| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypertension | D006973 | 115 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
Total
2
Tauroursodeoxycholic acid
Tauroursodeoxycholic acid is a lipid of Sterol Lipids (ST) class. Tauroursodeoxycholic acid is associated with abnormalities such as Hyperglycemia, Obesity, Wiskott-Aldrich Syndrome, neurogenic hypertension and Cholestatic liver disease. The involved functions are known as Cell Death, Apoptosis, Homeostasis, Process and mRNA Expression. Tauroursodeoxycholic acid often locates in Body tissue, Endoplasmic Reticulum, Hepatic, Blood and Protoplasm. The associated genes with Tauroursodeoxycholic acid are Homologous Gene and Mutant Proteins. The related lipids are cholanic acid, taurolithocholic acid 3-sulfate, Sterols, 7-dehydrocholesterol and tauromuricholic acid. The related experimental models are Disease model.
Cross Reference
Introduction
To understand associated biological information of Tauroursodeoxycholic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Tauroursodeoxycholic acid?
Tauroursodeoxycholic acid is suspected in Endothelial dysfunction, Hyperglycemia, Obesity, neurogenic hypertension, Cholestatic liver disease, Heart failure and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Diabetes (3)
- Am. J. Physiol. Heart Circ. Physiol. (1)
- Am. J. Physiol. Lung Cell Mol. Physiol. (1)
- Others (5)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Tauroursodeoxycholic acid
PubChem Associated disorders and diseases
What pathways are associated with Tauroursodeoxycholic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Tauroursodeoxycholic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Tauroursodeoxycholic acid?
Disease model
Disease model are used in the study 'Bile Acids Reduce Prion Conversion, Reduce Neuronal Loss, and Prolong Male Survival in Models of Prion Disease.' (Cortez LM et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Tauroursodeoxycholic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Oshitari T et al. | Increased expression of phosphorylated c-Jun and phosphorylated c-Jun N-terminal kinase associated with neuronal cell death in diabetic and high glucose exposed rat retinas. | 2014 | Brain Res. Bull. | pmid:24333191 |
| Shen S et al. | Ursolic acid induces autophagy in U87MG cells via ROS-dependent endoplasmic reticulum stress. | 2014 | Chem. Biol. Interact. | pmid:24802810 |
| Xavier JM et al. | Tauroursodeoxycholic acid increases neural stem cell pool and neuronal conversion by regulating mitochondria-cell cycle retrograde signaling. | 2014 | Cell Cycle | pmid:25483094 |
| Ishimura S et al. | Reduction of endoplasmic reticulum stress inhibits neointima formation after vascular injury. | 2014 | Sci Rep | pmid:25373918 |
| Noailles A et al. | Microglia activation in a model of retinal degeneration and TUDCA neuroprotective effects. | 2014 | J Neuroinflammation | pmid:25359524 |
| Laukens D et al. | Tauroursodeoxycholic acid inhibits experimental colitis by preventing early intestinal epithelial cell death. | 2014 | Lab. Invest. | pmid:25310532 |
| Park SW et al. | Rab11, but not Rab4, facilitates cyclic AMP- and tauroursodeoxycholate-induced MRP2 translocation to the plasma membrane. | 2014 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:25190474 |
| Cha BH et al. | The role of tauroursodeoxycholic acid on adipogenesis of human adipose-derived stem cells by modulation of ER stress. | 2014 | Biomaterials | pmid:24424209 |
| Myronovych A et al. | Vertical sleeve gastrectomy reduces hepatic steatosis while increasing serum bile acids in a weight-loss-independent manner. | 2014 | Obesity (Silver Spring) | pmid:23804416 |
| Hamano M et al. | Lipid overloading during liver regeneration causes delayed hepatocyte DNA replication by increasing ER stress in mice with simple hepatic steatosis. | 2014 | J. Gastroenterol. | pmid:23512345 |
| Simoni P et al. | A new point-of-care portable immunosensor for non-invasive assessment of oro-ileal transit time by oral fluid tauroursodeoxycholate measurement after its oral load. | 2013 Jul-Aug | J Pharm Biomed Anal | pmid:23587552 |
| Wang R et al. | Defective canalicular transport and toxicity of dietary ursodeoxycholic acid in the abcb11-/- mouse: transport and gene expression studies. | 2013 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:23764895 |
| Shin J et al. | SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease. | 2013 | Cell Rep | pmid:24210820 |
| Yao XH et al. | Prenatal ethanol exposure causes glucose intolerance with increased hepatic gluconeogenesis and histone deacetylases in adult rat offspring: reversal by tauroursodeoxycholic acid. | 2013 | PLoS ONE | pmid:23544086 |
| Cai Z et al. | Endoplasmic reticulum stress participates in aortic valve calcification in hypercholesterolemic animals. | 2013 | Arterioscler. Thromb. Vasc. Biol. | pmid:23928865 |
| Mališová L et al. | Ursodeoxycholic acid but not tauroursodeoxycholic acid inhibits proliferation and differentiation of human subcutaneous adipocytes. | 2013 | PLoS ONE | pmid:24312631 |
| Gaspar JM et al. | Tauroursodeoxycholic acid protects retinal neural cells from cell death induced by prolonged exposure to elevated glucose. | 2013 | Neuroscience | pmid:24012838 |
| Xu H et al. | The ER luminal binding protein (BiP) alleviates Cd(2+)-induced programmed cell death through endoplasmic reticulum stress-cell death signaling pathway in tobacco cells. | 2013 | J. Plant Physiol. | pmid:23867017 |
| Takeda N et al. | Altered unfolded protein response is implicated in the age-related exacerbation of proteinuria-induced proximal tubular cell damage. | 2013 | Am. J. Pathol. | pmid:23871833 |
| Fang L et al. | Involvement of endoplasmic reticulum stress in albuminuria induced inflammasome activation in renal proximal tubular cells. | 2013 | PLoS ONE | pmid:23977286 |