Tauroursodeoxycholic acid

Tauroursodeoxycholic acid is a lipid of Sterol Lipids (ST) class. Tauroursodeoxycholic acid is associated with abnormalities such as Hyperglycemia, Obesity, Wiskott-Aldrich Syndrome, neurogenic hypertension and Cholestatic liver disease. The involved functions are known as Cell Death, Apoptosis, Homeostasis, Process and mRNA Expression. Tauroursodeoxycholic acid often locates in Body tissue, Endoplasmic Reticulum, Hepatic, Blood and Protoplasm. The associated genes with Tauroursodeoxycholic acid are Homologous Gene and Mutant Proteins. The related lipids are cholanic acid, taurolithocholic acid 3-sulfate, Sterols, 7-dehydrocholesterol and tauromuricholic acid. The related experimental models are Disease model.

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Introduction

To understand associated biological information of Tauroursodeoxycholic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Tauroursodeoxycholic acid?

Tauroursodeoxycholic acid is suspected in Endothelial dysfunction, Hyperglycemia, Obesity, neurogenic hypertension, Cholestatic liver disease, Heart failure and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Tauroursodeoxycholic acid

MeSH term MeSH ID Detail
Hypertension D006973 115 associated lipids
Insulin Resistance D007333 99 associated lipids
Total 2

PubChem Associated disorders and diseases

What pathways are associated with Tauroursodeoxycholic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Tauroursodeoxycholic acid?

Related references are published most in these journals:

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What functions are associated with Tauroursodeoxycholic acid?


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What lipids are associated with Tauroursodeoxycholic acid?

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What genes are associated with Tauroursodeoxycholic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Tauroursodeoxycholic acid?

Disease model

Disease model are used in the study 'Bile Acids Reduce Prion Conversion, Reduce Neuronal Loss, and Prolong Male Survival in Models of Prion Disease.' (Cortez LM et al., 2015).

Related references are published most in these journals:

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NCBI Entrez Crosslinks

All references with Tauroursodeoxycholic acid

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Authors Title Published Journal PubMed Link
Tanaka Y et al. The exacerbating roles of CCAAT/enhancer-binding protein homologous protein (CHOP) in the development of bleomycin-induced pulmonary fibrosis and the preventive effects of tauroursodeoxycholic acid (TUDCA) against pulmonary fibrosis in mice. 2015 Pharmacol. Res. pmid:26005208
Cortez LM et al. Bile Acids Reduce Prion Conversion, Reduce Neuronal Loss, and Prolong Male Survival in Models of Prion Disease. 2015 J. Virol. pmid:25972546
Sommerfeld A et al. Tauroursodeoxycholate Protects Rat Hepatocytes from Bile Acid-Induced Apoptosis via β1-Integrin- and Protein Kinase A-Dependent Mechanisms. 2015 Cell. Physiol. Biochem. pmid:26044599
Cai Z et al. Involvement of Endoplasmic Reticulum Stress-Mediated C/EBP Homologous Protein Activation in Coxsackievirus B3-Induced Acute Viral Myocarditis. 2015 Circ Heart Fail pmid:25985795
Oishi N et al. XBP1 mitigates aminoglycoside-induced endoplasmic reticulum stress and neuronal cell death. 2015 Cell Death Dis pmid:25973683
Cheng S et al. Pachymic acid inhibits growth and induces apoptosis of pancreatic cancer in vitro and in vivo by targeting ER stress. 2015 PLoS ONE pmid:25915041
Xu LH et al. Critical Role of Endoplasmic Reticulum Stress in Chronic Intermittent Hypoxia-Induced Deficits in Synaptic Plasticity and Long-Term Memory. 2015 Antioxid. Redox Signal. pmid:25843188
Liu F et al. Tauroursodeoxycholic acid attenuates inorganic phosphate-induced osteoblastic differentiation and mineralization in NIH3T3 fibroblasts by inhibiting the ER stress response PERK-eIF2α-ATF4 pathway. 2015 Drug Discov Ther pmid:25788050
Xia H et al. Brain ACE2 overexpression reduces DOCA-salt hypertension independently of endoplasmic reticulum stress. 2015 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:25519733
Shi Z et al. Vasonatrin peptide attenuates myocardial ischemia-reperfusion injury in diabetic rats and underlying mechanisms. 2015 Am. J. Physiol. Heart Circ. Physiol. pmid:25485902
Cho JG et al. Tauroursodeoxycholic acid, a bile acid, promotes blood vessel repair by recruiting vasculogenic progenitor cells. 2015 Stem Cells pmid:25407160
Oshitari T et al. Increased expression of phosphorylated c-Jun and phosphorylated c-Jun N-terminal kinase associated with neuronal cell death in diabetic and high glucose exposed rat retinas. 2014 Brain Res. Bull. pmid:24333191
Noailles A et al. Microglia activation in a model of retinal degeneration and TUDCA neuroprotective effects. 2014 J Neuroinflammation pmid:25359524
Yan F et al. Endoplasmic reticulum stress is associated with neuroprotection against apoptosis via autophagy activation in a rat model of subarachnoid hemorrhage. 2014 Neurosci. Lett. pmid:24513235
Laukens D et al. Tauroursodeoxycholic acid inhibits experimental colitis by preventing early intestinal epithelial cell death. 2014 Lab. Invest. pmid:25310532
Park SW et al. Rab11, but not Rab4, facilitates cyclic AMP- and tauroursodeoxycholate-induced MRP2 translocation to the plasma membrane. 2014 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:25190474
van der Harg JM et al. The unfolded protein response mediates reversible tau phosphorylation induced by metabolic stress. 2014 Cell Death Dis pmid:25165879
Yanguas-Casás N et al. Tauroursodeoxycholic acid reduces glial cell activation in an animal model of acute neuroinflammation. 2014 J Neuroinflammation pmid:24645669
Cha BH et al. The role of tauroursodeoxycholic acid on adipogenesis of human adipose-derived stem cells by modulation of ER stress. 2014 Biomaterials pmid:24424209
Fu Y and Zhang T Pathophysilogical mechanism and treatment strategies for Leber congenital amaurosis. 2014 Adv. Exp. Med. Biol. pmid:24664772