| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypertension | D006973 | 115 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
Total
2
Tauroursodeoxycholic acid
Tauroursodeoxycholic acid is a lipid of Sterol Lipids (ST) class. Tauroursodeoxycholic acid is associated with abnormalities such as Hyperglycemia, Obesity, Wiskott-Aldrich Syndrome, neurogenic hypertension and Cholestatic liver disease. The involved functions are known as Cell Death, Apoptosis, Homeostasis, Process and mRNA Expression. Tauroursodeoxycholic acid often locates in Body tissue, Endoplasmic Reticulum, Hepatic, Blood and Protoplasm. The associated genes with Tauroursodeoxycholic acid are Homologous Gene and Mutant Proteins. The related lipids are cholanic acid, taurolithocholic acid 3-sulfate, Sterols, 7-dehydrocholesterol and tauromuricholic acid. The related experimental models are Disease model.
Cross Reference
Introduction
To understand associated biological information of Tauroursodeoxycholic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Tauroursodeoxycholic acid?
Tauroursodeoxycholic acid is suspected in Endothelial dysfunction, Hyperglycemia, Obesity, neurogenic hypertension, Cholestatic liver disease, Heart failure and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Diabetes (3)
- Am. J. Physiol. Heart Circ. Physiol. (1)
- Am. J. Physiol. Lung Cell Mol. Physiol. (1)
- Others (5)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Tauroursodeoxycholic acid
PubChem Associated disorders and diseases
What pathways are associated with Tauroursodeoxycholic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Tauroursodeoxycholic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Tauroursodeoxycholic acid?
Disease model
Disease model are used in the study 'Bile Acids Reduce Prion Conversion, Reduce Neuronal Loss, and Prolong Male Survival in Models of Prion Disease.' (Cortez LM et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Tauroursodeoxycholic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Shefer S et al. | Regulation of cholesterol 7 alpha-hydroxylase by hepatic 7 alpha-hydroxylated bile acid flux and newly synthesized cholesterol supply. | 1991 | J. Biol. Chem. | pmid:1993648 |
| Nakai T et al. | Microtubule-independent choleresis and anti-cholestatic action of tauroursodeoxycholate in colchicine-treated rat liver. | 1992 | Biochem. J. | pmid:1361125 |
| Häussinger D et al. | Cell volume and bile acid excretion. | 1992 | Biochem. J. | pmid:1463469 |
| Thibault N and Ballet F | Effect of bile acids on intracellular calcium in isolated rat hepatocyte couplets. | 1993 | Biochem. Pharmacol. | pmid:8435088 |
| Alvaro D et al. | Effect of ursodeoxycholic acid on intracellular pH regulation in isolated rat bile duct epithelial cells. | 1993 | Am. J. Physiol. | pmid:8238362 |
| Beuers U et al. | Effects of tauroursodeoxycholic acid on cytosolic Ca2+ signals in isolated rat hepatocytes. | 1993 | Gastroenterology | pmid:8425704 |
| Sano N et al. | Estradiol-17 beta-glucuronide-induced cholestasis. Effects of ursodeoxycholate-3-O-glucuronide and 3,7-disulfate. | 1993 | J. Hepatol. | pmid:8445238 |
| Shamburek RD and Schwartz CC | Selective composition of biliary phosphatidylcholines is affected by secretion rate but not by bile acid hydrophobicity. | 1993 | J. Lipid Res. | pmid:8263408 |
| Beuers U et al. | Tauroursodeoxycholic acid stimulates hepatocellular exocytosis and mobilizes extracellular Ca++ mechanisms defective in cholestasis. | 1993 | J. Clin. Invest. | pmid:8254052 |
| Pak JM and Lee SS | Vasoactive effects of bile salts in cirrhotic rats: in vivo and in vitro studies. | 1993 | Hepatology | pmid:8225224 |
| Tsukahara K et al. | Taurine conjugate of ursodeoxycholate plays a major role in the hepatoprotective effect against cholestasis induced by taurochenodeoxycholate in rats. | 1993 | Liver | pmid:8259039 |
| Ohiwa T et al. | Tauroursodeoxycholate and tauro-beta-muricholate exert cytoprotection by reducing intrahepatocyte taurochenodeoxycholate content. | 1993 | Hepatology | pmid:8383089 |
| Bouchard G et al. | Influence of oral treatment with ursodeoxycholic and tauroursodeoxycholic acids on estrogen-induced cholestasis in rats: effects on bile formation and liver plasma membranes. | 1993 | Liver | pmid:8377596 |
| Aldini R et al. | Hepatic uptake and intestinal absorption of bile acids in the rabbit. | 1994 | Eur. J. Clin. Invest. | pmid:7851470 |
| Nguyen LB et al. | Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity in the rat ileum: effects of bile acids and lovastatin. | 1994 | Metab. Clin. Exp. | pmid:7968602 |
| Kitani K et al. | Tauro alpha-muricholate is as effective as tauro beta-muricholate and tauroursodeoxycholate in preventing taurochenodeoxycholate-induced liver damage in the rat. | 1994 | Hepatology | pmid:8138240 |
| Krähenbühl S et al. | Ursodeoxycholate protects oxidative mitochondrial metabolism from bile acid toxicity: dose-response study in isolated rat liver mitochondria. | 1994 | Hepatology | pmid:7982660 |
| Sakisaka S et al. | Tubulovesicular transport of horseradish peroxidase in isolated rat hepatocyte couplets: effects of low temperature, cytochalasin B and bile acids. | 1994 | Hepatology | pmid:7927203 |
| Alvaro D et al. | Functional and ultrastructural features of ethanol/bile salts interaction in the isolated perfused rat liver. | 1995 | Hepatology | pmid:7705787 |
| Sánchez Pozzi EJ et al. | Differential effect of ursodeoxycholate and its taurine conjugate on biliary transport maximum of bilirubin in the rat. | 1995 | Life Sci. | pmid:7643722 |
| Groen AK et al. | Regulation of protein secretion into bile: studies in mice with a disrupted mdr2 p-glycoprotein gene. | 1995 | Gastroenterology | pmid:7498666 |
| Rodrigues CM et al. | Tauroursodeoxycholate increases rat liver ursodeoxycholate levels and limits lithocholate formation better than ursodeoxycholate. | 1995 | Gastroenterology | pmid:7615207 |
| Angelico M et al. | N-ethyl-tauroursodeoxycholic acid, a novel deconjugation-resistant bile salt analogue: effects of acute feeding in the rat. | 1995 | Hepatology | pmid:7657297 |
| Ono T et al. | Effect of tauroursodeoxycholic acid on bile flow and calcium excretion in ischemia-reperfusion injury of rat livers. | 1995 | J. Hepatol. | pmid:8583148 |
| Neuman MG et al. | Effect of tauroursodeoxycholic and ursodeoxycholic acid on ethanol-induced cell injuries in the human Hep G2 cell line. | 1995 | Gastroenterology | pmid:7615206 |
| Takikawa H et al. | Colchicine inhibits lithocholate-3-O-glucuronide-induced cholestasis in rats. | 1995 | J. Hepatol. | pmid:7751593 |
| Hillaire S et al. | Effects of ursodeoxycholic acid and chenodeoxycholic acid on human hepatocytes in primary culture. | 1995 | Hepatology | pmid:7601437 |
| Azer SA et al. | Hepatoprotection in ethinylestradiol-treated rats is provided by tauroursodeoxycholic acid, but not by ursodeoxycholic acid. | 1995 May-Jun | J. Gastroenterol. Hepatol. | pmid:7548801 |
| Beuers U et al. | Tauroursodeoxycholic acid activates protein kinase C in isolated rat hepatocytes. | 1996 | Gastroenterology | pmid:8613063 |
| Stravitz RT et al. | Hepatocellular protein kinase C activation by bile acids: implications for regulation of cholesterol 7 alpha-hydroxylase. | 1996 | Am. J. Physiol. | pmid:8770045 |
| Muraca M et al. | Protective effect of tauroursodeoxycholate against acute gastric mucosal injury induced by hydrophobic bile salts. | 1996 | Dig. Dis. Sci. | pmid:8654150 |
| Sugata K et al. | Differential effects between tauroursodeoxycholic and taurochenodeoxycholic acids in hepatic fibrosis: an assessment by primary cultured Ito and Kupffer cells from the rat liver. | 1996 | J. Gastroenterol. Hepatol. | pmid:8743917 |
| Barone M et al. | Modulation of rat hepatocyte proliferation by bile salts: in vitro and in vivo studies. | 1996 | Hepatology | pmid:8621149 |
| Albalak A et al. | Effects of submicellar bile salt concentrations on biological membrane permeability to low molecular weight non-ionic solutes. | 1996 | Biochemistry | pmid:8672496 |
| Nebe B et al. | Induction of a physical linkage between integrins and the cytoskeleton depends on intracellular calcium in an epithelial cell line. | 1996 | Exp. Cell Res. | pmid:8940254 |
| Groen AK et al. | Control analysis of biliary lipid secretion. | 1996 | J. Theor. Biol. | pmid:8944177 |
| Van Erpecum KJ et al. | Effects of bile salt hydrophobicity on crystallization of cholesterol in model bile. | 1996 | Eur. J. Clin. Invest. | pmid:8864423 |
| Heuman DM et al. | Adsorption of mixtures of bile salt taurine conjugates to lecithin-cholesterol membranes: implications for bile salt toxicity and cytoprotection. | 1996 | J. Lipid Res. | pmid:8728319 |
| Setchell KD et al. | Metabolism of orally administered tauroursodeoxycholic acid in patients with primary biliary cirrhosis. | 1996 | Gut | pmid:8675100 |
| Bellentani S et al. | Chronic administration of ursodeoxycholic and tauroursodeoxycholic acid changes microsomal membrane lipid content and fatty acid compositions in rats. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8607791 |
| Crosignani A et al. | Tauroursodeoxycholic acid for treatment of primary biliary cirrhosis. A dose-response study. | 1996 | Dig. Dis. Sci. | pmid:8674405 |
| Klinkspoor JH et al. | Mechanism of bile salt-induced mucin secretion by cultured dog gallbladder epithelial cells. | 1996 | Biochem. J. | pmid:8670165 |
| Takikawa H et al. | Effects of ursodeoxycholate and its conjugates on biliary glutathione excretion in rats. | 1996 | Dig. Dis. Sci. | pmid:8888706 |
| Luk AS et al. | Structural mechanisms of bile salt-induced growth of small unilamellar cholesterol-lecithin vesicles. | 1997 | Biochemistry | pmid:9153403 |
| Crocenzi FA et al. | Role of bile salts in colchicine-induced hepatotoxicity. Implications for hepatocellular integrity and function. | 1997 | Toxicology | pmid:9230445 |
| Takikawa H et al. | Absorption of unconjugated bile acids and tauroursodeoxycholate in the rat intestine. | 1997 | J. Gastroenterol. Hepatol. | pmid:9504891 |
| Loria P et al. | Effect of taurohyodeoxycholic acid on biliary lipid secretion in humans. | 1997 | Hepatology | pmid:9185744 |
| Schliess F et al. | Mitogen-activated protein kinases mediate the stimulation of bile acid secretion by tauroursodeoxycholate in rat liver. | 1997 | Gastroenterology | pmid:9322526 |
| Meier PJ et al. | Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver. | 1997 | Hepatology | pmid:9398014 |
| Ishizaki K et al. | Effect of sodium tauroursodeoxycholate (UR-906) on liver dysfunction in bile duct-ligated rats. | 1997 | Eur. J. Pharmacol. | pmid:9314037 |