| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypertension | D006973 | 115 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
Total
2
Tauroursodeoxycholic acid
Tauroursodeoxycholic acid is a lipid of Sterol Lipids (ST) class. Tauroursodeoxycholic acid is associated with abnormalities such as Hyperglycemia, Obesity, Wiskott-Aldrich Syndrome, neurogenic hypertension and Cholestatic liver disease. The involved functions are known as Cell Death, Apoptosis, Homeostasis, Process and mRNA Expression. Tauroursodeoxycholic acid often locates in Body tissue, Endoplasmic Reticulum, Hepatic, Blood and Protoplasm. The associated genes with Tauroursodeoxycholic acid are Homologous Gene and Mutant Proteins. The related lipids are cholanic acid, taurolithocholic acid 3-sulfate, Sterols, 7-dehydrocholesterol and tauromuricholic acid. The related experimental models are Disease model.
Cross Reference
Introduction
To understand associated biological information of Tauroursodeoxycholic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Tauroursodeoxycholic acid?
Tauroursodeoxycholic acid is suspected in Endothelial dysfunction, Hyperglycemia, Obesity, neurogenic hypertension, Cholestatic liver disease, Heart failure and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Diabetes (3)
- Am. J. Physiol. Heart Circ. Physiol. (1)
- Am. J. Physiol. Lung Cell Mol. Physiol. (1)
- Others (5)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Tauroursodeoxycholic acid
PubChem Associated disorders and diseases
What pathways are associated with Tauroursodeoxycholic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Tauroursodeoxycholic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Tauroursodeoxycholic acid?
Disease model
Disease model are used in the study 'Bile Acids Reduce Prion Conversion, Reduce Neuronal Loss, and Prolong Male Survival in Models of Prion Disease.' (Cortez LM et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Tauroursodeoxycholic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Liu Y et al. | Quercetin induces protective autophagy and apoptosis through ER stress via the p-STAT3/Bcl-2 axis in ovarian cancer. | 2017 | Apoptosis | pmid:28188387 |
| Fernández-Sánchez L et al. | Controlled delivery of tauroursodeoxycholic acid from biodegradable microspheres slows retinal degeneration and vision loss in P23H rats. | 2017 | PLoS ONE | pmid:28542454 |
| Rani S et al. | Tauroursodeoxycholic acid (TUDCA) attenuates pressure overload-induced cardiac remodeling by reducing endoplasmic reticulum stress. | 2017 | PLoS ONE | pmid:28426781 |
| Paridaens A et al. | Modulation of the Unfolded Protein Response by Tauroursodeoxycholic Acid Counteracts Apoptotic Cell Death and Fibrosis in a Mouse Model for Secondary Biliary Liver Fibrosis. | 2017 | Int J Mol Sci | pmid:28117681 |
| Xie C et al. | An Intestinal Farnesoid X Receptor-Ceramide Signaling Axis Modulates Hepatic Gluconeogenesis in Mice. | 2017 | Diabetes | pmid:28223344 |
| Cheang WS et al. | PPARδ Is Required for Exercise to Attenuate Endoplasmic Reticulum Stress and Endothelial Dysfunction in Diabetic Mice. | 2017 | Diabetes | pmid:27856609 |
| Guo Q et al. | Fibroblast growth factor 21 reverses suppression of adiponectin expression via inhibiting endoplasmic reticulum stress in adipose tissue of obese mice. | 2017 | Exp. Biol. Med. (Maywood) | pmid:27811171 |
| Contreras C et al. | Reduction of Hypothalamic Endoplasmic Reticulum Stress Activates Browning of White Fat and Ameliorates Obesity. | 2017 | Diabetes | pmid:27634226 |
| Zhang J et al. | Baicalin protects AML-12 cells from lipotoxicity via the suppression of ER stress and TXNIP/NLRP3 inflammasome activation. | 2017 | Chem. Biol. Interact. | pmid:29031535 |
| Wong MK et al. | Nicotine Directly Induces Endoplasmic Reticulum Stress Response in Rat Placental Trophoblast Giant Cells. | 2016 | Toxicol. Sci. | pmid:26803847 |
| Keune WJ et al. | Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling. | 2016 | Nat Commun | pmid:27075612 |
| Fu J et al. | Endoplasmic reticulum stress is involved in 2,4-dichlorophenol-induced hepatotoxicity. | 2016 | J Toxicol Sci | pmid:27853103 |
| Guo H et al. | Endoplasmic Reticulum Chaperon Tauroursodeoxycholic Acid Attenuates Aldosterone-Infused Renal Injury. | 2016 | Mediators Inflamm. | pmid:27721575 |
| Zhang J et al. | Tauroursodeoxycholic Acid Attenuates Renal Tubular Injury in a Mouse Model of Type 2 Diabetes. | 2016 | Nutrients | pmid:27669287 |
| Walsh LK et al. | Administration of tauroursodeoxycholic acid prevents endothelial dysfunction caused by an oral glucose load. | 2016 | Clin. Sci. | pmid:27503949 |
| Wei SG et al. | Endoplasmic reticulum stress increases brain MAPK signaling, inflammation and renin-angiotensin system activity and sympathetic nerve activity in heart failure. | 2016 | Am. J. Physiol. Heart Circ. Physiol. | pmid:27496879 |
| Groenendyk J et al. | Inhibition of the Unfolded Protein Response Mechanism Prevents Cardiac Fibrosis. | 2016 | PLoS ONE | pmid:27441395 |
| Yung HW et al. | Placental endoplasmic reticulum stress in gestational diabetes: the potential for therapeutic intervention with chemical chaperones and antioxidants. | 2016 | Diabetologia | pmid:27406815 |
| Kim GW et al. | Calorie-induced ER stress suppresses uroguanylin satiety signaling in diet-induced obesity. | 2016 | Nutr Diabetes | pmid:27214655 |
| Siddesha JM et al. | Effect of a chemical chaperone, tauroursodeoxycholic acid, on HDM-induced allergic airway disease. | 2016 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:27154200 |
| Memme JM et al. | Chronology of UPR activation in skeletal muscle adaptations to chronic contractile activity. | 2016 | Am. J. Physiol., Cell Physiol. | pmid:27122157 |
| Keestra-Gounder AM et al. | NOD1 and NOD2 signalling links ER stress with inflammation. | 2016 | Nature | pmid:27007849 |
| Flodby P et al. | The 78-kD Glucose-Regulated Protein Regulates Endoplasmic Reticulum Homeostasis and Distal Epithelial Cell Survival during Lung Development. | 2016 | Am. J. Respir. Cell Mol. Biol. | pmid:26816051 |
| Ding W et al. | Involvement of Endoplasmic Reticulum Stress in Uremic Cardiomyopathy: Protective Effects of Tauroursodeoxycholic Acid. | 2016 | Cell. Physiol. Biochem. | pmid:26765262 |
| Hu J et al. | Tauroursodeoxycholic acid prevents hearing loss and hair cell death in Cdh23(erl/erl) mice. | 2016 | Neuroscience | pmid:26748055 |
| Yang X et al. | Activation of autophagy by unfolded proteins during endoplasmic reticulum stress. | 2016 | Plant J. | pmid:26616142 |
| Zhou Q et al. | Effect of Tauroursodeoxycholic Acid and 4-Phenylbutyric Acid on Metabolism of Copper and Zinc in Type 1 Diabetic Mice Model. | 2016 | Biol Trace Elem Res | pmid:26282527 |
| Elia AE et al. | Tauroursodeoxycholic acid in the treatment of patients with amyotrophic lateral sclerosis. | 2016 | Eur. J. Neurol. | pmid:25664595 |
| Ma H et al. | A multicenter, randomized, double-blind trial comparing the efficacy and safety of TUDCA and UDCA in Chinese patients with primary biliary cholangitis. | 2016 | Medicine (Baltimore) | pmid:27893675 |
| Yang Z et al. | Quercetin induces endoplasmic reticulum stress to enhance cDDP cytotoxicity in ovarian cancer: involvement of STAT3 signaling. | 2015 | FEBS J. | pmid:25611565 |
| Tanaka Y et al. | The exacerbating roles of CCAAT/enhancer-binding protein homologous protein (CHOP) in the development of bleomycin-induced pulmonary fibrosis and the preventive effects of tauroursodeoxycholic acid (TUDCA) against pulmonary fibrosis in mice. | 2015 | Pharmacol. Res. | pmid:26005208 |
| Cortez LM et al. | Bile Acids Reduce Prion Conversion, Reduce Neuronal Loss, and Prolong Male Survival in Models of Prion Disease. | 2015 | J. Virol. | pmid:25972546 |
| Dubrey S et al. | The transthyretin amyloidoses: advances in therapy. | 2015 | Postgrad Med J | pmid:26048914 |
| Sommerfeld A et al. | Tauroursodeoxycholate Protects Rat Hepatocytes from Bile Acid-Induced Apoptosis via β1-Integrin- and Protein Kinase A-Dependent Mechanisms. | 2015 | Cell. Physiol. Biochem. | pmid:26044599 |
| Dong Y et al. | Neuroprotective effects and impact on caspase-12 expression of tauroursodeoxycholic acid after acute spinal cord injury in rats. | 2015 | Int J Clin Exp Pathol | pmid:26884858 |
| Shi Z et al. | [Tauroursodeoxycholic acid suppresses endoplasmic reticulum stress in pulmonary tissues of intermittent hypoxia mice]. | 2015 | Zhong Nan Da Xue Xue Bao Yi Xue Ban | pmid:26643417 |
| Muramatsu-Kato K et al. | Undernourishment in utero Primes Hepatic Steatosis in Adult Mice Offspring on an Obesogenic Diet; Involvement of Endoplasmic Reticulum Stress. | 2015 | Sci Rep | pmid:26581663 |
| Gómez-Vicente V et al. | Neuroprotective Effect of Tauroursodeoxycholic Acid on N-Methyl-D-Aspartate-Induced Retinal Ganglion Cell Degeneration. | 2015 | PLoS ONE | pmid:26379056 |
| Vandewynckel YP et al. | Tauroursodeoxycholic acid dampens oncogenic apoptosis induced by endoplasmic reticulum stress during hepatocarcinogen exposure. | 2015 | Oncotarget | pmid:26293671 |
| Koyama S et al. | Gefitinib and Erlotinib Lead to Phosphorylation of Eukaryotic Initiation Factor 2 Alpha Independent of Epidermal Growth Factor Receptor in A549 Cells. | 2015 | PLoS ONE | pmid:26288223 |
| Yu KN et al. | Titanium Dioxide Nanoparticles Induce Endoplasmic Reticulum Stress-Mediated Autophagic Cell Death via Mitochondria-Associated Endoplasmic Reticulum Membrane Disruption in Normal Lung Cells. | 2015 | PLoS ONE | pmid:26121477 |
| Bikbova G et al. | Altered Expression of NF- κ B and SP1 after Exposure to Advanced Glycation End-Products and Effects of Neurotrophic Factors in AGEs Exposed Rat Retinas. | 2015 | J Diabetes Res | pmid:26078979 |
| Cai Z et al. | Involvement of Endoplasmic Reticulum Stress-Mediated C/EBP Homologous Protein Activation in Coxsackievirus B3-Induced Acute Viral Myocarditis. | 2015 | Circ Heart Fail | pmid:25985795 |
| Oishi N et al. | XBP1 mitigates aminoglycoside-induced endoplasmic reticulum stress and neuronal cell death. | 2015 | Cell Death Dis | pmid:25973683 |
| Cheng S et al. | Pachymic acid inhibits growth and induces apoptosis of pancreatic cancer in vitro and in vivo by targeting ER stress. | 2015 | PLoS ONE | pmid:25915041 |
| Xu LH et al. | Critical Role of Endoplasmic Reticulum Stress in Chronic Intermittent Hypoxia-Induced Deficits in Synaptic Plasticity and Long-Term Memory. | 2015 | Antioxid. Redox Signal. | pmid:25843188 |
| Liu F et al. | Tauroursodeoxycholic acid attenuates inorganic phosphate-induced osteoblastic differentiation and mineralization in NIH3T3 fibroblasts by inhibiting the ER stress response PERK-eIF2α-ATF4 pathway. | 2015 | Drug Discov Ther | pmid:25788050 |
| Shi Z et al. | Vasonatrin peptide attenuates myocardial ischemia-reperfusion injury in diabetic rats and underlying mechanisms. | 2015 | Am. J. Physiol. Heart Circ. Physiol. | pmid:25485902 |
| Cho JG et al. | Tauroursodeoxycholic acid, a bile acid, promotes blood vessel repair by recruiting vasculogenic progenitor cells. | 2015 | Stem Cells | pmid:25407160 |
| Hakim F et al. | Chronic sleep fragmentation during the sleep period induces hypothalamic endoplasmic reticulum stress and PTP1b-mediated leptin resistance in male mice. | 2015 | Sleep | pmid:25325461 |