| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypertension | D006973 | 115 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
Total
2
Tauroursodeoxycholic acid
Tauroursodeoxycholic acid is a lipid of Sterol Lipids (ST) class. Tauroursodeoxycholic acid is associated with abnormalities such as Hyperglycemia, Obesity, Wiskott-Aldrich Syndrome, neurogenic hypertension and Cholestatic liver disease. The involved functions are known as Cell Death, Apoptosis, Homeostasis, Process and mRNA Expression. Tauroursodeoxycholic acid often locates in Body tissue, Endoplasmic Reticulum, Hepatic, Blood and Protoplasm. The associated genes with Tauroursodeoxycholic acid are Homologous Gene and Mutant Proteins. The related lipids are cholanic acid, taurolithocholic acid 3-sulfate, Sterols, 7-dehydrocholesterol and tauromuricholic acid. The related experimental models are Disease model.
Cross Reference
Introduction
To understand associated biological information of Tauroursodeoxycholic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Tauroursodeoxycholic acid?
Tauroursodeoxycholic acid is suspected in Endothelial dysfunction, Hyperglycemia, Obesity, neurogenic hypertension, Cholestatic liver disease, Heart failure and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Tauroursodeoxycholic acid
PubChem Associated disorders and diseases
What pathways are associated with Tauroursodeoxycholic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Tauroursodeoxycholic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Tauroursodeoxycholic acid?
Disease model
Disease model are used in the study 'Bile Acids Reduce Prion Conversion, Reduce Neuronal Loss, and Prolong Male Survival in Models of Prion Disease.' (Cortez LM et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Tauroursodeoxycholic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Walsh LK et al. | Administration of tauroursodeoxycholic acid prevents endothelial dysfunction caused by an oral glucose load. | 2016 | Clin. Sci. | pmid:27503949 |
| Chen W et al. | Bile acids for viral hepatitis. | 2003 | Cochrane Database Syst Rev | pmid:12804455 |
| Chen W and Gluud C | Bile acids for liver-transplanted patients. | 2005 | Cochrane Database Syst Rev | pmid:16034975 |
| Sökmen HM et al. | Situs inversus totalis and secondary biliary cirrhosis: a case report. | 2011 | Comp Hepatol | pmid:21813017 |
| Luoma PV | Gene-activation mechanisms in the regression of atherosclerosis, elimination of diabetes type 2, and prevention of dementia. | 2011 | Curr. Mol. Med. | pmid:21568932 |
| Xiao C et al. | Sodium phenylbutyrate, a drug with known capacity to reduce endoplasmic reticulum stress, partially alleviates lipid-induced insulin resistance and beta-cell dysfunction in humans. | 2011 | Diabetes | pmid:21270237 |
| Ye R et al. | Grp78 heterozygosity promotes adaptive unfolded protein response and attenuates diet-induced obesity and insulin resistance. | 2010 | Diabetes | pmid:19808896 |
| Zhou L et al. | DsbA-L alleviates endoplasmic reticulum stress-induced adiponectin downregulation. | 2010 | Diabetes | pmid:20699416 |
| Miki T et al. | Endoplasmic reticulum stress in diabetic hearts abolishes erythropoietin-induced myocardial protection by impairment of phospho-glycogen synthase kinase-3beta-mediated suppression of mitochondrial permeability transition. | 2009 | Diabetes | pmid:19755525 |
| Kars M et al. | Tauroursodeoxycholic Acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women. | 2010 | Diabetes | pmid:20522594 |
| Xie C et al. | An Intestinal Farnesoid X Receptor-Ceramide Signaling Axis Modulates Hepatic Gluconeogenesis in Mice. | 2017 | Diabetes | pmid:28223344 |
| Cheang WS et al. | PPARδ Is Required for Exercise to Attenuate Endoplasmic Reticulum Stress and Endothelial Dysfunction in Diabetic Mice. | 2017 | Diabetes | pmid:27856609 |
| Contreras C et al. | Reduction of Hypothalamic Endoplasmic Reticulum Stress Activates Browning of White Fat and Ameliorates Obesity. | 2017 | Diabetes | pmid:27634226 |
| Raciti GA et al. | Glucosamine-induced endoplasmic reticulum stress affects GLUT4 expression via activating transcription factor 6 in rat and human skeletal muscle cells. | 2010 | Diabetologia | pmid:20165829 |
| Tang C et al. | Glucose-induced beta cell dysfunction in vivo in rats: link between oxidative stress and endoplasmic reticulum stress. | 2012 | Diabetologia | pmid:22396011 |
| Yung HW et al. | Placental endoplasmic reticulum stress in gestational diabetes: the potential for therapeutic intervention with chemical chaperones and antioxidants. | 2016 | Diabetologia | pmid:27406815 |
| Panzhinskiy E et al. | Endoplasmic reticulum stress upregulates protein tyrosine phosphatase 1B and impairs glucose uptake in cultured myotubes. | 2013 | Diabetologia | pmid:23178931 |
| Piazza F et al. | Competition in liver transport between chenodeoxycholic acid and ursodeoxycholic acid as a mechanism for ursodeoxycholic acid and its amidates' protection of liver damage induced by chenodeoxycholic acid. | 2000 | Dig Liver Dis | pmid:11515630 |
| Petruzzelli M et al. | Indomethacin enhances bile salt detergent activity: relevance for NSAIDs-induced gastrointestinal mucosal injury. | 2006 | Dig. Dis. Sci. | pmid:16615001 |
| Takikawa H et al. | Effects of ursodeoxycholate and its conjugates on biliary glutathione excretion in rats. | 1996 | Dig. Dis. Sci. | pmid:8888706 |