| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypertension | D006973 | 115 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
Total
2
Tauroursodeoxycholic acid
Tauroursodeoxycholic acid is a lipid of Sterol Lipids (ST) class. Tauroursodeoxycholic acid is associated with abnormalities such as Hyperglycemia, Obesity, Wiskott-Aldrich Syndrome, neurogenic hypertension and Cholestatic liver disease. The involved functions are known as Cell Death, Apoptosis, Homeostasis, Process and mRNA Expression. Tauroursodeoxycholic acid often locates in Body tissue, Endoplasmic Reticulum, Hepatic, Blood and Protoplasm. The associated genes with Tauroursodeoxycholic acid are Homologous Gene and Mutant Proteins. The related lipids are cholanic acid, taurolithocholic acid 3-sulfate, Sterols, 7-dehydrocholesterol and tauromuricholic acid. The related experimental models are Disease model.
Cross Reference
Introduction
To understand associated biological information of Tauroursodeoxycholic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Tauroursodeoxycholic acid?
Tauroursodeoxycholic acid is suspected in Endothelial dysfunction, Hyperglycemia, Obesity, neurogenic hypertension, Cholestatic liver disease, Heart failure and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Diabetes (3)
- Am. J. Physiol. Heart Circ. Physiol. (1)
- Am. J. Physiol. Lung Cell Mol. Physiol. (1)
- Others (5)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Tauroursodeoxycholic acid
PubChem Associated disorders and diseases
What pathways are associated with Tauroursodeoxycholic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Tauroursodeoxycholic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Tauroursodeoxycholic acid?
Disease model
Disease model are used in the study 'Bile Acids Reduce Prion Conversion, Reduce Neuronal Loss, and Prolong Male Survival in Models of Prion Disease.' (Cortez LM et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Tauroursodeoxycholic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Baiocchi L et al. | Taurohyodeoxycholate- and tauroursodeoxycholate-induced hypercholeresis is augmented in bile duct ligated rats. | 2003 | J. Hepatol. | pmid:12547401 |
| Ma J et al. | Inhibitory effects of ursodeoxycholic acid on the induction of nitric oxide synthase in vascular smooth muscle cells. | 2003 | Eur. J. Pharmacol. | pmid:12620498 |
| Beuers U et al. | Taurolithocholic acid exerts cholestatic effects via phosphatidylinositol 3-kinase-dependent mechanisms in perfused rat livers and rat hepatocyte couplets. | 2003 | J. Biol. Chem. | pmid:12626520 |
| Rodrigues CM et al. | Tauroursodeoxycholic acid prevents Bax-induced membrane perturbation and cytochrome C release in isolated mitochondria. | 2003 | Biochemistry | pmid:12627974 |
| Tsuboi K et al. | Hydrophilic bile salts have a cytoprotective effect against cyclosporine A-induced cholestasis through enhanced canalicular membrane fluidity and transporter activity. | 2003 | Hepatol. Res. | pmid:12644037 |
| Sánchez Pozzi EJ et al. | Ursodeoxycholate reduces ethinylestradiol glucuronidation in the rat: role in prevention of estrogen-induced cholestasis. | 2003 | J. Pharmacol. Exp. Ther. | pmid:12663690 |
| pmid:12702047 | ||||
| Rodrigues CM et al. | Tauroursodeoxycholic acid reduces apoptosis and protects against neurological injury after acute hemorrhagic stroke in rats. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12721362 |
| Häussinger D et al. | Involvement of integrins and Src in tauroursodeoxycholate-induced and swelling-induced choleresis. | 2003 | Gastroenterology | pmid:12730886 |
| pmid:12769806 | ||||
| Chen W et al. | Bile acids for viral hepatitis. | 2003 | Cochrane Database Syst Rev | pmid:12804455 |
| pmid:12825132 | ||||
| Schoemaker MH et al. | Resistance of rat hepatocytes against bile acid-induced apoptosis in cholestatic liver injury is due to nuclear factor-kappa B activation. | 2003 | J. Hepatol. | pmid:12873810 |
| Reinehr R et al. | Bile salt-induced hepatocyte apoptosis involves epidermal growth factor receptor-dependent CD95 tyrosine phosphorylation. | 2003 | Gastroenterology | pmid:12949729 |
| Nakai T et al. | Microtubule-independent choleresis and anti-cholestatic action of tauroursodeoxycholate in colchicine-treated rat liver. | 1992 | Biochem. J. | pmid:1361125 |
| Liu Y et al. | Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis. | 2003 | J. Clin. Invest. | pmid:14623915 |
| Häussinger D et al. | Cell volume and bile acid excretion. | 1992 | Biochem. J. | pmid:1463469 |
| Tessier E et al. | High-performance liquid chromatographic mass spectrometric method for the determination of ursodeoxycholic acid and its glycine and taurine conjugates in human plasma. | 2003 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:14643509 |
| Alpini G et al. | Tauroursodeoxycholate inhibits human cholangiocarcinoma growth via Ca2+-, PKC-, and MAPK-dependent pathways. | 2004 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:14701718 |
| Komichi D et al. | Unique inhibition of bile salt-induced apoptosis by lecithins and cytoprotective bile salts in immortalized mouse cholangiocytes. | 2003 | Dig. Dis. Sci. | pmid:14714619 |
| Henzel K et al. | Toxicity of ethanol and acetaldehyde in hepatocytes treated with ursodeoxycholic or tauroursodeoxycholic acid. | 2004 | Biochim. Biophys. Acta | pmid:14741743 |
| Kubitz R et al. | Trafficking of the bile salt export pump from the Golgi to the canalicular membrane is regulated by the p38 MAP kinase. | 2004 | Gastroenterology | pmid:14762791 |
| pmid:14965230 | ||||
| Rolo AP et al. | Role of mitochondrial dysfunction in combined bile acid-induced cytotoxicity: the switch between apoptosis and necrosis. | 2004 | Toxicol. Sci. | pmid:14976352 |
| Lee DK et al. | [Deoxycholic acid-induced signal transduction in HT-29 cells: role of NF-kappa B and interleukin-8]. | 2004 | Korean J Gastroenterol | pmid:15034288 |
| Klett EL et al. | A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol. | 2004 | BMC Med | pmid:15040800 |
| pmid:15057918 | ||||
| Schoemaker MH et al. | Tauroursodeoxycholic acid protects rat hepatocytes from bile acid-induced apoptosis via activation of survival pathways. | 2004 | Hepatology | pmid:15185297 |
| Castro RE et al. | The bile acid tauroursodeoxycholic acid modulates phosphorylation and translocation of bad via phosphatidylinositol 3-kinase in glutamate-induced apoptosis of rat cortical neurons. | 2004 | J. Pharmacol. Exp. Ther. | pmid:15190125 |
| Solá S et al. | Tauroursodeoxycholic acid prevents amyloid-beta peptide-induced neuronal death via a phosphatidylinositol 3-kinase-dependent signaling pathway. | 2003 Sep-Dec | Mol. Med. | pmid:15208744 |
| Solá S et al. | Modulation of nuclear steroid receptors by ursodeoxycholic acid inhibits TGF-beta1-induced E2F-1/p53-mediated apoptosis of rat hepatocytes. | 2004 | Biochemistry | pmid:15222754 |
| Ramalho RM et al. | Inhibition of the E2F-1/p53/Bax pathway by tauroursodeoxycholic acid in amyloid beta-peptide-induced apoptosis of PC12 cells. | 2004 | J. Neurochem. | pmid:15255934 |
| Mita S et al. | Vectorial transport of bile salts across MDCK cells expressing both rat Na+-taurocholate cotransporting polypeptide and rat bile salt export pump. | 2005 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:15297262 |
| Tachizawa H et al. | Effects of colchicine on the maximum biliary excretion of cholephilic compounds in rats. | 2004 | J. Gastroenterol. Hepatol. | pmid:15304119 |
| pmid:15312152 | ||||
| Zhao XM and Montet JC | Effects of bile salt supplementation on biliary secretion in estrogen-treated rats. | 1990 | J. Nutr. Biochem. | pmid:15539232 |
| Marumo T et al. | Biliary excretion of bile acids and organic anions in rats with dichloroethylene-induced bile canalicular injury. | 2004 | J. Gastroenterol. | pmid:15549452 |
| Ma J et al. | Ursodeoxycholic acid inhibits endothelin-1 production in human vascular endothelial cells. | 2004 | Eur. J. Pharmacol. | pmid:15556138 |
| pmid:15652244 | ||||
| Pusl T et al. | Gap junctional intercellular communication is not needed for the anticholestatic effect of tauroursodeoxycholic acid in mouse liver. | 2005 | J. Hepatol. | pmid:15763348 |
| pmid:15810635 | ||||
| Crocenzi FA et al. | Prevention of Mrp2 activity impairment in ethinylestradiol-induced cholestasis by ursodeoxycholate in the rat. | 2005 | Drug Metab. Dispos. | pmid:15843489 |
| Takayanagi M et al. | Biliary excretion of olmesartan, an anigotensin II receptor antagonist, in the rat. | 2005 | J. Gastroenterol. Hepatol. | pmid:15853995 |
| Wang L et al. | Activation of CREB by tauroursodeoxycholic acid protects cholangiocytes from apoptosis induced by mTOR inhibition. | 2005 | Hepatology | pmid:15861431 |
| pmid:15869421 | ||||
| Cai W et al. | Interferon-alpha-induced modulation of glucocorticoid and serotonin receptors as a mechanism of depression. | 2005 | J. Hepatol. | pmid:15885359 |
| Castro RE et al. | A distinct microarray gene expression profile in primary rat hepatocytes incubated with ursodeoxycholic acid. | 2005 | J. Hepatol. | pmid:15885361 |
| pmid:15910498 | ||||
| Chen W and Gluud C | Bile acids for liver-transplanted patients. | 2005 | Cochrane Database Syst Rev | pmid:16034975 |
| Sokol RJ et al. | Human hepatic mitochondria generate reactive oxygen species and undergo the permeability transition in response to hydrophobic bile acids. | 2005 | J. Pediatr. Gastroenterol. Nutr. | pmid:16056106 |