| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypertension | D006973 | 115 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
Total
2
Tauroursodeoxycholic acid
Tauroursodeoxycholic acid is a lipid of Sterol Lipids (ST) class. Tauroursodeoxycholic acid is associated with abnormalities such as Hyperglycemia, Obesity, Wiskott-Aldrich Syndrome, neurogenic hypertension and Cholestatic liver disease. The involved functions are known as Cell Death, Apoptosis, Homeostasis, Process and mRNA Expression. Tauroursodeoxycholic acid often locates in Body tissue, Endoplasmic Reticulum, Hepatic, Blood and Protoplasm. The associated genes with Tauroursodeoxycholic acid are Homologous Gene and Mutant Proteins. The related lipids are cholanic acid, taurolithocholic acid 3-sulfate, Sterols, 7-dehydrocholesterol and tauromuricholic acid. The related experimental models are Disease model.
Cross Reference
Introduction
To understand associated biological information of Tauroursodeoxycholic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Tauroursodeoxycholic acid?
Tauroursodeoxycholic acid is suspected in Endothelial dysfunction, Hyperglycemia, Obesity, neurogenic hypertension, Cholestatic liver disease, Heart failure and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Diabetes (3)
- Am. J. Physiol. Heart Circ. Physiol. (1)
- Am. J. Physiol. Lung Cell Mol. Physiol. (1)
- Others (5)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Tauroursodeoxycholic acid
PubChem Associated disorders and diseases
What pathways are associated with Tauroursodeoxycholic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Tauroursodeoxycholic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Tauroursodeoxycholic acid?
Disease model
Disease model are used in the study 'Bile Acids Reduce Prion Conversion, Reduce Neuronal Loss, and Prolong Male Survival in Models of Prion Disease.' (Cortez LM et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Tauroursodeoxycholic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Trottier J et al. | Profiling circulating and urinary bile acids in patients with biliary obstruction before and after biliary stenting. | 2011 | PLoS ONE | pmid:21760958 |
| Ma Y et al. | Growth hormone secretagogues protect mouse cardiomyocytes from in vitro ischemia/reperfusion injury through regulation of intracellular calcium. | 2012 | PLoS ONE | pmid:22493744 |
| Yang JS et al. | Changes in hepatic gene expression upon oral administration of taurine-conjugated ursodeoxycholic acid in ob/ob mice. | 2010 | PLoS ONE | pmid:21079772 |
| Úriz M et al. | Ursodeoxycholic acid is conjugated with taurine to promote secretin-stimulated biliary hydrocholeresis in the normal rat. | 2011 | PLoS ONE | pmid:22194894 |
| Sheu ML et al. | Honokiol induces calpain-mediated glucose-regulated protein-94 cleavage and apoptosis in human gastric cancer cells and reduces tumor growth. | 2007 | PLoS ONE | pmid:17971859 |
| Nguyen MT et al. | Regulation of chemokine and chemokine receptor expression by PPARγ in adipocytes and macrophages. | 2012 | PLoS ONE | pmid:22529965 |
| Mantopoulos D et al. | Tauroursodeoxycholic acid (TUDCA) protects photoreceptors from cell death after experimental retinal detachment. | 2011 | PLoS ONE | pmid:21961034 |
| Fernández-Sánchez L et al. | Controlled delivery of tauroursodeoxycholic acid from biodegradable microspheres slows retinal degeneration and vision loss in P23H rats. | 2017 | PLoS ONE | pmid:28542454 |
| Zhang JY et al. | Inhibition of endoplasmic reticulum stress improves mouse embryo development. | 2012 | PLoS ONE | pmid:22808162 |
| Rani S et al. | Tauroursodeoxycholic acid (TUDCA) attenuates pressure overload-induced cardiac remodeling by reducing endoplasmic reticulum stress. | 2017 | PLoS ONE | pmid:28426781 |
| Groenendyk J et al. | Inhibition of the Unfolded Protein Response Mechanism Prevents Cardiac Fibrosis. | 2016 | PLoS ONE | pmid:27441395 |
| Fang L et al. | Autophagy attenuates diabetic glomerular damage through protection of hyperglycemia-induced podocyte injury. | 2013 | PLoS ONE | pmid:23593240 |
| Turdi S et al. | Tauroursodeoxycholic acid mitigates high fat diet-induced cardiomyocyte contractile and intracellular Ca2+ anomalies. | 2013 | PLoS ONE | pmid:23667647 |
| Gómez-Vicente V et al. | Neuroprotective Effect of Tauroursodeoxycholic Acid on N-Methyl-D-Aspartate-Induced Retinal Ganglion Cell Degeneration. | 2015 | PLoS ONE | pmid:26379056 |
| Koyama S et al. | Gefitinib and Erlotinib Lead to Phosphorylation of Eukaryotic Initiation Factor 2 Alpha Independent of Epidermal Growth Factor Receptor in A549 Cells. | 2015 | PLoS ONE | pmid:26288223 |
| Yao XH et al. | Prenatal ethanol exposure causes glucose intolerance with increased hepatic gluconeogenesis and histone deacetylases in adult rat offspring: reversal by tauroursodeoxycholic acid. | 2013 | PLoS ONE | pmid:23544086 |
| Yu KN et al. | Titanium Dioxide Nanoparticles Induce Endoplasmic Reticulum Stress-Mediated Autophagic Cell Death via Mitochondria-Associated Endoplasmic Reticulum Membrane Disruption in Normal Lung Cells. | 2015 | PLoS ONE | pmid:26121477 |
| Cheng S et al. | Pachymic acid inhibits growth and induces apoptosis of pancreatic cancer in vitro and in vivo by targeting ER stress. | 2015 | PLoS ONE | pmid:25915041 |
| Mališová L et al. | Ursodeoxycholic acid but not tauroursodeoxycholic acid inhibits proliferation and differentiation of human subcutaneous adipocytes. | 2013 | PLoS ONE | pmid:24312631 |
| Fang L et al. | Involvement of endoplasmic reticulum stress in albuminuria induced inflammasome activation in renal proximal tubular cells. | 2013 | PLoS ONE | pmid:23977286 |