| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypertension | D006973 | 115 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
Total
2
Tauroursodeoxycholic acid
Tauroursodeoxycholic acid is a lipid of Sterol Lipids (ST) class. Tauroursodeoxycholic acid is associated with abnormalities such as Hyperglycemia, Obesity, Wiskott-Aldrich Syndrome, neurogenic hypertension and Cholestatic liver disease. The involved functions are known as Cell Death, Apoptosis, Homeostasis, Process and mRNA Expression. Tauroursodeoxycholic acid often locates in Body tissue, Endoplasmic Reticulum, Hepatic, Blood and Protoplasm. The associated genes with Tauroursodeoxycholic acid are Homologous Gene and Mutant Proteins. The related lipids are cholanic acid, taurolithocholic acid 3-sulfate, Sterols, 7-dehydrocholesterol and tauromuricholic acid. The related experimental models are Disease model.
Cross Reference
Introduction
To understand associated biological information of Tauroursodeoxycholic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Tauroursodeoxycholic acid?
Tauroursodeoxycholic acid is suspected in Endothelial dysfunction, Hyperglycemia, Obesity, neurogenic hypertension, Cholestatic liver disease, Heart failure and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Diabetes (3)
- Am. J. Physiol. Heart Circ. Physiol. (1)
- Am. J. Physiol. Lung Cell Mol. Physiol. (1)
- Others (5)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Tauroursodeoxycholic acid
PubChem Associated disorders and diseases
What pathways are associated with Tauroursodeoxycholic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Tauroursodeoxycholic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Tauroursodeoxycholic acid?
Disease model
Disease model are used in the study 'Bile Acids Reduce Prion Conversion, Reduce Neuronal Loss, and Prolong Male Survival in Models of Prion Disease.' (Cortez LM et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Tauroursodeoxycholic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Eckhardt U et al. | Polyspecific substrate uptake by the hepatic organic anion transporter Oatp1 in stably transfected CHO cells. | 1999 | Am. J. Physiol. | pmid:10198348 |
| Funaoka M et al. | Tauroursodeoxycholic acid enhances phagocytosis of the cultured rat Kupffer cell. | 1999 | J. Gastroenterol. Hepatol. | pmid:10440209 |
| Hertl M et al. | Tauroursodeoxycholate ameliorates reperfusion injury after pig liver transplantation. | 1999 | Transpl. Int. | pmid:10654358 |
| Benz C et al. | Effect of tauroursodeoxycholic acid on bile acid-induced apoptosis in primary human hepatocytes. | 2000 | Eur. J. Clin. Invest. | pmid:10691996 |
| Falasca L et al. | Tauroursodeoxycholate reduces ischemic damage in human allografts: a biochemical and ultrastructural study. | 2000 | Transplant. Proc. | pmid:10700964 |
| Kurz AK et al. | Phosphoinositide 3-kinase-dependent Ras activation by tauroursodesoxycholate in rat liver. | 2000 | Biochem. J. | pmid:10926845 |
| Rodrigues CM et al. | Tauroursodeoxycholic acid partially prevents apoptosis induced by 3-nitropropionic acid: evidence for a mitochondrial pathway independent of the permeability transition. | 2000 | J. Neurochem. | pmid:11080188 |
| Rodrigues CM et al. | Amyloid beta-peptide disrupts mitochondrial membrane lipid and protein structure: protective role of tauroursodeoxycholate. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11181071 |
| Chignard N et al. | Bile acid transport and regulating functions in the human biliary epithelium. | 2001 | Hepatology | pmid:11230727 |
| Milkiewicz P et al. | Effect of tauroursodeoxycholate and S-adenosyl-L-methionine on 17beta-estradiol glucuronide-induced cholestasis. | 2001 | J. Hepatol. | pmid:11281545 |
| Ejiri S et al. | Cellular distribution of thrombomodulin as an early marker for warm ischemic liver injury in porcine liver transplantation: protective effect of prostaglandin I2 analogue and tauroursodeoxycholic acid. | 2001 | Transplantation | pmid:11330532 |
| Beuers U et al. | Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C-dependent mechanisms in cholestatic rat liver. | 2001 | Hepatology | pmid:11343250 |
| Moschetta A et al. | Hydrophilic bile salts enhance differential distribution of sphingomyelin and phosphatidylcholine between micellar and vesicular phases: potential implications for their effects in vivo. | 2001 | J. Hepatol. | pmid:11394647 |
| Falasca L et al. | Protective role of tauroursodeoxycholate during harvesting and cold storage of human liver: a pilot study in transplant recipients. | 2001 | Transplantation | pmid:11397961 |
| Ishizaki K et al. | Effect of sodium tauroursodeoxycholate on phalloidin-induced cholestasis in rats. | 2001 | Eur. J. Pharmacol. | pmid:11408049 |
| Calmus Y and Podevin P | Tauroursodeoxycholic acid for the cytoprotection of liver grafts during cold storage: a new aspect of its anti-apoptotic properties? | 2001 | Transplantation | pmid:11408962 |
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| Crocenzi FA et al. | Beneficial effects of silymarin on estrogen-induced cholestasis in the rat: a study in vivo and in isolated hepatocyte couplets. | 2001 | Hepatology | pmid:11481618 |
| Moschetta A et al. | Cholesterol crystallization in model biles: effects of bile salt and phospholipid species composition. | 2001 | J. Lipid Res. | pmid:11483629 |
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| Nathanson MH et al. | Stimulation of ATP secretion in the liver by therapeutic bile acids. | 2001 | Biochem. J. | pmid:11485545 |
| Kurz AK et al. | Tauroursodesoxycholate-induced choleresis involves p38(MAPK) activation and translocation of the bile salt export pump in rats. | 2001 | Gastroenterology | pmid:11487550 |
| Piazza F et al. | Competition in liver transport between chenodeoxycholic acid and ursodeoxycholic acid as a mechanism for ursodeoxycholic acid and its amidates' protection of liver damage induced by chenodeoxycholic acid. | 2000 | Dig Liver Dis | pmid:11515630 |
| Keene CD et al. | A bile acid protects against motor and cognitive deficits and reduces striatal degeneration in the 3-nitropropionic acid model of Huntington's disease. | 2001 | Exp. Neurol. | pmid:11573988 |
| Asamoto Y et al. | Bile-salt hydrophobicity is a key factor regulating rat liver plasma-membrane communication: relation to bilayer structure, fluidity and transporter expression and function. | 2001 | Biochem. J. | pmid:11672435 |
| Colell A et al. | Tauroursodeoxycholic acid protects hepatocytes from ethanol-fed rats against tumor necrosis factor-induced cell death by replenishing mitochondrial glutathione. | 2001 | Hepatology | pmid:11679967 |
| Ishigami F et al. | Bile salt tauroursodeoxycholic acid modulation of Bax translocation to mitochondria protects the liver from warm ischemia-reperfusion injury in the rat. | 2001 | Transplantation | pmid:11740392 |
| Rodrigues CM et al. | Neuroprotection by a bile acid in an acute stroke model in the rat. | 2002 | J. Cereb. Blood Flow Metab. | pmid:11919517 |
| Carubbi F et al. | Comparative cytotoxic and cytoprotective effects of taurohyodeoxycholic acid (THDCA) and tauroursodeoxycholic acid (TUDCA) in HepG2 cell line. | 2002 | Biochim. Biophys. Acta | pmid:11923098 |
| Alpini G et al. | Ursodeoxycholate and tauroursodeoxycholate inhibit cholangiocyte growth and secretion of BDL rats through activation of PKC alpha. | 2002 | Hepatology | pmid:11981754 |
| Graf D et al. | Taurolithocholic acid-3 sulfate induces CD95 trafficking and apoptosis in a c-Jun N-terminal kinase-dependent manner. | 2002 | Gastroenterology | pmid:11984527 |
| Veggi LM et al. | Dapsone-induced cholestasis and impairment of bile salt output in the rat. | 2002 | Biochem. Pharmacol. | pmid:11996898 |
| Pandak WM et al. | Regulation of oxysterol 7alpha-hydroxylase (CYP7B1) in primary cultures of rat hepatocytes. | 2002 | Hepatology | pmid:12029625 |
| Glasova H et al. | Tauroursodeoxycholic acid mobilizes alpha-PKC after uptake in human HepG2 hepatoma cells. | 2002 | Eur. J. Clin. Invest. | pmid:12059989 |
| Xiao ZL et al. | Effects of bile acids on the muscle functions of guinea pig gallbladder. | 2002 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12065295 |
| Duan WM et al. | Tauroursodeoxycholic acid improves the survival and function of nigral transplants in a rat model of Parkinson's disease. | 2002 | Cell Transplant | pmid:12075985 |
| Milkiewicz P et al. | Hepatoprotection with tauroursodeoxycholate and beta muricholate against taurolithocholate induced cholestasis: involvement of signal transduction pathways. | 2002 | Gut | pmid:12077103 |
| Azzaroli F et al. | Ursodeoxycholic acid diminishes Fas-ligand-induced apoptosis in mouse hepatocytes. | 2002 | Hepatology | pmid:12085348 |
| Kim YH and Shin MJ | Effects of high taurocholate load on activities of hepatic alcohol metabolizing enzymes. | 2002 | Exp. Mol. Med. | pmid:12085987 |
| Venneman NG et al. | Effects of hydrophobic and hydrophilic bile salt mixtures on cholesterol crystallization in model biles. | 2002 | Biochim. Biophys. Acta | pmid:12117566 |
| Keene CD et al. | Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12149470 |
| Yamashita Y et al. | High metabolic function of primary human and porcine hepatocytes in a polyurethane foam/spheroid culture system in plasma from patients with fulminant hepatic failure. | 2002 | Cell Transplant | pmid:12162378 |
| Heubi JE et al. | Tauroursodeoxycholic acid (TUDCA) in the prevention of total parenteral nutrition-associated liver disease. | 2002 | J. Pediatr. | pmid:12183720 |
| Xie Q et al. | Effect of tauroursodeoxycholic acid on endoplasmic reticulum stress-induced caspase-12 activation. | 2002 | Hepatology | pmid:12198651 |
| Piepoli AL et al. | Tauroursodeoxycholic acid reduces damaging effects of taurodeoxycholic acid on fundus gastric mucosa. | 2002 | Arch. Physiol. Biochem. | pmid:12221520 |
| Kok T et al. | Peroxisome proliferator-activated receptor alpha (PPARalpha)-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in mice. | 2003 | Biochem. J. | pmid:12381268 |
| Noé J et al. | Functional expression of the canalicular bile salt export pump of human liver. | 2002 | Gastroenterology | pmid:12404240 |
| Chignard N et al. | Bile salts potentiate adenylyl cyclase activity and cAMP-regulated secretion in human gallbladder epithelium. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12421748 |
| Lamireau T et al. | Effects of bile acids on biliary epithelial cells: proliferation, cytotoxicity, and cytokine secretion. | 2003 | Life Sci. | pmid:12527037 |
| Baiocchi L et al. | Taurohyodeoxycholate- and tauroursodeoxycholate-induced hypercholeresis is augmented in bile duct ligated rats. | 2003 | J. Hepatol. | pmid:12547401 |
| Ma J et al. | Inhibitory effects of ursodeoxycholic acid on the induction of nitric oxide synthase in vascular smooth muscle cells. | 2003 | Eur. J. Pharmacol. | pmid:12620498 |
| Beuers U et al. | Taurolithocholic acid exerts cholestatic effects via phosphatidylinositol 3-kinase-dependent mechanisms in perfused rat livers and rat hepatocyte couplets. | 2003 | J. Biol. Chem. | pmid:12626520 |
| Rodrigues CM et al. | Tauroursodeoxycholic acid prevents Bax-induced membrane perturbation and cytochrome C release in isolated mitochondria. | 2003 | Biochemistry | pmid:12627974 |
| Tsuboi K et al. | Hydrophilic bile salts have a cytoprotective effect against cyclosporine A-induced cholestasis through enhanced canalicular membrane fluidity and transporter activity. | 2003 | Hepatol. Res. | pmid:12644037 |
| Sánchez Pozzi EJ et al. | Ursodeoxycholate reduces ethinylestradiol glucuronidation in the rat: role in prevention of estrogen-induced cholestasis. | 2003 | J. Pharmacol. Exp. Ther. | pmid:12663690 |
| pmid:12702047 | ||||
| Rodrigues CM et al. | Tauroursodeoxycholic acid reduces apoptosis and protects against neurological injury after acute hemorrhagic stroke in rats. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12721362 |
| Häussinger D et al. | Involvement of integrins and Src in tauroursodeoxycholate-induced and swelling-induced choleresis. | 2003 | Gastroenterology | pmid:12730886 |
| pmid:12769806 | ||||
| Chen W et al. | Bile acids for viral hepatitis. | 2003 | Cochrane Database Syst Rev | pmid:12804455 |
| pmid:12825132 | ||||
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| Kubitz R et al. | Trafficking of the bile salt export pump from the Golgi to the canalicular membrane is regulated by the p38 MAP kinase. | 2004 | Gastroenterology | pmid:14762791 |
| pmid:14965230 | ||||
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| pmid:15057918 | ||||
| Schoemaker MH et al. | Tauroursodeoxycholic acid protects rat hepatocytes from bile acid-induced apoptosis via activation of survival pathways. | 2004 | Hepatology | pmid:15185297 |
| Castro RE et al. | The bile acid tauroursodeoxycholic acid modulates phosphorylation and translocation of bad via phosphatidylinositol 3-kinase in glutamate-induced apoptosis of rat cortical neurons. | 2004 | J. Pharmacol. Exp. Ther. | pmid:15190125 |
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| Ramalho RM et al. | Inhibition of the E2F-1/p53/Bax pathway by tauroursodeoxycholic acid in amyloid beta-peptide-induced apoptosis of PC12 cells. | 2004 | J. Neurochem. | pmid:15255934 |
| Mita S et al. | Vectorial transport of bile salts across MDCK cells expressing both rat Na+-taurocholate cotransporting polypeptide and rat bile salt export pump. | 2005 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:15297262 |
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| pmid:15312152 | ||||
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| pmid:15652244 | ||||
| Pusl T et al. | Gap junctional intercellular communication is not needed for the anticholestatic effect of tauroursodeoxycholic acid in mouse liver. | 2005 | J. Hepatol. | pmid:15763348 |
| pmid:15810635 | ||||
| Crocenzi FA et al. | Prevention of Mrp2 activity impairment in ethinylestradiol-induced cholestasis by ursodeoxycholate in the rat. | 2005 | Drug Metab. Dispos. | pmid:15843489 |
| Takayanagi M et al. | Biliary excretion of olmesartan, an anigotensin II receptor antagonist, in the rat. | 2005 | J. Gastroenterol. Hepatol. | pmid:15853995 |
| Wang L et al. | Activation of CREB by tauroursodeoxycholic acid protects cholangiocytes from apoptosis induced by mTOR inhibition. | 2005 | Hepatology | pmid:15861431 |
| pmid:15869421 | ||||
| Cai W et al. | Interferon-alpha-induced modulation of glucocorticoid and serotonin receptors as a mechanism of depression. | 2005 | J. Hepatol. | pmid:15885359 |
| Castro RE et al. | A distinct microarray gene expression profile in primary rat hepatocytes incubated with ursodeoxycholic acid. | 2005 | J. Hepatol. | pmid:15885361 |
| pmid:15910498 | ||||
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