| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypertension | D006973 | 115 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
Total
2
Tauroursodeoxycholic acid
Tauroursodeoxycholic acid is a lipid of Sterol Lipids (ST) class. Tauroursodeoxycholic acid is associated with abnormalities such as Hyperglycemia, Obesity, Wiskott-Aldrich Syndrome, neurogenic hypertension and Cholestatic liver disease. The involved functions are known as Cell Death, Apoptosis, Homeostasis, Process and mRNA Expression. Tauroursodeoxycholic acid often locates in Body tissue, Endoplasmic Reticulum, Hepatic, Blood and Protoplasm. The associated genes with Tauroursodeoxycholic acid are Homologous Gene and Mutant Proteins. The related lipids are cholanic acid, taurolithocholic acid 3-sulfate, Sterols, 7-dehydrocholesterol and tauromuricholic acid. The related experimental models are Disease model.
Cross Reference
Introduction
To understand associated biological information of Tauroursodeoxycholic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Tauroursodeoxycholic acid?
Tauroursodeoxycholic acid is suspected in Endothelial dysfunction, Hyperglycemia, Obesity, neurogenic hypertension, Cholestatic liver disease, Heart failure and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Diabetes (3)
- Am. J. Physiol. Heart Circ. Physiol. (1)
- Am. J. Physiol. Lung Cell Mol. Physiol. (1)
- Others (5)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Tauroursodeoxycholic acid
PubChem Associated disorders and diseases
What pathways are associated with Tauroursodeoxycholic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Tauroursodeoxycholic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Tauroursodeoxycholic acid?
Disease model
Disease model are used in the study 'Bile Acids Reduce Prion Conversion, Reduce Neuronal Loss, and Prolong Male Survival in Models of Prion Disease.' (Cortez LM et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Tauroursodeoxycholic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Luk AS et al. | Structural mechanisms of bile salt-induced growth of small unilamellar cholesterol-lecithin vesicles. | 1997 | Biochemistry | pmid:9153403 |
| Rodrigues CM et al. | Tauroursodeoxycholic acid prevents Bax-induced membrane perturbation and cytochrome C release in isolated mitochondria. | 2003 | Biochemistry | pmid:12627974 |
| Dreger SC et al. | Killing of rat basophilic leukemia cells by lethal toxin from Clostridium sordellii: critical role of phosphatidylinositide 3'-OH kinase/Akt signaling. | 2009 | Biochemistry | pmid:19199813 |
| Schulz F et al. | Prevention of Clostridium sordellii lethal toxin-induced apoptotic cell death by tauroursodeoxycholic acid. | 2009 | Biochemistry | pmid:19691300 |
| Solá S et al. | Modulation of nuclear steroid receptors by ursodeoxycholic acid inhibits TGF-beta1-induced E2F-1/p53-mediated apoptosis of rat hepatocytes. | 2004 | Biochemistry | pmid:15222754 |
| Albalak A et al. | Effects of submicellar bile salt concentrations on biological membrane permeability to low molecular weight non-ionic solutes. | 1996 | Biochemistry | pmid:8672496 |
| Henzel K et al. | Toxicity of ethanol and acetaldehyde in hepatocytes treated with ursodeoxycholic or tauroursodeoxycholic acid. | 2004 | Biochim. Biophys. Acta | pmid:14741743 |
| Macedo B et al. | Anti-apoptotic treatment reduces transthyretin deposition in a transgenic mouse model of Familial Amyloidotic Polyneuropathy. | 2008 | Biochim. Biophys. Acta | pmid:18572024 |
| Schulz S et al. | Progressive stages of mitochondrial destruction caused by cell toxic bile salts. | 2013 | Biochim. Biophys. Acta | pmid:23685124 |
| Reynier MO et al. | Intestinal cholesterol uptake from mixed micelles. In vitro effects of taurocholate, taurochenodeoxycholate and tauroursodeoxycholate. | 1981 | Biochim. Biophys. Acta | pmid:7272324 |
| Carubbi F et al. | Comparative cytotoxic and cytoprotective effects of taurohyodeoxycholic acid (THDCA) and tauroursodeoxycholic acid (TUDCA) in HepG2 cell line. | 2002 | Biochim. Biophys. Acta | pmid:11923098 |
| Venneman NG et al. | Effects of hydrophobic and hydrophilic bile salt mixtures on cholesterol crystallization in model biles. | 2002 | Biochim. Biophys. Acta | pmid:12117566 |
| Alvaro D et al. | Influence of tauroursodeoxycholic and taurodeoxycholic acids on hepatic metabolism and biliary secretion of phosphatidylcholine in the isolated rat liver. | 1986 | Biochim. Biophys. Acta | pmid:3756193 |
| Montet JC et al. | Mixed micelle properties and intestinal cholesterol uptake. | 1982 | Biochimie | pmid:7093350 |
| Zhou Q et al. | Effect of Tauroursodeoxycholic Acid and 4-Phenylbutyric Acid on Metabolism of Copper and Zinc in Type 1 Diabetic Mice Model. | 2016 | Biol Trace Elem Res | pmid:26282527 |
| Brandes V et al. | Protection from Clostridium difficile toxin B-catalysed Rac1/Cdc42 glucosylation by tauroursodeoxycholic acid-induced Rac1/Cdc42 phosphorylation. | 2012 | Biol. Chem. | pmid:22628301 |
| Zhang JY et al. | Effect of endoplasmic reticulum stress on porcine oocyte maturation and parthenogenetic embryonic development in vitro. | 2012 | Biol. Reprod. | pmid:22190710 |
| Cha BH et al. | The role of tauroursodeoxycholic acid on adipogenesis of human adipose-derived stem cells by modulation of ER stress. | 2014 | Biomaterials | pmid:24424209 |
| Zhang W et al. | Binding studies of bile acids using the native fluorescence of the tryptophan residue Of Bax protein. | 2006 | Biosci. Rep. | pmid:16850250 |
| Powell AA et al. | Resistance to ursodeoxycholic acid-induced growth arrest can also result in resistance to deoxycholic acid-induced apoptosis and increased tumorgenicity. | 2006 | BMC Cancer | pmid:16948850 |
| Lawless MW et al. | Expression of hereditary hemochromatosis C282Y HFE protein in HEK293 cells activates specific endoplasmic reticulum stress responses. | 2007 | BMC Cell Biol. | pmid:17650303 |
| Aranha MM et al. | Apoptosis-associated microRNAs are modulated in mouse, rat and human neural differentiation. | 2010 | BMC Genomics | pmid:20868483 |
| Klett EL et al. | A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol. | 2004 | BMC Med | pmid:15040800 |
| Taffetani S et al. | Prolactin stimulates the proliferation of normal female cholangiocytes by differential regulation of Ca2+-dependent PKC isoforms. | 2007 | BMC Physiol. | pmid:17640386 |
| Oshitari T et al. | Increased expression of phosphorylated c-Jun and phosphorylated c-Jun N-terminal kinase associated with neuronal cell death in diabetic and high glucose exposed rat retinas. | 2014 | Brain Res. Bull. | pmid:24333191 |
| Kim SY et al. | Tauroursodeoxycholate (TUDCA) inhibits neointimal hyperplasia by suppression of ERK via PKCα-mediated MKP-1 induction. | 2011 | Cardiovasc. Res. | pmid:21840882 |
| Xavier JM et al. | Tauroursodeoxycholic acid increases neural stem cell pool and neuronal conversion by regulating mitochondria-cell cycle retrograde signaling. | 2014 | Cell Cycle | pmid:25483094 |
| Elanchezhian R et al. | Low glucose under hypoxic conditions induces unfolded protein response and produces reactive oxygen species in lens epithelial cells. | 2012 | Cell Death Dis | pmid:22513875 |
| Ben Mosbah I et al. | Endoplasmic reticulum stress inhibition protects steatotic and non-steatotic livers in partial hepatectomy under ischemia-reperfusion. | 2010 | Cell Death Dis | pmid:21364657 |
| Mitra A et al. | Role of α-crystallin B as a regulatory switch in modulating cardiomyocyte apoptosis by mitochondria or endoplasmic reticulum during cardiac hypertrophy and myocardial infarction. | 2013 | Cell Death Dis | pmid:23559016 |
| Oishi N et al. | XBP1 mitigates aminoglycoside-induced endoplasmic reticulum stress and neuronal cell death. | 2015 | Cell Death Dis | pmid:25973683 |
| van der Harg JM et al. | The unfolded protein response mediates reversible tau phosphorylation induced by metabolic stress. | 2014 | Cell Death Dis | pmid:25165879 |
| Ozcan L et al. | Endoplasmic reticulum stress plays a central role in development of leptin resistance. | 2009 | Cell Metab. | pmid:19117545 |
| Shin J et al. | SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease. | 2013 | Cell Rep | pmid:24210820 |
| Song S et al. | Cholesterol-derived bile acids enhance the chaperone activity of α-crystallins. | 2011 | Cell Stress Chaperones | pmid:21380614 |
| Duan WM et al. | Tauroursodeoxycholic acid improves the survival and function of nigral transplants in a rat model of Parkinson's disease. | 2002 | Cell Transplant | pmid:12075985 |
| Yamashita Y et al. | High metabolic function of primary human and porcine hepatocytes in a polyurethane foam/spheroid culture system in plasma from patients with fulminant hepatic failure. | 2002 | Cell Transplant | pmid:12162378 |
| Viana RJ et al. | Tauroursodeoxycholic acid prevents E22Q Alzheimer's Abeta toxicity in human cerebral endothelial cells. | 2009 | Cell. Mol. Life Sci. | pmid:19189048 |
| Mannack G et al. | Taurolithocholic acid-3 sulfate impairs insulin signaling in cultured rat hepatocytes and perfused rat liver. | 2008 | Cell. Physiol. Biochem. | pmid:18209481 |
| Sommerfeld A et al. | Tauroursodeoxycholate Protects Rat Hepatocytes from Bile Acid-Induced Apoptosis via β1-Integrin- and Protein Kinase A-Dependent Mechanisms. | 2015 | Cell. Physiol. Biochem. | pmid:26044599 |
| Younce C and Kolattukudy P | MCP-1 induced protein promotes adipogenesis via oxidative stress, endoplasmic reticulum stress and autophagy. | 2012 | Cell. Physiol. Biochem. | pmid:22739135 |
| Ding W et al. | Involvement of Endoplasmic Reticulum Stress in Uremic Cardiomyopathy: Protective Effects of Tauroursodeoxycholic Acid. | 2016 | Cell. Physiol. Biochem. | pmid:26765262 |
| Roy A and Kolattukudy PE | Monocyte chemotactic protein-induced protein (MCPIP) promotes inflammatory angiogenesis via sequential induction of oxidative stress, endoplasmic reticulum stress and autophagy. | 2012 | Cell. Signal. | pmid:22820500 |
| Shen S et al. | Ursolic acid induces autophagy in U87MG cells via ROS-dependent endoplasmic reticulum stress. | 2014 | Chem. Biol. Interact. | pmid:24802810 |
| Basiglio CL et al. | Tauroursodeoxycholate counteracts hepatocellular lysis induced by tensioactive bile salts by preventing plasma membrane-micelle transition. | 2010 | Chem. Biol. Interact. | pmid:20797393 |
| Zhang J et al. | Baicalin protects AML-12 cells from lipotoxicity via the suppression of ER stress and TXNIP/NLRP3 inflammasome activation. | 2017 | Chem. Biol. Interact. | pmid:29031535 |
| Yeo J et al. | Effects of a multi-herbal extract on type 2 diabetes. | 2011 | Chin Med | pmid:21375727 |
| Cai Z et al. | Involvement of Endoplasmic Reticulum Stress-Mediated C/EBP Homologous Protein Activation in Coxsackievirus B3-Induced Acute Viral Myocarditis. | 2015 | Circ Heart Fail | pmid:25985795 |
| Dong Y et al. | Reduction of AMP-activated protein kinase alpha2 increases endoplasmic reticulum stress and atherosclerosis in vivo. | 2010 | Circulation | pmid:20124121 |
| Dromparis P et al. | Attenuating endoplasmic reticulum stress as a novel therapeutic strategy in pulmonary hypertension. | 2013 | Circulation | pmid:23149668 |