MeSH term | MeSH ID | Detail |
---|---|---|
Hypertension | D006973 | 115 associated lipids |
Insulin Resistance | D007333 | 99 associated lipids |
Tauroursodeoxycholic acid is a lipid of Sterol Lipids (ST) class. Tauroursodeoxycholic acid is associated with abnormalities such as Hyperglycemia, Obesity, Wiskott-Aldrich Syndrome, neurogenic hypertension and Cholestatic liver disease. The involved functions are known as Cell Death, Apoptosis, Homeostasis, Process and mRNA Expression. Tauroursodeoxycholic acid often locates in Body tissue, Endoplasmic Reticulum, Hepatic, Blood and Protoplasm. The associated genes with Tauroursodeoxycholic acid are Homologous Gene and Mutant Proteins. The related lipids are cholanic acid, taurolithocholic acid 3-sulfate, Sterols, 7-dehydrocholesterol and tauromuricholic acid. The related experimental models are Disease model.
To understand associated biological information of Tauroursodeoxycholic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Tauroursodeoxycholic acid is suspected in Endothelial dysfunction, Hyperglycemia, Obesity, neurogenic hypertension, Cholestatic liver disease, Heart failure and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Tauroursodeoxycholic acid
MeSH term | MeSH ID | Detail |
---|---|---|
Hypertension | D006973 | 115 associated lipids |
Insulin Resistance | D007333 | 99 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Disease model are used in the study 'Bile Acids Reduce Prion Conversion, Reduce Neuronal Loss, and Prolong Male Survival in Models of Prion Disease.' (Cortez LM et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Keune WJ et al. | Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling. | 2016 | Nat Commun | pmid:27075612 |
Fu J et al. | Endoplasmic reticulum stress is involved in 2,4-dichlorophenol-induced hepatotoxicity. | 2016 | J Toxicol Sci | pmid:27853103 |
Groenendyk J et al. | Inhibition of the Unfolded Protein Response Mechanism Prevents Cardiac Fibrosis. | 2016 | PLoS ONE | pmid:27441395 |
Yung HW et al. | Placental endoplasmic reticulum stress in gestational diabetes: the potential for therapeutic intervention with chemical chaperones and antioxidants. | 2016 | Diabetologia | pmid:27406815 |
Kim GW et al. | Calorie-induced ER stress suppresses uroguanylin satiety signaling in diet-induced obesity. | 2016 | Nutr Diabetes | pmid:27214655 |
Siddesha JM et al. | Effect of a chemical chaperone, tauroursodeoxycholic acid, on HDM-induced allergic airway disease. | 2016 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:27154200 |
Memme JM et al. | Chronology of UPR activation in skeletal muscle adaptations to chronic contractile activity. | 2016 | Am. J. Physiol., Cell Physiol. | pmid:27122157 |
Keestra-Gounder AM et al. | NOD1 and NOD2 signalling links ER stress with inflammation. | 2016 | Nature | pmid:27007849 |
Zhou Q et al. | Effect of Tauroursodeoxycholic Acid and 4-Phenylbutyric Acid on Metabolism of Copper and Zinc in Type 1 Diabetic Mice Model. | 2016 | Biol Trace Elem Res | pmid:26282527 |
Cortez LM et al. | Bile Acids Reduce Prion Conversion, Reduce Neuronal Loss, and Prolong Male Survival in Models of Prion Disease. | 2015 | J. Virol. | pmid:25972546 |