| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypertension | D006973 | 115 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
Total
2
Tauroursodeoxycholic acid
Tauroursodeoxycholic acid is a lipid of Sterol Lipids (ST) class. Tauroursodeoxycholic acid is associated with abnormalities such as Hyperglycemia, Obesity, Wiskott-Aldrich Syndrome, neurogenic hypertension and Cholestatic liver disease. The involved functions are known as Cell Death, Apoptosis, Homeostasis, Process and mRNA Expression. Tauroursodeoxycholic acid often locates in Body tissue, Endoplasmic Reticulum, Hepatic, Blood and Protoplasm. The associated genes with Tauroursodeoxycholic acid are Homologous Gene and Mutant Proteins. The related lipids are cholanic acid, taurolithocholic acid 3-sulfate, Sterols, 7-dehydrocholesterol and tauromuricholic acid. The related experimental models are Disease model.
Cross Reference
Introduction
To understand associated biological information of Tauroursodeoxycholic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Tauroursodeoxycholic acid?
Tauroursodeoxycholic acid is suspected in Endothelial dysfunction, Hyperglycemia, Obesity, neurogenic hypertension, Cholestatic liver disease, Heart failure and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Diabetes (3)
- Am. J. Physiol. Heart Circ. Physiol. (1)
- Am. J. Physiol. Lung Cell Mol. Physiol. (1)
- Others (5)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Tauroursodeoxycholic acid
PubChem Associated disorders and diseases
What pathways are associated with Tauroursodeoxycholic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Tauroursodeoxycholic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Tauroursodeoxycholic acid?
Disease model
Disease model are used in the study 'Bile Acids Reduce Prion Conversion, Reduce Neuronal Loss, and Prolong Male Survival in Models of Prion Disease.' (Cortez LM et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Tauroursodeoxycholic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Shefer S et al. | Regulation of cholesterol 7 alpha-hydroxylase by hepatic 7 alpha-hydroxylated bile acid flux and newly synthesized cholesterol supply. | 1991 | J. Biol. Chem. | pmid:1993648 |
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| Beuers U et al. | Effects of tauroursodeoxycholic acid on cytosolic Ca2+ signals in isolated rat hepatocytes. | 1993 | Gastroenterology | pmid:8425704 |
| Sano N et al. | Estradiol-17 beta-glucuronide-induced cholestasis. Effects of ursodeoxycholate-3-O-glucuronide and 3,7-disulfate. | 1993 | J. Hepatol. | pmid:8445238 |
| Shamburek RD and Schwartz CC | Selective composition of biliary phosphatidylcholines is affected by secretion rate but not by bile acid hydrophobicity. | 1993 | J. Lipid Res. | pmid:8263408 |
| Beuers U et al. | Tauroursodeoxycholic acid stimulates hepatocellular exocytosis and mobilizes extracellular Ca++ mechanisms defective in cholestasis. | 1993 | J. Clin. Invest. | pmid:8254052 |
| Pak JM and Lee SS | Vasoactive effects of bile salts in cirrhotic rats: in vivo and in vitro studies. | 1993 | Hepatology | pmid:8225224 |
| Tsukahara K et al. | Taurine conjugate of ursodeoxycholate plays a major role in the hepatoprotective effect against cholestasis induced by taurochenodeoxycholate in rats. | 1993 | Liver | pmid:8259039 |
| Ohiwa T et al. | Tauroursodeoxycholate and tauro-beta-muricholate exert cytoprotection by reducing intrahepatocyte taurochenodeoxycholate content. | 1993 | Hepatology | pmid:8383089 |
| Bouchard G et al. | Influence of oral treatment with ursodeoxycholic and tauroursodeoxycholic acids on estrogen-induced cholestasis in rats: effects on bile formation and liver plasma membranes. | 1993 | Liver | pmid:8377596 |
| Aldini R et al. | Hepatic uptake and intestinal absorption of bile acids in the rabbit. | 1994 | Eur. J. Clin. Invest. | pmid:7851470 |
| Nguyen LB et al. | Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity in the rat ileum: effects of bile acids and lovastatin. | 1994 | Metab. Clin. Exp. | pmid:7968602 |
| Kitani K et al. | Tauro alpha-muricholate is as effective as tauro beta-muricholate and tauroursodeoxycholate in preventing taurochenodeoxycholate-induced liver damage in the rat. | 1994 | Hepatology | pmid:8138240 |
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| Alvaro D et al. | Functional and ultrastructural features of ethanol/bile salts interaction in the isolated perfused rat liver. | 1995 | Hepatology | pmid:7705787 |
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| Groen AK et al. | Regulation of protein secretion into bile: studies in mice with a disrupted mdr2 p-glycoprotein gene. | 1995 | Gastroenterology | pmid:7498666 |
| Rodrigues CM et al. | Tauroursodeoxycholate increases rat liver ursodeoxycholate levels and limits lithocholate formation better than ursodeoxycholate. | 1995 | Gastroenterology | pmid:7615207 |
| Angelico M et al. | N-ethyl-tauroursodeoxycholic acid, a novel deconjugation-resistant bile salt analogue: effects of acute feeding in the rat. | 1995 | Hepatology | pmid:7657297 |
| Ono T et al. | Effect of tauroursodeoxycholic acid on bile flow and calcium excretion in ischemia-reperfusion injury of rat livers. | 1995 | J. Hepatol. | pmid:8583148 |
| Neuman MG et al. | Effect of tauroursodeoxycholic and ursodeoxycholic acid on ethanol-induced cell injuries in the human Hep G2 cell line. | 1995 | Gastroenterology | pmid:7615206 |
| Takikawa H et al. | Colchicine inhibits lithocholate-3-O-glucuronide-induced cholestasis in rats. | 1995 | J. Hepatol. | pmid:7751593 |
| Hillaire S et al. | Effects of ursodeoxycholic acid and chenodeoxycholic acid on human hepatocytes in primary culture. | 1995 | Hepatology | pmid:7601437 |
| Azer SA et al. | Hepatoprotection in ethinylestradiol-treated rats is provided by tauroursodeoxycholic acid, but not by ursodeoxycholic acid. | 1995 May-Jun | J. Gastroenterol. Hepatol. | pmid:7548801 |
| Beuers U et al. | Tauroursodeoxycholic acid activates protein kinase C in isolated rat hepatocytes. | 1996 | Gastroenterology | pmid:8613063 |
| Stravitz RT et al. | Hepatocellular protein kinase C activation by bile acids: implications for regulation of cholesterol 7 alpha-hydroxylase. | 1996 | Am. J. Physiol. | pmid:8770045 |
| Muraca M et al. | Protective effect of tauroursodeoxycholate against acute gastric mucosal injury induced by hydrophobic bile salts. | 1996 | Dig. Dis. Sci. | pmid:8654150 |
| Sugata K et al. | Differential effects between tauroursodeoxycholic and taurochenodeoxycholic acids in hepatic fibrosis: an assessment by primary cultured Ito and Kupffer cells from the rat liver. | 1996 | J. Gastroenterol. Hepatol. | pmid:8743917 |
| Barone M et al. | Modulation of rat hepatocyte proliferation by bile salts: in vitro and in vivo studies. | 1996 | Hepatology | pmid:8621149 |
| Albalak A et al. | Effects of submicellar bile salt concentrations on biological membrane permeability to low molecular weight non-ionic solutes. | 1996 | Biochemistry | pmid:8672496 |
| Nebe B et al. | Induction of a physical linkage between integrins and the cytoskeleton depends on intracellular calcium in an epithelial cell line. | 1996 | Exp. Cell Res. | pmid:8940254 |
| Groen AK et al. | Control analysis of biliary lipid secretion. | 1996 | J. Theor. Biol. | pmid:8944177 |
| Van Erpecum KJ et al. | Effects of bile salt hydrophobicity on crystallization of cholesterol in model bile. | 1996 | Eur. J. Clin. Invest. | pmid:8864423 |
| Heuman DM et al. | Adsorption of mixtures of bile salt taurine conjugates to lecithin-cholesterol membranes: implications for bile salt toxicity and cytoprotection. | 1996 | J. Lipid Res. | pmid:8728319 |
| Setchell KD et al. | Metabolism of orally administered tauroursodeoxycholic acid in patients with primary biliary cirrhosis. | 1996 | Gut | pmid:8675100 |
| Bellentani S et al. | Chronic administration of ursodeoxycholic and tauroursodeoxycholic acid changes microsomal membrane lipid content and fatty acid compositions in rats. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8607791 |
| Crosignani A et al. | Tauroursodeoxycholic acid for treatment of primary biliary cirrhosis. A dose-response study. | 1996 | Dig. Dis. Sci. | pmid:8674405 |
| Klinkspoor JH et al. | Mechanism of bile salt-induced mucin secretion by cultured dog gallbladder epithelial cells. | 1996 | Biochem. J. | pmid:8670165 |
| Takikawa H et al. | Effects of ursodeoxycholate and its conjugates on biliary glutathione excretion in rats. | 1996 | Dig. Dis. Sci. | pmid:8888706 |
| Luk AS et al. | Structural mechanisms of bile salt-induced growth of small unilamellar cholesterol-lecithin vesicles. | 1997 | Biochemistry | pmid:9153403 |
| Larghi A et al. | Ursodeoxycholic and tauro-ursodeoxycholic acids for the treatment of primary biliary cirrhosis: a pilot crossover study. | 1997 | Aliment. Pharmacol. Ther. | pmid:9146783 |
| van Nieuwerk CM et al. | The role of bile salt composition in liver pathology of mdr2 (-/-) mice: differences between males and females. | 1997 | J. Hepatol. | pmid:9148004 |
| van de Heijning BJ et al. | Membrane cholesterol content of cholesterol/phospholipid vesicles determines the susceptibility to both damage and protection by bile salts: implications for bile physiology. | 1997 | Eur J Gastroenterol Hepatol | pmid:9187880 |
| Setchell KD et al. | Bile acid concentrations in human and rat liver tissue and in hepatocyte nuclei. | 1997 | Gastroenterology | pmid:8978363 |
| Gilani SS et al. | Use of 1H NMR spectroscopy (T2 relaxation times) to examine the effects of conjugated ursodeoxycholic acid on phospholipid fluidity of human gallbladder bile. | 1997 | Biochem. Soc. Trans. | pmid:9056921 |
| Crocenzi FA et al. | Role of bile salts in colchicine-induced hepatotoxicity. Implications for hepatocellular integrity and function. | 1997 | Toxicology | pmid:9230445 |
| Rao YP et al. | Activation of protein kinase C alpha and delta by bile acids: correlation with bile acid structure and diacylglycerol formation. | 1997 | J. Lipid Res. | pmid:9458268 |
| Takikawa H et al. | Absorption of unconjugated bile acids and tauroursodeoxycholate in the rat intestine. | 1997 | J. Gastroenterol. Hepatol. | pmid:9504891 |
| Balandraud-Pieri N et al. | Effects of tauroursodeoxycholate solutions on cyclosporin A bioavailability in rats. | 1997 | Drug Metab. Dispos. | pmid:9280397 |
| Loria P et al. | Effect of taurohyodeoxycholic acid on biliary lipid secretion in humans. | 1997 | Hepatology | pmid:9185744 |
| Arrese M et al. | Adaptive regulation of hepatic bile salt transport: role of bile salt hydrophobicity and microtubule-dependent vesicular pathway. | 1997 | J. Hepatol. | pmid:9075679 |
| Takikawa H et al. | Effect of tauro-alpha-muricholate and tauro-beta-muricholate on oestradiol-17 beta-glucuronide-induced cholestasis in rats. | 1997 | J. Gastroenterol. Hepatol. | pmid:9076630 |
| Schliess F et al. | Mitogen-activated protein kinases mediate the stimulation of bile acid secretion by tauroursodeoxycholate in rat liver. | 1997 | Gastroenterology | pmid:9322526 |
| Meier PJ et al. | Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver. | 1997 | Hepatology | pmid:9398014 |
| Ishizaki K et al. | Effect of sodium tauroursodeoxycholate (UR-906) on liver dysfunction in bile duct-ligated rats. | 1997 | Eur. J. Pharmacol. | pmid:9314037 |
| Beuers U | Effects of bile acids on hepatocellular signaling and secretion. | 1997 Jul-Aug | Yale J Biol Med | pmid:9626754 |
| Roda A et al. | Taurohyodeoxycholic acid protects against taurochenodeoxycholic acid-induced cholestasis in the rat. | 1998 | Hepatology | pmid:9462652 |
| Sreejayan N and von Ritter C | Effect of bile acids on lipid peroxidation: the role of iron. | 1998 | Free Radic. Biol. Med. | pmid:9655521 |
| Benz C et al. | Effect of tauroursodeoxycholic acid on bile-acid-induced apoptosis and cytolysis in rat hepatocytes. | 1998 | J. Hepatol. | pmid:9537871 |
| Schroeder A et al. | Substrate specificity of the rat liver Na(+)-bile salt cotransporter in Xenopus laevis oocytes and in CHO cells. | 1998 | Am. J. Physiol. | pmid:9486191 |
| Peterson TC et al. | The inhibitory effect of ursodeoxycholic acid and pentoxifylline on platelet derived growth factor-stimulated proliferation is distinct from an effect by cyclic AMP. | 1998 | Immunopharmacology | pmid:9754904 |
| Klinkspoor JH et al. | Bile salts stimulate mucin secretion by cultured dog gallbladder epithelial cells independent of their detergent effect. | 1998 | Biochem. J. | pmid:9576876 |
| Vendemiale G et al. | Ethanol-induced changes of intracellular thiol compartmentation and protein redox status in the rat liver: effect of tauroursodeoxycholate. | 1998 | J. Hepatol. | pmid:9537863 |
| Bouscarel B et al. | Changes in G protein expression account for impaired modulation of hepatic cAMP formation after BDL. | 1998 | Am. J. Physiol. | pmid:9696716 |
| Yamaguchi Y et al. | Taurin-conjugated ursodeoxycholic acid has a reversible inhibitory effect on human keratinocyte growth. | 1998 | J. Dermatol. Sci. | pmid:9747660 |
| Ono T et al. | Tauroursodeoxycholic acid protects cholestasis in rat reperfused livers: its roles in hepatic calcium mobilization. | 1998 | Dig. Dis. Sci. | pmid:9790455 |
| Benz C et al. | Effect of S-adenosylmethionine versus tauroursodeoxycholic acid on bile acid-induced apoptosis and cytolysis in rat hepatocytes. | 1998 | Eur. J. Clin. Invest. | pmid:9726039 |
| Funaoka M et al. | Tauroursodeoxycholic acid enhances phagocytosis of the cultured rat Kupffer cell. | 1999 | J. Gastroenterol. Hepatol. | pmid:10440209 |
| Miyake H et al. | Partial characterization of mechanisms of cytoprotective action of hydrophilic bile salts against hydrophobic bile salts in rats: relation to canalicular membrane fluidity and packing density. | 1999 | Dig. Dis. Sci. | pmid:9952244 |
| Milkiewicz P et al. | Tauroursodeoxycholate and S-adenosyl-L-methionine exert an additive ameliorating effect on taurolithocholate-induced cholestasis: a study in isolated rat hepatocyte couplets. | 1999 | Hepatology | pmid:9918924 |
| Hertl M et al. | Tauroursodeoxycholate ameliorates reperfusion injury after pig liver transplantation. | 1999 | Transpl. Int. | pmid:10654358 |
| Invernizzi P et al. | Differences in the metabolism and disposition of ursodeoxycholic acid and of its taurine-conjugated species in patients with primary biliary cirrhosis. | 1999 | Hepatology | pmid:9918905 |
| Eckhardt U et al. | Polyspecific substrate uptake by the hepatic organic anion transporter Oatp1 in stably transfected CHO cells. | 1999 | Am. J. Physiol. | pmid:10198348 |
| Kurz AK et al. | Phosphoinositide 3-kinase-dependent Ras activation by tauroursodesoxycholate in rat liver. | 2000 | Biochem. J. | pmid:10926845 |
| Falasca L et al. | Tauroursodeoxycholate reduces ischemic damage in human allografts: a biochemical and ultrastructural study. | 2000 | Transplant. Proc. | pmid:10700964 |
| Benz C et al. | Effect of tauroursodeoxycholic acid on bile acid-induced apoptosis in primary human hepatocytes. | 2000 | Eur. J. Clin. Invest. | pmid:10691996 |
| Piazza F et al. | Competition in liver transport between chenodeoxycholic acid and ursodeoxycholic acid as a mechanism for ursodeoxycholic acid and its amidates' protection of liver damage induced by chenodeoxycholic acid. | 2000 | Dig Liver Dis | pmid:11515630 |
| Rodrigues CM et al. | Tauroursodeoxycholic acid partially prevents apoptosis induced by 3-nitropropionic acid: evidence for a mitochondrial pathway independent of the permeability transition. | 2000 | J. Neurochem. | pmid:11080188 |
| Asamoto Y et al. | Bile-salt hydrophobicity is a key factor regulating rat liver plasma-membrane communication: relation to bilayer structure, fluidity and transporter expression and function. | 2001 | Biochem. J. | pmid:11672435 |
| Ejiri S et al. | Cellular distribution of thrombomodulin as an early marker for warm ischemic liver injury in porcine liver transplantation: protective effect of prostaglandin I2 analogue and tauroursodeoxycholic acid. | 2001 | Transplantation | pmid:11330532 |
| Moschetta A et al. | Cholesterol crystallization in model biles: effects of bile salt and phospholipid species composition. | 2001 | J. Lipid Res. | pmid:11483629 |
| Kurz AK et al. | Tauroursodesoxycholate-induced choleresis involves p38(MAPK) activation and translocation of the bile salt export pump in rats. | 2001 | Gastroenterology | pmid:11487550 |
| Ishizaki K et al. | Effect of sodium tauroursodeoxycholate on phalloidin-induced cholestasis in rats. | 2001 | Eur. J. Pharmacol. | pmid:11408049 |
| Danchenko E et al. | Effect of bile acids on the proliferative activity and apoptosis of rat hepatocytes. | 2001 | Exp. Toxicol. Pathol. | pmid:11484843 |
| Nathanson MH et al. | Stimulation of ATP secretion in the liver by therapeutic bile acids. | 2001 | Biochem. J. | pmid:11485545 |
| Crocenzi FA et al. | Beneficial effects of silymarin on estrogen-induced cholestasis in the rat: a study in vivo and in isolated hepatocyte couplets. | 2001 | Hepatology | pmid:11481618 |
| Moschetta A et al. | Hydrophilic bile salts enhance differential distribution of sphingomyelin and phosphatidylcholine between micellar and vesicular phases: potential implications for their effects in vivo. | 2001 | J. Hepatol. | pmid:11394647 |
| Fimognari C et al. | Micronuclei induction, cell cycle delay and apoptosis as markers of cellular stress caused by ursodeoxycholic acid in human lymphocytes. | 2001 | Mutat. Res. | pmid:11448637 |
| Rodrigues CM et al. | Amyloid beta-peptide disrupts mitochondrial membrane lipid and protein structure: protective role of tauroursodeoxycholate. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11181071 |
| Colell A et al. | Tauroursodeoxycholic acid protects hepatocytes from ethanol-fed rats against tumor necrosis factor-induced cell death by replenishing mitochondrial glutathione. | 2001 | Hepatology | pmid:11679967 |
| Keene CD et al. | A bile acid protects against motor and cognitive deficits and reduces striatal degeneration in the 3-nitropropionic acid model of Huntington's disease. | 2001 | Exp. Neurol. | pmid:11573988 |
| Ishigami F et al. | Bile salt tauroursodeoxycholic acid modulation of Bax translocation to mitochondria protects the liver from warm ischemia-reperfusion injury in the rat. | 2001 | Transplantation | pmid:11740392 |
| Beuers U et al. | Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C-dependent mechanisms in cholestatic rat liver. | 2001 | Hepatology | pmid:11343250 |
| Chignard N et al. | Bile acid transport and regulating functions in the human biliary epithelium. | 2001 | Hepatology | pmid:11230727 |
| Calmus Y and Podevin P | Tauroursodeoxycholic acid for the cytoprotection of liver grafts during cold storage: a new aspect of its anti-apoptotic properties? | 2001 | Transplantation | pmid:11408962 |
| Falasca L et al. | Protective role of tauroursodeoxycholate during harvesting and cold storage of human liver: a pilot study in transplant recipients. | 2001 | Transplantation | pmid:11397961 |