholate content. | 1993 | Hepatology | pmid:8383089 |
| Beuers U | β1 integrin is a long-sought sensor for tauroursodeoxycholic acid. | 2013 | Hepatology | pmid:23456677 |
| Colell A et al. | Tauroursodeoxycholic acid protects hepatocytes from ethanol-fed rats against tumor necrosis factor-induced cell death by replenishing mitochondrial glutathione. | 2001 | Hepatology | pmid:11679967 |
| Xie Q et al. | Effect of tauroursodeoxycholic acid on endoplasmic reticulum stress-induced caspase-12 activation. | 2002 | Hepatology | pmid:12198651 |
| Sakisaka S et al. | Tubulovesicular transport of horseradish peroxidase in isolated rat hepatocyte couplets: effects of low temperature, cytochalasin B and bile acids. | 1994 | Hepatology | pmid:7927203 |
| Miller SD et al. | Tauroursodeoxycholic acid inhibits apoptosis induced by Z alpha-1 antitrypsin via inhibition of Bad. | 2007 | Hepatology | pmid:17559149 |
| Alpini G et al. | Ursodeoxycholate and tauroursodeoxycholate inhibit cholangiocyte growth and secretion of BDL rats through activation of PKC alpha. | 2002 | Hepatology | pmid:11981754 |
| Wei H et al. | ER and oxidative stresses are common mediators of apoptosis in both neurodegenerative and non-neurodegenerative lysosomal storage disorders and are alleviated by chemical chaperones. | 2008 | Hum. Mol. Genet. | pmid:17989065 |
| Galán M et al. | A novel role for epidermal growth factor receptor tyrosine kinase and its downstream endoplasmic reticulum stress in cardiac damage and microvascular dysfunction in type 1 diabetes mellitus. | 2012 | Hypertension | pmid:22665120 |
| Peterson TC et al. | The inhibitory effect of ursodeoxycholic acid and pentoxifylline on platelet derived growth factor-stimulated proliferation is distinct from an effect by cyclic AMP. | 1998 | Immunopharmacology | pmid:9754904 |
| Fulda S et al. | Cellular stress responses: cell survival and cell death. | 2010 | Int J Cell Biol | pmid:20182529 |
| Dong Y et al. | Neuroprotective effects and impact on caspase-12 expression of tauroursodeoxycholic acid after acute spinal cord injury in rats. | 2015 | Int J Clin Exp Pathol | pmid:26884858 |
| Paridaens A et al. | Modulation of the Unfolded Protein Response by Tauroursodeoxycholic Acid Counteracts Apoptotic Cell Death and Fibrosis in a Mouse Model for Secondary Biliary Liver Fibrosis. | 2017 | Int J Mol Sci | pmid:28117681 |
| Lim SC et al. | Ursodeoxycholic acid switches oxaliplatin-induced necrosis to apoptosis by inhibiting reactive oxygen species production and activating p53-caspase 8 pathway in HepG2 hepatocellular carcinoma. | 2010 | Int. J. Cancer | pmid:19728331 |
| Boost KA et al. | c-Met responsiveness of isolated hepatocytes evaluated in an in vitro de-differentiation model. | 2006 | Int. J. Mol. Med. | pmid:16465395 |
| Fernández-Sánchez L et al. | Tauroursodeoxycholic acid prevents retinal degeneration in transgenic P23H rats. | 2011 | Invest. Ophthalmol. Vis. Sci. | pmid:21508111 |
| Drack AV et al. | TUDCA slows retinal degeneration in two different mouse models of retinitis pigmentosa and prevents obesity in Bardet-Biedl syndrome type 1 mice. | 2012 | Invest. Ophthalmol. Vis. Sci. | pmid:22110077 |
| Phillips MJ et al. | Tauroursodeoxycholic acid preservation of photoreceptor structure and function in the rd10 mouse through postnatal day 30. | 2008 | Invest. Ophthalmol. Vis. Sci. | pmid:18436848 |
| Zhang T et al. | Chemical chaperone TUDCA preserves cone photoreceptors in a mouse model of Leber congenital amaurosis. | 2012 | Invest. Ophthalmol. Vis. Sci. | pmid:22531707 |
| Qiao X et al. | Differentiation of various traditional Chinese medicines derived from animal bile and gallstone: simultaneous determination of bile acids by liquid chromatography coupled with triple quadrupole mass spectrometry. | 2011 | J Chromatogr A | pmid:21111425 |
| Kanazawa I | Therapeutic Strategies in Huntington's Disease. | 2006 | J Clin Neurol | pmid:20396523 |
| Colak A et al. | Tauroursodeoxycholic acid and secondary damage after spinal cord injury in rats. | 2008 | J Clin Neurosci | pmid:18343118 |
| Bikbova G et al. | Altered Expression of NF- κ B and SP1 after Exposure to Advanced Glycation End-Products and Effects of Neurotrophic Factors in AGEs Exposed Rat Retinas. | 2015 | J Diabetes Res | pmid:26078979 |
| Feng Y et al. | Bear bile: dilemma of traditional medicinal use and animal protection. | 2009 | J Ethnobiol Ethnomed | pmid:19138420 |
| Noailles A et al. | Microglia activation in a model of retinal degeneration and TUDCA neuroprotective effects. | 2014 | J Neuroinflammation | pmid:25359524 |
| Yanguas-Casás N et al. | Tauroursodeoxycholic acid reduces glial cell activation in an animal model of acute neuroinflammation. | 2014 | J Neuroinflammation | pmid:24645669 |
| Woo SJ et al. | Ursodeoxycholic acid and tauroursodeoxycholic acid suppress choroidal neovascularization in a laser-treated rat model. | 2010 | J Ocul Pharmacol Ther | pmid:20565307 |
| Simoni P et al. | A new point-of-care portable immunosensor for non-invasive assessment of oro-ileal transit time by oral fluid tauroursodeoxycholate measurement after its oral load. | 2013 Jul-Aug | J Pharm Biomed Anal | pmid:23587552 |
| Higuchi WI et al. | Estimation of cholesterol solubilization by a mixed micelle binding model in aqueous tauroursodeoxycholate:lecithin:cholesterol solutions. | 2008 | J Pharm Sci | pmid:17786967 |
| Fu J et al. | Endoplasmic reticulum stress is involved in 2,4-dichlorophenol-induced hepatotoxicity. | 2016 | J Toxicol Sci | pmid:27853103 |
| Cardoso I et al. | Synergy of combined doxycycline/TUDCA treatment in lowering Transthyretin deposition and associated biomarkers: studies in FAP mouse models. | 2010 | J Transl Med | pmid:20673327 |
| Cursio R and Gugenheim J | Ischemia-Reperfusion Injury and Ischemic-Type Biliary Lesions following Liver Transplantation. | 2012 | J Transplant | pmid:22530107 |
| Viana RJ et al. | Modulation of amyloid-β peptide-induced toxicity through inhibition of JNK nuclear localization and caspase-2 activation. | 2010 | J. Alzheimers Dis. | pmid:20847398 |
| Fonseca MB et al. | c-Jun regulates the stability of anti-apoptotic ΔNp63 in amyloid-β-induced apoptosis. | 2012 | J. Alzheimers Dis. | pmid:22045494 |
| Viana RJ et al. | Amyloid-β peptide-induced secretion of endoplasmic reticulum chaperone glycoprotein GRP94. | 2011 | J. Alzheimers Dis. | pmid:21750376 |
| de Almeida SF et al. | Chemical chaperones reduce endoplasmic reticulum stress and prevent mutant HFE aggregate formation. | 2007 | J. Biol. Chem. | pmid:17626021 |
| Sabeva NS et al. | Defects in the leptin axis reduce abundance of the ABCG5-ABCG8 sterol transporter in liver. | 2007 | J. Biol. Chem. | pmid:17561514 |
| Schmidt DR et al. | Regulation of bile acid synthesis by fat-soluble vitamins A and D. | 2010 | J. Biol. Chem. | pmid:20233723 |