| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypertension | D006973 | 115 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
Total
2
Tauroursodeoxycholic acid
Tauroursodeoxycholic acid is a lipid of Sterol Lipids (ST) class. Tauroursodeoxycholic acid is associated with abnormalities such as Hyperglycemia, Obesity, Wiskott-Aldrich Syndrome, neurogenic hypertension and Cholestatic liver disease. The involved functions are known as Cell Death, Apoptosis, Homeostasis, Process and mRNA Expression. Tauroursodeoxycholic acid often locates in Body tissue, Endoplasmic Reticulum, Hepatic, Blood and Protoplasm. The associated genes with Tauroursodeoxycholic acid are Homologous Gene and Mutant Proteins. The related lipids are cholanic acid, taurolithocholic acid 3-sulfate, Sterols, 7-dehydrocholesterol and tauromuricholic acid. The related experimental models are Disease model.
Cross Reference
Introduction
To understand associated biological information of Tauroursodeoxycholic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Tauroursodeoxycholic acid?
Tauroursodeoxycholic acid is suspected in Endothelial dysfunction, Hyperglycemia, Obesity, neurogenic hypertension, Cholestatic liver disease, Heart failure and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Diabetes (3)
- Am. J. Physiol. Heart Circ. Physiol. (1)
- Am. J. Physiol. Lung Cell Mol. Physiol. (1)
- Others (5)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Tauroursodeoxycholic acid
PubChem Associated disorders and diseases
What pathways are associated with Tauroursodeoxycholic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Tauroursodeoxycholic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Tauroursodeoxycholic acid?
Disease model
Disease model are used in the study 'Bile Acids Reduce Prion Conversion, Reduce Neuronal Loss, and Prolong Male Survival in Models of Prion Disease.' (Cortez LM et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Tauroursodeoxycholic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kok T et al. | Peroxisome proliferator-activated receptor alpha (PPARalpha)-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in mice. | 2003 | Biochem. J. | pmid:12381268 |
| Rodrigues CM et al. | Tauroursodeoxycholic acid reduces apoptosis and protects against neurological injury after acute hemorrhagic stroke in rats. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12721362 |
| Häussinger D et al. | Involvement of integrins and Src in tauroursodeoxycholate-induced and swelling-induced choleresis. | 2003 | Gastroenterology | pmid:12730886 |
| Chen W et al. | Bile acids for viral hepatitis. | 2003 | Cochrane Database Syst Rev | pmid:12804455 |
| Chignard N et al. | Bile salts potentiate adenylyl cyclase activity and cAMP-regulated secretion in human gallbladder epithelium. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12421748 |
| Schoemaker MH et al. | Resistance of rat hepatocytes against bile acid-induced apoptosis in cholestatic liver injury is due to nuclear factor-kappa B activation. | 2003 | J. Hepatol. | pmid:12873810 |
| Beuers U et al. | Taurolithocholic acid exerts cholestatic effects via phosphatidylinositol 3-kinase-dependent mechanisms in perfused rat livers and rat hepatocyte couplets. | 2003 | J. Biol. Chem. | pmid:12626520 |
| Reinehr R et al. | Bile salt-induced hepatocyte apoptosis involves epidermal growth factor receptor-dependent CD95 tyrosine phosphorylation. | 2003 | Gastroenterology | pmid:12949729 |
| Sánchez Pozzi EJ et al. | Ursodeoxycholate reduces ethinylestradiol glucuronidation in the rat: role in prevention of estrogen-induced cholestasis. | 2003 | J. Pharmacol. Exp. Ther. | pmid:12663690 |
| Lamireau T et al. | Effects of bile acids on biliary epithelial cells: proliferation, cytotoxicity, and cytokine secretion. | 2003 | Life Sci. | pmid:12527037 |
| Liu Y et al. | Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis. | 2003 | J. Clin. Invest. | pmid:14623915 |
| Heubi JE et al. | Tauroursodeoxycholic acid (TUDCA) in the prevention of total parenteral nutrition-associated liver disease. | 2002 | J. Pediatr. | pmid:12183720 |
| Duan WM et al. | Tauroursodeoxycholic acid improves the survival and function of nigral transplants in a rat model of Parkinson's disease. | 2002 | Cell Transplant | pmid:12075985 |
| Xiao ZL et al. | Effects of bile acids on the muscle functions of guinea pig gallbladder. | 2002 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12065295 |
| Glasova H et al. | Tauroursodeoxycholic acid mobilizes alpha-PKC after uptake in human HepG2 hepatoma cells. | 2002 | Eur. J. Clin. Invest. | pmid:12059989 |
| Noé J et al. | Functional expression of the canalicular bile salt export pump of human liver. | 2002 | Gastroenterology | pmid:12404240 |
| Piepoli AL et al. | Tauroursodeoxycholic acid reduces damaging effects of taurodeoxycholic acid on fundus gastric mucosa. | 2002 | Arch. Physiol. Biochem. | pmid:12221520 |
| Pandak WM et al. | Regulation of oxysterol 7alpha-hydroxylase (CYP7B1) in primary cultures of rat hepatocytes. | 2002 | Hepatology | pmid:12029625 |
| Azzaroli F et al. | Ursodeoxycholic acid diminishes Fas-ligand-induced apoptosis in mouse hepatocytes. | 2002 | Hepatology | pmid:12085348 |
| Milkiewicz P et al. | Hepatoprotection with tauroursodeoxycholate and beta muricholate against taurolithocholate induced cholestasis: involvement of signal transduction pathways. | 2002 | Gut | pmid:12077103 |
| Graf D et al. | Taurolithocholic acid-3 sulfate induces CD95 trafficking and apoptosis in a c-Jun N-terminal kinase-dependent manner. | 2002 | Gastroenterology | pmid:11984527 |
| Yamashita Y et al. | High metabolic function of primary human and porcine hepatocytes in a polyurethane foam/spheroid culture system in plasma from patients with fulminant hepatic failure. | 2002 | Cell Transplant | pmid:12162378 |
| Veggi LM et al. | Dapsone-induced cholestasis and impairment of bile salt output in the rat. | 2002 | Biochem. Pharmacol. | pmid:11996898 |
| Kim YH and Shin MJ | Effects of high taurocholate load on activities of hepatic alcohol metabolizing enzymes. | 2002 | Exp. Mol. Med. | pmid:12085987 |
| Rodrigues CM et al. | Neuroprotection by a bile acid in an acute stroke model in the rat. | 2002 | J. Cereb. Blood Flow Metab. | pmid:11919517 |
| Carubbi F et al. | Comparative cytotoxic and cytoprotective effects of taurohyodeoxycholic acid (THDCA) and tauroursodeoxycholic acid (TUDCA) in HepG2 cell line. | 2002 | Biochim. Biophys. Acta | pmid:11923098 |
| Xie Q et al. | Effect of tauroursodeoxycholic acid on endoplasmic reticulum stress-induced caspase-12 activation. | 2002 | Hepatology | pmid:12198651 |
| Venneman NG et al. | Effects of hydrophobic and hydrophilic bile salt mixtures on cholesterol crystallization in model biles. | 2002 | Biochim. Biophys. Acta | pmid:12117566 |
| Keene CD et al. | Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12149470 |
| Alpini G et al. | Ursodeoxycholate and tauroursodeoxycholate inhibit cholangiocyte growth and secretion of BDL rats through activation of PKC alpha. | 2002 | Hepatology | pmid:11981754 |
| Asamoto Y et al. | Bile-salt hydrophobicity is a key factor regulating rat liver plasma-membrane communication: relation to bilayer structure, fluidity and transporter expression and function. | 2001 | Biochem. J. | pmid:11672435 |
| Ejiri S et al. | Cellular distribution of thrombomodulin as an early marker for warm ischemic liver injury in porcine liver transplantation: protective effect of prostaglandin I2 analogue and tauroursodeoxycholic acid. | 2001 | Transplantation | pmid:11330532 |
| Moschetta A et al. | Cholesterol crystallization in model biles: effects of bile salt and phospholipid species composition. | 2001 | J. Lipid Res. | pmid:11483629 |
| Kurz AK et al. | Tauroursodesoxycholate-induced choleresis involves p38(MAPK) activation and translocation of the bile salt export pump in rats. | 2001 | Gastroenterology | pmid:11487550 |
| Ishizaki K et al. | Effect of sodium tauroursodeoxycholate on phalloidin-induced cholestasis in rats. | 2001 | Eur. J. Pharmacol. | pmid:11408049 |
| Danchenko E et al. | Effect of bile acids on the proliferative activity and apoptosis of rat hepatocytes. | 2001 | Exp. Toxicol. Pathol. | pmid:11484843 |
| Nathanson MH et al. | Stimulation of ATP secretion in the liver by therapeutic bile acids. | 2001 | Biochem. J. | pmid:11485545 |
| Crocenzi FA et al. | Beneficial effects of silymarin on estrogen-induced cholestasis in the rat: a study in vivo and in isolated hepatocyte couplets. | 2001 | Hepatology | pmid:11481618 |
| Milkiewicz P et al. | Effect of tauroursodeoxycholate and S-adenosyl-L-methionine on 17beta-estradiol glucuronide-induced cholestasis. | 2001 | J. Hepatol. | pmid:11281545 |
| Moschetta A et al. | Hydrophilic bile salts enhance differential distribution of sphingomyelin and phosphatidylcholine between micellar and vesicular phases: potential implications for their effects in vivo. | 2001 | J. Hepatol. | pmid:11394647 |
| Fimognari C et al. | Micronuclei induction, cell cycle delay and apoptosis as markers of cellular stress caused by ursodeoxycholic acid in human lymphocytes. | 2001 | Mutat. Res. | pmid:11448637 |
| Rodrigues CM et al. | Amyloid beta-peptide disrupts mitochondrial membrane lipid and protein structure: protective role of tauroursodeoxycholate. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11181071 |
| Colell A et al. | Tauroursodeoxycholic acid protects hepatocytes from ethanol-fed rats against tumor necrosis factor-induced cell death by replenishing mitochondrial glutathione. | 2001 | Hepatology | pmid:11679967 |
| Keene CD et al. | A bile acid protects against motor and cognitive deficits and reduces striatal degeneration in the 3-nitropropionic acid model of Huntington's disease. | 2001 | Exp. Neurol. | pmid:11573988 |
| Ishigami F et al. | Bile salt tauroursodeoxycholic acid modulation of Bax translocation to mitochondria protects the liver from warm ischemia-reperfusion injury in the rat. | 2001 | Transplantation | pmid:11740392 |
| Beuers U et al. | Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C-dependent mechanisms in cholestatic rat liver. | 2001 | Hepatology | pmid:11343250 |
| Chignard N et al. | Bile acid transport and regulating functions in the human biliary epithelium. | 2001 | Hepatology | pmid:11230727 |
| Calmus Y and Podevin P | Tauroursodeoxycholic acid for the cytoprotection of liver grafts during cold storage: a new aspect of its anti-apoptotic properties? | 2001 | Transplantation | pmid:11408962 |
| Falasca L et al. | Protective role of tauroursodeoxycholate during harvesting and cold storage of human liver: a pilot study in transplant recipients. | 2001 | Transplantation | pmid:11397961 |
| Kurz AK et al. | Phosphoinositide 3-kinase-dependent Ras activation by tauroursodesoxycholate in rat liver. | 2000 | Biochem. J. | pmid:10926845 |
| Falasca L et al. | Tauroursodeoxycholate reduces ischemic damage in human allografts: a biochemical and ultrastructural study. | 2000 | Transplant. Proc. | pmid:10700964 |
| Benz C et al. | Effect of tauroursodeoxycholic acid on bile acid-induced apoptosis in primary human hepatocytes. | 2000 | Eur. J. Clin. Invest. | pmid:10691996 |
| Piazza F et al. | Competition in liver transport between chenodeoxycholic acid and ursodeoxycholic acid as a mechanism for ursodeoxycholic acid and its amidates' protection of liver damage induced by chenodeoxycholic acid. | 2000 | Dig Liver Dis | pmid:11515630 |
| Rodrigues CM et al. | Tauroursodeoxycholic acid partially prevents apoptosis induced by 3-nitropropionic acid: evidence for a mitochondrial pathway independent of the permeability transition. | 2000 | J. Neurochem. | pmid:11080188 |
| Funaoka M et al. | Tauroursodeoxycholic acid enhances phagocytosis of the cultured rat Kupffer cell. | 1999 | J. Gastroenterol. Hepatol. | pmid:10440209 |
| Miyake H et al. | Partial characterization of mechanisms of cytoprotective action of hydrophilic bile salts against hydrophobic bile salts in rats: relation to canalicular membrane fluidity and packing density. | 1999 | Dig. Dis. Sci. | pmid:9952244 |
| Milkiewicz P et al. | Tauroursodeoxycholate and S-adenosyl-L-methionine exert an additive ameliorating effect on taurolithocholate-induced cholestasis: a study in isolated rat hepatocyte couplets. | 1999 | Hepatology | pmid:9918924 |
| Hertl M et al. | Tauroursodeoxycholate ameliorates reperfusion injury after pig liver transplantation. | 1999 | Transpl. Int. | pmid:10654358 |
| Invernizzi P et al. | Differences in the metabolism and disposition of ursodeoxycholic acid and of its taurine-conjugated species in patients with primary biliary cirrhosis. | 1999 | Hepatology | pmid:9918905 |
| Eckhardt U et al. | Polyspecific substrate uptake by the hepatic organic anion transporter Oatp1 in stably transfected CHO cells. | 1999 | Am. J. Physiol. | pmid:10198348 |
| Roda A et al. | Taurohyodeoxycholic acid protects against taurochenodeoxycholic acid-induced cholestasis in the rat. | 1998 | Hepatology | pmid:9462652 |
| Sreejayan N and von Ritter C | Effect of bile acids on lipid peroxidation: the role of iron. | 1998 | Free Radic. Biol. Med. | pmid:9655521 |
| Benz C et al. | Effect of tauroursodeoxycholic acid on bile-acid-induced apoptosis and cytolysis in rat hepatocytes. | 1998 | J. Hepatol. | pmid:9537871 |
| Schroeder A et al. | Substrate specificity of the rat liver Na(+)-bile salt cotransporter in Xenopus laevis oocytes and in CHO cells. | 1998 | Am. J. Physiol. | pmid:9486191 |
| Peterson TC et al. | The inhibitory effect of ursodeoxycholic acid and pentoxifylline on platelet derived growth factor-stimulated proliferation is distinct from an effect by cyclic AMP. | 1998 | Immunopharmacology | pmid:9754904 |
| Klinkspoor JH et al. | Bile salts stimulate mucin secretion by cultured dog gallbladder epithelial cells independent of their detergent effect. | 1998 | Biochem. J. | pmid:9576876 |
| Vendemiale G et al. | Ethanol-induced changes of intracellular thiol compartmentation and protein redox status in the rat liver: effect of tauroursodeoxycholate. | 1998 | J. Hepatol. | pmid:9537863 |
| Bouscarel B et al. | Changes in G protein expression account for impaired modulation of hepatic cAMP formation after BDL. | 1998 | Am. J. Physiol. | pmid:9696716 |
| Yamaguchi Y et al. | Taurin-conjugated ursodeoxycholic acid has a reversible inhibitory effect on human keratinocyte growth. | 1998 | J. Dermatol. Sci. | pmid:9747660 |
| Ono T et al. | Tauroursodeoxycholic acid protects cholestasis in rat reperfused livers: its roles in hepatic calcium mobilization. | 1998 | Dig. Dis. Sci. | pmid:9790455 |
| Benz C et al. | Effect of S-adenosylmethionine versus tauroursodeoxycholic acid on bile acid-induced apoptosis and cytolysis in rat hepatocytes. | 1998 | Eur. J. Clin. Invest. | pmid:9726039 |
| Beuers U | Effects of bile acids on hepatocellular signaling and secretion. | 1997 Jul-Aug | Yale J Biol Med | pmid:9626754 |
| Luk AS et al. | Structural mechanisms of bile salt-induced growth of small unilamellar cholesterol-lecithin vesicles. | 1997 | Biochemistry | pmid:9153403 |
| Larghi A et al. | Ursodeoxycholic and tauro-ursodeoxycholic acids for the treatment of primary biliary cirrhosis: a pilot crossover study. | 1997 | Aliment. Pharmacol. Ther. | pmid:9146783 |
| van Nieuwerk CM et al. | The role of bile salt composition in liver pathology of mdr2 (-/-) mice: differences between males and females. | 1997 | J. Hepatol. | pmid:9148004 |
| van de Heijning BJ et al. | Membrane cholesterol content of cholesterol/phospholipid vesicles determines the susceptibility to both damage and protection by bile salts: implications for bile physiology. | 1997 | Eur J Gastroenterol Hepatol | pmid:9187880 |
| Setchell KD et al. | Bile acid concentrations in human and rat liver tissue and in hepatocyte nuclei. | 1997 | Gastroenterology | pmid:8978363 |
| Gilani SS et al. | Use of 1H NMR spectroscopy (T2 relaxation times) to examine the effects of conjugated ursodeoxycholic acid on phospholipid fluidity of human gallbladder bile. | 1997 | Biochem. Soc. Trans. | pmid:9056921 |
| Crocenzi FA et al. | Role of bile salts in colchicine-induced hepatotoxicity. Implications for hepatocellular integrity and function. | 1997 | Toxicology | pmid:9230445 |
| Rao YP et al. | Activation of protein kinase C alpha and delta by bile acids: correlation with bile acid structure and diacylglycerol formation. | 1997 | J. Lipid Res. | pmid:9458268 |
| Takikawa H et al. | Absorption of unconjugated bile acids and tauroursodeoxycholate in the rat intestine. | 1997 | J. Gastroenterol. Hepatol. | pmid:9504891 |
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| Loria P et al. | Effect of taurohyodeoxycholic acid on biliary lipid secretion in humans. | 1997 | Hepatology | pmid:9185744 |
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| Takikawa H et al. | Effect of tauro-alpha-muricholate and tauro-beta-muricholate on oestradiol-17 beta-glucuronide-induced cholestasis in rats. | 1997 | J. Gastroenterol. Hepatol. | pmid:9076630 |
| Schliess F et al. | Mitogen-activated protein kinases mediate the stimulation of bile acid secretion by tauroursodeoxycholate in rat liver. | 1997 | Gastroenterology | pmid:9322526 |
| Meier PJ et al. | Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver. | 1997 | Hepatology | pmid:9398014 |
| Ishizaki K et al. | Effect of sodium tauroursodeoxycholate (UR-906) on liver dysfunction in bile duct-ligated rats. | 1997 | Eur. J. Pharmacol. | pmid:9314037 |
| Stravitz RT et al. | Hepatocellular protein kinase C activation by bile acids: implications for regulation of cholesterol 7 alpha-hydroxylase. | 1996 | Am. J. Physiol. | pmid:8770045 |
| Muraca M et al. | Protective effect of tauroursodeoxycholate against acute gastric mucosal injury induced by hydrophobic bile salts. | 1996 | Dig. Dis. Sci. | pmid:8654150 |
| Sugata K et al. | Differential effects between tauroursodeoxycholic and taurochenodeoxycholic acids in hepatic fibrosis: an assessment by primary cultured Ito and Kupffer cells from the rat liver. | 1996 | J. Gastroenterol. Hepatol. | pmid:8743917 |
| Barone M et al. | Modulation of rat hepatocyte proliferation by bile salts: in vitro and in vivo studies. | 1996 | Hepatology | pmid:8621149 |
| Albalak A et al. | Effects of submicellar bile salt concentrations on biological membrane permeability to low molecular weight non-ionic solutes. | 1996 | Biochemistry | pmid:8672496 |
| Nebe B et al. | Induction of a physical linkage between integrins and the cytoskeleton depends on intracellular calcium in an epithelial cell line. | 1996 | Exp. Cell Res. | pmid:8940254 |
| Groen AK et al. | Control analysis of biliary lipid secretion. | 1996 | J. Theor. Biol. | pmid:8944177 |
| Van Erpecum KJ et al. | Effects of bile salt hydrophobicity on crystallization of cholesterol in model bile. | 1996 | Eur. J. Clin. Invest. | pmid:8864423 |
| Heuman DM et al. | Adsorption of mixtures of bile salt taurine conjugates to lecithin-cholesterol membranes: implications for bile salt toxicity and cytoprotection. | 1996 | J. Lipid Res. | pmid:8728319 |
| Setchell KD et al. | Metabolism of orally administered tauroursodeoxycholic acid in patients with primary biliary cirrhosis. | 1996 | Gut | pmid:8675100 |
| Klinkspoor JH et al. | Mechanism of bile salt-induced mucin secretion by cultured dog gallbladder epithelial cells. | 1996 | Biochem. J. | pmid:8670165 |
| Takikawa H et al. | Effects of ursodeoxycholate and its conjugates on biliary glutathione excretion in rats. | 1996 | Dig. Dis. Sci. | pmid:8888706 |