| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypertension | D006973 | 115 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
Total
2
Tauroursodeoxycholic acid
Tauroursodeoxycholic acid is a lipid of Sterol Lipids (ST) class. Tauroursodeoxycholic acid is associated with abnormalities such as Hyperglycemia, Obesity, Wiskott-Aldrich Syndrome, neurogenic hypertension and Cholestatic liver disease. The involved functions are known as Cell Death, Apoptosis, Homeostasis, Process and mRNA Expression. Tauroursodeoxycholic acid often locates in Body tissue, Endoplasmic Reticulum, Hepatic, Blood and Protoplasm. The associated genes with Tauroursodeoxycholic acid are Homologous Gene and Mutant Proteins. The related lipids are cholanic acid, taurolithocholic acid 3-sulfate, Sterols, 7-dehydrocholesterol and tauromuricholic acid. The related experimental models are Disease model.
Cross Reference
Introduction
To understand associated biological information of Tauroursodeoxycholic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Tauroursodeoxycholic acid?
Tauroursodeoxycholic acid is suspected in Endothelial dysfunction, Hyperglycemia, Obesity, neurogenic hypertension, Cholestatic liver disease, Heart failure and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Diabetes (3)
- Am. J. Physiol. Heart Circ. Physiol. (1)
- Am. J. Physiol. Lung Cell Mol. Physiol. (1)
- Others (5)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Tauroursodeoxycholic acid
PubChem Associated disorders and diseases
What pathways are associated with Tauroursodeoxycholic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Tauroursodeoxycholic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Tauroursodeoxycholic acid?
Disease model
Disease model are used in the study 'Bile Acids Reduce Prion Conversion, Reduce Neuronal Loss, and Prolong Male Survival in Models of Prion Disease.' (Cortez LM et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Tauroursodeoxycholic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ramalho RM et al. | Tauroursodeoxycholic acid suppresses amyloid β-induced synaptic toxicity in vitro and in APP/PS1 mice. | 2013 | Neurobiol. Aging | pmid:22621777 |
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| Lenin R et al. | Amelioration of glucolipotoxicity-induced endoplasmic reticulum stress by a "chemical chaperone" in human THP-1 monocytes. | 2012 | Exp Diabetes Res | pmid:22550476 |
| Elanchezhian R et al. | Low glucose under hypoxic conditions induces unfolded protein response and produces reactive oxygen species in lens epithelial cells. | 2012 | Cell Death Dis | pmid:22513875 |
| Ma Y et al. | Growth hormone secretagogues protect mouse cardiomyocytes from in vitro ischemia/reperfusion injury through regulation of intracellular calcium. | 2012 | PLoS ONE | pmid:22493744 |
| Beriault DR and Werstuck GH | The role of glucosamine-induced ER stress in diabetic atherogenesis. | 2012 | Exp Diabetes Res | pmid:22474416 |
| Xu J et al. | Endoplasmic reticulum stress and diabetic cardiomyopathy. | 2012 | Exp Diabetes Res | pmid:22144992 |
| Cai D and Liu T | Inflammatory cause of metabolic syndrome via brain stress and NF-κB. | 2012 | Aging (Albany NY) | pmid:22328600 |
| Matsubara T et al. | TGF-β-SMAD3 signaling mediates hepatic bile acid and phospholipid metabolism following lithocholic acid-induced liver injury. | 2012 | J. Lipid Res. | pmid:23034213 |
| Nguyen MT et al. | Regulation of chemokine and chemokine receptor expression by PPARγ in adipocytes and macrophages. | 2012 | PLoS ONE | pmid:22529965 |
| Basseri S and Austin RC | Endoplasmic reticulum stress and lipid metabolism: mechanisms and therapeutic potential. | 2012 | Biochem Res Int | pmid:22195283 |
| Drack AV et al. | TUDCA slows retinal degeneration in two different mouse models of retinitis pigmentosa and prevents obesity in Bardet-Biedl syndrome type 1 mice. | 2012 | Invest. Ophthalmol. Vis. Sci. | pmid:22110077 |
| Amin A et al. | Chronic inhibition of endoplasmic reticulum stress and inflammation prevents ischaemia-induced vascular pathology in type II diabetic mice. | 2012 | J. Pathol. | pmid:22081301 |
| Fonseca MB et al. | c-Jun regulates the stability of anti-apoptotic ΔNp63 in amyloid-β-induced apoptosis. | 2012 | J. Alzheimers Dis. | pmid:22045494 |
| Studer E et al. | Conjugated bile acids activate the sphingosine-1-phosphate receptor 2 in primary rodent hepatocytes. | 2012 | Hepatology | pmid:21932398 |
| Brites D | The evolving landscape of neurotoxicity by unconjugated bilirubin: role of glial cells and inflammation. | 2012 | Front Pharmacol | pmid:22661946 |
| Mühlfeld S et al. | Short-term feedback regulation of bile salt uptake by bile salts in rodent liver. | 2012 | Hepatology | pmid:22806967 |
| Farrell GC et al. | NASH is an Inflammatory Disorder: Pathogenic, Prognostic and Therapeutic Implications. | 2012 | Gut Liver | pmid:22570745 |
| Achard CS and Laybutt DR | Lipid-induced endoplasmic reticulum stress in liver cells results in two distinct outcomes: adaptation with enhanced insulin signaling or insulin resistance. | 2012 | Endocrinology | pmid:22374970 |
| Brandes V et al. | Protection from Clostridium difficile toxin B-catalysed Rac1/Cdc42 glucosylation by tauroursodeoxycholic acid-induced Rac1/Cdc42 phosphorylation. | 2012 | Biol. Chem. | pmid:22628301 |
| Cursio R and Gugenheim J | Ischemia-Reperfusion Injury and Ischemic-Type Biliary Lesions following Liver Transplantation. | 2012 | J Transplant | pmid:22530107 |
| Obici L et al. | Doxycycline plus tauroursodeoxycholic acid for transthyretin amyloidosis: a phase II study. | 2012 | Amyloid | pmid:22551192 |
| Zhang T et al. | Chemical chaperone TUDCA preserves cone photoreceptors in a mouse model of Leber congenital amaurosis. | 2012 | Invest. Ophthalmol. Vis. Sci. | pmid:22531707 |
| Jiménez-Castro MB et al. | Tauroursodeoxycholic acid affects PPARγ and TLR4 in Steatotic liver transplantation. | 2012 | Am. J. Transplant. | pmid:22994543 |
| Kim JS et al. | Tauroursodeoxycholic acid enhances the pre-implantation embryo development by reducing apoptosis in pigs. | 2012 | Reprod. Domest. Anim. | pmid:22151574 |
| Zhang JY et al. | Effect of endoplasmic reticulum stress on porcine oocyte maturation and parthenogenetic embryonic development in vitro. | 2012 | Biol. Reprod. | pmid:22190710 |
| Hassan IH et al. | Influenza A viral replication is blocked by inhibition of the inositol-requiring enzyme 1 (IRE1) stress pathway. | 2012 | J. Biol. Chem. | pmid:22194594 |
| Gao X et al. | The nephroprotective effect of tauroursodeoxycholic acid on ischaemia/reperfusion-induced acute kidney injury by inhibiting endoplasmic reticulum stress. | 2012 | Basic Clin. Pharmacol. Toxicol. | pmid:22212133 |
| Rieusset J et al. | Reduction of endoplasmic reticulum stress using chemical chaperones or Grp78 overexpression does not protect muscle cells from palmitate-induced insulin resistance. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22177958 |
| Younce C and Kolattukudy P | MCP-1 induced protein promotes adipogenesis via oxidative stress, endoplasmic reticulum stress and autophagy. | 2012 | Cell. Physiol. Biochem. | pmid:22739135 |
| Roy A and Kolattukudy PE | Monocyte chemotactic protein-induced protein (MCPIP) promotes inflammatory angiogenesis via sequential induction of oxidative stress, endoplasmic reticulum stress and autophagy. | 2012 | Cell. Signal. | pmid:22820500 |
| Zhang Y et al. | Organic anion transporting polypeptide 1a1 null mice are sensitive to cholestatic liver injury. | 2012 | Toxicol. Sci. | pmid:22461449 |
| Cash JG et al. | Apolipoprotein E4 impairs macrophage efferocytosis and potentiates apoptosis by accelerating endoplasmic reticulum stress. | 2012 | J. Biol. Chem. | pmid:22730380 |
| Castro-Caldas M et al. | Tauroursodeoxycholic acid prevents MPTP-induced dopaminergic cell death in a mouse model of Parkinson's disease. | 2012 | Mol. Neurobiol. | pmid:22773138 |
| Zhang JY et al. | Inhibition of endoplasmic reticulum stress improves mouse embryo development. | 2012 | PLoS ONE | pmid:22808162 |
| Galán M et al. | A novel role for epidermal growth factor receptor tyrosine kinase and its downstream endoplasmic reticulum stress in cardiac damage and microvascular dysfunction in type 1 diabetes mellitus. | 2012 | Hypertension | pmid:22665120 |
| Nunes AF et al. | TUDCA, a bile acid, attenuates amyloid precursor protein processing and amyloid-β deposition in APP/PS1 mice. | 2012 | Mol. Neurobiol. | pmid:22438081 |
| Tang C et al. | Glucose-induced beta cell dysfunction in vivo in rats: link between oxidative stress and endoplasmic reticulum stress. | 2012 | Diabetologia | pmid:22396011 |
| van Heumen BW et al. | Celecoxib and tauro-ursodeoxycholic acid co-treatment inhibits cell growth in familial adenomatous polyposis derived LT97 colon adenoma cells. | 2012 | Exp. Cell Res. | pmid:22366264 |
| Kawasaki N et al. | Obesity-induced endoplasmic reticulum stress causes chronic inflammation in adipose tissue. | 2012 | Sci Rep | pmid:23150771 |
| Young CN et al. | ER stress in the brain subfornical organ mediates angiotensin-dependent hypertension. | 2012 | J. Clin. Invest. | pmid:23064361 |
| Henkel AS et al. | Reducing endoplasmic reticulum stress does not improve steatohepatitis in mice fed a methionine- and choline-deficient diet. | 2012 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:22556147 |
| Daood MJ et al. | Lipid peroxidation is not the primary mechanism of bilirubin-induced neurologic dysfunction in jaundiced Gunn rat pups. | 2012 | Pediatr. Res. | pmid:22902434 |
| Gupta S et al. | Prevention of acute kidney injury by tauroursodeoxycholic acid in rat and cell culture models. | 2012 | PLoS ONE | pmid:23152827 |
| Qi HP et al. | Ursodeoxycholic acid prevents selenite-induced oxidative stress and alleviates cataract formation: In vitro and in vivo studies. | 2012 | Mol. Vis. | pmid:22275806 |
| Min JH et al. | Oral solubilized ursodeoxycholic acid therapy in amyotrophic lateral sclerosis: a randomized cross-over trial. | 2012 | J. Korean Med. Sci. | pmid:22323869 |
| Bodewes FA et al. | Ursodeoxycholate modulates bile flow and bile salt pool independently from the cystic fibrosis transmembrane regulator (Cftr) in mice. | 2012 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:22301109 |
| Cheng F et al. | Refined Qingkailing Protects MCAO Mice from Endoplasmic Reticulum Stress-Induced Apoptosis with a Broad Time Window. | 2012 | Evid Based Complement Alternat Med | pmid:22536287 |
| Trottier J et al. | Profiling circulating and urinary bile acids in patients with biliary obstruction before and after biliary stenting. | 2011 | PLoS ONE | pmid:21760958 |
| Leong ML et al. | Neuronal loss in the rostral ventromedial medulla in a rat model of neuropathic pain. | 2011 | J. Neurosci. | pmid:22114272 |
| Sökmen HM et al. | Situs inversus totalis and secondary biliary cirrhosis: a case report. | 2011 | Comp Hepatol | pmid:21813017 |
| Luoma PV | Gene-activation mechanisms in the regression of atherosclerosis, elimination of diabetes type 2, and prevention of dementia. | 2011 | Curr. Mol. Med. | pmid:21568932 |
| Zhang Y et al. | Activation of Akt rescues endoplasmic reticulum stress-impaired murine cardiac contractile function via glycogen synthase kinase-3β-mediated suppression of mitochondrial permeation pore opening. | 2011 | Antioxid. Redox Signal. | pmid:21542787 |
| Úriz M et al. | Ursodeoxycholic acid is conjugated with taurine to promote secretin-stimulated biliary hydrocholeresis in the normal rat. | 2011 | PLoS ONE | pmid:22194894 |
| Yeo J et al. | Effects of a multi-herbal extract on type 2 diabetes. | 2011 | Chin Med | pmid:21375727 |
| Xiao C et al. | Sodium phenylbutyrate, a drug with known capacity to reduce endoplasmic reticulum stress, partially alleviates lipid-induced insulin resistance and beta-cell dysfunction in humans. | 2011 | Diabetes | pmid:21270237 |
| Song S et al. | Cholesterol-derived bile acids enhance the chaperone activity of α-crystallins. | 2011 | Cell Stress Chaperones | pmid:21380614 |
| Qiao X et al. | Differentiation of various traditional Chinese medicines derived from animal bile and gallstone: simultaneous determination of bile acids by liquid chromatography coupled with triple quadrupole mass spectrometry. | 2011 | J Chromatogr A | pmid:21111425 |
| Ishiyama J et al. | Unsaturated FAs prevent palmitate-induced LOX-1 induction via inhibition of ER stress in macrophages. | 2011 | J. Lipid Res. | pmid:21078775 |
| Jiao P et al. | FFA-induced adipocyte inflammation and insulin resistance: involvement of ER stress and IKKβ pathways. | 2011 | Obesity (Silver Spring) | pmid:20829802 |
| Megaraj V et al. | Functional analysis of nonsynonymous single nucleotide polymorphisms of multidrug resistance-associated protein 2 (ABCC2). | 2011 | Pharmacogenet. Genomics | pmid:21691255 |
| Ceylan-Isik AF et al. | Endoplasmic reticulum chaperon tauroursodeoxycholic acid alleviates obesity-induced myocardial contractile dysfunction. | 2011 | J. Mol. Cell. Cardiol. | pmid:21035453 |
| Oveson BC et al. | Constituents of bile, bilirubin and TUDCA, protect against oxidative stress-induced retinal degeneration. | 2011 | J. Neurochem. | pmid:21054389 |
| Fernández-Sánchez L et al. | Tauroursodeoxycholic acid prevents retinal degeneration in transgenic P23H rats. | 2011 | Invest. Ophthalmol. Vis. Sci. | pmid:21508111 |
| da-Silva WS et al. | The chemical chaperones tauroursodeoxycholic and 4-phenylbutyric acid accelerate thyroid hormone activation and energy expenditure. | 2011 | FEBS Lett. | pmid:21237159 |
| Anderson CD et al. | Endoplasmic reticulum stress is a mediator of posttransplant injury in severely steatotic liver allografts. | 2011 | Liver Transpl. | pmid:21280192 |
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| Montagnani M et al. | A new model for portal protein profile analysis in course of ileal intraluminal bile acid infusion using an in situ perfused rat intestine. | 2011 | Med Chem | pmid:21568879 |
| Viana RJ et al. | Amyloid-β peptide-induced secretion of endoplasmic reticulum chaperone glycoprotein GRP94. | 2011 | J. Alzheimers Dis. | pmid:21750376 |
| Seyhun E et al. | Tauroursodeoxycholic acid reduces endoplasmic reticulum stress, acinar cell damage, and systemic inflammation in acute pancreatitis. | 2011 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:21778463 |
| Kim SY et al. | Tauroursodeoxycholate (TUDCA) inhibits neointimal hyperplasia by suppression of ERK via PKCα-mediated MKP-1 induction. | 2011 | Cardiovasc. Res. | pmid:21840882 |
| Kirkpatrick CL et al. | Hepatic nuclear factor 1alpha (HNF1alpha) dysfunction down-regulates X-box-binding protein 1 (XBP1) and sensitizes beta-cells to endoplasmic reticulum stress. | 2011 | J. Biol. Chem. | pmid:21784843 |
| Mantopoulos D et al. | Tauroursodeoxycholic acid (TUDCA) protects photoreceptors from cell death after experimental retinal detachment. | 2011 | PLoS ONE | pmid:21961034 |
| Purkayastha S et al. | Neural dysregulation of peripheral insulin action and blood pressure by brain endoplasmic reticulum stress. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:21282643 |
| Yang JS et al. | Changes in hepatic gene expression upon oral administration of taurine-conjugated ursodeoxycholic acid in ob/ob mice. | 2010 | PLoS ONE | pmid:21079772 |
| Ropelle ER et al. | IL-6 and IL-10 anti-inflammatory activity links exercise to hypothalamic insulin and leptin sensitivity through IKKbeta and ER stress inhibition. | 2010 | PLoS Biol. | pmid:20808781 |
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| Ceylan-Isik AF et al. | Cardiac overexpression of metallothionein rescues cardiac contractile dysfunction and endoplasmic reticulum stress but not autophagy in sepsis. | 2010 | J. Mol. Cell. Cardiol. | pmid:19914257 |
| Ye R et al. | Grp78 heterozygosity promotes adaptive unfolded protein response and attenuates diet-induced obesity and insulin resistance. | 2010 | Diabetes | pmid:19808896 |
| Lim SC et al. | Ursodeoxycholic acid switches oxaliplatin-induced necrosis to apoptosis by inhibiting reactive oxygen species production and activating p53-caspase 8 pathway in HepG2 hepatocellular carcinoma. | 2010 | Int. J. Cancer | pmid:19728331 |
| Basiglio CL et al. | Tauroursodeoxycholate counteracts hepatocellular lysis induced by tensioactive bile salts by preventing plasma membrane-micelle transition. | 2010 | Chem. Biol. Interact. | pmid:20797393 |
| Fulda S et al. | Cellular stress responses: cell survival and cell death. | 2010 | Int J Cell Biol | pmid:20182529 |
| Malo A et al. | Tauroursodeoxycholic acid reduces endoplasmic reticulum stress, trypsin activation, and acinar cell apoptosis while increasing secretion in rat pancreatic acini. | 2010 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:20671193 |
| Cardoso I et al. | Synergy of combined doxycycline/TUDCA treatment in lowering Transthyretin deposition and associated biomarkers: studies in FAP mouse models. | 2010 | J Transl Med | pmid:20673327 |
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| Aranha MM et al. | Apoptosis-associated microRNAs are modulated in mouse, rat and human neural differentiation. | 2010 | BMC Genomics | pmid:20868483 |
| Ge W et al. | Cardiac-specific overexpression of catalase attenuates paraquat-induced myocardial geometric and contractile alteration: role of ER stress. | 2010 | Free Radic. Biol. Med. | pmid:20937379 |
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| López-Sánchez LM et al. | Inhibition of nitric oxide synthesis during induced cholestasis ameliorates hepatocellular injury by facilitating S-nitrosothiol homeostasis. | 2010 | Lab. Invest. | pmid:19806079 |
| Cruz LN et al. | Regulation of multidrug resistance-associated protein 2 by calcium signaling in mouse liver. | 2010 | Hepatology | pmid:20578149 |
| Kars M et al. | Tauroursodeoxycholic Acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women. | 2010 | Diabetes | pmid:20522594 |
| Lee YY et al. | Tauroursodeoxycholate (TUDCA), chemical chaperone, enhances function of islets by reducing ER stress. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20541525 |
| Viana RJ et al. | Modulation of amyloid-β peptide-induced toxicity through inhibition of JNK nuclear localization and caspase-2 activation. | 2010 | J. Alzheimers Dis. | pmid:20847398 |
| Hua Y et al. | Tauroursodeoxycholic acid attenuates lipid accumulation in endoplasmic reticulum-stressed macrophages. | 2010 | J. Cardiovasc. Pharmacol. | pmid:19834331 |
| Schmidt DR et al. | Regulation of bile acid synthesis by fat-soluble vitamins A and D. | 2010 | J. Biol. Chem. | pmid:20233723 |
| Hohenester S et al. | Phosphatidylinositol-3-kinase p110γ contributes to bile salt-induced apoptosis in primary rat hepatocytes and human hepatoma cells. | 2010 | J. Hepatol. | pmid:20675006 |
| Raciti GA et al. | Glucosamine-induced endoplasmic reticulum stress affects GLUT4 expression via activating transcription factor 6 in rat and human skeletal muscle cells. | 2010 | Diabetologia | pmid:20165829 |
| RodrÃguez-Ortigosa CM et al. | Biliary secretion of S-nitrosoglutathione is involved in the hypercholeresis induced by ursodeoxycholic acid in the normal rat. | 2010 | Hepatology | pmid:20683964 |
| Woo SJ et al. | Ursodeoxycholic acid and tauroursodeoxycholic acid suppress choroidal neovascularization in a laser-treated rat model. | 2010 | J Ocul Pharmacol Ther | pmid:20565307 |