MeSH term | MeSH ID | Detail |
---|---|---|
Hypertension | D006973 | 115 associated lipids |
Insulin Resistance | D007333 | 99 associated lipids |
Tauroursodeoxycholic acid is a lipid of Sterol Lipids (ST) class. Tauroursodeoxycholic acid is associated with abnormalities such as Hyperglycemia, Obesity, Wiskott-Aldrich Syndrome, neurogenic hypertension and Cholestatic liver disease. The involved functions are known as Cell Death, Apoptosis, Homeostasis, Process and mRNA Expression. Tauroursodeoxycholic acid often locates in Body tissue, Endoplasmic Reticulum, Hepatic, Blood and Protoplasm. The associated genes with Tauroursodeoxycholic acid are Homologous Gene and Mutant Proteins. The related lipids are cholanic acid, taurolithocholic acid 3-sulfate, Sterols, 7-dehydrocholesterol and tauromuricholic acid. The related experimental models are Disease model.
To understand associated biological information of Tauroursodeoxycholic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Tauroursodeoxycholic acid is suspected in Endothelial dysfunction, Hyperglycemia, Obesity, neurogenic hypertension, Cholestatic liver disease, Heart failure and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Tauroursodeoxycholic acid
MeSH term | MeSH ID | Detail |
---|---|---|
Hypertension | D006973 | 115 associated lipids |
Insulin Resistance | D007333 | 99 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Disease model are used in the study 'Bile Acids Reduce Prion Conversion, Reduce Neuronal Loss, and Prolong Male Survival in Models of Prion Disease.' (Cortez LM et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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pmid: | ||||
Eckhardt U et al. | Polyspecific substrate uptake by the hepatic organic anion transporter Oatp1 in stably transfected CHO cells. | 1999 | Am. J. Physiol. | pmid:10198348 |
Funaoka M et al. | Tauroursodeoxycholic acid enhances phagocytosis of the cultured rat Kupffer cell. | 1999 | J. Gastroenterol. Hepatol. | pmid:10440209 |
Hertl M et al. | Tauroursodeoxycholate ameliorates reperfusion injury after pig liver transplantation. | 1999 | Transpl. Int. | pmid:10654358 |
Benz C et al. | Effect of tauroursodeoxycholic acid on bile acid-induced apoptosis in primary human hepatocytes. | 2000 | Eur. J. Clin. Invest. | pmid:10691996 |
Falasca L et al. | Tauroursodeoxycholate reduces ischemic damage in human allografts: a biochemical and ultrastructural study. | 2000 | Transplant. Proc. | pmid:10700964 |
Kurz AK et al. | Phosphoinositide 3-kinase-dependent Ras activation by tauroursodesoxycholate in rat liver. | 2000 | Biochem. J. | pmid:10926845 |
Rodrigues CM et al. | Tauroursodeoxycholic acid partially prevents apoptosis induced by 3-nitropropionic acid: evidence for a mitochondrial pathway independent of the permeability transition. | 2000 | J. Neurochem. | pmid:11080188 |
Rodrigues CM et al. | Amyloid beta-peptide disrupts mitochondrial membrane lipid and protein structure: protective role of tauroursodeoxycholate. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11181071 |
Chignard N et al. | Bile acid transport and regulating functions in the human biliary epithelium. | 2001 | Hepatology | pmid:11230727 |