| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypertension | D006973 | 115 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
Total
2
Tauroursodeoxycholic acid
Tauroursodeoxycholic acid is a lipid of Sterol Lipids (ST) class. Tauroursodeoxycholic acid is associated with abnormalities such as Hyperglycemia, Obesity, Wiskott-Aldrich Syndrome, neurogenic hypertension and Cholestatic liver disease. The involved functions are known as Cell Death, Apoptosis, Homeostasis, Process and mRNA Expression. Tauroursodeoxycholic acid often locates in Body tissue, Endoplasmic Reticulum, Hepatic, Blood and Protoplasm. The associated genes with Tauroursodeoxycholic acid are Homologous Gene and Mutant Proteins. The related lipids are cholanic acid, taurolithocholic acid 3-sulfate, Sterols, 7-dehydrocholesterol and tauromuricholic acid. The related experimental models are Disease model.
Cross Reference
Introduction
To understand associated biological information of Tauroursodeoxycholic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Tauroursodeoxycholic acid?
Tauroursodeoxycholic acid is suspected in Endothelial dysfunction, Hyperglycemia, Obesity, neurogenic hypertension, Cholestatic liver disease, Heart failure and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Diabetes (3)
- Am. J. Physiol. Heart Circ. Physiol. (1)
- Am. J. Physiol. Lung Cell Mol. Physiol. (1)
- Others (5)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Tauroursodeoxycholic acid
PubChem Associated disorders and diseases
What pathways are associated with Tauroursodeoxycholic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Tauroursodeoxycholic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Tauroursodeoxycholic acid?
Disease model
Disease model are used in the study 'Bile Acids Reduce Prion Conversion, Reduce Neuronal Loss, and Prolong Male Survival in Models of Prion Disease.' (Cortez LM et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Tauroursodeoxycholic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ben Mosbah I et al. | Endoplasmic reticulum stress inhibition protects steatotic and non-steatotic livers in partial hepatectomy under ischemia-reperfusion. | 2010 | Cell Death Dis | pmid:21364657 |
| Guo R et al. | Metallothionein alleviates oxidative stress-induced endoplasmic reticulum stress and myocardial dysfunction. | 2009 | J. Mol. Cell. Cardiol. | pmid:19344729 |
| Xiang X et al. | Effect of SLCO1B1 polymorphism on the plasma concentrations of bile acids and bile acid synthesis marker in humans. | 2009 | Pharmacogenet. Genomics | pmid:19387419 |
| Fimognari C et al. | Apoptosis and modulation of cell cycle control by bile acids in human leukemia T cells. | 2009 | Ann. N. Y. Acad. Sci. | pmid:19723064 |
| Feng Y et al. | Bear bile: dilemma of traditional medicinal use and animal protection. | 2009 | J Ethnobiol Ethnomed | pmid:19138420 |
| Dreger SC et al. | Killing of rat basophilic leukemia cells by lethal toxin from Clostridium sordellii: critical role of phosphatidylinositide 3'-OH kinase/Akt signaling. | 2009 | Biochemistry | pmid:19199813 |
| Viana RJ et al. | Tauroursodeoxycholic acid prevents E22Q Alzheimer's Abeta toxicity in human cerebral endothelial cells. | 2009 | Cell. Mol. Life Sci. | pmid:19189048 |
| Schulz F et al. | Prevention of Clostridium sordellii lethal toxin-induced apoptotic cell death by tauroursodeoxycholic acid. | 2009 | Biochemistry | pmid:19691300 |
| Miki T et al. | Endoplasmic reticulum stress in diabetic hearts abolishes erythropoietin-induced myocardial protection by impairment of phospho-glycogen synthase kinase-3beta-mediated suppression of mitochondrial permeability transition. | 2009 | Diabetes | pmid:19755525 |
| Ozcan L et al. | Endoplasmic reticulum stress plays a central role in development of leptin resistance. | 2009 | Cell Metab. | pmid:19117545 |
| Hohenester S et al. | Primary biliary cirrhosis. | 2009 | Semin Immunopathol | pmid:19603170 |
| Zhou L et al. | Autophagy-mediated insulin receptor down-regulation contributes to endoplasmic reticulum stress-induced insulin resistance. | 2009 | Mol. Pharmacol. | pmid:19541767 |
| Gnewuch C et al. | Serum bile acid profiling reflects enterohepatic detoxification state and intestinal barrier function in inflammatory bowel disease. | 2009 | World J. Gastroenterol. | pmid:19575493 |
| Sommerfeld A et al. | Bile acid-induced epidermal growth factor receptor activation in quiescent rat hepatic stellate cells can trigger both proliferation and apoptosis. | 2009 | J. Biol. Chem. | pmid:19553664 |
| Ramalho RM et al. | Apoptosis in transgenic mice expressing the P301L mutated form of human tau. | 2008 May-Jun | Mol. Med. | pmid:18368144 |
| Udawatte C et al. | Taurine suppresses the spread of cell death in electrically coupled RPE cells. | 2008 | Mol. Vis. | pmid:18958305 |
| Roma MG et al. | Dynamic localization of hepatocellular transporters in health and disease. | 2008 | World J. Gastroenterol. | pmid:19058304 |
| Watanabe N and Lam E | BAX inhibitor-1 modulates endoplasmic reticulum stress-mediated programmed cell death in Arabidopsis. | 2008 | J. Biol. Chem. | pmid:18039663 |
| Higuchi WI et al. | Estimation of cholesterol solubilization by a mixed micelle binding model in aqueous tauroursodeoxycholate:lecithin:cholesterol solutions. | 2008 | J Pharm Sci | pmid:17786967 |
| Monte MJ et al. | Cytosol-nucleus traffic and colocalization with FXR of conjugated bile acids in rat hepatocytes. | 2008 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:18467501 |
| Wei H et al. | ER and oxidative stresses are common mediators of apoptosis in both neurodegenerative and non-neurodegenerative lysosomal storage disorders and are alleviated by chemical chaperones. | 2008 | Hum. Mol. Genet. | pmid:17989065 |
| Ramalho RM et al. | Bile acids and apoptosis modulation: an emerging role in experimental Alzheimer's disease. | 2008 | Trends Mol Med | pmid:18218342 |
| Mannack G et al. | Taurolithocholic acid-3 sulfate impairs insulin signaling in cultured rat hepatocytes and perfused rat liver. | 2008 | Cell. Physiol. Biochem. | pmid:18209481 |
| Lawless MW et al. | Tauroursodeoxycholic acid: relieving the pathogenesis of HFE C282Y hereditary hemochromatosis. | 2008 | Hepatology | pmid:18203149 |
| Colak A et al. | Tauroursodeoxycholic acid and secondary damage after spinal cord injury in rats. | 2008 | J Clin Neurosci | pmid:18343118 |
| Baiocchi L et al. | TUDCA prevents cholestasis and canalicular damage induced by ischemia-reperfusion injury in the rat, modulating PKCalpha-ezrin pathway. | 2008 | Transpl. Int. | pmid:18435680 |
| Phillips MJ et al. | Tauroursodeoxycholic acid preservation of photoreceptor structure and function in the rd10 mouse through postnatal day 30. | 2008 | Invest. Ophthalmol. Vis. Sci. | pmid:18436848 |
| Nonaka M et al. | Cytoprotective effect of tauroursodeoxycholate on hepatocyte apoptosis induced by peroxisome proliferator-activated receptor gamma ligand. | 2008 | J. Gastroenterol. Hepatol. | pmid:17868335 |
| Macedo B et al. | Anti-apoptotic treatment reduces transthyretin deposition in a transgenic mouse model of Familial Amyloidotic Polyneuropathy. | 2008 | Biochim. Biophys. Acta | pmid:18572024 |
| Wimmer R et al. | Tauroursodeoxycholic acid exerts anticholestatic effects by a cooperative cPKC alpha-/PKA-dependent mechanism in rat liver. | 2008 | Gut | pmid:18583398 |
| Pusl T et al. | Tauroursodeoxycholic acid reduces bile acid-induced apoptosis by modulation of AP-1. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18164257 |
| Chen Y et al. | Effect of taurine-conjugated ursodeoxycholic acid on endoplasmic reticulum stress and apoptosis induced by advanced glycation end products in cultured mouse podocytes. | 2008 | Am. J. Nephrol. | pmid:18648192 |
| Park IH et al. | Ursodeoxycholic acid prevents apoptosis of mouse sensory neurons induced by cisplatin by reducing P53 accumulation. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18558085 |
| Sheu ML et al. | Honokiol induces calpain-mediated glucose-regulated protein-94 cleavage and apoptosis in human gastric cancer cells and reduces tumor growth. | 2007 | PLoS ONE | pmid:17971859 |
| Xie Y et al. | Conditional intestinal lipotoxicity in Apobec-1-/- Mttp-IKO mice: a survival advantage for mammalian intestinal apolipoprotein B mRNA editing. | 2007 | J. Biol. Chem. | pmid:17855359 |
| Taffetani S et al. | Prolactin stimulates the proliferation of normal female cholangiocytes by differential regulation of Ca2+-dependent PKC isoforms. | 2007 | BMC Physiol. | pmid:17640386 |
| de Almeida SF et al. | Chemical chaperones reduce endoplasmic reticulum stress and prevent mutant HFE aggregate formation. | 2007 | J. Biol. Chem. | pmid:17626021 |
| Sabeva NS et al. | Defects in the leptin axis reduce abundance of the ABCG5-ABCG8 sterol transporter in liver. | 2007 | J. Biol. Chem. | pmid:17561514 |
| Roda A et al. | A new oral formulation for the release of sodium butyrate in the ileo-cecal region and colon. | 2007 | World J. Gastroenterol. | pmid:17373743 |
| Gerk PM et al. | Human multidrug resistance protein 2 transports the therapeutic bile salt tauroursodeoxycholate. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17108237 |
| Lawless MW et al. | Expression of hereditary hemochromatosis C282Y HFE protein in HEK293 cells activates specific endoplasmic reticulum stress responses. | 2007 | BMC Cell Biol. | pmid:17650303 |
| Castro RE et al. | Differential regulation of cyclin D1 and cell death by bile acids in primary rat hepatocytes. | 2007 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:17431217 |
| Rivard AL et al. | Administration of tauroursodeoxycholic acid (TUDCA) reduces apoptosis following myocardial infarction in rat. | 2007 | Am. J. Chin. Med. | pmid:17436368 |
| Amaral JD et al. | p53 is a key molecular target of ursodeoxycholic acid in regulating apoptosis. | 2007 | J. Biol. Chem. | pmid:17881359 |
| Gregor MF and Hotamisligil GS | Thematic review series: Adipocyte Biology. Adipocyte stress: the endoplasmic reticulum and metabolic disease. | 2007 | J. Lipid Res. | pmid:17699733 |
| Miller SD et al. | Tauroursodeoxycholic acid inhibits apoptosis induced by Z alpha-1 antitrypsin via inhibition of Bad. | 2007 | Hepatology | pmid:17559149 |
| Vaidya SS and Gerk PM | Lack of interaction between tauroursodeoxycholate and ATP-binding cassette transporter isoform G2 (ABCG2). | 2006 May-Jun | Mol. Pharm. | pmid:16749862 |
| Kanazawa I | Therapeutic Strategies in Huntington's Disease. | 2006 | J Clin Neurol | pmid:20396523 |
| Kim HS et al. | [Modulation of colon cancer cell invasiveness induced by deoxycholic acid]. | 2006 | Korean J Gastroenterol | pmid:16861876 |
| Zhang W et al. | Binding studies of bile acids using the native fluorescence of the tryptophan residue Of Bax protein. | 2006 | Biosci. Rep. | pmid:16850250 |
| Boost KA et al. | c-Met responsiveness of isolated hepatocytes evaluated in an in vitro de-differentiation model. | 2006 | Int. J. Mol. Med. | pmid:16465395 |
| Marzioni M et al. | Ca2+-dependent cytoprotective effects of ursodeoxycholic and tauroursodeoxycholic acid on the biliary epithelium in a rat model of cholestasis and loss of bile ducts. | 2006 | Am. J. Pathol. | pmid:16436655 |
| Crocenzi FA et al. | Galactosamine prevents ethinylestradiol-induced cholestasis. | 2006 | Drug Metab. Dispos. | pmid:16554370 |
| Plösch T et al. | Abcg5/Abcg8-independent pathways contribute to hepatobiliary cholesterol secretion in mice. | 2006 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:16614371 |
| Cui H et al. | [Experimental study of the permeability of Fel Ursi's in eye]. | 2006 | Zhonghua Yan Ke Za Zhi | pmid:17386143 |
| Dombrowski F et al. | Tauroursodeoxycholic acid inserts the bile salt export pump into canalicular membranes of cholestatic rat liver. | 2006 | Lab. Invest. | pmid:16344857 |
| Kosters A et al. | The mechanism of ABCG5/ABCG8 in biliary cholesterol secretion in mice. | 2006 | J. Lipid Res. | pmid:16741293 |
| Powell AA et al. | Resistance to ursodeoxycholic acid-induced growth arrest can also result in resistance to deoxycholic acid-induced apoptosis and increased tumorgenicity. | 2006 | BMC Cancer | pmid:16948850 |
| Ramalho RM et al. | Tauroursodeoxycholic acid modulates p53-mediated apoptosis in Alzheimer's disease mutant neuroblastoma cells. | 2006 | J. Neurochem. | pmid:16923170 |
| Ozcan U et al. | Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. | 2006 | Science | pmid:16931765 |
| Petruzzelli M et al. | Indomethacin enhances bile salt detergent activity: relevance for NSAIDs-induced gastrointestinal mucosal injury. | 2006 | Dig. Dis. Sci. | pmid:16615001 |
| Solá S et al. | Functional modulation of nuclear steroid receptors by tauroursodeoxycholic acid reduces amyloid beta-peptide-induced apoptosis. | 2006 | Mol. Endocrinol. | pmid:16728529 |
| Boatright JH et al. | Tool from ancient pharmacopoeia prevents vision loss. | 2006 | Mol. Vis. | pmid:17213800 |
| Barth A et al. | Bile acid transport and metabolism in rat liver slices. | 2006 | Exp. Toxicol. Pathol. | pmid:16413764 |
| Park JY et al. | Bile acid analysis in biliary tract cancer. | 2006 | Yonsei Med. J. | pmid:17191311 |
| van Minnen LP et al. | Cholesterol crystals enhance and phospholipids protect against pancreatitis induced by hydrophobic bile salts: a rat model study. | 2006 | Pancreas | pmid:16670619 |
| Terry C et al. | Preincubation of rat and human hepatocytes with cytoprotectants prior to cryopreservation can improve viability and function upon thawing. | 2006 | Liver Transpl. | pmid:16382475 |
| Mrówczynska L et al. | Inhibition of MRP1-mediated efflux in human erythrocytes by mono-anionic bile salts. | 2005 Sep-Oct | Anticancer Res. | pmid:16101123 |
| Castro RE et al. | A distinct microarray gene expression profile in primary rat hepatocytes incubated with ursodeoxycholic acid. | 2005 | J. Hepatol. | pmid:15885361 |
| Ved R et al. | Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans. | 2005 | J. Biol. Chem. | pmid:16239214 |
| Pusl T et al. | Gap junctional intercellular communication is not needed for the anticholestatic effect of tauroursodeoxycholic acid in mouse liver. | 2005 | J. Hepatol. | pmid:15763348 |
| Cai W et al. | Interferon-alpha-induced modulation of glucocorticoid and serotonin receptors as a mechanism of depression. | 2005 | J. Hepatol. | pmid:15885359 |
| Terry C et al. | Preincubation of rat and human hepatocytes with cytoprotectants prior to cryopreservation can improve viability and function upon thawing. | 2005 | Liver Transpl. | pmid:16315306 |
| Mita S et al. | Vectorial transport of bile salts across MDCK cells expressing both rat Na+-taurocholate cotransporting polypeptide and rat bile salt export pump. | 2005 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:15297262 |
| Dent P et al. | Conjugated bile acids promote ERK1/2 and AKT activation via a pertussis toxin-sensitive mechanism in murine and human hepatocytes. | 2005 | Hepatology | pmid:16317705 |
| Crocenzi FA et al. | Prevention of Mrp2 activity impairment in ethinylestradiol-induced cholestasis by ursodeoxycholate in the rat. | 2005 | Drug Metab. Dispos. | pmid:15843489 |
| Sokol RJ et al. | Human hepatic mitochondria generate reactive oxygen species and undergo the permeability transition in response to hydrophobic bile acids. | 2005 | J. Pediatr. Gastroenterol. Nutr. | pmid:16056106 |
| Chen W and Gluud C | Bile acids for liver-transplanted patients. | 2005 | Cochrane Database Syst Rev | pmid:16034975 |
| Takayanagi M et al. | Biliary excretion of olmesartan, an anigotensin II receptor antagonist, in the rat. | 2005 | J. Gastroenterol. Hepatol. | pmid:15853995 |
| Wang L et al. | Activation of CREB by tauroursodeoxycholic acid protects cholangiocytes from apoptosis induced by mTOR inhibition. | 2005 | Hepatology | pmid:15861431 |
| Castro RE et al. | The bile acid tauroursodeoxycholic acid modulates phosphorylation and translocation of bad via phosphatidylinositol 3-kinase in glutamate-induced apoptosis of rat cortical neurons. | 2004 | J. Pharmacol. Exp. Ther. | pmid:15190125 |
| Ramalho RM et al. | Inhibition of the E2F-1/p53/Bax pathway by tauroursodeoxycholic acid in amyloid beta-peptide-induced apoptosis of PC12 cells. | 2004 | J. Neurochem. | pmid:15255934 |
| Kubitz R et al. | Trafficking of the bile salt export pump from the Golgi to the canalicular membrane is regulated by the p38 MAP kinase. | 2004 | Gastroenterology | pmid:14762791 |
| Alpini G et al. | Tauroursodeoxycholate inhibits human cholangiocarcinoma growth via Ca2+-, PKC-, and MAPK-dependent pathways. | 2004 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:14701718 |
| Solá S et al. | Modulation of nuclear steroid receptors by ursodeoxycholic acid inhibits TGF-beta1-induced E2F-1/p53-mediated apoptosis of rat hepatocytes. | 2004 | Biochemistry | pmid:15222754 |
| Klett EL et al. | A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol. | 2004 | BMC Med | pmid:15040800 |
| Schoemaker MH et al. | Tauroursodeoxycholic acid protects rat hepatocytes from bile acid-induced apoptosis via activation of survival pathways. | 2004 | Hepatology | pmid:15185297 |
| Lee DK et al. | [Deoxycholic acid-induced signal transduction in HT-29 cells: role of NF-kappa B and interleukin-8]. | 2004 | Korean J Gastroenterol | pmid:15034288 |
| Henzel K et al. | Toxicity of ethanol and acetaldehyde in hepatocytes treated with ursodeoxycholic or tauroursodeoxycholic acid. | 2004 | Biochim. Biophys. Acta | pmid:14741743 |
| Ma J et al. | Ursodeoxycholic acid inhibits endothelin-1 production in human vascular endothelial cells. | 2004 | Eur. J. Pharmacol. | pmid:15556138 |
| Marumo T et al. | Biliary excretion of bile acids and organic anions in rats with dichloroethylene-induced bile canalicular injury. | 2004 | J. Gastroenterol. | pmid:15549452 |
| Rolo AP et al. | Role of mitochondrial dysfunction in combined bile acid-induced cytotoxicity: the switch between apoptosis and necrosis. | 2004 | Toxicol. Sci. | pmid:14976352 |
| Tachizawa H et al. | Effects of colchicine on the maximum biliary excretion of cholephilic compounds in rats. | 2004 | J. Gastroenterol. Hepatol. | pmid:15304119 |
| Solá S et al. | Tauroursodeoxycholic acid prevents amyloid-beta peptide-induced neuronal death via a phosphatidylinositol 3-kinase-dependent signaling pathway. | 2003 Sep-Dec | Mol. Med. | pmid:15208744 |
| Rodrigues CM et al. | Tauroursodeoxycholic acid prevents Bax-induced membrane perturbation and cytochrome C release in isolated mitochondria. | 2003 | Biochemistry | pmid:12627974 |
| Baiocchi L et al. | Taurohyodeoxycholate- and tauroursodeoxycholate-induced hypercholeresis is augmented in bile duct ligated rats. | 2003 | J. Hepatol. | pmid:12547401 |
| Tessier E et al. | High-performance liquid chromatographic mass spectrometric method for the determination of ursodeoxycholic acid and its glycine and taurine conjugates in human plasma. | 2003 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:14643509 |
| Komichi D et al. | Unique inhibition of bile salt-induced apoptosis by lecithins and cytoprotective bile salts in immortalized mouse cholangiocytes. | 2003 | Dig. Dis. Sci. | pmid:14714619 |
| Ma J et al. | Inhibitory effects of ursodeoxycholic acid on the induction of nitric oxide synthase in vascular smooth muscle cells. | 2003 | Eur. J. Pharmacol. | pmid:12620498 |
| Tsuboi K et al. | Hydrophilic bile salts have a cytoprotective effect against cyclosporine A-induced cholestasis through enhanced canalicular membrane fluidity and transporter activity. | 2003 | Hepatol. Res. | pmid:12644037 |