| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypertension | D006973 | 115 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
Total
2
Tauroursodeoxycholic acid
Tauroursodeoxycholic acid is a lipid of Sterol Lipids (ST) class. Tauroursodeoxycholic acid is associated with abnormalities such as Hyperglycemia, Obesity, Wiskott-Aldrich Syndrome, neurogenic hypertension and Cholestatic liver disease. The involved functions are known as Cell Death, Apoptosis, Homeostasis, Process and mRNA Expression. Tauroursodeoxycholic acid often locates in Body tissue, Endoplasmic Reticulum, Hepatic, Blood and Protoplasm. The associated genes with Tauroursodeoxycholic acid are Homologous Gene and Mutant Proteins. The related lipids are cholanic acid, taurolithocholic acid 3-sulfate, Sterols, 7-dehydrocholesterol and tauromuricholic acid. The related experimental models are Disease model.
Cross Reference
Introduction
To understand associated biological information of Tauroursodeoxycholic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Tauroursodeoxycholic acid?
Tauroursodeoxycholic acid is suspected in Endothelial dysfunction, Hyperglycemia, Obesity, neurogenic hypertension, Cholestatic liver disease, Heart failure and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Diabetes (3)
- Am. J. Physiol. Heart Circ. Physiol. (1)
- Am. J. Physiol. Lung Cell Mol. Physiol. (1)
- Others (5)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Tauroursodeoxycholic acid
PubChem Associated disorders and diseases
What pathways are associated with Tauroursodeoxycholic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Tauroursodeoxycholic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Tauroursodeoxycholic acid?
Disease model
Disease model are used in the study 'Bile Acids Reduce Prion Conversion, Reduce Neuronal Loss, and Prolong Male Survival in Models of Prion Disease.' (Cortez LM et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Tauroursodeoxycholic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Milkiewicz P et al. | Effect of tauroursodeoxycholate and S-adenosyl-L-methionine on 17beta-estradiol glucuronide-induced cholestasis. | 2001 | J. Hepatol. | pmid:11281545 |
| Heubi JE et al. | Tauroursodeoxycholic acid (TUDCA) in the prevention of total parenteral nutrition-associated liver disease. | 2002 | J. Pediatr. | pmid:12183720 |
| Duan WM et al. | Tauroursodeoxycholic acid improves the survival and function of nigral transplants in a rat model of Parkinson's disease. | 2002 | Cell Transplant | pmid:12075985 |
| Xiao ZL et al. | Effects of bile acids on the muscle functions of guinea pig gallbladder. | 2002 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12065295 |
| Glasova H et al. | Tauroursodeoxycholic acid mobilizes alpha-PKC after uptake in human HepG2 hepatoma cells. | 2002 | Eur. J. Clin. Invest. | pmid:12059989 |
| Noé J et al. | Functional expression of the canalicular bile salt export pump of human liver. | 2002 | Gastroenterology | pmid:12404240 |
| Piepoli AL et al. | Tauroursodeoxycholic acid reduces damaging effects of taurodeoxycholic acid on fundus gastric mucosa. | 2002 | Arch. Physiol. Biochem. | pmid:12221520 |
| Pandak WM et al. | Regulation of oxysterol 7alpha-hydroxylase (CYP7B1) in primary cultures of rat hepatocytes. | 2002 | Hepatology | pmid:12029625 |
| Azzaroli F et al. | Ursodeoxycholic acid diminishes Fas-ligand-induced apoptosis in mouse hepatocytes. | 2002 | Hepatology | pmid:12085348 |
| Milkiewicz P et al. | Hepatoprotection with tauroursodeoxycholate and beta muricholate against taurolithocholate induced cholestasis: involvement of signal transduction pathways. | 2002 | Gut | pmid:12077103 |
| Graf D et al. | Taurolithocholic acid-3 sulfate induces CD95 trafficking and apoptosis in a c-Jun N-terminal kinase-dependent manner. | 2002 | Gastroenterology | pmid:11984527 |
| Yamashita Y et al. | High metabolic function of primary human and porcine hepatocytes in a polyurethane foam/spheroid culture system in plasma from patients with fulminant hepatic failure. | 2002 | Cell Transplant | pmid:12162378 |
| Veggi LM et al. | Dapsone-induced cholestasis and impairment of bile salt output in the rat. | 2002 | Biochem. Pharmacol. | pmid:11996898 |
| Kim YH and Shin MJ | Effects of high taurocholate load on activities of hepatic alcohol metabolizing enzymes. | 2002 | Exp. Mol. Med. | pmid:12085987 |
| Rodrigues CM et al. | Neuroprotection by a bile acid in an acute stroke model in the rat. | 2002 | J. Cereb. Blood Flow Metab. | pmid:11919517 |
| Carubbi F et al. | Comparative cytotoxic and cytoprotective effects of taurohyodeoxycholic acid (THDCA) and tauroursodeoxycholic acid (TUDCA) in HepG2 cell line. | 2002 | Biochim. Biophys. Acta | pmid:11923098 |
| Xie Q et al. | Effect of tauroursodeoxycholic acid on endoplasmic reticulum stress-induced caspase-12 activation. | 2002 | Hepatology | pmid:12198651 |
| Venneman NG et al. | Effects of hydrophobic and hydrophilic bile salt mixtures on cholesterol crystallization in model biles. | 2002 | Biochim. Biophys. Acta | pmid:12117566 |
| Keene CD et al. | Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12149470 |
| Alpini G et al. | Ursodeoxycholate and tauroursodeoxycholate inhibit cholangiocyte growth and secretion of BDL rats through activation of PKC alpha. | 2002 | Hepatology | pmid:11981754 |
| Kok T et al. | Peroxisome proliferator-activated receptor alpha (PPARalpha)-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in mice. | 2003 | Biochem. J. | pmid:12381268 |
| Rodrigues CM et al. | Tauroursodeoxycholic acid prevents Bax-induced membrane perturbation and cytochrome C release in isolated mitochondria. | 2003 | Biochemistry | pmid:12627974 |
| Rodrigues CM et al. | Tauroursodeoxycholic acid reduces apoptosis and protects against neurological injury after acute hemorrhagic stroke in rats. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12721362 |
| Häussinger D et al. | Involvement of integrins and Src in tauroursodeoxycholate-induced and swelling-induced choleresis. | 2003 | Gastroenterology | pmid:12730886 |
| Baiocchi L et al. | Taurohyodeoxycholate- and tauroursodeoxycholate-induced hypercholeresis is augmented in bile duct ligated rats. | 2003 | J. Hepatol. | pmid:12547401 |
| Chen W et al. | Bile acids for viral hepatitis. | 2003 | Cochrane Database Syst Rev | pmid:12804455 |
| Chignard N et al. | Bile salts potentiate adenylyl cyclase activity and cAMP-regulated secretion in human gallbladder epithelium. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12421748 |
| Tessier E et al. | High-performance liquid chromatographic mass spectrometric method for the determination of ursodeoxycholic acid and its glycine and taurine conjugates in human plasma. | 2003 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:14643509 |
| Schoemaker MH et al. | Resistance of rat hepatocytes against bile acid-induced apoptosis in cholestatic liver injury is due to nuclear factor-kappa B activation. | 2003 | J. Hepatol. | pmid:12873810 |
| Komichi D et al. | Unique inhibition of bile salt-induced apoptosis by lecithins and cytoprotective bile salts in immortalized mouse cholangiocytes. | 2003 | Dig. Dis. Sci. | pmid:14714619 |
| Beuers U et al. | Taurolithocholic acid exerts cholestatic effects via phosphatidylinositol 3-kinase-dependent mechanisms in perfused rat livers and rat hepatocyte couplets. | 2003 | J. Biol. Chem. | pmid:12626520 |
| Reinehr R et al. | Bile salt-induced hepatocyte apoptosis involves epidermal growth factor receptor-dependent CD95 tyrosine phosphorylation. | 2003 | Gastroenterology | pmid:12949729 |
| Ma J et al. | Inhibitory effects of ursodeoxycholic acid on the induction of nitric oxide synthase in vascular smooth muscle cells. | 2003 | Eur. J. Pharmacol. | pmid:12620498 |
| Tsuboi K et al. | Hydrophilic bile salts have a cytoprotective effect against cyclosporine A-induced cholestasis through enhanced canalicular membrane fluidity and transporter activity. | 2003 | Hepatol. Res. | pmid:12644037 |
| Sánchez Pozzi EJ et al. | Ursodeoxycholate reduces ethinylestradiol glucuronidation in the rat: role in prevention of estrogen-induced cholestasis. | 2003 | J. Pharmacol. Exp. Ther. | pmid:12663690 |
| Lamireau T et al. | Effects of bile acids on biliary epithelial cells: proliferation, cytotoxicity, and cytokine secretion. | 2003 | Life Sci. | pmid:12527037 |
| Liu Y et al. | Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis. | 2003 | J. Clin. Invest. | pmid:14623915 |
| Solá S et al. | Tauroursodeoxycholic acid prevents amyloid-beta peptide-induced neuronal death via a phosphatidylinositol 3-kinase-dependent signaling pathway. | 2003 Sep-Dec | Mol. Med. | pmid:15208744 |
| Castro RE et al. | The bile acid tauroursodeoxycholic acid modulates phosphorylation and translocation of bad via phosphatidylinositol 3-kinase in glutamate-induced apoptosis of rat cortical neurons. | 2004 | J. Pharmacol. Exp. Ther. | pmid:15190125 |
| Ramalho RM et al. | Inhibition of the E2F-1/p53/Bax pathway by tauroursodeoxycholic acid in amyloid beta-peptide-induced apoptosis of PC12 cells. | 2004 | J. Neurochem. | pmid:15255934 |
| Kubitz R et al. | Trafficking of the bile salt export pump from the Golgi to the canalicular membrane is regulated by the p38 MAP kinase. | 2004 | Gastroenterology | pmid:14762791 |
| Alpini G et al. | Tauroursodeoxycholate inhibits human cholangiocarcinoma growth via Ca2+-, PKC-, and MAPK-dependent pathways. | 2004 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:14701718 |
| Solá S et al. | Modulation of nuclear steroid receptors by ursodeoxycholic acid inhibits TGF-beta1-induced E2F-1/p53-mediated apoptosis of rat hepatocytes. | 2004 | Biochemistry | pmid:15222754 |
| Klett EL et al. | A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol. | 2004 | BMC Med | pmid:15040800 |
| Schoemaker MH et al. | Tauroursodeoxycholic acid protects rat hepatocytes from bile acid-induced apoptosis via activation of survival pathways. | 2004 | Hepatology | pmid:15185297 |
| Lee DK et al. | [Deoxycholic acid-induced signal transduction in HT-29 cells: role of NF-kappa B and interleukin-8]. | 2004 | Korean J Gastroenterol | pmid:15034288 |
| Henzel K et al. | Toxicity of ethanol and acetaldehyde in hepatocytes treated with ursodeoxycholic or tauroursodeoxycholic acid. | 2004 | Biochim. Biophys. Acta | pmid:14741743 |
| Ma J et al. | Ursodeoxycholic acid inhibits endothelin-1 production in human vascular endothelial cells. | 2004 | Eur. J. Pharmacol. | pmid:15556138 |
| Marumo T et al. | Biliary excretion of bile acids and organic anions in rats with dichloroethylene-induced bile canalicular injury. | 2004 | J. Gastroenterol. | pmid:15549452 |
| Rolo AP et al. | Role of mitochondrial dysfunction in combined bile acid-induced cytotoxicity: the switch between apoptosis and necrosis. | 2004 | Toxicol. Sci. | pmid:14976352 |
| Tachizawa H et al. | Effects of colchicine on the maximum biliary excretion of cholephilic compounds in rats. | 2004 | J. Gastroenterol. Hepatol. | pmid:15304119 |
| Castro RE et al. | A distinct microarray gene expression profile in primary rat hepatocytes incubated with ursodeoxycholic acid. | 2005 | J. Hepatol. | pmid:15885361 |
| Ved R et al. | Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans. | 2005 | J. Biol. Chem. | pmid:16239214 |
| Pusl T et al. | Gap junctional intercellular communication is not needed for the anticholestatic effect of tauroursodeoxycholic acid in mouse liver. | 2005 | J. Hepatol. | pmid:15763348 |
| Cai W et al. | Interferon-alpha-induced modulation of glucocorticoid and serotonin receptors as a mechanism of depression. | 2005 | J. Hepatol. | pmid:15885359 |
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| Mita S et al. | Vectorial transport of bile salts across MDCK cells expressing both rat Na+-taurocholate cotransporting polypeptide and rat bile salt export pump. | 2005 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:15297262 |
| Dent P et al. | Conjugated bile acids promote ERK1/2 and AKT activation via a pertussis toxin-sensitive mechanism in murine and human hepatocytes. | 2005 | Hepatology | pmid:16317705 |
| Crocenzi FA et al. | Prevention of Mrp2 activity impairment in ethinylestradiol-induced cholestasis by ursodeoxycholate in the rat. | 2005 | Drug Metab. Dispos. | pmid:15843489 |
| Sokol RJ et al. | Human hepatic mitochondria generate reactive oxygen species and undergo the permeability transition in response to hydrophobic bile acids. | 2005 | J. Pediatr. Gastroenterol. Nutr. | pmid:16056106 |
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| Takayanagi M et al. | Biliary excretion of olmesartan, an anigotensin II receptor antagonist, in the rat. | 2005 | J. Gastroenterol. Hepatol. | pmid:15853995 |
| Wang L et al. | Activation of CREB by tauroursodeoxycholic acid protects cholangiocytes from apoptosis induced by mTOR inhibition. | 2005 | Hepatology | pmid:15861431 |
| Mrówczynska L et al. | Inhibition of MRP1-mediated efflux in human erythrocytes by mono-anionic bile salts. | 2005 Sep-Oct | Anticancer Res. | pmid:16101123 |
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| Marzioni M et al. | Ca2+-dependent cytoprotective effects of ursodeoxycholic and tauroursodeoxycholic acid on the biliary epithelium in a rat model of cholestasis and loss of bile ducts. | 2006 | Am. J. Pathol. | pmid:16436655 |
| Crocenzi FA et al. | Galactosamine prevents ethinylestradiol-induced cholestasis. | 2006 | Drug Metab. Dispos. | pmid:16554370 |
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| Ramalho RM et al. | Tauroursodeoxycholic acid modulates p53-mediated apoptosis in Alzheimer's disease mutant neuroblastoma cells. | 2006 | J. Neurochem. | pmid:16923170 |
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| Solá S et al. | Functional modulation of nuclear steroid receptors by tauroursodeoxycholic acid reduces amyloid beta-peptide-induced apoptosis. | 2006 | Mol. Endocrinol. | pmid:16728529 |
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| van Minnen LP et al. | Cholesterol crystals enhance and phospholipids protect against pancreatitis induced by hydrophobic bile salts: a rat model study. | 2006 | Pancreas | pmid:16670619 |
| Terry C et al. | Preincubation of rat and human hepatocytes with cytoprotectants prior to cryopreservation can improve viability and function upon thawing. | 2006 | Liver Transpl. | pmid:16382475 |
| Vaidya SS and Gerk PM | Lack of interaction between tauroursodeoxycholate and ATP-binding cassette transporter isoform G2 (ABCG2). | 2006 May-Jun | Mol. Pharm. | pmid:16749862 |
| Sheu ML et al. | Honokiol induces calpain-mediated glucose-regulated protein-94 cleavage and apoptosis in human gastric cancer cells and reduces tumor growth. | 2007 | PLoS ONE | pmid:17971859 |
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| Gerk PM et al. | Human multidrug resistance protein 2 transports the therapeutic bile salt tauroursodeoxycholate. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17108237 |
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| Castro RE et al. | Differential regulation of cyclin D1 and cell death by bile acids in primary rat hepatocytes. | 2007 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:17431217 |
| Rivard AL et al. | Administration of tauroursodeoxycholic acid (TUDCA) reduces apoptosis following myocardial infarction in rat. | 2007 | Am. J. Chin. Med. | pmid:17436368 |
| Amaral JD et al. | p53 is a key molecular target of ursodeoxycholic acid in regulating apoptosis. | 2007 | J. Biol. Chem. | pmid:17881359 |
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| Miller SD et al. | Tauroursodeoxycholic acid inhibits apoptosis induced by Z alpha-1 antitrypsin via inhibition of Bad. | 2007 | Hepatology | pmid:17559149 |
| Wimmer R et al. | Tauroursodeoxycholic acid exerts anticholestatic effects by a cooperative cPKC alpha-/PKA-dependent mechanism in rat liver. | 2008 | Gut | pmid:18583398 |
| Chen Y et al. | Effect of taurine-conjugated ursodeoxycholic acid on endoplasmic reticulum stress and apoptosis induced by advanced glycation end products in cultured mouse podocytes. | 2008 | Am. J. Nephrol. | pmid:18648192 |