| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypertension | D006973 | 115 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
Total
2
Tauroursodeoxycholic acid
Tauroursodeoxycholic acid is a lipid of Sterol Lipids (ST) class. Tauroursodeoxycholic acid is associated with abnormalities such as Hyperglycemia, Obesity, Wiskott-Aldrich Syndrome, neurogenic hypertension and Cholestatic liver disease. The involved functions are known as Cell Death, Apoptosis, Homeostasis, Process and mRNA Expression. Tauroursodeoxycholic acid often locates in Body tissue, Endoplasmic Reticulum, Hepatic, Blood and Protoplasm. The associated genes with Tauroursodeoxycholic acid are Homologous Gene and Mutant Proteins. The related lipids are cholanic acid, taurolithocholic acid 3-sulfate, Sterols, 7-dehydrocholesterol and tauromuricholic acid. The related experimental models are Disease model.
Cross Reference
Introduction
To understand associated biological information of Tauroursodeoxycholic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Tauroursodeoxycholic acid?
Tauroursodeoxycholic acid is suspected in Endothelial dysfunction, Hyperglycemia, Obesity, neurogenic hypertension, Cholestatic liver disease, Heart failure and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Diabetes (3)
- Am. J. Physiol. Heart Circ. Physiol. (1)
- Am. J. Physiol. Lung Cell Mol. Physiol. (1)
- Others (5)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Tauroursodeoxycholic acid
PubChem Associated disorders and diseases
What pathways are associated with Tauroursodeoxycholic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Tauroursodeoxycholic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Tauroursodeoxycholic acid?
Disease model
Disease model are used in the study 'Bile Acids Reduce Prion Conversion, Reduce Neuronal Loss, and Prolong Male Survival in Models of Prion Disease.' (Cortez LM et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Tauroursodeoxycholic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Udawatte C et al. | Taurine suppresses the spread of cell death in electrically coupled RPE cells. | 2008 | Mol. Vis. | pmid:18958305 |
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| Higuchi WI et al. | Estimation of cholesterol solubilization by a mixed micelle binding model in aqueous tauroursodeoxycholate:lecithin:cholesterol solutions. | 2008 | J Pharm Sci | pmid:17786967 |
| Monte MJ et al. | Cytosol-nucleus traffic and colocalization with FXR of conjugated bile acids in rat hepatocytes. | 2008 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:18467501 |
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| Mannack G et al. | Taurolithocholic acid-3 sulfate impairs insulin signaling in cultured rat hepatocytes and perfused rat liver. | 2008 | Cell. Physiol. Biochem. | pmid:18209481 |
| Lawless MW et al. | Tauroursodeoxycholic acid: relieving the pathogenesis of HFE C282Y hereditary hemochromatosis. | 2008 | Hepatology | pmid:18203149 |
| Colak A et al. | Tauroursodeoxycholic acid and secondary damage after spinal cord injury in rats. | 2008 | J Clin Neurosci | pmid:18343118 |
| Baiocchi L et al. | TUDCA prevents cholestasis and canalicular damage induced by ischemia-reperfusion injury in the rat, modulating PKCalpha-ezrin pathway. | 2008 | Transpl. Int. | pmid:18435680 |
| Phillips MJ et al. | Tauroursodeoxycholic acid preservation of photoreceptor structure and function in the rd10 mouse through postnatal day 30. | 2008 | Invest. Ophthalmol. Vis. Sci. | pmid:18436848 |
| Nonaka M et al. | Cytoprotective effect of tauroursodeoxycholate on hepatocyte apoptosis induced by peroxisome proliferator-activated receptor gamma ligand. | 2008 | J. Gastroenterol. Hepatol. | pmid:17868335 |
| Macedo B et al. | Anti-apoptotic treatment reduces transthyretin deposition in a transgenic mouse model of Familial Amyloidotic Polyneuropathy. | 2008 | Biochim. Biophys. Acta | pmid:18572024 |
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| Schulz F et al. | Prevention of Clostridium sordellii lethal toxin-induced apoptotic cell death by tauroursodeoxycholic acid. | 2009 | Biochemistry | pmid:19691300 |
| Miki T et al. | Endoplasmic reticulum stress in diabetic hearts abolishes erythropoietin-induced myocardial protection by impairment of phospho-glycogen synthase kinase-3beta-mediated suppression of mitochondrial permeability transition. | 2009 | Diabetes | pmid:19755525 |
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| Gnewuch C et al. | Serum bile acid profiling reflects enterohepatic detoxification state and intestinal barrier function in inflammatory bowel disease. | 2009 | World J. Gastroenterol. | pmid:19575493 |
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| Yang JS et al. | Changes in hepatic gene expression upon oral administration of taurine-conjugated ursodeoxycholic acid in ob/ob mice. | 2010 | PLoS ONE | pmid:21079772 |
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| Ye R et al. | Grp78 heterozygosity promotes adaptive unfolded protein response and attenuates diet-induced obesity and insulin resistance. | 2010 | Diabetes | pmid:19808896 |
| Lim SC et al. | Ursodeoxycholic acid switches oxaliplatin-induced necrosis to apoptosis by inhibiting reactive oxygen species production and activating p53-caspase 8 pathway in HepG2 hepatocellular carcinoma. | 2010 | Int. J. Cancer | pmid:19728331 |
| Basiglio CL et al. | Tauroursodeoxycholate counteracts hepatocellular lysis induced by tensioactive bile salts by preventing plasma membrane-micelle transition. | 2010 | Chem. Biol. Interact. | pmid:20797393 |
| Fulda S et al. | Cellular stress responses: cell survival and cell death. | 2010 | Int J Cell Biol | pmid:20182529 |
| Malo A et al. | Tauroursodeoxycholic acid reduces endoplasmic reticulum stress, trypsin activation, and acinar cell apoptosis while increasing secretion in rat pancreatic acini. | 2010 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:20671193 |
| Cardoso I et al. | Synergy of combined doxycycline/TUDCA treatment in lowering Transthyretin deposition and associated biomarkers: studies in FAP mouse models. | 2010 | J Transl Med | pmid:20673327 |
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| Aranha MM et al. | Apoptosis-associated microRNAs are modulated in mouse, rat and human neural differentiation. | 2010 | BMC Genomics | pmid:20868483 |
| Ge W et al. | Cardiac-specific overexpression of catalase attenuates paraquat-induced myocardial geometric and contractile alteration: role of ER stress. | 2010 | Free Radic. Biol. Med. | pmid:20937379 |
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| Cruz LN et al. | Regulation of multidrug resistance-associated protein 2 by calcium signaling in mouse liver. | 2010 | Hepatology | pmid:20578149 |
| Kars M et al. | Tauroursodeoxycholic Acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women. | 2010 | Diabetes | pmid:20522594 |
| Lee YY et al. | Tauroursodeoxycholate (TUDCA), chemical chaperone, enhances function of islets by reducing ER stress. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20541525 |
| Viana RJ et al. | Modulation of amyloid-β peptide-induced toxicity through inhibition of JNK nuclear localization and caspase-2 activation. | 2010 | J. Alzheimers Dis. | pmid:20847398 |
| Hua Y et al. | Tauroursodeoxycholic acid attenuates lipid accumulation in endoplasmic reticulum-stressed macrophages. | 2010 | J. Cardiovasc. Pharmacol. | pmid:19834331 |
| Ben Mosbah I et al. | Endoplasmic reticulum stress inhibition protects steatotic and non-steatotic livers in partial hepatectomy under ischemia-reperfusion. | 2010 | Cell Death Dis | pmid:21364657 |
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| RodrÃguez-Ortigosa CM et al. | Biliary secretion of S-nitrosoglutathione is involved in the hypercholeresis induced by ursodeoxycholic acid in the normal rat. | 2010 | Hepatology | pmid:20683964 |
| Woo SJ et al. | Ursodeoxycholic acid and tauroursodeoxycholic acid suppress choroidal neovascularization in a laser-treated rat model. | 2010 | J Ocul Pharmacol Ther | pmid:20565307 |
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| Mantopoulos D et al. | Tauroursodeoxycholic acid (TUDCA) protects photoreceptors from cell death after experimental retinal detachment. | 2011 | PLoS ONE | pmid:21961034 |
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| Jiménez-Castro MB et al. | Tauroursodeoxycholic acid affects PPARγ and TLR4 in Steatotic liver transplantation. | 2012 | Am. J. Transplant. | pmid:22994543 |
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| Cash JG et al. | Apolipoprotein E4 impairs macrophage efferocytosis and potentiates apoptosis by accelerating endoplasmic reticulum stress. | 2012 | J. Biol. Chem. | pmid:22730380 |
| Castro-Caldas M et al. | Tauroursodeoxycholic acid prevents MPTP-induced dopaminergic cell death in a mouse model of Parkinson's disease. | 2012 | Mol. Neurobiol. | pmid:22773138 |
| Zhang JY et al. | Inhibition of endoplasmic reticulum stress improves mouse embryo development. | 2012 | PLoS ONE | pmid:22808162 |
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| Gupta S et al. | Prevention of acute kidney injury by tauroursodeoxycholic acid in rat and cell culture models. | 2012 | PLoS ONE | pmid:23152827 |